DE3751865D1 - Lasermagnetisches immuntestverfahren und vorrichtung dazu - Google Patents
Lasermagnetisches immuntestverfahren und vorrichtung dazuInfo
- Publication number
- DE3751865D1 DE3751865D1 DE3751865T DE3751865T DE3751865D1 DE 3751865 D1 DE3751865 D1 DE 3751865D1 DE 3751865 T DE3751865 T DE 3751865T DE 3751865 T DE3751865 T DE 3751865T DE 3751865 D1 DE3751865 D1 DE 3751865D1
- Authority
- DE
- Germany
- Prior art keywords
- test method
- device therefor
- immunity test
- laser magnetic
- magnetic immunity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22456786A JPH07111429B2 (ja) | 1986-09-22 | 1986-09-22 | レ−ザ−磁気免疫測定法 |
JP25242786A JPS63106559A (ja) | 1986-10-23 | 1986-10-23 | レ−ザ磁気免疫測定方法及び装置 |
JP61254164A JP2502546B2 (ja) | 1986-10-25 | 1986-10-25 | レ−ザ磁気免疫測定方法 |
JP2206287A JPS63188766A (ja) | 1987-02-02 | 1987-02-02 | レ−ザ磁気免疫測定法および測定装置 |
JP2206387A JPS63188764A (ja) | 1987-02-02 | 1987-02-02 | レ−ザ磁気免疫測定方法のための検体容器並びに該検体容器を用いた検体の調製方法 |
JP15279287A JP2509227B2 (ja) | 1987-06-19 | 1987-06-19 | レ−ザ磁気免疫測定装置 |
JP15279187A JPH07122636B2 (ja) | 1987-06-19 | 1987-06-19 | レ−ザ磁気免疫測定装置 |
JP62184902A JPH0820450B2 (ja) | 1987-07-24 | 1987-07-24 | レ−ザ磁気免疫測定方法及び装置 |
PCT/JP1987/000694 WO1988002118A1 (en) | 1986-09-22 | 1987-09-22 | Laser magnetic immunoassay method and apparatus therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3751865D1 true DE3751865D1 (de) | 1996-09-05 |
DE3751865T2 DE3751865T2 (de) | 1997-01-16 |
Family
ID=27571927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751865T Expired - Lifetime DE3751865T2 (de) | 1986-09-22 | 1987-09-22 | Lasermagnetisches immuntestverfahren und vorrichtung dazu |
Country Status (4)
Country | Link |
---|---|
US (1) | US5252493A (de) |
EP (1) | EP0287665B1 (de) |
DE (1) | DE3751865T2 (de) |
WO (1) | WO1988002118A1 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0339623B1 (de) * | 1988-04-26 | 1993-12-15 | Nippon Telegraph And Telephone Corporation | Lasermagnetisches Immuntestverfahren und Gerät dazu |
DE68916843T2 (de) * | 1988-04-26 | 1995-02-02 | Nippon Telegraph & Telephone | Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben. |
US5236824A (en) * | 1988-04-26 | 1993-08-17 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and method by a magnetophoresis apparatus therefor |
EP0479448A3 (en) * | 1990-10-02 | 1992-12-23 | Beckman Instruments, Inc. | Magnetic separation device |
US5445970A (en) * | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
US5445971A (en) * | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
JP2625578B2 (ja) * | 1992-03-20 | 1997-07-02 | アボツト・ラボラトリーズ | 磁気標識した結合要素を用いた結合親和力の測定方法 |
DE69333569T2 (de) * | 1992-03-20 | 2005-08-04 | Abbott Laboratories, Abbott Park | Magnetisch assistierte bindungsassays unter verwendung von magnetisch markierten bindungspartnern. |
TW239881B (de) * | 1992-12-22 | 1995-02-01 | Sienna Biotech Inc | |
US6200820B1 (en) | 1992-12-22 | 2001-03-13 | Sienna Biotech, Inc. | Light scatter-based immunoassay |
US5413939A (en) * | 1993-06-29 | 1995-05-09 | First Medical, Inc. | Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor |
JP3115501B2 (ja) * | 1994-06-15 | 2000-12-11 | プレシジョン・システム・サイエンス株式会社 | 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置 |
AU3493295A (en) * | 1994-08-31 | 1996-03-22 | First Medical, Inc. | Quantitative assays employing magnetizable particles for rate enhancement |
