DE3709851A1 - Nmr-diagnostische fluessigkeitszusammensetzungen - Google Patents
Nmr-diagnostische fluessigkeitszusammensetzungenInfo
- Publication number
- DE3709851A1 DE3709851A1 DE19873709851 DE3709851A DE3709851A1 DE 3709851 A1 DE3709851 A1 DE 3709851A1 DE 19873709851 DE19873709851 DE 19873709851 DE 3709851 A DE3709851 A DE 3709851A DE 3709851 A1 DE3709851 A1 DE 3709851A1
- Authority
- DE
- Germany
- Prior art keywords
- nmr
- acid
- substances
- magnetic
- diagnostic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873709851 DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
| ES88730073T ES2052766T3 (es) | 1987-03-24 | 1988-03-23 | Composiciones magneticas en estado liquido. |
| AT88730073T ATE78175T1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
| DE8888730073T DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
| EP88730073A EP0284549B1 (de) | 1987-03-24 | 1988-03-23 | Magnetische Flüssigkeitszusammensetzungen |
| JP63068349A JP2663976B2 (ja) | 1987-03-24 | 1988-03-24 | 生理学的に認容される超常磁性液体組成物，その製造方法並びにそれよりなる画像形成ｎｍｒ，ｘ線及び超音波診断剤 |
| US07/638,134 US5160725A (en) | 1987-03-24 | 1991-01-04 | Magnetic liquid compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873709851 DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3709851A1 true DE3709851A1 (de) | 1988-10-06 |
Family
ID=6323973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873709851 Withdrawn DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
| DE8888730073T Expired - Lifetime DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888730073T Expired - Lifetime DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5160725A (enExample) |
| EP (1) | EP0284549B1 (enExample) |
| JP (1) | JP2663976B2 (enExample) |
| AT (1) | ATE78175T1 (enExample) |
| DE (2) | DE3709851A1 (enExample) |
| ES (1) | ES2052766T3 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240626A (en) * | 1990-09-21 | 1993-08-31 | Minnesota Mining And Manufacturing Company | Aqueous ferrofluid |
| DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| DE19514515A1 (de) * | 1995-04-12 | 1996-11-21 | Dirk Dipl Chem Guenther | Magnetisierbare Dispersionen |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612019A (en) * | 1988-12-19 | 1997-03-18 | Gordon, Deceased; David | Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles |
| US5385707A (en) * | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
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| GB8916780D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| GB8916782D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
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| US5358702A (en) * | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
| US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
| WO1991015753A1 (en) * | 1990-04-10 | 1991-10-17 | Unger Evan C | Polymers as contrast media for magnetic resonance imaging |
| US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| US5179955A (en) * | 1991-02-22 | 1993-01-19 | Molecular Biosystems, Inc. | Method of abdominal ultrasound imaging |
| DE4117782C2 (de) * | 1991-05-28 | 1997-07-17 | Diagnostikforschung Inst | Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel |
| US5407659A (en) * | 1991-10-22 | 1995-04-18 | Mallinckrodt Medical, Inc. | Treated calcium/oxyanion-containing particles for medical diagnostic imaging |
| US5342609A (en) * | 1991-10-22 | 1994-08-30 | Mallinckrodt Medical, Inc. | Microfluidization of calcium/oxyanion-containing particles |
| US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
| WO1993010440A1 (en) * | 1991-11-19 | 1993-05-27 | Unger Evan C | Gel particle contrast media for improved diagnostic imaging |
| US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| JPH05262673A (ja) * | 1992-03-19 | 1993-10-12 | Nippon Paint Co Ltd | 超音波診断用造影剤 |
