DE3630866C2 - Verfahren und Vorrichtung zur Aufbringung von Flüssigkeit auf einer dünnen Probe - Google Patents
Verfahren und Vorrichtung zur Aufbringung von Flüssigkeit auf einer dünnen ProbeInfo
- Publication number
- DE3630866C2 DE3630866C2 DE3630866A DE3630866A DE3630866C2 DE 3630866 C2 DE3630866 C2 DE 3630866C2 DE 3630866 A DE3630866 A DE 3630866A DE 3630866 A DE3630866 A DE 3630866A DE 3630866 C2 DE3630866 C2 DE 3630866C2
- Authority
- DE
- Germany
- Prior art keywords
- slide
- liquid
- gap
- slides
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims description 77
- 238000000034 method Methods 0.000 title claims description 40
- 239000000463 material Substances 0.000 claims description 24
- 230000002745 absorbent Effects 0.000 claims description 17
- 239000002250 absorbent Substances 0.000 claims description 17
- 239000006096 absorbing agent Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 45
- 125000006850 spacer group Chemical group 0.000 description 36
- 239000003153 chemical reaction reagent Substances 0.000 description 30
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 16
- 238000010186 staining Methods 0.000 description 12
- 230000009471 action Effects 0.000 description 10
- 229960002685 biotin Drugs 0.000 description 9
- 239000011616 biotin Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 235000020958 biotin Nutrition 0.000 description 8
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 6
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 108090001008 Avidin Proteins 0.000 description 5
- 241001510071 Pyrrhocoridae Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000003298 DNA probe Substances 0.000 description 4
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
- 230000000712 assembly Effects 0.000 description 4
- 238000000429 assembly Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- JORABGDXCIBAFL-UHFFFAOYSA-M iodonitrotetrazolium chloride Chemical compound [Cl-].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C=CC=CC=2)=N1 JORABGDXCIBAFL-UHFFFAOYSA-M 0.000 description 3
- 239000002853 nucleic acid probe Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 108020004518 RNA Probes Proteins 0.000 description 2
- 239000003391 RNA probe Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000012192 staining solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- MZQMNOHLXGCPFX-UHFFFAOYSA-N (3-bromo-4-chloro-1H-indol-5-yl) dihydrogen phosphate Chemical compound OP(O)(=O)OC1=CC=C2NC=C(Br)C2=C1Cl MZQMNOHLXGCPFX-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- GPKUGWDQUVWHIC-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine tetrahydrochloride Chemical compound Cl.Cl.Cl.Cl.NNC1=CC=C(C=C1)C1=CC=C(NN)C=C1 GPKUGWDQUVWHIC-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N2001/1031—Sampling from special places
- G01N2001/1037—Sampling from special places from an enclosure (hazardous waste, radioactive)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24802—Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]
- Y10T428/24926—Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.] including ceramic, glass, porcelain or quartz layer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/775,864 US4731335A (en) | 1985-09-13 | 1985-09-13 | Method for treating thin samples on a surface employing capillary flow |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3630866A1 DE3630866A1 (de) | 1987-03-26 |
| DE3630866C2 true DE3630866C2 (de) | 1996-12-12 |
Family