US6437563B1 (en) | 1997-11-21 | 2002-08-20 | Quantum Design, Inc. | Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes |
GB9726888D0 (en) * | 1997-12-20 | 1998-02-18 | Eev Ltd | Detection |
JP2000121511A (ja) * | 1998-10-13 | 2000-04-28 | Hitachi Koki Co Ltd | 自動分離抽出装置及びその制御方法 |
CA2358069A1 (en) * | 1999-01-06 | 2000-07-13 | University Of Medicine And Dentistry Of New Jersey | Method and apparatus for separating biological materials and other substances |
CN1185492C (zh) | 1999-03-15 | 2005-01-19 | 清华大学 | 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用 |
TW496775B (en) | 1999-03-15 | 2002-08-01 | Aviva Bioscience Corp | Individually addressable micro-electromagnetic unit array chips |
EP1325333A4 (de) * | 2000-10-10 | 2006-03-22 | Aviva Biosciences Corp | Array-chips mit einzeln adressierbarer mikroelektromagnetischer einheit in horizontalen konfigurationen |
EP1239284A1 (de) * | 2001-03-08 | 2002-09-11 | The Technology Partnership Public Limited Company | Nicht-trennender Testverfahren und System mit opaken Partikeln |
DE10130727C2 (de) * | 2001-06-21 | 2003-09-18 | Mediquant Gmbh | Verfahren und Vorrichtung zur Messung von Mikroviskositätsveränderungen als Immuntest |
JP4089808B2 (ja) * | 2001-12-25 | 2008-05-28 | ケミテック株式会社 | 上消し可能なマイクロカプセル磁気泳動表示シート |
US7018849B2 (en) * | 2002-01-15 | 2006-03-28 | Piasio Roger N | Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout |
US8697029B2 (en) * | 2002-04-18 | 2014-04-15 | The Regents Of The University Of Michigan | Modulated physical and chemical sensors |
ITBO20040420A1 (it) | 2004-07-07 | 2004-10-07 | Type S R L | Macchina per taglio e formatura di piattine metalliche |
ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
ITBO20050646A1 (it) | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | Metodo ed apparato per la caratterizzazione ed il conteggio di particelle |
ITTO20060226A1 (it) | 2006-03-27 | 2007-09-28 | Silicon Biosystem S P A | Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche |
US9068977B2 (en) * | 2007-03-09 | 2015-06-30 | The Regents Of The University Of Michigan | Non-linear rotation rates of remotely driven particles and uses thereof |
US8283912B2 (en) * | 2007-04-03 | 2012-10-09 | Koninklijke Philips Electronics N.V. | Sensor device with magnetic washing means |
ITTO20070771A1 (it) | 2007-10-29 | 2009-04-30 | Silicon Biosystems Spa | Metodo e apparato per la identificazione e manipolazione di particelle |
SE532617C2 (sv) * | 2007-11-13 | 2010-03-02 | Lifeassays Ab Publ | Spolmekanism för magnetisk detektor |
US7927561B2 (en) | 2008-01-10 | 2011-04-19 | Becton, Dickinson And Company | Rapid particle detection assay |
US10895575B2 (en) | 2008-11-04 | 2021-01-19 | Menarini Silicon Biosystems S.P.A. | Method for identification, selection and analysis of tumour cells |
IT1391619B1 (it) | 2008-11-04 | 2012-01-11 | Silicon Biosystems Spa | Metodo per l'individuazione, selezione e analisi di cellule tumorali |
CA3013992A1 (en) | 2008-12-30 | 2010-07-08 | Children's Medical Center Corporation | Method of predicting acute appendicitis |
CN102427883B (zh) | 2009-03-17 | 2014-08-20 | 硅生物系统股份公司 | 用于细胞隔离的微流体装置 |
WO2012012596A2 (en) * | 2010-07-22 | 2012-01-26 | University Of Houston System | Force-induced magnetization contrast for diagnosis and imaging |
