ES2052766T3 - Composiciones magneticas en estado liquido. - Google Patents

Composiciones magneticas en estado liquido.

Info

Publication number
ES2052766T3
ES2052766T3 ES88730073T ES88730073T ES2052766T3 ES 2052766 T3 ES2052766 T3 ES 2052766T3 ES 88730073 T ES88730073 T ES 88730073T ES 88730073 T ES88730073 T ES 88730073T ES 2052766 T3 ES2052766 T3 ES 2052766T3
Authority
ES
Spain
Prior art keywords
liquid compositions
magnetic liquid
liquid state
substances
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88730073T
Other languages
English (en)
Spanish (es)
Inventor
Herbert Dr Pilgrimm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Silica Gel GmbH
Original Assignee
Silica Gel GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silica Gel GmbH filed Critical Silica Gel GmbH
Application granted granted Critical
Publication of ES2052766T3 publication Critical patent/ES2052766T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/20Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/80Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/80Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Soft Magnetic Materials (AREA)
ES88730073T 1987-03-24 1988-03-23 Composiciones magneticas en estado liquido. Expired - Lifetime ES2052766T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873709851 DE3709851A1 (de) 1987-03-24 1987-03-24 Nmr-diagnostische fluessigkeitszusammensetzungen

Publications (1)

Publication Number Publication Date
ES2052766T3 true ES2052766T3 (es) 1994-07-16

Family

ID=6323973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88730073T Expired - Lifetime ES2052766T3 (es) 1987-03-24 1988-03-23 Composiciones magneticas en estado liquido.

Country Status (6)