ID=25105771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3630866A Expired - Lifetime DE3630866C2 (de) | 1985-09-13 | 1986-09-11 | Verfahren und Vorrichtung zur Aufbringung von Flüssigkeit auf einer dünnen Probe |
Country Status (4)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19933838A1 (de) * | 1999-07-20 | 2001-02-01 | Max Planck Gesellschaft | Nadel und Verfahren zum Transfer von Liquiden sowie Verfahren zum Herstellen der Nadel |
| DE10239739A1 (de) * | 2002-08-29 | 2004-12-23 | Leica Mikrosysteme Gmbh | Vorrichtung und Verfahren zur Durchführung von immunolosichen Markierungstechniken für Gewebedünnschnitte |
| US7303729B2 (en) | 2003-02-28 | 2007-12-04 | Leica Mikrosysteme Gmbh | Apparatus and method for immunological labeling for thin tissue sections |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023187A (en) * | 1985-09-13 | 1991-06-11 | Fisher Scientific Company | Method and device for accelerated treatment of thin sample on surface |
| US5002736A (en) * | 1987-03-31 | 1991-03-26 | Fisher Scientific Co. | Microscope slide and slide assembly |
| GB8722902D0 (en) * | 1987-09-30 | 1987-11-04 | Shandon Southern Prod | Tissue &c processing |
| US4832914A (en) * | 1988-02-08 | 1989-05-23 | Board Of Regents/The University Of Texas System | Two-dimensional uniformly fed unstirred chemical reactor |
| GB8809611D0 (en) * | 1988-04-22 | 1988-05-25 | Darougar S | Deposition apparatus |
| EP0366241A3 (en) * | 1988-10-04 | 1990-05-23 | Fisher Scientific Company | Device with adsorbent surface and method |
| US5237016A (en) * | 1989-01-05 | 1993-08-17 | Siska Diagnostics, Inc. | End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids |
| AU636875B2 (en) * | 1989-03-17 | 1993-05-13 | Abbott Laboratories | Method and device for improved reaction kinetics in nucleic acid hybridizations |
| ES2063348T3 (es) * | 1989-04-11 | 1995-01-01 | Ars Holding 89 Nv | Vehiculo de ensayo multianalitico. |
| US4935374A (en) * | 1989-05-02 | 1990-06-19 | Eastman Kodak Company | Polyethylene evaporation covers |
| US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US4975250A (en) * | 1989-08-21 | 1990-12-04 | Fisher Scientific Co. | Aligned slideholder and assembly |
| US5116727A (en) * | 1989-08-31 | 1992-05-26 | Iniziative Marittime 1991, S.R.L. | Hybridization method and composition with alternating polysaccharide of sulfated N-acetylgalactosamine |
| US5270012A (en) * | 1989-09-06 | 1993-12-14 | Toa Medical Electronics Co., Ltd. | Synethic apparatus for inspection of blood |
| US5116732A (en) * | 1989-09-11 | 1992-05-26 | Fisher Scientific Co. | Tetrazolium halide compounds and methods |
| US5346672A (en) * | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
| US5021218A (en) * | 1990-01-19 | 1991-06-04 | Dlp, Inc. | Apparatus for transporting specimen slides |
| US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
| US5192503A (en) * | 1990-05-23 | 1993-03-09 | Mcgrath Charles M | Probe clip in situ assay apparatus |
| DE69132905T2 (de) * | 1990-12-06 | 2002-08-01 | Affymetrix Inc N D Ges D Staat | Detektion von Nukleinsäuresequenzen |
| US5273905A (en) * | 1991-02-22 | 1993-12-28 | Amoco Corporation | Processing of slide mounted material |
| JP2554115Y2 (ja) * | 1991-03-22 | 1997-11-12 | 澄晴 野地 | スライドグラス用ホルダ |
| US5213766A (en) * | 1991-04-30 | 1993-05-25 | Apogee Designs, Ltd. | Liquid collecting apparatus for sample testing |
| US5696887A (en) | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
