DE3584260D1 - Die synthese eines proteins mittels eines identifizierungspeptids. - Google Patents

Die synthese eines proteins mittels eines identifizierungspeptids.

Info

Publication number
DE3584260D1
DE3584260D1 DE8585300432T DE3584260T DE3584260D1 DE 3584260 D1 DE3584260 D1 DE 3584260D1 DE 8585300432 T DE8585300432 T DE 8585300432T DE 3584260 T DE3584260 T DE 3584260T DE 3584260 D1 DE3584260 D1 DE 3584260D1
Authority
DE
Germany
Prior art keywords
identification peptide
functional protein
protein
hybrid polypeptide
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585300432T
Other languages
English (en)
Inventor
Thomas P Hopp
Susan L Bektesh
Iii Paul J Conlon
Carl J March
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Aldrich Co LLC
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24293537&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3584260(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DE3584260D1 publication Critical patent/DE3584260D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/28Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin
DE8585300432T 1984-01-24 1985-01-23 Die synthese eines proteins mittels eines identifizierungspeptids. Expired - Lifetime DE3584260D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/573,825 US4703004A (en) 1984-01-24 1984-01-24 Synthesis of protein with an identification peptide

Publications (1)

Publication Number Publication Date
DE3584260D1 true DE3584260D1 (de) 1991-11-07

Family

ID=24293537

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585300432T Expired - Lifetime DE3584260D1 (de) 1984-01-24 1985-01-23 Die synthese eines proteins mittels eines identifizierungspeptids.

Country Status (5)