US8638435B2 (en) * | 2010-07-27 | 2014-01-28 | Radiation Monitoring Devices, Inc. | Magnetic particle-based bioassays |
WO2012027747A2 (en) | 2010-08-27 | 2012-03-01 | The Regents Of The University Of Michigan | Asynchronous magnetic bead rotation sensing systems and methods |
DE102010041621B4 (de) * | 2010-09-29 | 2016-11-03 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Verfahren zum Transport magnetischer Partikel |
IT1403518B1 (it) | 2010-12-22 | 2013-10-31 | Silicon Biosystems Spa | Dispositivo microfluidico per la manipolazione di particelle |
WO2012142179A2 (en) | 2011-04-11 | 2012-10-18 | The Regents Of The University Of Michigan | Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells |
DE102011050550A1 (de) * | 2011-05-20 | 2012-11-22 | Wolfgang Göhde | Verfahren und Anordnung zur Quantifizierung von Untergruppen aus einer Mischpopulation von Zellen |
EP2541230A1 (de) | 2011-06-30 | 2013-01-02 | Koninklijke Philips Electronics N.V. | Erkennung von Clustern aus magnetischen Partikeln |
ITTO20110990A1 (it) | 2011-10-28 | 2013-04-29 | Silicon Biosystems Spa | Metodo ed apparato per l'analisi ottica di particelle a basse temperature |
ITBO20110766A1 (it) | 2011-12-28 | 2013-06-29 | Silicon Biosystems Spa | Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico |
US9797817B2 (en) | 2012-05-03 | 2017-10-24 | The Regents Of The University Of Michigan | Multi-mode separation for target detection |
WO2014163593A1 (en) * | 2013-04-03 | 2014-10-09 | Sanko Ozel Egitim Hizmetleri A.S. | A machine enabling separation of the blood by magnetism and autonomous radioactive substance marking of the white blood cells |
AU2014301652B2 (en) * | 2013-06-28 | 2018-04-19 | Cic Nanogune | Biosensor based on measurements of the clustering dynamics of magnetic particles |
US9983110B2 (en) | 2013-11-04 | 2018-05-29 | The Regents Of The University Of Michigan | Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes |
MX2017011601A (es) * | 2015-03-10 | 2017-11-17 | Microbix Biosystems Inc | Metodos, sistemas y aparato para seleccionar y procesar analitos. |
CN108051348A (zh) * | 2017-12-05 | 2018-05-18 | 西人马(厦门)科技有限公司 | 一种流体非金属颗粒浓度的检测系统及方法 |
US10161856B1 (en) * | 2018-01-19 | 2018-12-25 | Ping-Chieh Wu | Magneto-optical bio-detection devices having high sensitivity |
JP7411219B2 (ja) * | 2020-03-26 | 2024-01-11 | 国立研究開発法人産業技術総合研究所 | 磁場と重力を用いる標的物質検出装置及び標的物質検出方法 |
WO2024102837A1 (en) * | 2022-11-08 | 2024-05-16 | Zhong Li | Methods for detecting target compounds and uses thereof |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US849165A (en) * | 1906-12-11 | 1907-04-02 | Annie C Schneider | Drip-pan. |
US4152210A (en) * | 1971-08-27 | 1979-05-01 | Beecham Group Limited | Biologically active materials attached to a ferromagnetic support |
DE2409273A1 (de) * | 1974-02-27 | 1975-09-04 | Behringwerke Ag | Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen |
US3933997A (en) * | 1974-03-01 | 1976-01-20 | Corning Glass Works | Solid phase radioimmunoassay of digoxin |
US4001583A (en) * | 1974-10-04 | 1977-01-04 | Barrett M James | Covalently bound biological substances to plastic materials and use in radioassay |
US4018886A (en) * | 1975-07-01 | 1977-04-19 | General Electric Company | Diagnostic method and device employing protein-coated magnetic particles |
US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