| US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| US6849462B1 (en) | 1991-11-22 | 2005-02-01 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| US5354370A (en) * | 1992-04-15 | 1994-10-11 | Hacker Industries, Inc. | Tissue processor |
| US20040191128A1 (en) * | 1992-05-11 | 2004-09-30 | Cytologix Corporation | Slide stainer with heating |
| US6180061B1 (en) | 1992-05-11 | 2001-01-30 | Cytologix Corporation | Moving platform slide stainer with heating elements |
| US5947167A (en) * | 1992-05-11 | 1999-09-07 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| ES2119166T3 (es) * | 1993-02-03 | 1998-10-01 | Histaggen Inc | Sistema de encapsulacion y aparato de histocitoquimica automatica destinados al tratamiento de sustancias biologicas. |
| US5965454A (en) * | 1993-02-03 | 1999-10-12 | Histaggen Incorporated | Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials |
| US5492837A (en) * | 1993-08-27 | 1996-02-20 | Biogenex Laboratories | Mounting medium for microscope slide preparations |
| US7625697B2 (en) | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| US7323298B1 (en) | 1994-06-17 | 2008-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray for determining the relative abundances of polynuceotide sequences |
| US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| US20020022261A1 (en) * | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
| JP3643863B2 (ja) * | 1995-08-09 | 2005-04-27 | アークレイ株式会社 | 液体保持具とその製造方法 |
| US5632959A (en) * | 1995-08-14 | 1997-05-27 | Mohajer; Reza S. | Combination holder for specimen slide |
| US5804141A (en) * | 1996-10-15 | 1998-09-08 | Chianese; David | Reagent strip slide treating apparatus |
| US7285422B1 (en) * | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
| DE19782096T1 (de) | 1996-11-06 | 2000-03-23 | Sequenom Inc | Immobiliserung von Nucleinsäuren in hoher Dichte |
| AU735416B2 (en) | 1996-11-06 | 2001-07-05 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| US6703247B1 (en) * | 1996-12-23 | 2004-03-09 | American Registry Of Pathology | Apparatus and methods for efficient processing of biological samples on slides |
| US5958341A (en) * | 1996-12-23 | 1999-09-28 | American Registry Of Pathology | Apparatus for efficient processing of tissue samples on slides |
| US6489171B1 (en) * | 1997-04-18 | 2002-12-03 | Cell Marque Corporation | Chemical dispensing system and method |
| US5989692A (en) | 1997-09-02 | 1999-11-23 | Cytonix Corporation | Porous surface for laboratory apparatus and laboratory apparatus having said surface |
| DE69804653T2 (de) * | 1997-10-31 | 2002-11-28 | Pe Corp Ny Foster City | Verfahren und vorrichtung zur herstellung von matrixen von proben |
| US5882930A (en) * | 1997-11-10 | 1999-03-16 | Hyseq, Inc. | Reagent transfer device |
| US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
| US5957167A (en) * | 1997-12-18 | 1999-09-28 | Pharmacopeia, Inc. | Article for dispensing small volumes of liquid |
| US6050719A (en) | 1998-01-30 | 2000-04-18 | Affymetrix, Inc. | Rotational mixing method using a cartridge having a narrow interior |
| US6565813B1 (en) * | 1998-02-04 | 2003-05-20 | Merck & Co., Inc. | Virtual wells for use in high throughput screening assays |
| US6582962B1 (en) * | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6096271A (en) * | 1998-02-27 | 2000-08-01 | Cytologix Corporation | Random access slide stainer with liquid waste segregation |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| US6183693B1 (en) | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