Country Link
US (1) US5160725A (enExample)
EP (1) EP0284549B1 (enExample)
JP (1) JP2663976B2 (enExample)
AT (1) ATE78175T1 (enExample)
DE (2) DE3709851A1 (enExample)
ES (1) ES2052766T3 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612019A (en) * 1988-12-19 1997-03-18 Gordon, Deceased; David Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
GB8916782D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
GB8916780D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5547682A (en) * 1989-12-22 1996-08-20 Bioquest, Incorporated Preparation and use of novel injectable RES avoiding inorganic particles for medical application
US5358702A (en) * 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
ES2138122T3 (es) * 1990-04-10 2000-01-01 Imarx Pharmaceutical Corp Polimeros como medios de contraste para resonancia magnetica.
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5240626A (en) * 1990-09-21 1993-08-31 Minnesota Mining And Manufacturing Company Aqueous ferrofluid
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5179955A (en) * 1991-02-22 1993-01-19 Molecular Biosystems, Inc. Method of abdominal ultrasound imaging
DE4117782C2 (de) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel
US5407659A (en) * 1991-10-22 1995-04-18 Mallinckrodt Medical, Inc. Treated calcium/oxyanion-containing particles for medical diagnostic imaging
US5344640A (en) * 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
US5342609A (en) * 1991-10-22 1994-08-30 Mallinckrodt Medical, Inc. Microfluidization of calcium/oxyanion-containing particles
CA2121681A1 (en) * 1991-11-19 1993-05-27 Evan C. Unger Gel particle contrast media for improved diagnostic imaging
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
JPH05262673A (ja) * 1992-03-19 1993-10-12 Nippon Paint Co Ltd 超音波診断用造影剤
ATE132758T1 (de) * 1992-06-01 1996-01-15 Basf Ag Anwendung von dispersionen von magneto-ionischen partikeln in mri-kontrast-mitteln
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
WO1994005203A1 (en) * 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
US5718884A (en) * 1992-09-16 1998-02-17 Nycomed Imaging As Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells
US5336923A (en) * 1992-12-31 1994-08-09 Honeywell, Inc. Varactor diode having a stepped capacitance-voltage profile
WO1994021240A2 (de) * 1993-03-17 1994-09-29 Silica Gel Ges.M.B.H Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
JP3436760B2 (ja) * 1994-07-27 2003-08-18 ハーバート ピルグリム 超常磁性粒子
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
DE19514515C2 (de) * 1995-04-12 1997-03-20 Dirk Dipl Chem Guenther Magnetisierbare Dispersionen
WO1996040273A2 (en) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Conjugates of ferrites and oligonucleotides, which bond specifically to certain target structures
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
CZ219498A3 (cs) 1996-01-10 1998-12-16 Nycomed Imaging A/S Kontrastní prostředek
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
DE19612001A1 (de) 1996-03-18 1997-09-25 Silica Gel Gmbh Adsorptions Te Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung
US5855868A (en) * 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
US6306384B1 (en) * 1996-10-01 2001-10-23 E-L Management Corp. Skin battery cosmetic composition
CN1268056A (zh) * 1997-08-29 2000-09-27 查珀尔希尔北卡罗来纳大学 尿苷5’-二磷酸酯及其类似物在治疗肺疾病中的应用
US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
MXPA02003912A (es) * 1999-10-19 2002-09-30 Kimberly Clark Co Remocion selectiva de contaminantes de una superficie usando imanes.
US6503761B1 (en) 1999-10-19 2003-01-07 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using articles having magnets
WO2003049936A1 (en) * 2001-04-13 2003-06-19 Cornell Research Foundation, Inc. Superparamagnetic nanostructured materials
US20030022203A1 (en) * 2001-04-23 2003-01-30 Rajan Kumar Cellular Arrays
DE10154016B4 (de) * 2001-10-26 2004-02-12 Berlin Heart Ag Magnetflüssigkeit und Verfahren zur ihrer Herstellung
BR0105499F1 (pt) * 2001-11-05 2018-01-09 Univ Minas Gerais processo de obtenção de nanocompósitos ferrita/ciclodextrina e uso como dispositivos de descontaminação magneticamente dirigível
US20030185757A1 (en) * 2002-03-27 2003-10-02 Mayk Kresse Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
DE10222481A1 (de) * 2002-05-22 2003-12-04 Eucro Europe Contract Res Gmbh Kontrastmittel für die Verwendung in bildgebenden Verfahren
DE50213399D1 (de) * 2002-10-09 2009-05-07 Pilgrimm Helga Stabilisierte superparamagnetische teilchen
US6887295B2 (en) * 2002-10-25 2005-05-03 Hoeganaes Corporation Powder metallurgy lubricants, compositions, and methods for using the same
DE10331439B3 (de) * 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetische Nanopartikel mit verbesserten Magneteigenschaften
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
WO2006028129A1 (ja) * 2004-09-10 2006-03-16 Toray Industries, Inc. 医薬品製剤
WO2006106513A2 (en) * 2005-04-05 2006-10-12 Bar-Ilan University New core and core-shell nanoparticles containing iodine for x-ray imaging
US20070036026A1 (en) * 2005-05-16 2007-02-15 Laibinis Paul E Magnetic Particle Systems and Methods
JP5321772B2 (ja) * 2005-06-15 2013-10-23 戸田工業株式会社 磁性粒子含有医薬用原薬
US20070098640A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