| EP0580878B1 (en) * | 1992-06-01 | 1996-01-10 | BASF Aktiengesellschaft | The use of dispersions of magneto-ionic particles as MRI contrast media |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| JPH08501097A (ja) * | 1992-09-04 | 1996-02-06 | ザ ゼネラル ホスピタル コーポレーション | 臨床診断及び治療用部分を含む生体適合性ポリマー |
| US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| JPH08501776A (ja) * | 1992-09-16 | 1996-02-27 | ニユコメド・イメージング・アクシエセルカペト | 造影剤における又はそれに関する改良 |
| US5336923A (en) * | 1992-12-31 | 1994-08-09 | Honeywell, Inc. | Varactor diode having a stepped capacitance-voltage profile |
| US5916539A (en) * | 1993-03-02 | 1999-06-29 | Silica Gel Ges. M.B.H. | Superparamagnetic particles, process for producing the same and their use |
| US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| US5411730A (en) * | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| EP0772776B1 (de) * | 1994-07-27 | 2000-03-22 | Herbert Dr. Pilgrimm | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
| DE4428851C2 (de) * | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US5520904A (en) * | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
| WO1996040273A2 (en) * | 1995-06-07 | 1996-12-19 | Schering Aktiengesellschaft | Conjugates of ferrites and oligonucleotides, which bond specifically to certain target structures |
| WO1997025073A2 (en) | 1996-01-10 | 1997-07-17 | Nycomed Imaging A/S | Contrast media |
| GB9600427D0 (en) * | 1996-01-10 | 1996-03-13 | Nycomed Imaging As | Contrast media |
| DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| DE19612001A1 (de) * | 1996-03-18 | 1997-09-25 | Silica Gel Gmbh Adsorptions Te | Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung |
| US5855868A (en) * | 1996-04-01 | 1999-01-05 | Nycomed Imaging As | Method of T1 -weighted resonance imaging of RES organs |
| US6306384B1 (en) * | 1996-10-01 | 2001-10-23 | E-L Management Corp. | Skin battery cosmetic composition |
| US6143279A (en) * | 1997-08-29 | 2000-11-07 | The University Of North Carolina At Chapel Hill | Uridine 5'-diphosphate and analogs useful for treating lung diseases |
| US6841393B2 (en) | 1999-10-19 | 2005-01-11 | Kimberly-Clark Worldwide, Inc. | Selective removal of contaminants from a surface using colored particles and articles having magnets |
| GB2372703A (en) * | 1999-10-19 | 2002-09-04 | Kimberly Clark Co | Selective removal of contaminants from a surface using magnets |
| US6503761B1 (en) * | 1999-10-19 | 2003-01-07 | Kimberly-Clark Worldwide, Inc. | Selective removal of contaminants from a surface using articles having magnets |
| EP1397243B1 (en) * | 2001-04-13 | 2011-08-31 | Cornell Research Foundation, Inc. | Superparamagnetic nanostructured materials |
| US20030022203A1 (en) * | 2001-04-23 | 2003-01-30 | Rajan Kumar | Cellular Arrays |
| DE10154016B4 (de) * | 2001-10-26 | 2004-02-12 | Berlin Heart Ag | Magnetflüssigkeit und Verfahren zur ihrer Herstellung |
| BR0105499F1 (pt) * | 2001-11-05 | 2018-01-09 | Univ Minas Gerais | processo de obtenção de nanocompósitos ferrita/ciclodextrina e uso como dispositivos de descontaminação magneticamente dirigível |
| US20030185757A1 (en) * | 2002-03-27 | 2003-10-02 | Mayk Kresse | Iron-containing nanoparticles with double coating and their use in diagnosis and therapy |
| DE10222481A1 (de) * | 2002-05-22 | 2003-12-04 | Eucro Europe Contract Res Gmbh | Kontrastmittel für die Verwendung in bildgebenden Verfahren |
| WO2004034411A1 (de) * | 2002-10-09 | 2004-04-22 | Ferropharm Gmbh Forschungslabor | Stabilisierte superparamagnetische teilchen |
| US6887295B2 (en) * | 2002-10-25 | 2005-05-03 | Hoeganaes Corporation | Powder metallurgy lubricants, compositions, and methods for using the same |
| DE10331439B3 (de) | 2003-07-10 | 2005-02-03 | Micromod Partikeltechnologie Gmbh | Magnetische Nanopartikel mit verbesserten Magneteigenschaften |
| US7723311B2 (en) * | 2003-06-18 | 2010-05-25 | Nanobiomagnetics, Inc. | Delivery of bioactive substances to target cells |
| US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