| US6350618B1 (en) | 1998-04-27 | 2002-02-26 | Corning Incorporated | Redrawn capillary imaging reservoir |
| EP0955084B1 (en) | 1998-04-27 | 2006-07-26 | Corning Incorporated | Method of depositing an array of biological samples using a redrawn capillary reservoir |
| US6884626B1 (en) | 1998-04-27 | 2005-04-26 | Corning Incorporated | Redrawn capillary imaging reservoir |
| US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6020995A (en) * | 1998-05-15 | 2000-02-01 | Systec Inc. | Folding rack for microscope slides |
| US6094301A (en) * | 1998-05-15 | 2000-07-25 | Systec Inc. | Folding rack for vertical presentation of microscope slides |
| US6762061B1 (en) | 1998-07-03 | 2004-07-13 | Corning Incorporated | Redrawn capillary imaging reservoir |
| US6309891B1 (en) * | 1998-09-09 | 2001-10-30 | Incyte Genomics, Inc. | Capillary printing systems |
| CA2356354A1 (en) * | 1998-12-23 | 2000-07-06 | American Registry Of Pathology | Apparatus and methods for efficient processing of biological samples on slides |
| US6416642B1 (en) * | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US6673620B1 (en) * | 1999-04-20 | 2004-01-06 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
| US6399394B1 (en) | 1999-06-30 | 2002-06-04 | Agilent Technologies, Inc. | Testing multiple fluid samples with multiple biopolymer arrays |
| US6258593B1 (en) * | 1999-06-30 | 2001-07-10 | Agilent Technologies Inc. | Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber |
| EP1204851A1 (en) | 1999-07-21 | 2002-05-15 | Dako A/S | A method of controlling the temperature of a specimen in or on a solid support member |
| EP1230029A1 (en) * | 1999-07-23 | 2002-08-14 | Merck & Co., Inc. | Method and apparatus for transferring small volume liquid samples |
| DE19948087B4 (de) * | 1999-10-06 | 2008-04-17 | Evotec Ag | Verfahren zur Herstellung eines Reaktionssubstrats |
| US6386749B1 (en) * | 2000-06-26 | 2002-05-14 | Affymetrix, Inc. | Systems and methods for heating and mixing fluids |
| US20040018615A1 (en) * | 2000-08-02 | 2004-01-29 | Garyantes Tina K. | Virtual wells for use in high throughput screening assays |
| EP1332000B1 (en) | 2000-10-30 | 2012-06-20 | Sequenom, Inc. | Method for delivery of submicroliter volumes onto a substrate |
| US20020068022A1 (en) * | 2000-12-04 | 2002-06-06 | Jinghua Schneider | Mini-tube rack |
| JP4766789B2 (ja) * | 2001-07-10 | 2011-09-07 | トミー工業株式会社 | スライドガラスの遠心機用ラック |
| AU2002326663A1 (en) * | 2001-08-16 | 2003-03-03 | Amersham Biosciences Corporation | Fixtures for use in parallel processing bio-chips |
| US7425306B1 (en) | 2001-09-11 | 2008-09-16 | Ventana Medical Systems, Inc. | Slide heater |
| SE0103072D0 (sv) * | 2001-09-17 | 2001-09-17 | Pharmacia Diagnostics Ab | Multi-analyte assay device with multi-spot detection zone |
| US6939032B2 (en) * | 2001-10-25 | 2005-09-06 | Erie Scientific Company | Cover slip mixing apparatus |
| US7270785B1 (en) * | 2001-11-02 | 2007-09-18 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
| US7943093B2 (en) * | 2001-12-12 | 2011-05-17 | Erie Scientific Company | Cover slip |
| ATE292793T1 (de) * | 2002-01-22 | 2005-04-15 | Mpb Meltec Patent Und Beteilig | Verfahren und vorrichtung für die probenvorbereitung zur analyse von biologischen proben |
| EP1890127B1 (en) * | 2002-04-15 | 2013-07-03 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
| US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| CN1650159A (zh) * | 2002-04-26 | 2005-08-03 | 万堂医药系统公司 | 具有固定载玻片平台的自动化分子病理学装置 |