Country Link
US (1) US4703004A (de)
EP (1) EP0150126B1 (de)
JP (1) JPH074255B2 (de)
AT (1) ATE68014T1 (de)
DE (1) DE3584260D1 (de)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002200A1 (en) * 1983-11-14 1985-05-23 Chiron Corporation Interleukin-2 production using cloned genes for interleukin-2 and yeast alpha-factor
US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
US6808901B1 (en) * 1984-09-03 2004-10-26 Celltech R&D Limited Production of chimeric antibodies
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5853978A (en) * 1985-12-04 1998-12-29 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
US6534285B1 (en) * 1984-12-24 2003-03-18 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
JPS61264000A (ja) * 1985-03-21 1986-11-21 イミユネツクス コ−ポレイシヨン 標識ペプチドによるタンパク質の合成
EP0207044A1 (de) * 1985-06-20 1986-12-30 Monsanto Company Freisetzung von Peptiden aus Polypeptiden
EP0440311A1 (de) * 1985-06-20 1991-08-07 Fujisawa Pharmaceutical Co., Ltd. Herstellungsverfahren für menschliches alpha-Atrio-natriuretisches Polypeptid
US4828799A (en) * 1985-06-26 1989-05-09 Research Corporation Therapeutic drug monitoring and analyte determination utilizing micellar chromatography
FR2594846B1 (fr) * 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4851341A (en) * 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5215896A (en) * 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
US5200509A (en) * 1987-04-06 1993-04-06 Celtrix Pharmaceuticals, Inc. Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides
FR2615528B1 (fr) * 1987-05-18 1991-05-24 Pasteur Institut Procede de production d'un polypeptide ayant des proprietes choisies determinees, dans un organisme-hote transforme par un adn recombinant contenant des sequences nucleiques codant pour ce polypeptide et pour une proteine affine d'ose
ZA887773B (en) 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
ZA888978B (en) * 1987-12-04 1990-07-25 Du Pont Immobilized interleukin 2 and interleukin 2 containing a carboxylterminal extension
US4931498A (en) * 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4927879A (en) * 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
USRE39760E1 (en) * 1988-03-31 2007-08-07 International Bio-Immune Systems Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
US5108919A (en) * 1988-06-24 1992-04-28 Genentech, Inc. Dna sequences encoding yeast ubiquitin hydrolase
US5262322A (en) * 1988-06-24 1993-11-16 Genentech, Inc. Host transformed with yeast gene and ubiquitin/polypeptide fusions
US5156968A (en) * 1988-06-24 1992-10-20 Genentech, Inc. Purified yeast ubiquitin hydrolase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
ZA902949B (en) * 1989-05-05 1992-02-26 Res Dev Foundation A novel antibody delivery system for biological response modifiers
DE69019609T2 (de) * 1989-07-07 1995-11-30 Takeda Chemical Industries Ltd Proteine und deren Herstellung.
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
US5595887A (en) * 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
WO1992006191A1 (en) * 1990-09-28 1992-04-16 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
US6083686A (en) * 1990-10-26 2000-07-04 Johnson & Johnson Clinical Diagnostic Systems, Inc. Increased production of Thermus aquaticus DNA polymerase in E. coli
CZ109393A3 (en) * 1990-12-13 1994-01-19 Upjohn Co Bonded proteins
US5270197A (en) * 1990-12-20 1993-12-14 The Children's Medical Center Corporation Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
ES2287206T3 (es) * 1991-03-01 2007-12-16 Dyax Corporation Proceso para el desarrollo de mini-proteinas de union.
ES2123515T3 (es) 1991-03-29 1999-01-16 Immunex Corp Antagonistas de citoquinas a base de proteinas virales aisladas.
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5731425A (en) * 1994-10-28 1998-03-24 Eastman Kodak Company Polypeptide surface marker for cells
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US5795966A (en) 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
EP1666591B1 (de) 1995-06-29 2011-03-23 Immunex Corporation Cytokin welches Apoptose induziert
US5908839A (en) 1995-08-24 1999-06-01 Magainin Pharmaceuticals, Inc. Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
WO1998028424A2 (en) 1996-12-23 1998-07-02 Immunex Corporation Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily
US6913749B2 (en) * 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
WO2002100432A1 (en) * 2001-06-08 2002-12-19 Genaera Corporation Methods for the modulation of il-13
WO2000077179A2 (en) 1999-06-16 2000-12-21 Icos Corporation Human poly(adp-ribose) polymerase 2 materials and methods
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
WO2001068674A2 (en) * 2000-03-13 2001-09-20 Monsanto Technology Llc Preparation of recombinant proteins containing repeating units