| US7344491B1 (en) | 2003-11-26 | 2008-03-18 | Nanobiomagnetics, Inc. | Method and apparatus for improving hearing |
| KR20070052747A (ko) * | 2004-09-10 | 2007-05-22 | 도레이 가부시끼가이샤 | 의약품제제 |
| WO2006106513A2 (en) * | 2005-04-05 | 2006-10-12 | Bar-Ilan University | New core and core-shell nanoparticles containing iodine for x-ray imaging |
| US20070036026A1 (en) * | 2005-05-16 | 2007-02-15 | Laibinis Paul E | Magnetic Particle Systems and Methods |
| JP5321772B2 (ja) * | 2005-06-15 | 2013-10-23 | 戸田工業株式会社 | 磁性粒子含有医薬用原薬 |
| US20070098641A1 (en) * | 2005-11-02 | 2007-05-03 | General Electric Company | Nanoparticle-based imaging agents for X-ray/computed tomography |
| DE102005059751A1 (de) * | 2005-12-09 | 2007-06-14 | Ferropharm Gmbh Forschungslabor | Wässrige Dispersion von superparamagnetischen Eindomänenteilchen, deren Herstellung und Verwendung zur Diagnose und Therapie |
| KR100819378B1 (ko) * | 2006-02-24 | 2008-04-04 | (주)에이티젠 | 양친매성 화합물을 이용한 자성 나노복합체 및 이를포함하는 약제학적 조성물 |
| US20070297988A1 (en) * | 2006-06-21 | 2007-12-27 | Bin Wu | Optical probes for in vivo imaging |
| KR101489830B1 (ko) * | 2006-12-18 | 2015-02-04 | 콜로로삐아 이탈리아 에스.피.에이 | 발열요법에 적용하기 위한 자성 나노 입자, 그의 제조 및 약리 적용을 갖는 구조체에의 용도 |
| FR2921837B1 (fr) * | 2007-10-05 | 2015-07-31 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice organique couplee a des ligands de ciblage |
| WO2010101737A1 (en) | 2009-03-04 | 2010-09-10 | Lubrizol Advanced Materials, Inc. | Dispersant composition |
| GB2472446A (en) * | 2009-08-07 | 2011-02-09 | Ct Fuer Angewandte Nanotechnologie | Metal oxide particles coated with polyethylene glycol and their synthesis |
| JP2011057473A (ja) * | 2009-09-07 | 2011-03-24 | Univ Of Miyazaki | マグネタイト微粒子の製造方法 |
| US9205155B2 (en) * | 2009-10-30 | 2015-12-08 | General Electric Company | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
| US20110217379A1 (en) * | 2010-03-08 | 2011-09-08 | Davis Llp | Magnetic nanomaterials and methods for chemoembolisation |
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| DE102010020784A1 (de) * | 2010-05-18 | 2011-11-24 | Siemens Aktiengesellschaft | Verfahren zum Erkennen von magnetisch gekennzeichneten Objekten sowie entsprechende Vorrichtung |
| BR112013002346A2 (pt) | 2010-08-05 | 2018-02-20 | Hanwha Chemical Corp | preparação de nanopartículas paragmagnéticas ou pseudoparamagnéticas de tamanho extremamente pequeno e uniforme com base em óxido de ferro e agentes de contraste t1 de irm usando o mesmo |
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| FR3031063B1 (fr) | 2014-12-30 | 2017-02-10 | Biomerieux Sa | Complexe multicouches, procede de fabrication et utilisation du complexe |
| CN107551271B (zh) * | 2017-08-28 | 2020-11-27 | 上海长海医院 | 一种磁性-ros双重智能靶向纳米粒及其制备方法 |
Citations (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1978000005A1 (en) * | 1977-06-02 | 1978-12-07 | K H Mosbach | Magnetic polymer particles |
| DE2828941A1 (de) * | 1978-06-30 | 1980-01-10 | Robert Thomas Gordon | Mittel zur behandlung von krebs |
| EP0071564A1 (de) * | 1981-07-24 | 1983-02-09 | Schering Aktiengesellschaft | Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik |
| DE3401052A1 (de) * | 1983-01-21 | 1984-07-26 | Schering AG, 1000 Berlin und 4709 Bergkamen | Diagnostische mittel |
| DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
| EP0133603A1 (fr) * | 1983-08-12 | 1985-02-27 | Société anonyme: COMPAGNIE ORIS INDUSTRIE | Agents de relaxation spécifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie médicale par résonance magnétique nucléaire |
| EP0136812A2 (en) * | 1983-08-25 | 1985-04-10 | Technicare Corporation | Reagents for enhancing the contrast in NMR images |
| WO1985002772A1 (en) * | 1983-12-21 | 1985-07-04 | Schroeder Ulf | Diagnostic and contrast agent |
| WO1985004330A1 (en) * | 1984-03-29 | 1985-10-10 | Nyegaard & Co A/S | Use of ferromagnetic particles in contrast agents for nmr imaging and contrast agents |
| EP0160552A2 (en) * | 1984-04-27 | 1985-11-06 | Vestar, Inc. | Contrast agents for NMR imaging |