| US7537936B2 (en) * | 2002-05-31 | 2009-05-26 | Agilent Technologies, Inc. | Method of testing multiple fluid samples with multiple biopolymer arrays |
| US7919308B2 (en) * | 2002-06-14 | 2011-04-05 | Agilent Technologies, Inc. | Form in place gaskets for assays |
| CN105258988A (zh) * | 2002-06-20 | 2016-01-20 | 徕卡病理系统墨尔本控股有限公司 | 带有排放机构的生物反应装置 |
| AUPS309002A0 (en) * | 2002-06-20 | 2002-07-11 | Vision Biosystems Limited | A covertile for a substrate |
| AU2003901871A0 (en) * | 2003-03-31 | 2003-05-08 | Vision Biosystems Limited | A method and apparatus for fluid dispensation, preparation and dilation |
| DE10251338B4 (de) * | 2002-11-05 | 2008-05-21 | Intavis Bioanalytical Instruments Ag | Vorrichtung zur Durchführung von Färbe- und Hybridisierungsreaktionen |
| WO2005000469A1 (en) * | 2003-06-16 | 2005-01-06 | Schering Corporation | Virtual well plate system |
| HUP0301911A2 (hu) * | 2003-06-24 | 2005-03-29 | 3Dhistech Kft. | Tárgylemezadagoló-egység automatikus szkennelő mikroszkóphoz |
| WO2005001443A1 (en) * | 2003-06-25 | 2005-01-06 | Waters Investments Limited | An apparatus used to prevent cross-contamination along a platform and methods of manufacturing the same |
| DE10336849A1 (de) | 2003-08-11 | 2005-03-10 | Thinxxs Gmbh | Flusszelle |
| US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
| US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
| US9518899B2 (en) * | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
| US7744817B2 (en) * | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
| US7517498B2 (en) * | 2003-08-19 | 2009-04-14 | Agilent Technologies, Inc. | Apparatus for substrate handling |
| JP3879001B2 (ja) * | 2003-11-06 | 2007-02-07 | 独立行政法人情報通信研究機構 | 生物試料を高精度に測定する方法 |
| DE102004062280A1 (de) * | 2003-12-29 | 2005-07-28 | Siemens Ag | Verfahren und Vorrichtung zum Dispensieren von Flüssigkeiten im Mikroraster |
| US7238535B2 (en) * | 2004-09-01 | 2007-07-03 | World Properties, Inc. | Test cell for evaluating phosphor |
| EP1658897A1 (en) * | 2004-11-22 | 2006-05-24 | Roche Diagnostics GmbH | Bent microfluidic device |
| US7514044B2 (en) * | 2004-11-24 | 2009-04-07 | Cytyc Corporation | Vial presentation module, slide dispenser and slide presentation module |
| NO321927B1 (no) | 2004-12-23 | 2006-07-24 | Oystein Ljungmann | Apparat for utforelse av behandlingsoperasjoner pa objektglass med vevsprover |
| US20060218994A1 (en) * | 2005-03-31 | 2006-10-05 | Szu-Min Lin | Monitoring of cleaning process |
| US20060246576A1 (en) * | 2005-04-06 | 2006-11-02 | Affymetrix, Inc. | Fluidic system and method for processing biological microarrays in personal instrumentation |
| CA2623241A1 (en) * | 2005-04-21 | 2006-11-02 | Celerus Diagnostics, Inc. | Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry |
| US20070175897A1 (en) * | 2006-01-24 | 2007-08-02 | Labcyte Inc. | Multimember closures whose members change relative position |
| US8459509B2 (en) | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
| US20080081368A1 (en) * | 2006-10-03 | 2008-04-03 | Anne Marie Bailey | Method and apparatus that increases efficiency and reproducibility in immunohistochemistry and immunocytochemistry |
| US20090170152A1 (en) * | 2007-06-01 | 2009-07-02 | Ventana Medical Systems, Inc. | Tissue Conditioning Protocols |
| US20090180931A1 (en) | 2007-09-17 | 2009-07-16 | Sequenom, Inc. | Integrated robotic sample transfer device |
| JP5474080B2 (ja) | 2008-11-12 | 2014-04-16 | ヴェンタナ メディカル システムズ， インコーポレイテッド | 標本担持スライドを加熱するための装置 |