AU5566701A (en) 2000-04-25 2001-11-07 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
EP1939203B1 (de) 2000-04-25 2014-11-19 ICOS Corporation Hemmer der delta-Isoform der menschlichen Phosphatidyl-Inositol-3-Kinase
DE60138922D1 (de) * 2000-10-10 2009-07-16 Univ Oklahoma Vergleichende ligandenabbildung aus mhc-positiven zellen
US6756215B1 (en) 2000-10-20 2004-06-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Functionalized TGF-β fusion proteins
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
DE10112851C1 (de) * 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
CA2442935A1 (en) 2001-04-05 2002-10-17 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
CN1555268B (zh) 2001-07-17 2013-04-03 研究发展基金会 含促调亡蛋白质的治疗剂
US8088602B1 (en) 2001-12-05 2012-01-03 Elizabeth Gay Frayne Manipulation of RNA stability and protein synthesis using thio-phosphate
WO2003074676A2 (en) 2002-03-01 2003-09-12 Monsanto Technology Llc Wax ester synthase dna sequence, protein and uses thereof
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
CN1695058B (zh) 2002-09-09 2011-04-13 生命树股份有限公司 诊断宫颈癌的方法
AU2003270619A1 (en) * 2002-09-12 2004-04-30 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
JP4773947B2 (ja) * 2003-01-09 2011-09-14 マクロジェニクス,インコーポレーテッド 細菌細胞及び哺乳動物細胞における抗体発現のための二重発現ベクター系
US20040259162A1 (en) * 2003-05-02 2004-12-23 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
ES2383328T3 (es) 2003-07-25 2012-06-20 Amgen, Inc Métodos relacionados con LDCAM y CRTAM
US20050178959A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
EP1761540B1 (de) 2004-05-13 2016-09-28 Icos Corporation Chinazolinone als inhibitoren der humanen phosphatidylinosit-3-kinase delta
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
WO2006138700A2 (en) * 2005-06-17 2006-12-28 Biorexis Pharmaceutical Corporation Anchored transferrin fusion protein libraries
US20070275416A1 (en) * 2006-05-16 2007-11-29 Gsf-Forschungszentrum Fuer Umwelt Und Gesundheit Gmbh Affinity marker for purification of proteins
EP1878744A1 (de) * 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-Tag für an der Oberfläche exprimierte T-Zell Rezeptor Proteine, deren Anwendung und Verfahren zur Selection von Wirtszellen, die sie exprimieren
EP2061887B1 (de) * 2006-10-04 2018-01-24 The University Of Queensland Zuführungssystem für impfstoff gegen grippe auf vlp-basis
CA2666415C (en) 2006-10-11 2012-11-27 Oriental Yeast Co., Ltd. Agent containing fused protein of soluble rankl with epitope tag
US20080118524A1 (en) * 2006-10-20 2008-05-22 Stefan Persson Anti-IgE Vaccines
KR20090098880A (ko) 2006-12-12 2009-09-17 바이오렉시스 파마슈티칼 코포레이션 트랜스페린 융합 단백질 라이브러리
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
EP2142217B1 (de) * 2007-03-27 2014-11-05 Merck Sharp & Dohme Corp. Verfahren zum nachweis von automatisch aufbereitetem sezerniertem pcsk9
US7897369B2 (en) * 2007-08-27 2011-03-01 Regents Of The University Of Minnesota Isoprenoid wax ester synthases, isoprenoid acyl CoA-synthetases, and uses thereof
WO2009064802A2 (en) * 2007-11-13 2009-05-22 Eli Lilly & Co. Inhibitors of human phosphatidyl-inositol 3-kinase delta
US20110129857A1 (en) * 2009-11-27 2011-06-02 Msdx, Inc. Methods Of Detecting Or Monitoring Activity Of An Inflammatory Condition Or Neurodegenerative Condition
WO2009075798A2 (en) * 2007-12-05 2009-06-18 University Of Georgia Research Foundation, Inc. Hydrogenase polypeptide and methods of use
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
US20110071049A1 (en) 2008-03-12 2011-03-24 Nathaniel Heintz Methods and compositions for translational profiling and molecular phenotyping
RU2530555C2 (ru) 2008-04-17 2014-10-10 ПиДиЭс БАЙОТЕКНОЛОДЖИ КОРПОРЭЙШН Стимуляция иммунного ответа энантиомерами катионных липидов
US8546553B2 (en) 2008-07-25 2013-10-01 University Of Georgia Research Foundation, Inc. Prokaryotic RNAi-like system and methods of use
CA2737544A1 (en) 2008-09-18 2010-03-25 University Of Georgia Research Foundation, Inc. Methods and compositions for degrading pectin
WO2010054108A2 (en) * 2008-11-06 2010-05-14 University Of Georgia Research Foundation, Inc. Cas6 polypeptides and methods of use
CN102272153B (zh) 2008-11-24 2015-04-15 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 高亲和力t细胞受体及其应用
WO2010089412A1 (en) 2009-02-09 2010-08-12 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific t cell receptor sequences and use thereof
EP2258719A1 (de) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Mehrfachziel-T-Zellen-Rezeptor
CN102482329B (zh) 2009-07-24 2017-11-14 免疫设计公司 用辛德毕斯病毒包膜糖蛋白假型化的慢病毒载体
EA201792376A3 (ru) 2009-10-23 2018-08-31 Милленниум Фармасьютикалз, Инк. Молекулы анти-gcc антитела и соответствующие композиции и способы
US8911743B2 (en) 2009-11-04 2014-12-16 Regents Of The University Of Minnesota Haemophilus parasuis polypeptides and methods of use