| WO1985005554A1 (en) * | 1984-05-31 | 1985-12-19 | Amersham International Plc | Nmr contrast agents |
| EP0165728A1 (en) * | 1984-05-30 | 1985-12-27 | Nycomed As | NMR contrast agents |
| EP0173163A1 (en) * | 1984-08-13 | 1986-03-05 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| DE3443251A1 (de) * | 1984-11-23 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Eisenoxid-komplexe fuer die nmr-diagnostik |
| DE3443252A1 (de) * | 1984-11-23 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dextran-magnetit-komplexe fuer die nmr-diagnostik |
| EP0184899A1 (en) * | 1984-11-01 | 1986-06-18 | Nycomed As | Paramagnetic contrast agents for use in "in vivo" diagnostic methods using NMR, and their preparation |
| EP0186616A1 (de) * | 1984-11-23 | 1986-07-02 | Schering Aktiengesellschaft | Magnetische Partikel für die Diagnostik |
| EP0186947A1 (en) * | 1984-11-01 | 1986-07-09 | Nycomed As | Paramagnetic contrast agents for use in "in vivo" diagnostic methods using NMR, and their preparation |
| DE3590398T1 (de) * | 1984-08-10 | 1986-08-28 | Fox Chase Cancer Center, Philadelphia, Pa. | Magnetische Mikroteilchen als Kontrastmittel für magnetische Kernresonanzabbildung |
| DE3508000A1 (de) * | 1985-03-04 | 1986-09-04 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Ferromagnetische partikel fuer die nmr-diagnostik |
| US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
| DE3518267A1 (de) * | 1985-05-17 | 1986-11-20 | Martin Prof. Dr. 1000 Berlin Wenzel | Mittel zur kontrast-erhoehung bei der kernspin-tomographie |
| US4637929A (en) * | 1985-01-04 | 1987-01-20 | Salutar, Inc. | Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| EP0210043A2 (en) * | 1985-07-19 | 1987-01-28 | Guerbet S.A. | Contrast agent for NMR scanning |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| WO1987001594A1 (en) * | 1985-09-11 | 1987-03-26 | Amersham International Plc | Contrast agent for nmr imaging |
| US4656026A (en) * | 1984-12-10 | 1987-04-07 | University Of Iowa Research Foundation | Magnetic resonance (MR) image enhancement compounds for specific areas of the brain |
| US4675173A (en) * | 1985-05-08 | 1987-06-23 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging of the liver and spleen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267234A (en) * | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| EP0184849A1 (de) * | 1984-12-12 | 1986-06-18 | Rainer Bauer | Aufnahmeeinrichtung für elektronische Bauelemente |
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
-
1987
- 1987-03-24 DE DE19873709851 patent/DE3709851A1/de not_active Withdrawn
-
1988
- 1988-03-23 DE DE8888730073T patent/DE3872741D1/de not_active Expired - Lifetime
- 1988-03-23 AT AT88730073T patent/ATE78175T1/de not_active IP Right Cessation
- 1988-03-23 ES ES88730073T patent/ES2052766T3/es not_active Expired - Lifetime
- 1988-03-23 EP EP88730073A patent/EP0284549B1/de not_active Expired - Lifetime
- 1988-03-24 JP JP63068349A patent/JP2663976B2/ja not_active Expired - Fee Related
-
1991
- 1991-01-04 US US07/638,134 patent/US5160725A/en not_active Expired - Fee Related
Patent Citations (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1978000005A1 (en) * | 1977-06-02 | 1978-12-07 | K H Mosbach | Magnetic polymer particles |
| DE2828941A1 (de) * | 1978-06-30 | 1980-01-10 | Robert Thomas Gordon | Mittel zur behandlung von krebs |
| EP0169299A2 (de) * | 1981-07-24 | 1986-01-29 | Schering Aktiengesellschaft | Verwendung von paramagnetischen Komplexsalzen zur Herstellung von Mitteln für die NMR-Diagnostik |
| EP0071564A1 (de) * | 1981-07-24 | 1983-02-09 | Schering Aktiengesellschaft | Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik |
| DE3129906A1 (de) * | 1981-07-24 | 1983-02-10 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Paramagnetische komplexsalze, deren herstellung und verwendung bei der nmr-diagnostik |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3401052A1 (de) * | 1983-01-21 | 1984-07-26 | Schering AG, 1000 Berlin und 4709 Bergkamen | Diagnostische mittel |
| DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
| EP0133603A1 (fr) * | 1983-08-12 | 1985-02-27 | Société anonyme: COMPAGNIE ORIS INDUSTRIE | Agents de relaxation spécifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie médicale par résonance magnétique nucléaire |
| EP0136812A2 (en) * | 1983-08-25 | 1985-04-10 | Technicare Corporation | Reagents for enhancing the contrast in NMR images |
| US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
| WO1985002772A1 (en) * | 1983-12-21 | 1985-07-04 | Schroeder Ulf | Diagnostic and contrast agent |
| WO1985004330A1 (en) * | 1984-03-29 | 1985-10-10 | Nyegaard & Co A/S | Use of ferromagnetic particles in contrast agents for nmr imaging and contrast agents |
| EP0160552A2 (en) * | 1984-04-27 | 1985-11-06 | Vestar, Inc. | Contrast agents for NMR imaging |
| EP0165728A1 (en) * | 1984-05-30 | 1985-12-27 | Nycomed As | NMR contrast agents |
| WO1985005554A1 (en) * | 1984-05-31 | 1985-12-19 | Amersham International Plc | Nmr contrast agents |
| DE3590398T1 (de) * | 1984-08-10 | 1986-08-28 | Fox Chase Cancer Center, Philadelphia, Pa. | Magnetische Mikroteilchen als Kontrastmittel für magnetische Kernresonanzabbildung |
| EP0173163A1 (en) * | 1984-08-13 | 1986-03-05 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| EP0186947A1 (en) * | 1984-11-01 | 1986-07-09 | Nycomed As | Paramagnetic contrast agents for use in "in vivo" diagnostic methods using NMR, and their preparation |
| EP0184899A1 (en) * | 1984-11-01 | 1986-06-18 | Nycomed As | Paramagnetic contrast agents for use in "in vivo" diagnostic methods using NMR, and their preparation |
| DE3443252A1 (de) * | 1984-11-23 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dextran-magnetit-komplexe fuer die nmr-diagnostik |
| DE3443251A1 (de) * | 1984-11-23 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Eisenoxid-komplexe fuer die nmr-diagnostik |
| EP0186616A1 (de) * | 1984-11-23 | 1986-07-02 | Schering Aktiengesellschaft | Magnetische Partikel für die Diagnostik |
| US4656026A (en) * | 1984-12-10 | 1987-04-07 | University Of Iowa Research Foundation | Magnetic resonance (MR) image enhancement compounds for specific areas of the brain |
| US4637929A (en) * | 1985-01-04 | 1987-01-20 | Salutar, Inc. | Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use |
| DE3508000A1 (de) * | 1985-03-04 | 1986-09-04 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Ferromagnetische partikel fuer die nmr-diagnostik |
| US4675173A (en) * | 1985-05-08 | 1987-06-23 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging of the liver and spleen |
| DE3518267A1 (de) * | 1985-05-17 | 1986-11-20 | Martin Prof. Dr. 1000 Berlin Wenzel | Mittel zur kontrast-erhoehung bei der kernspin-tomographie |
| EP0210043A2 (en) * | 1985-07-19 | 1987-01-28 | Guerbet S.A. | Contrast agent for NMR scanning |
| WO1987001594A1 (en) * | 1985-09-11 | 1987-03-26 | Amersham International Plc | Contrast agent for nmr imaging |
Non-Patent Citations (1)
| Title |
|---|
| DE-Z: Fortschr.Röntgenstr., Bd.145, H.2, 1986, S.130-139 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240626A (en) * | 1990-09-21 | 1993-08-31 | Minnesota Mining And Manufacturing Company | Aqueous ferrofluid |
| DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| DE19514515A1 (de) * | 1995-04-12 | 1996-11-21 | Dirk Dipl Chem Guenther | Magnetisierbare Dispersionen |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2052766T3 (es) | 1994-07-16 |
| JP2663976B2 (ja) | 1997-10-15 |
| DE3872741D1 (de) | 1992-08-20 |
| ATE78175T1 (de) | 1992-08-15 |
| EP0284549A3 (en) | 1989-09-13 |
| JPS63255237A (ja) | 1988-10-21 |
| EP0284549A2 (de) | 1988-09-28 |
| EP0284549B1 (de) | 1992-07-15 |
| US5160725A (en) | 1992-11-03 |
| DE3872741T (enExample) | 1992-08-20 |
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