| CN101403667B (zh) * | 2008-11-18 | 2011-10-05 | 中国科学院上海硅酸盐研究所 | 一种用于制备连接件标准抗弯强度测试样品的夹具 |
| IN2012DN03245A (US20020095090A1-20020718-M00002.png) | 2009-11-13 | 2015-10-23 | Ventana Med Syst Inc | |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
| US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
| US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
| SG11201401911XA (en) | 2011-09-30 | 2014-08-28 | Life Technologies Corp | Systems and methods for biological analysis |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| WO2014184005A1 (en) * | 2013-05-15 | 2014-11-20 | Koninklijke Philips N.V. | Tissue separation from a sample |
| WO2015086484A1 (en) | 2013-12-13 | 2015-06-18 | Ventana Medical Systems, Inc. | Automated histological processing of biological specimens and associated technology |
| US10209166B2 (en) | 2014-11-18 | 2019-02-19 | Alfonso Heras | System and method for processing biological specimens |
| DE202015004524U1 (de) * | 2015-06-24 | 2016-09-29 | C. Gerhardt GmbH & Co. KG | Analyseeinrichtung für die Elementaranalyse |
| EP4164796A4 (en) * | 2020-06-10 | 2024-03-06 | 10x Genomics, Inc. | FLUID DISTRIBUTION PROCESSES |
| CN115773920B (zh) * | 2021-09-06 | 2024-04-19 | 南京泰立瑞信息科技有限公司 | 一种低损耗、自动化的切片样本染色方法和系统 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2119773A (en) * | 1933-10-20 | 1938-06-07 | Ernest G Buckner | Coin container and assorter |
| US2119407A (en) * | 1937-08-14 | 1938-05-31 | Edwin C Weiskopf | Means for filing micro-slides |
| US2302830A (en) * | 1940-10-30 | 1942-11-24 | Sol A Axelrad | Microscope test slide |
| US2415480A (en) * | 1945-04-02 | 1947-02-11 | Ethel M Gassert | Blood count equipment |
| US2488535A (en) * | 1945-08-04 | 1949-11-22 | Joseph H Meyer Brothers | Bead dipping apparatus |
| US2511730A (en) * | 1948-04-09 | 1950-06-13 | Harry A Mcclain | Holder and file for photographic slides |
| US2863319A (en) * | 1958-02-04 | 1958-12-09 | Mclin Marvin Hampton | Capillary pipette |
| US3005375A (en) * | 1959-05-06 | 1961-10-24 | Sherman Leonard | Blood typing slides |
| DE1180166B (de) * | 1961-12-06 | 1964-10-22 | Dr Egon Stahl | Breitband-Pipette, insbesondere fuer Papier- und Duennschichtchromatographie sowie fuer Elektrophorese, zum Auftragen von Fluessigkeiten auf Sorptionsschichten |
| US3358496A (en) * | 1965-08-03 | 1967-12-19 | Larry B Farmer | Chromatographic applicator |
| GB1244844A (en) * | 1967-07-27 | 1971-09-02 | Jack Fielding | Specimen holder for use with an optical measuring instrument |
| US3656833A (en) * | 1970-06-29 | 1972-04-18 | Medical Plastics Inc | Combined plastic-glass microscope slides |
| US3736042A (en) * | 1971-05-05 | 1973-05-29 | Clinical Sciences Inc | Microscope slide assembly |
| US3837795A (en) * | 1971-11-05 | 1974-09-24 | Biomatics Instr Corp | Method and apparatus for staining slides |
| US3904781A (en) * | 1973-10-15 | 1975-09-09 | Donald E Henry | Method of preparing cells for inspection |
| US3961346A (en) * | 1975-01-30 | 1976-06-01 | Miles Laboratories, Inc. | Liquid inspection slide |
| JPS5295491U (US20020095090A1-20020718-M00002.png) * | 1976-01-16 | 1977-07-16 | ||
| US4199613A (en) * | 1977-10-11 | 1980-04-22 | Miles Laboratories, Inc. | Staining method by capillary action |
| US4129093A (en) * | 1977-10-11 | 1978-12-12 | Miles Laboratories, Inc. | Staining apparatus |
| US4233029A (en) * | 1978-10-25 | 1980-11-11 | Eastman Kodak Company | Liquid transport device and method |