CN102762565A (zh) 2010-02-22 2012-10-31 弗·哈夫曼-拉罗切有限公司 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法
US8734780B2 (en) 2010-06-04 2014-05-27 Medtronic, Inc. Methods for treating cardiac pacing conditions
KR101531117B1 (ko) 2010-07-14 2015-06-23 에프. 호프만-라 로슈 아게 Pi3k p110 델타에 대해 선택적인 퓨린 화합물, 및 사용 방법
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
KR20140018837A (ko) 2010-08-27 2014-02-13 스템 센트알엑스 인코포레이티드 노텀 단백질 조절 인자 및 사용 방법
US9458231B2 (en) 2010-09-03 2016-10-04 Stemcentrx, Inc. Modulators and methods of use
AU2011295722B2 (en) 2010-09-03 2016-04-21 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
WO2013119964A2 (en) 2012-02-08 2013-08-15 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
TWI585106B (zh) 2010-12-08 2017-06-01 艾伯維史坦森特瑞斯有限責任公司 新穎調節劑及其使用方法
US9339526B2 (en) 2011-01-17 2016-05-17 University Of Manitoba Methods for treating disorders that involve immunoglobulin A
US8673309B2 (en) * 2011-02-11 2014-03-18 Msdx, Inc. Methods for measuring high molecular weight complexes of fibrinogen with fibronectin and fibulin-1
EP2675473A1 (de) 2011-02-15 2013-12-25 Immune Design Corp. Verfahren zur verbesserung von immunogenspezifischen immunreaktionen durch vektorisierte impfstoffe
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
US9244073B2 (en) 2011-02-25 2016-01-26 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
MX350795B (es) 2011-04-08 2017-09-19 Inmune Design Corp Composiciones inmunogenicas y metodos para utilizar las composiciones para inducir respuestas inmunes humorales y celulares.
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
EP2817338B1 (de) 2012-02-24 2017-07-26 AbbVie Stemcentrx LLC Dll3-modulatoren und verwendungsverfahren
MX360245B (es) 2012-03-09 2018-10-26 Csl Behring Ag Composiciones que comprenden inmunoglobulinas de tipo secretor.
HUE034593T2 (en) 2012-03-28 2018-02-28 Univ Texas TGF II-III. types of receptor fusions
ES2707288T3 (es) 2012-03-30 2019-04-03 Immune Design Corp Partículas de vectores lentivíricos que tienen eficiencia de transducción mejorada para células que expresan DC-SIGN
WO2014039879A1 (en) 2012-09-06 2014-03-13 North Carolina State University Sequestration of carbon dioxide with hydrogen to useful products
AU2013317805B2 (en) 2012-09-21 2018-07-26 Pds Biotechnology Corporation Improved vaccine compositions and methods of use
US10036047B2 (en) 2013-06-10 2018-07-31 University Of Georgia Research Foundation, Inc. Methods for hydroxylating phenylpropanoids
US9353390B2 (en) 2013-06-13 2016-05-31 University Of Georgia Research Foundation, Inc. Genetically engineered microbes and methods for producing 4-hydroxycoumarin
JP6599861B2 (ja) 2013-08-07 2019-10-30 リグスホスピタレット コペンハーゲン ユニバーシティ ホスピタル 男性不妊治療用の抗体、化合物、およびその誘導体
CA2922547C (en) 2013-08-28 2020-03-10 Stemcentrx, Inc. Site-specific antibody conjugation methods and compositions
WO2015031541A1 (en) 2013-08-28 2015-03-05 Stem Centrx, Inc. Novel sez6 modulators and methods of use
AU2015218365A1 (en) 2014-02-14 2016-09-01 Immune Design Corp. Immunotherapy of cancer through combination of local and systemic immune stimulation
EP3134439B1 (de) 2014-04-21 2018-12-26 Millennium Pharmaceuticals, Inc. Anti-psyk-antikörpermoleküle und verwendung davon für eine auf syk abzielende therapie
MA51688A (fr) 2014-05-26 2020-12-02 Academisch Ziekenhuis Leiden Protéines prohémostatiques pour le traitement de saignement
EP3169352A1 (de) 2014-07-15 2017-05-24 Immune Design Corp. Prime-boost-therapieschemata mit einem tlr4-agonist-adjuvans und einem lentivirusvektor
EP3012269A1 (de) 2014-10-20 2016-04-27 Erhard Hofer Zytokin-ähnliches 1 (CYTL1)-Protein und Verwendungen davon
DK3244911T3 (da) 2015-01-12 2019-12-16 Rigshospitalet Copenhagen Univ Hospital Fremgangsmåde til bestemmelse af en sandsynlig virkning af en behandling til forbedring af mandlig ufrugtbarhed
IL282614B2 (en) 2015-02-06 2024-02-01 Cell Idx Inc Antigen-conjugated immune reagents
CA2981509A1 (en) 2015-03-30 2016-10-06 The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La Compositions comprising talens and methods of treating hiv
CN107750163A (zh) 2015-05-29 2018-03-02 犹他大学研究基金会 免疫耐受性和非免疫耐受性弹性蛋白样重组肽及使用方法
US10858760B2 (en) 2015-06-01 2020-12-08 Medigene Immunotherapies Gmbh T cell receptor library
NZ737423A (en) 2015-06-01 2019-08-30 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
CN108350037A (zh) 2015-11-09 2018-07-31 免疫设计股份有限公司 包含表达il-12的慢病毒载体的组合物及其使用方法
AU2016354102B2 (en) 2015-11-09 2022-05-12 Immune Design Corp. A retroviral vector for the administration and expression of replicon RNA expressing heterologous nucleic acids
EP3374496A4 (de) 2015-11-13 2019-07-10 PDS Biotechnology Corporation Lipide als synthetische vektoren zur verbesserung der antigenverarbeitung und präsentation ex-vivo in der dendritischen zelltherapie