US4272510A (en) * | 1976-04-26 | 1981-06-09 | Smith Kendall O | Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods |
US4171956A (en) * | 1977-06-13 | 1979-10-23 | General Electric Company | Laser immunoassay |
US4115535A (en) * | 1977-06-22 | 1978-09-19 | General Electric Company | Diagnostic method employing a mixture of normally separable protein-coated particles |
US4219335A (en) * | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
EP0030087A1 (de) * | 1979-11-13 | 1981-06-10 | Technicon Instruments Company Limited | Immunoassay-Verfahren und -Vorrichtung und Ausrüstung zur Durchführung des Verfahrens |
JPS57175957A (en) * | 1981-04-24 | 1982-10-29 | Chugai Pharmaceut Co Ltd | Measuring method and device for antigen- antibody reaction |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
FR2530029A1 (fr) * | 1982-07-06 | 1984-01-13 | Centre Nat Rech Scient | Nephelometre a laser perfectionne pour la detection des antigenes et des anticorps |
US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
DE3321238C2 (de) * | 1983-06-11 | 1985-05-02 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren und Vorrichtung zur Fusion von Zellen |
JPS60177265A (ja) * | 1984-02-24 | 1985-09-11 | Japan Synthetic Rubber Co Ltd | 抗体の免疫グロブリンのクラス別検出法 |
FI842992A0 (fi) * | 1984-07-26 | 1984-07-26 | Labsystems Oy | Immunologiskt definitionsfoerfarande. |
US4762413A (en) * | 1984-09-07 | 1988-08-09 | Olympus Optical Co., Ltd. | Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light |
JPS6165144A (ja) * | 1984-09-07 | 1986-04-03 | Olympus Optical Co Ltd | 光強度ゆらぎを用いる免疫反応測定装置 |
NL8403091A (nl) * | 1984-10-11 | 1986-05-01 | Gen Electric | Thermoplastisch mengsel met polyfunctionele verbinding. |
JPS61128168A (ja) * | 1984-11-27 | 1986-06-16 | Mitsubishi Chem Ind Ltd | 免疫分析方法 |
FI850481A0 (fi) * | 1985-02-06 | 1985-02-06 | Labsystems Oy | Foerfarande foer bestaemning av motmedel eller antigener. |
DE3669077D1 (de) * | 1985-03-08 | 1990-03-29 | Sanko Junyaku Co | Methode zur messung der menge eines immunantikoerpers im serum. |
JPS62104066A (ja) * | 1985-10-31 | 1987-05-14 | Toshiba Corp | 半導体保護装置 |
JPS62118255A (ja) * | 1985-11-19 | 1987-05-29 | Toshimitsu Musha | 磁界を用いた免疫反応の検出法 |
JPS62137988A (ja) * | 1985-12-12 | 1987-06-20 | Mitsubishi Electric Corp | 2値化画像処理方法 |
US4741619A (en) * | 1987-05-05 | 1988-05-03 | Molecular Devices Corporation | Hydrophilic microplates for vertical beam photometry |
US4859612A (en) * | 1987-10-07 | 1989-08-22 | Hygeia Sciences, Inc. | Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite |
US4990075A (en) * | 1988-04-11 | 1991-02-05 | Miles Inc. | Reaction vessel for performing sequential analytical assays |
JP2813275B2 (ja) * | 1992-10-30 | 1998-10-22 | 株式会社クボタ | 炊飯装置 |
JP3532222B2 (ja) * | 1992-11-25 | 2004-05-31 | ソニー株式会社 | 高能率符号化方法とその装置 |
-
1987
- 1987-09-22 EP EP87906109A patent/EP0287665B1/de not_active Expired - Lifetime
- 1987-09-22 WO PCT/JP1987/000694 patent/WO1988002118A1/ja active IP Right Grant
- 1987-09-22 DE DE3751865T patent/DE3751865T2/de not_active Expired - Lifetime
- 1987-09-22 US US07/221,248 patent/US5252493A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1988002118A1 (en) | 1988-03-24 |
EP0287665A1 (de) | 1988-10-26 |
DE3751865T2 (de) | 1997-01-16 |
US5252493A (en) | 1993-10-12 |
EP0287665B1 (de) | 1996-07-31 |
EP0287665A4 (en) | 1990-10-03 |
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