DE3786403T2 - Verfahren zur Synthese von N-Formyl-aspartyl-phenylalanin und dessen Methylester. - Google Patents

Verfahren zur Synthese von N-Formyl-aspartyl-phenylalanin und dessen Methylester.

Info

Publication number
DE3786403T2
DE3786403T2 DE87113554T DE3786403T DE3786403T2 DE 3786403 T2 DE3786403 T2 DE 3786403T2 DE 87113554 T DE87113554 T DE 87113554T DE 3786403 T DE3786403 T DE 3786403T DE 3786403 T2 DE3786403 T2 DE 3786403T2
Authority
DE
Germany
Prior art keywords
aspartyl
formyl
phenylalanine
synthesis
methyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE87113554T
Other languages
English (en)
Other versions
DE3786403D1 (de
Inventor
Toshiaki C O Tokai Plant Tsuji
Shinichi C O Tokai P Kishimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE3786403D1 publication Critical patent/DE3786403D1/de
Application granted granted Critical
Publication of DE3786403T2 publication Critical patent/DE3786403T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
DE87113554T 1986-09-04 1987-09-16 Verfahren zur Synthese von N-Formyl-aspartyl-phenylalanin und dessen Methylester. Expired - Lifetime DE3786403T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61208483A JPH085912B2 (ja) 1986-09-04 1986-09-04 Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
EP87113554A EP0307496B1 (de) 1986-09-04 1987-09-16 Verfahren zur Synthese von N-Formyl-aspartyl-phenylalanin und dessen Methylester

Publications (2)

Publication Number Publication Date
DE3786403D1 DE3786403D1 (de) 1993-08-05
DE3786403T2 true DE3786403T2 (de) 1993-10-14

Family

ID=39672046

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87113554T Expired - Lifetime DE3786403T2 (de) 1986-09-04 1987-09-16 Verfahren zur Synthese von N-Formyl-aspartyl-phenylalanin und dessen Methylester.

Country Status (4)

Country Link
US (1) US4810816A (de)
EP (1) EP0307496B1 (de)
JP (1) JPH085912B2 (de)
DE (1) DE3786403T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053532A (en) * 1988-02-12 1991-10-01 The Nutra Sweet Company One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
WO1992000953A1 (en) * 1988-02-12 1992-01-23 The Nutrasweet Company A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride
US4945172A (en) * 1988-02-12 1990-07-31 The Nutra Sweet Company Preparation of N-formyl-L-aspartic anhydride
AU649623B2 (en) * 1988-02-12 1994-06-02 Nutrasweet Company, The Process for the preparation of N-formyl-L-aspartic anhydride
JP2647420B2 (ja) * 1988-03-22 1997-08-27 三井東圧化学株式会社 Ｎ−保護−α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
JP2647439B2 (ja) * 1988-06-13 1997-08-27 三井東圧化学株式会社 Ｎ−保護−α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
US5183937A (en) * 1990-02-07 1993-02-02 The Nutrasweet Company Acetic acid recovery
DK0471833T3 (da) * 1990-03-12 1995-09-25 Nutrasweet Co Fremgangsmåde til forøgelse af alfa/beta-forholdet ved en aspartam-koblingsreaktion
JP3591004B2 (ja) 1994-09-28 2004-11-17 味の素株式会社 Ｎ−ホルミル−ｌ−アスパラギン酸無水物の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786039A (en) * 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
FR2078640A5 (en) * 1970-02-21 1971-11-05 Beecham Group Ltd Alpha-asparaginyl dipeptides prepn
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
IT1152488B (it) * 1982-08-06 1986-12-31 Pierrel Spa Procedimento per la preparazione dell'anidride dell'acido n-formil-l-aspartico
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法

Also Published As

Publication number Publication date
EP0307496A1 (de) 1989-03-22
DE3786403D1 (de) 1993-08-05
US4810816A (en) 1989-03-07
JPS6363699A (ja) 1988-03-22
JPH085912B2 (ja) 1996-01-24
EP0307496B1 (de) 1993-06-30

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Legal Events

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8364 No opposition during term of opposition