KR20180089439A (ko) 2015-11-25 2018-08-08 아카데미슈 지켄후이스 라이덴 재조합 세린 프로테아제
US10882891B2 (en) 2015-12-23 2021-01-05 Medigene Immunotherapies Gmbh Dendritic cell composition
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
WO2017180998A2 (en) 2016-04-15 2017-10-19 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
UA127310C2 (uk) 2016-05-16 2023-07-19 Презідент Енд Феллоуз Оф Гарвард Колледж Спосіб очищення і активації ботулінічного нейротоксину
WO2018026283A1 (en) 2016-08-04 2018-02-08 Stichting Vumc Embryonic angiogenesis markers and diagnostic and therapeutic strategies based thereon
KR20230119735A (ko) 2017-02-12 2023-08-16 바이오엔테크 유에스 인크. Hla 기반 방법 및 조성물, 및 이들의 용도
EP3668309A4 (de) 2017-08-14 2021-06-09 University of Georgia Research Foundation, Inc. Proteine mit pneumokokken-kapsel-abbauender aktivität und verwendungsverfahren
US11198722B2 (en) 2017-10-06 2021-12-14 University Of Utah Research Foundation Immune tolerant elastin-like peptide tetramer guided nanoparticles and methods of use
CA3090917A1 (en) 2018-02-26 2019-08-29 Medigene Immunotherapies Gmbh Nyeso tcr
EP3806888B1 (de) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Von pde5 abgeleitete regulatorische konstrukte und verfahren zur verwendung in der immuntherapie
JP7174144B2 (ja) 2018-08-06 2022-11-17 メディジーン イミュノテラピーズ ゲーエムベーハー Ha-1特異的t細胞受容体およびその使用
WO2020070089A1 (en) 2018-10-01 2020-04-09 Ospedale San Raffaele S.R.L. Chromogranin a and uses thereof
WO2020086742A1 (en) 2018-10-24 2020-04-30 Obsidian Therapeutics, Inc. Er tunable protein regulation
BR102019025989A2 (pt) 2018-12-14 2020-06-23 Beckman Coulter, Inc. Modificação de corantes poliméricos e aplicações
WO2020132586A1 (en) 2018-12-21 2020-06-25 Neon Therapeutics, Inc. Method and systems for prediction of hla class ii-specific epitopes and characterization of cd4+ t cells
KR20210149251A (ko) 2019-03-08 2021-12-08 옵시디안 테라퓨틱스, 인크. 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
EP3714941A1 (de) 2019-03-27 2020-09-30 Medigene Immunotherapies GmbH Mage-a4-tcrs
TW202102530A (zh) 2019-04-04 2021-01-16 德商梅迪基因免疫治療公司 黑色素瘤相關抗原1(magea1)特異性t細胞受體及其用途
EP3983537A1 (de) 2019-06-12 2022-04-20 Obsidian Therapeutics, Inc. Ca2-zusammensetzungen und verfahren zur abstimmbaren regulierung
MX2021015097A (es) 2019-06-12 2022-04-01 Obsidian Therapeutics Inc Composiciones de ca2 y metodos para regulación ajustable.
KR20220052910A (ko) 2019-07-09 2022-04-28 메디진 이뮤노테라피스 게엠바하 Magea10 특이적 t 세포 수용체 및 이의 용도
US20220348937A1 (en) 2019-09-06 2022-11-03 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
WO2021067741A1 (en) 2019-10-02 2021-04-08 University Of Georgia Research Foundation, Inc. Glycopeptides for inducing an immune response and methods of use
US20230211004A1 (en) 2019-11-22 2023-07-06 University Of Georgia Research Foundation, Inc. Tetanus toxoid and crm-based peptides and methods of use
WO2021118976A1 (en) 2019-12-09 2021-06-17 University Of Georgia Research Foundation, Inc. M. tuberculosis ag85 proteins and methods of use
US20230285519A1 (en) 2020-07-17 2023-09-14 University Of Georgia Research Foundation, Inc. B-glucuronidase proteins having pneumococcal capsule degrading activity and methods of use
AU2021347595A1 (en) 2020-09-24 2023-05-04 Medigene Immunotherapies Gmbh Mage-a3 specific t cell receptors and their use
EP4288776A1 (de) 2021-02-05 2023-12-13 Beckman Coulter, Inc. Zusammensetzungen und verfahren zur verhinderung von nichtspezifischen wechselwirkungen zwischen polymerfarbstoff-antikörper-konjugaten
AU2022270947A1 (en) 2021-05-07 2023-11-16 Medigene Immunotherapies Gmbh Combination of prame specific t cell receptors and chimeric co-stimulatory receptors
WO2023025779A1 (en) 2021-08-25 2023-03-02 Medigene Immunotherapies Gmbh Combination of antigen specific t cell receptors and chimeric co-stimulatory receptors
WO2023056460A1 (en) 2021-09-30 2023-04-06 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
WO2024041761A1 (en) 2022-08-23 2024-02-29 Medigene Immunotherapies Gmbh Combination of ny-eso-1 specific t cell receptors and chimeric co-stimulatory receptors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
IE47890B1 (en) * 1977-11-08 1984-07-11 Genentech Inc Polypeptide production by expression in a recombinant microbial cloning vehicle, and cloning vehicles
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4563424A (en) * 1979-11-05 1986-01-07 Genentech, Inc. Method and means for somatostatin protein conjugate expression
US4571421A (en) * 1979-11-05 1986-02-18 Genentech, Inc. Mammalian gene for microbial expression
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4503142A (en) * 1982-06-25 1985-03-05 Litton Bionetics, Inc. Open reading frame vectors
US4559302A (en) * 1982-11-01 1985-12-17 Eli Lilly And Company DNA for directing transcription and expression of structural genes

Also Published As

Publication number Publication date
JPH074255B2 (ja) 1995-01-25
JPS60222429A (ja) 1985-11-07
ATE68014T1 (de) 1991-10-15
US4703004A (en) 1987-10-27
EP0150126A2 (de) 1985-07-31
EP0150126A3 (en) 1987-06-03
EP0150126B1 (de) 1991-10-02

Similar Documents

Publication Publication Date Title
DE3584260D1 (de) Die synthese eines proteins mittels eines identifizierungspeptids.
Sanger Chemistry of insulin
Aquila et al. Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria
ISEMURA et al. Isolation and amino acid sequence of SAP-1, an acidic protein of human whole saliva, and sequence homology with human γ-trace
ATE121454T1 (de) Ubiquitinspezifische protease.
IE883612L (en) Vectors and compounds for direct expression of activated human protein c
Watson et al. The amino acid sequence of chymopapain from Carica papaya
Grant et al. Amino acid sequence of a collagenolytic protease from the hepatopancreas of the fiddler crab, Uca pugilator
ATE73460T1 (de) Peptide aus alpha-aminoboronsaeuren.
NZ232742A (en) Yeast heterologous protein production method, vectors, dna constructs and proteins so produced and aprotinin (1-58) so produced
Geschwind et al. The Structure of the β-Melanocyte-stimulating Hormone
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
ES2114539T3 (es) Expresion de polipeptidos recombinados con purificacion mejorada.
ZA8860B (en) Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof
EP0195680A3 (de) Proteinsynthese mit einem Identifizierungspeptid
Graf et al. Cathepsin D generates γ-endorphin from β-endorphin
Proost et al. Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines
McClintock et al. Two distinct pathways of the streptokinase-mediated activation of highly purified human plasminogen
DE69233245D1 (de) Verfahren zur Herstellung von Peptiden
ATE317443T1 (de) N-terminal verlängerte proteine exprimiert in hefe
BR9714133A (pt) ácido nucleico isolado, molécula do mesmo, sonda, vetor de expressão recombinante, célula, polipeptìdeo, proteìna de fusão formulação de vacina e processos para produzir um polipeptìdeo de h. pylori, para detctar a presença de um ácido nucleico de helicobacter em uma amostra, para tratar ou reduzir um risco de infecção por h. pylori em um indivìduo e para produzir uma formulação de vacina
DE3686365T2 (de) Herstellungsverfahren fuer humanes atriales natriuretisches polypeptid.
KR860006484A (ko) 단백질 또는 당단백질의 제조방법
KR860008282A (ko) 재조합 사람 레닌의 제조방법
Goodman et al. Pyrrolidonecarboxylic acid at the N-terminal positions of polypeptide chains from leopard shark immunoglobulins

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EASTMAN KODAK CO., ROCHESTER, N.Y., US

8328 Change in the person/name/address of the agent

Free format text: BLICKLE, W., DIPL.-ING., PAT.-ASS., 70327 STUTTGART

8327 Change in the person/name/address of the patent owner

Owner name: SIGMA-ALDRICH CO., ST. LOUIS, MO., US

8328 Change in the person/name/address of the agent

Free format text: MAIWALD GMBH, 80335 MUENCHEN