| CA1129498A (en) * | 1978-10-25 | 1982-08-10 | Richard L. Columbus | Structural configuration and method for transport of a liquid drop through an ingress aperture |
| US4323536A (en) * | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
| US4308028A (en) * | 1980-04-14 | 1981-12-29 | Elkins Carlos D | Device and method for the chemical testing and microscopic examination of liquid specimens |
| US4320157A (en) * | 1980-08-08 | 1982-03-16 | Hagens Gunther Von | Method for preserving large sections of biological tissue with polymers |
| IT1137192B (it) * | 1981-07-03 | 1986-09-03 | Montedison Spa | Composizioni poliolefiniche rinforzate con mica |
| US4377641A (en) * | 1981-10-22 | 1983-03-22 | The United States Of America As Represented By The Secretary Of The Air Force | Method and apparatus for the continuous extraction of ingredients from samples |
| DE3313127A1 (de) * | 1982-04-28 | 1983-11-03 | Bio-Innovations, Camp Hill, Pa. | Vorrichtung zum faerben von biologischen proben |
| US4501496A (en) * | 1982-05-07 | 1985-02-26 | Griffin Gladys B | Specimen slide for analysis of liquid specimens |
| US4607921A (en) * | 1982-09-20 | 1986-08-26 | V-Tech, Inc. | Wet mount microscopic examination slide II |
| US4447140A (en) * | 1982-09-29 | 1984-05-08 | Campbell Jeptha E | Microscope slides |
| US4624882A (en) * | 1982-11-15 | 1986-11-25 | Sybron Corporation | Microscope slide with raised marking surface |
| US4481246A (en) * | 1982-11-15 | 1984-11-06 | Sybron Corporation | Microscope slide with raised marking surface |
| US4549952A (en) * | 1982-11-22 | 1985-10-29 | Eastman Kodak Company | Capillary transport device having means for increasing the viscosity of the transported liquid |
| US4441793A (en) * | 1983-01-10 | 1984-04-10 | Elkins Carlos D | Microscopic evaluation slide |
| US4518565A (en) * | 1983-06-06 | 1985-05-21 | Miles Laboratories, Inc. | Reagent test device holder |
| US4679914A (en) * | 1985-09-13 | 1987-07-14 | Erie Scientific Company | Microscope slide with top and bottom marking surfaces |
-
1985
- 1985-09-13 US US06/775,864 patent/US4731335A/en not_active Expired - Lifetime
-
1986
- 1986-09-11 DE DE3630866A patent/DE3630866C2/de not_active Expired - Lifetime
- 1986-09-12 JP JP61215578A patent/JPS6298231A/ja active Granted
- 1986-09-15 GB GB08622191A patent/GB2180647A/en active Granted
-
1987
- 1987-03-31 US US07/032,875 patent/US4798706A/en not_active Expired - Fee Related
- 1987-03-31 US US07/032,874 patent/US4801431A/en not_active Expired - Lifetime
- 1987-03-31 US US07/033,073 patent/US4777020A/en not_active Expired - Fee Related
-
1992
- 1992-09-03 JP JP4236067A patent/JPH0670603B2/ja not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19933838A1 (de) * | 1999-07-20 | 2001-02-01 | Max Planck Gesellschaft | Nadel und Verfahren zum Transfer von Liquiden sowie Verfahren zum Herstellen der Nadel |
| DE10239739A1 (de) * | 2002-08-29 | 2004-12-23 | Leica Mikrosysteme Gmbh | Vorrichtung und Verfahren zur Durchführung von immunolosichen Markierungstechniken für Gewebedünnschnitte |
| DE10239739B4 (de) * | 2002-08-29 | 2006-05-11 | Leica Mikrosysteme Gmbh | Vorrichtung und Verfahren zur Durchführung von immunologischen Markierungstechniken für Gewebedünnschnitte |
| US7303729B2 (en) | 2003-02-28 | 2007-12-04 | Leica Mikrosysteme Gmbh | Apparatus and method for immunological labeling for thin tissue sections |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2180647A (en) | 1987-04-01 |