DE102005059751A1 (de) * 2005-12-09 2007-06-14 Ferropharm Gmbh Forschungslabor Wässrige Dispersion von superparamagnetischen Eindomänenteilchen, deren Herstellung und Verwendung zur Diagnose und Therapie
KR100848931B1 (ko) * 2006-02-24 2008-07-29 (주)에이티젠 양친매성 화합물 및 조직 특이적 결합 성분을 이용한지능형 자성 나노복합체 및 이를 포함하는 조영제
US20070297988A1 (en) * 2006-06-21 2007-12-27 Bin Wu Optical probes for in vivo imaging
PL2117600T3 (pl) * 2006-12-18 2013-05-31 Colorobbia Italiana Spa Magnetyczne nanocząsteczki do stosowania w hipertermii, ich wytwarzanie i zastosowanie w konstruktach o zastosowaniu farmakologicznym
FR2921837B1 (fr) * 2007-10-05 2015-07-31 Guerbet Sa Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice organique couplee a des ligands de ciblage
BRPI1009763A2 (pt) 2009-03-04 2016-03-15 Lubrizol Advanced Mat Inc composição, e , uso de um composto.
GB2472446A (en) * 2009-08-07 2011-02-09 Ct Fuer Angewandte Nanotechnologie Metal oxide particles coated with polyethylene glycol and their synthesis
JP2011057473A (ja) * 2009-09-07 2011-03-24 Univ Of Miyazaki マグネタイト微粒子の製造方法
US9205155B2 (en) 2009-10-30 2015-12-08 General Electric Company Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents
US20110217379A1 (en) * 2010-03-08 2011-09-08 Davis Llp Magnetic nanomaterials and methods for chemoembolisation
KR20130054238A (ko) * 2010-04-01 2013-05-24 회가나에스 코오포레이션 자성 분말 야금 재료
JP5608851B2 (ja) * 2010-04-08 2014-10-15 サンノプコ株式会社 金属酸化物粒子分散体
DE102010020784A1 (de) * 2010-05-18 2011-11-24 Siemens Aktiengesellschaft Verfahren zum Erkennen von magnetisch gekennzeichneten Objekten sowie entsprechende Vorrichtung
CN103153348B (zh) 2010-08-05 2016-03-02 韩华石油化学株式会社 极其小且均匀尺寸的氧化铁基顺磁性或伪顺磁性纳米颗粒的制备和使用所述纳米颗粒的mri t1显影剂
KR101805873B1 (ko) 2011-08-03 2018-01-10 한화케미칼 주식회사 단당류 인산 또는 그 유도체로 표면이 개질된 친수성 나노입자, 그의 콜로이드 용액 및 그 용도
US8895068B2 (en) 2010-12-15 2014-11-25 General Electric Company Nanoparticle composition and associated methods thereof
US8889103B2 (en) 2010-12-15 2014-11-18 General Electric Company Diagnostic agent composition and associated methods thereof
KR101303567B1 (ko) * 2011-03-08 2013-09-23 주식회사 인트론바이오테크놀로지 카르복실기가 도입된 만난으로 코팅된 자기공명영상 조영제 및 그것의 제조 방법
CN102924977A (zh) * 2012-11-06 2013-02-13 广东工业大学 一种磁性Fe3O4 纳米粒子表面改性的方法
US11033640B2 (en) * 2013-03-15 2021-06-15 The Regents Of The University Of California Enteric CT contrast material based on low-z atoms
US10624976B2 (en) 2014-04-01 2020-04-21 Centre National De La Recherche Scientifique Dendronized metallic oxide nanoparticles, a process for preparing the same and their uses
FR3031063B1 (fr) 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
CN107551271B (zh) * 2017-08-28 2020-11-27 上海长海医院 一种磁性-ros双重智能靶向纳米粒及其制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431214B (sv) * 1977-06-02 1984-01-23 Klaus H Mosbach Sett att framstella magnetiska polymerpartiklar som berare av en foretredesvis biologiskt aktiv substans
US4267234A (en) * 1978-03-17 1981-05-12 California Institute Of Technology Polyglutaraldehyde synthesis and protein bonding substrates
GB2024007B (en) * 1978-06-30 1983-04-27 Gordon R T Cancer-treating composition containing inductively heatable particles
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4423158A (en) * 1983-01-27 1983-12-27 Gelinnovation Handelsaktiebolag Ion adsorbent for metals having a coordination number greater than two
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
FR2550449B1 (fr) * 1983-08-12 1986-01-31 Commissariat Energie Atomique Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
CA1243602A (en) * 1983-08-25 1988-10-25 Hong-Ning Yeung Methods for enhancing the contrast in nmr imaging
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
GB8413772D0 (en) * 1984-05-30 1984-07-04 Nyegaard & Co As Chemical compounds
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
CA1268208A (en) * 1984-08-10 1990-04-24 Truman Brown Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging
US4749560A (en) * 1984-08-13 1988-06-07 Research Corporation Metal organo phosphorous compounds for NMR analysis
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
EP0184899B1 (en) * 1984-11-01 1990-04-18 Nycomed As Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
PT81498B (pt) * 1984-11-23 1987-12-30 Schering Ag Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas
DE3508000A1 (de) * 1985-03-04 1986-09-04 Schering AG, Berlin und Bergkamen, 1000 Berlin Ferromagnetische partikel fuer die nmr-diagnostik
DE3443251C2 (de) * 1984-11-23 1998-03-12 Schering Ag Eisenoxid-Komplexe für die NMR-Diagnostik, diese Verbindungen enthaltende diagnostische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
DE3443252A1 (de) * 1984-11-23 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Dextran-magnetit-komplexe fuer die nmr-diagnostik
US4656026A (en) * 1984-12-10 1987-04-07 University Of Iowa Research Foundation Magnetic resonance (MR) image enhancement compounds for specific areas of the brain
EP0184849A1 (de) * 1984-12-12 1986-06-18 Rainer Bauer Aufnahmeeinrichtung für elektronische Bauelemente
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
DE3518267A1 (de) * 1985-05-17 1986-11-20 Martin Prof. Dr. 1000 Berlin Wenzel Mittel zur kontrast-erhoehung bei der kernspin-tomographie
GB8518300D0 (en) * 1985-07-19 1985-08-29 Amersham Int Plc Contrast agent
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles

Also Published As

Publication number Publication date
EP0284549B1 (de) 1992-07-15
DE3872741T (enExample) 1992-08-20
DE3709851A1 (de) 1988-10-06
EP0284549A3 (en) 1989-09-13
US5160725A (en) 1992-11-03
JPS63255237A (ja) 1988-10-21
JP2663976B2 (ja) 1997-10-15
DE3872741D1 (de) 1992-08-20
EP0284549A2 (de) 1988-09-28
ATE78175T1 (de) 1992-08-15

Similar Documents

Publication Publication Date Title
ES2052766T3 (es) Composiciones magneticas en estado liquido.
ATE45287T1 (de) Enterales kontrastmittel fuer die kernspintomographie und dessen herstellung.
DE3786005D1 (de) Traeger zur freisetzung mit einem an eine amphiphile substanz gekoppelten wirkstoff.
Tabor et al. MR of the salivary glands
BR0013791A (pt) Dispositivo para fins terapêuticos em tecido humano, de modo a influenciar partìculas magnéticas injetadas com um campo de gradiente eletromagnético alternado
ES2075468T3 (es) Vehiculos de suministro de farmacos suspendidos en un portador perfluorado no acuoso.
ATE71834T1 (de) Liposomzubereitung und ihre herstellung.
DE3779500D1 (de) Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
Forest et al. Cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials
ES2040228T3 (es) Preparado farmaceutico de emision prolongada.
ES2114878T3 (es) Representacion visual por resonancia magnetica.
AR001073A1 (es) Benzoilguanidinas basicamente sustituidas procedimientos para su preparación su empleo como medicamento o agente de diagnostico asi como medicamento que las contiene
ES2743740T3 (es) Aducto de ciclodextrina-panobinostat
ES8702145A1 (es) Procedimiento para la preparacion de un polvo para heridas, libremente fluyente, homogeneo, conteniendo yodoforo
DE3684953D1 (de) Verwendung einer waessrigen chloritmatrix-loesung zur herstellung von arzneimitteln zur intravenoesen behandlung von tumoren.
KR20180132566A (ko) 엽산 수용체 타겟팅 종양 진단 방사성 프로브의 개발 및 응용
CN215194914U (zh) 一种耳鼻喉科病人鼻部上药护理装置
ES2080954T3 (es) Uso de beta-aletina en cultivos de celulas y en terapia.
DE60001096D1 (de) Lipidmembran zusammensetzungen
Thorp Jr et al. Submucous myomas treated with gonadotropin releasing hormone agonist and resulting in vaginal hemorrhage. A case report
ES2031462T3 (es) Procedimiento para producir 1-b-d-arabinofuranosilcitosina-5'-estearilfosfato monosodico y monohidrato de la misma, y compuesto farmaceutico que contiene esta ultima.
GEYER et al. Triglyceride utilization by human HeLa and conjunctiva cells in tissue culture
AR048138A1 (es) Formulacion farmaceutica de liberacion controlada
Seregni et al. State of the art of palliative therapy
Wada et al. Permanent ventricular cannula, simplified multiple electrode system and behavioural observation box for the Macaca monkey

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 284549

Country of ref document: ES