| US4731335B1 (US20020095090A1-20020718-M00002.png) | 1991-07-09 |
| JPS6298231A (ja) | 1987-05-07 |
| US4801431A (en) | 1989-01-31 |
| US4777020A (en) | 1988-10-11 |
| GB2180647B (US20020095090A1-20020718-M00002.png) | 1989-11-22 |
| US4798706A (en) | 1989-01-17 |
| US4731335A (en) | 1988-03-15 |
| JPH05240748A (ja) | 1993-09-17 |
| GB8622191D0 (en) | 1986-10-22 |
| JPH0511857B2 (US20020095090A1-20020718-M00002.png) | 1993-02-16 |
| JPH0670603B2 (ja) | 1994-09-07 |
| DE3630866A1 (de) | 1987-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3630866C2 (de) | Verfahren und Vorrichtung zur Aufbringung von Flüssigkeit auf einer dünnen Probe | |
| DE69836562T2 (de) | Kasette zur bearbeitung einer auf der oberfläche eines trägers angebrachten probe | |
| DE68914182T2 (de) | Verfahren und Vorrichtung zur beschleunigten Behandlung einer dünnen Probe auf einer Oberfläche. | |
| DE69719782T2 (de) | Vorrichtung und verfahren zum durchfuehren von assays | |
| DE3855885T2 (de) | Bearbeitungsprozess von Geweben oder dergleichen | |
| DE2847444C2 (de) | Mikroelektrophoretische Vorrichtung zum Trennen und Identifizieren von Komponenten von zwei oder mehr Proteinsystemen | |
| EP0843169B1 (de) | Vorrichtung zur Bearbeitung von Proben auf Objekträgern | |
| EP3265796B1 (de) | Gelelektrophorese-system für einzelzell-gelelektrophorese | |
| CH627280A5 (US20020095090A1-20020718-M00002.png) | ||
| EP0163799A1 (de) | Mit Antigenen oder Antikörpern beschichteter Träger | |
| DE1642821C3 (de) | Vorrichtung zum Herstellen eines Objektträgers für elektrophoretisch zu untersuchende Proben, z.B. Blutsera, und Verfahren zum Herstellen eines solchen Objektträgers | |
| DE2844008B2 (de) | Halteeinrichtung fur mehrere Mikroskop-Objektträger | |
| DE10309211A1 (de) | Vorrichtung und Verfahren zur immunologischen Markierung für Gewebedünnschnitte | |
| EP0124882A1 (de) | Vorrichtung zum Aufsedimentieren von Teilen einer Probenflüssigkeit auf einen Objektträger | |
| DE10239739B4 (de) | Vorrichtung und Verfahren zur Durchführung von immunologischen Markierungstechniken für Gewebedünnschnitte | |
| DE3313127A1 (de) | Vorrichtung zum faerben von biologischen proben | |
| DE102008056583B4 (de) | Verfahren und Vorrichtung zur Feststellung der Reagenzienqualität | |
| DE10018788B4 (de) | Prozessieren von Proteinen aus Gelen für massenspektrometrische Analysen | |
| DE60034173T2 (de) | Schablone und Verfahren zu deren Verwendung | |
| WO2001070399A1 (de) | Mikrohybridisierungskammer | |
| DE10251338B4 (de) | Vorrichtung zur Durchführung von Färbe- und Hybridisierungsreaktionen | |
| EP3973288B1 (de) | Mikrofluidisches analysesystem zur analyse von blutproben | |
| DE3107964A1 (de) | Gestell fuer ein mikroanalysensystem | |
| DE102017130395A1 (de) | Verfahren zur ortsaufgelösten, flüssigkeitsunterstützten Untersuchung einer auf einem Objektträger angeordneten mikroskopischen Probe, Kompartimentierungseinrichtung und Untersuchungssystem | |
| CA1336653C (en) | Method and apparatus for treating thin sample on a surface employing capillary flow |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: FISHER SCIENTIFIC CO., PITTSBURGH, PA., US |
|
| 8110 | Request for examination paragraph 44 | ||
| 8127 | New person/name/address of the applicant |
Owner name: BIOTEK SOLUTIONS, INC., SANTA BARBARA, CALIF., US |
|
| 8128 | New person/name/address of the agent |
Representative=s name: PATENT- UND RECHTSANWAELTE WUESTHOFF & WUESTHOFF, |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |