ATE68014T1 - Die synthese eines proteins mittels eines identifizierungspeptids. - Google Patents

Die synthese eines proteins mittels eines identifizierungspeptids.

Info

Publication number
ATE68014T1
ATE68014T1 AT85300432T AT85300432T ATE68014T1 AT E68014 T1 ATE68014 T1 AT E68014T1 AT 85300432 T AT85300432 T AT 85300432T AT 85300432 T AT85300432 T AT 85300432T AT E68014 T1 ATE68014 T1 AT E68014T1
Authority
AT
Austria
Prior art keywords
identification peptide
functional protein
protein
hybrid polypeptide
terminal
Prior art date
Application number
AT85300432T
Other languages
English (en)
Inventor
Thomas P Hopp
Susan L Bektesh
Iii Paul J Conlon
Carl J March
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24293537&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE68014(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE68014T1 publication Critical patent/ATE68014T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT85300432T 1984-01-24 1985-01-23 Die synthese eines proteins mittels eines identifizierungspeptids. ATE68014T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/573,825 US4703004A (en) 1984-01-24 1984-01-24 Synthesis of protein with an identification peptide
EP85300432A EP0150126B1 (de) 1984-01-24 1985-01-23 Die Synthese eines Proteins mittels eines Identifizierungspeptids

Publications (1)

Publication Number Publication Date
ATE68014T1 true ATE68014T1 (de) 1991-10-15

Family

ID=24293537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85300432T ATE68014T1 (de) 1984-01-24 1985-01-23 Die synthese eines proteins mittels eines identifizierungspeptids.

Country Status (5)

Country Link
US (1) US4703004A (de)
EP (1) EP0150126B1 (de)
JP (1) JPH074255B2 (de)
AT (1) ATE68014T1 (de)
DE (1) DE3584260D1 (de)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61500586A (ja) * 1983-11-14 1986-04-03 チロン　コ−ポレイシヨン インタ−ロイキン−２産生のための方法及び組成物
US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
US6808901B1 (en) * 1984-09-03 2004-10-26 Celltech R&D Limited Production of chimeric antibodies
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US6534285B1 (en) 1984-12-24 2003-03-18 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
US5853978A (en) * 1985-12-04 1998-12-29 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
EP0195680A3 (de) * 1985-03-21 1987-06-10 Immunex Corporation Proteinsynthese mit einem Identifizierungspeptid
DE3686365T3 (de) * 1985-06-20 2000-07-27 Fujisawa Pharmaceutical Co., Ltd. Herstellungsverfahren für humanes atriales natriuretisches Polypeptid.
EP0207044A1 (de) * 1985-06-20 1986-12-30 Monsanto Company Freisetzung von Peptiden aus Polypeptiden
US4828799A (en) * 1985-06-26 1989-05-09 Research Corporation Therapeutic drug monitoring and analyte determination utilizing micellar chromatography
FR2594846B1 (fr) * 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4851341A (en) * 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5215896A (en) * 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
US5200509A (en) * 1987-04-06 1993-04-06 Celtrix Pharmaceuticals, Inc. Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides
FR2615528B1 (fr) * 1987-05-18 1991-05-24 Pasteur Institut Procede de production d'un polypeptide ayant des proprietes choisies determinees, dans un organisme-hote transforme par un adn recombinant contenant des sequences nucleiques codant pour ce polypeptide et pour une proteine affine d'ose
ZA887773B (en) 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
PT89121A (pt) * 1987-12-04 1989-12-29 Du Pont Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural
US4927879A (en) * 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US4931498A (en) * 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
USRE39760E1 (en) * 1988-03-31 2007-08-07 International Bio-Immune Systems Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
US5108919A (en) * 1988-06-24 1992-04-28 Genentech, Inc. Dna sequences encoding yeast ubiquitin hydrolase
US5262322A (en) * 1988-06-24 1993-11-16 Genentech, Inc. Host transformed with yeast gene and ubiquitin/polypeptide fusions
US5156968A (en) * 1988-06-24 1992-10-20 Genentech, Inc. Purified yeast ubiquitin hydrolase
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
ZA902949B (en) * 1989-05-05 1992-02-26 Res Dev Foundation A novel antibody delivery system for biological response modifiers
ATE123065T1 (de) * 1989-07-07 1995-06-15 Takeda Chemical Industries Ltd Proteine und deren herstellung.
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
AU646695B2 (en) 1990-04-09 1994-03-03 Immunex Corporation Isolated viral protein cytokine antagonists
US5595887A (en) * 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
WO1992006191A1 (en) * 1990-09-28 1992-04-16 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
US6083686A (en) * 1990-10-26 2000-07-04 Johnson & Johnson Clinical Diagnostic Systems, Inc. Increased production of Thermus aquaticus DNA polymerase in E. coli
SK60893A3 (en) * 1990-12-13 1993-10-06 Upjohn Co Fusion polypeptides
US5270197A (en) * 1990-12-20 1993-12-14 The Children's Medical Center Corporation Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
DK1820858T3 (da) * 1991-03-01 2009-11-02 Dyax Corp Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5731425A (en) * 1994-10-28 1998-03-24 Eastman Kodak Company Polypeptide surface marker for cells
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US5795966A (en) 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
ES2253753T3 (es) 1995-06-29 2006-06-01 Immunex Corporation Citocina que induce apoptosis.
US6037149A (en) 1995-08-24 2000-03-14 Magainin Pharmaceuticals Inc. DNA encoding human asthma associated factor 1
AU713471C (en) 1996-12-23 2002-04-18 Immunex Corporation Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily
US6913749B2 (en) * 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
KR20020026460A (ko) 1999-06-16 2002-04-10 게리 엘. 윌콕스 인체 폴리(ａｄｐ-리보스) 폴리메라제 2 물질 및 방법
US6379903B1 (en) 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
US7541429B2 (en) * 2000-10-10 2009-06-02 The Board Of Regents Of The University Of Oklahoma Comparative ligand mapping from MHC positive cells
US7060467B2 (en) * 2000-03-13 2006-06-13 Monsanto Technology Llc Recombinant proteins containing repeating units
SI2223922T1 (sl) 2000-04-25 2016-04-29 Icos Corporation Inhibitorji humane fosfatidil-inositol 3-kinazne delta izoforme
EP1939203B1 (de) 2000-04-25 2014-11-19 ICOS Corporation Hemmer der delta-Isoform der menschlichen Phosphatidyl-Inositol-3-Kinase
US6756215B1 (en) 2000-10-20 2004-06-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Functionalized TGF-β fusion proteins
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
DE10112851C1 (de) * 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
WO2002081650A2 (en) 2001-04-05 2002-10-17 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
ATE540695T1 (de) * 2001-06-08 2012-01-15 Genaera Corp Verfahren zur modulation von il-13
EP1414471B1 (de) 2001-07-17 2012-06-13 Research Development Foundation Therapeutische Mittel mit pro-apoptotischen Proteinen
US8088602B1 (en) 2001-12-05 2012-01-03 Elizabeth Gay Frayne Manipulation of RNA stability and protein synthesis using thio-phosphate
US7118896B2 (en) 2002-03-01 2006-10-10 Monsanto Technology, L.L.C. Methods and compositions for modification of lipid biosynthesis
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
BR0314155A (pt) 2002-09-09 2005-07-05 Arbor Vita Corp Métodos para diagnosticar câncer cervical
AU2003270619A1 (en) 2002-09-12 2004-04-30 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
EP1588166A4 (de) * 2003-01-09 2007-06-27 Macrogenics Inc Doppelexpressionsvektorsystem für die antikörperexpression in bakteriellen und säugetierzellen
WO2004099384A2 (en) * 2003-05-02 2004-11-18 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
AU2004261941B2 (en) 2003-07-25 2008-04-10 Amgen Inc. Antagonists and agonists of LDCAM and methods of use
US20050178959A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
ES2605792T3 (es) 2004-05-13 2017-03-16 Icos Corporation Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana
WO2006026248A1 (en) * 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
CA2610931A1 (en) * 2005-06-17 2006-12-28 Biorexis Pharmaceutical Corporation Anchored transferrin fusion protein libraries
US20070275416A1 (en) * 2006-05-16 2007-11-29 Gsf-Forschungszentrum Fuer Umwelt Und Gesundheit Gmbh Affinity marker for purification of proteins
EP1878744A1 (de) * 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-Tag für an der Oberfläche exprimierte T-Zell Rezeptor Proteine, deren Anwendung und Verfahren zur Selection von Wirtszellen, die sie exprimieren
WO2008040060A1 (en) * 2006-10-04 2008-04-10 The University Of Queensland Vlp based vaccine delivery system
EP2083073B1 (de) 2006-10-11 2013-09-04 Oriental Yeast Co., Ltd. Fusionsprotein aus löslichem rankl mit epitop-tag enthaltendes reagens
US20080118524A1 (en) * 2006-10-20 2008-05-22 Stefan Persson Anti-IgE Vaccines
KR20090098880A (ko) 2006-12-12 2009-09-17 바이오렉시스 파마슈티칼 코포레이션 트랜스페린 융합 단백질 라이브러리
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
WO2008118386A2 (en) * 2007-03-27 2008-10-02 Merck & Co., Inc. Method for detecting autoprocessed, secreted pcsk9
US7897369B2 (en) * 2007-08-27 2011-03-01 Regents Of The University Of Minnesota Isoprenoid wax ester synthases, isoprenoid acyl CoA-synthetases, and uses thereof
NZ585460A (en) * 2007-11-13 2013-02-22 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
US20110020875A1 (en) * 2007-12-05 2011-01-27 University Of Georgia Research Foundation, Inc. Hydrogenase polypeptide and methods of use
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
JP5670755B2 (ja) 2008-03-12 2015-02-18 ザ ロックフェラー ユニバーシティ 翻訳プロファイリング及び分子表現型解析のための方法及び組成物
EP2276495B1 (de) 2008-04-17 2018-11-21 PDS Biotechnology Corporation Stimulierung einer immunantwort durch enantiomere von kationischen lipiden
US8546553B2 (en) 2008-07-25 2013-10-01 University Of Georgia Research Foundation, Inc. Prokaryotic RNAi-like system and methods of use
CA2737544A1 (en) 2008-09-18 2010-03-25 University Of Georgia Research Foundation, Inc. Methods and compositions for degrading pectin
US9404098B2 (en) * 2008-11-06 2016-08-02 University Of Georgia Research Foundation, Inc. Method for cleaving a target RNA using a Cas6 polypeptide
DK2352756T3 (da) 2008-11-24 2012-12-03 Helmholtz Zentrum Muenchen Højaffin T-cellereceptor og anvendelse af denne
EP2393833A1 (de) 2009-02-09 2011-12-14 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Repertoire allorestringierter, peptidspezifischer t-zellen-rezeptorsequenzen und anwendung davon
EP2258719A1 (de) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Mehrfachziel-T-Zellen-Rezeptor
SG177744A1 (en) 2009-07-24 2012-02-28 Immune Design Corp Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
US8785600B2 (en) 2009-10-23 2014-07-22 Millennium Pharmaceuticals, Inc. Anti-GCC antibody molecules and related compositions and methods
US8911743B2 (en) 2009-11-04 2014-12-16 Regents Of The University Of Minnesota Haemophilus parasuis polypeptides and methods of use
WO2011066460A1 (en) * 2009-11-27 2011-06-03 Msdx, Inc. Methods of detecting or monitoring activity of an inflammatory or neurodegenerative condition
RU2012139182A (ru) 2010-02-22 2014-03-27 Ф. Хоффманн-Ля Рош Аг ПИРИДО[3,2-d]ПИРИМИДИНЫ - ИНГИБИТОРЫ PI3К ДЕЛЬТА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US8734780B2 (en) 2010-06-04 2014-05-27 Medtronic, Inc. Methods for treating cardiac pacing conditions
ES2536780T3 (es) 2010-07-14 2015-05-28 F. Hoffmann-La Roche Ag Compuestos de purina selectivos para I3 p110 delta, y métodos de uso
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
SG10201506782XA (en) 2010-08-27 2015-10-29 Stem Centrx Inc Notum protein modulators and methods of use
WO2012031273A2 (en) 2010-09-03 2012-03-08 Stem Centrx, Inc. Novel modulators and methods of use
SG189212A1 (en) 2010-09-03 2013-05-31 Stem Centrx Inc Identification and enrichment of cell subpopulations
WO2013119964A2 (en) 2012-02-08 2013-08-15 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
SG10201601792UA (en) 2010-12-08 2016-04-28 Stemcentrx Inc Novel modulators and methods of use
EP2665747A4 (de) 2011-01-17 2014-06-18 Univ Manitoba Verfahren zur behandlung von mit immunglobulin a assoziierten krankheiten
US8673309B2 (en) * 2011-02-11 2014-03-18 Msdx, Inc. Methods for measuring high molecular weight complexes of fibrinogen with fibronectin and fibulin-1
JP2014510721A (ja) 2011-02-15 2014-05-01 イミューン デザイン コーポレイション ベクターワクチンによる免疫原特異的免疫応答を強化するための方法
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
CA2864868A1 (en) 2011-02-25 2012-11-15 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
BR112013025799A2 (pt) 2011-04-08 2016-12-20 Immune Design Corp método para induzir uma resposta imune em um sujeito, e, preparação
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
CA2865404C (en) 2012-02-24 2019-08-27 Stem Centrx, Inc. Dll3-binding antibodies and drug conjugates thereof to treat cancer
AU2013201393B2 (en) 2012-03-09 2015-08-27 Csl Behring Ag Compositions
WO2013149094A1 (en) 2012-03-28 2013-10-03 The Board Of Regents Of The University Of Texas System TGFβ TYPE II-TYPE III RECEPTOR FUSIONS
NZ700340A (en) 2012-03-30 2017-02-24 Immune Design Corp Lentiviral vector particles having improved transduction efficiency for cells expressing dc- sign
US10286064B2 (en) 2012-06-15 2019-05-14 Pds Biotechnology Corporation Cationic lipid vaccine compositions and methods of use
WO2014039879A1 (en) 2012-09-06 2014-03-13 North Carolina State University Sequestration of carbon dioxide with hydrogen to useful products
EP4091630A1 (de) 2012-09-21 2022-11-23 PDS Biotechnology Corporation Impfstoffe mit r-dotap
US10036047B2 (en) 2013-06-10 2018-07-31 University Of Georgia Research Foundation, Inc. Methods for hydroxylating phenylpropanoids
US9353390B2 (en) 2013-06-13 2016-05-31 University Of Georgia Research Foundation, Inc. Genetically engineered microbes and methods for producing 4-hydroxycoumarin
WO2015018421A1 (en) 2013-08-07 2015-02-12 Rigshospitalet Copenhagen University Hospital Antibodies, compounds and derivatives thereof for use in the treatment of male infertility
EP3038634A4 (de) 2013-08-28 2017-10-11 AbbVie Stemcentrx LLC Neuartige sez6-modulatoren und verfahren zur verwendung
JP2016531915A (ja) 2013-08-28 2016-10-13 ステムセントリックス， インコーポレイテッド 部位特異的抗体コンジュゲーション方法および組成物
SG11201606625RA (en) 2014-02-14 2016-09-29 Immune Design Corp Immunotherapy of cancer through combination of local and systemic immune stimulation
JP2017518737A (ja) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＳＹＫ標的治療薬のための抗ｐＳＹＫ抗体分子及びその使用
EP3149163B1 (de) 2014-05-26 2020-06-03 Academisch Ziekenhuis Leiden Prohämostatische proteine zur behandlung von blutungen
EP3169352A1 (de) 2014-07-15 2017-05-24 Immune Design Corp. Prime-boost-therapieschemata mit einem tlr4-agonist-adjuvans und einem lentivirusvektor
EP3012269A1 (de) 2014-10-20 2016-04-27 Erhard Hofer Zytokin-ähnliches 1 (CYTL1)-Protein und Verwendungen davon
EP3244911B1 (de) 2015-01-12 2019-10-23 Rigshospitalet, Copenhagen University Hospital Eine metode zur bestimmung eines wahrscheinlichen effekts einer behandlung zur verbesserung männlicher unfruchtbarkeit
EP3253788A4 (de) 2015-02-06 2018-08-08 Cell IDX, Inc. Antigen-gekoppelte immunoreagenzien
CA2981509A1 (en) 2015-03-30 2016-10-06 The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La Compositions comprising talens and methods of treating hiv
CA2986766A1 (en) 2015-05-29 2016-12-08 University Of Utah Research Foundation Immune tolerant and non-immune tolerant elastin-like recombinant peptides and methods of use
WO2016193300A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
AU2016273213B2 (en) 2015-06-01 2019-03-14 Medigene Immunotherapies Gmbh T cell receptor library
BR112018008911A2 (pt) 2015-11-09 2018-11-27 Immune Design Corp composições compreendendo vetores lentivirais que expressam il-12 e métodos de uso das mesmas
CA3004132A1 (en) 2015-11-09 2017-05-18 Immune Design Corp. A retroviral vector for the administration and expression of replicon rna expressing heterologous nucleic acids
EP3374496A4 (de) 2015-11-13 2019-07-10 PDS Biotechnology Corporation Lipide als synthetische vektoren zur verbesserung der antigenverarbeitung und präsentation ex-vivo in der dendritischen zelltherapie
CA3006175A1 (en) 2015-11-25 2017-06-01 Academisch Ziekenhuis Leiden Recombinant serine proteases
MX2018007841A (es) 2015-12-23 2018-11-09 Medigene Immunotherapies Gmbh Composicion de celula dendritica.
EP3443001B1 (de) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. Regulierte bioschaltkreissysteme
KR102836360B1 (ko) 2016-04-15 2025-07-23 베크만 컬터, 인코포레이티드 광활성 거대분자 및 그의 용도
CN109641941B (zh) 2016-05-16 2023-06-16 哈佛大学校长及研究员协会 用于纯化和激活肉毒杆菌神经毒素的方法
EP3494128B1 (de) 2016-08-04 2023-11-29 Stichting VUmc Embryonale angiogenesemarker und darauf basierende diagnostische und therapeutische strategien
DK3512846T3 (da) 2016-09-16 2024-11-11 Lighthouse Pharmaceuticals Inc Ketonhæmmere af lysin-gingipain
KR102565256B1 (ko) 2017-02-12 2023-08-08 바이오엔테크 유에스 인크. Hla 기반 방법 및 조성물, 및 이들의 용도
KR102746901B1 (ko) 2017-03-03 2024-12-26 옵시디안 테라퓨틱스, 인크. Cd19 조성물 및 면역요법을 위한 방법
JP7660343B2 (ja) 2017-03-03 2025-04-11 オブシディアン セラピューティクス， インコーポレイテッド 免疫療法のための組成物及び方法
US11690900B2 (en) 2017-08-14 2023-07-04 University Of Georgia Research Foundation, Inc. Proteins having pneumococcal capsule degrading activity and methods of use
EP3691693A4 (de) 2017-10-06 2021-08-25 University Of Utah Research Foundation Fusionsprotein zur gezielten therapie einer autoimmunerkrankung
WO2019113200A1 (en) 2017-12-05 2019-06-13 Pds Biotechnology Corporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
EP3555124B1 (de) 2018-02-26 2024-05-01 Medigene Immunotherapies GmbH Nyeso-tcr
EP3806888B1 (de) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Von pde5 abgeleitete regulatorische konstrukte und verfahren zur verwendung in der immuntherapie
EP3833681A1 (de) 2018-08-06 2021-06-16 Medigene Immunotherapies GmbH Ha-1-spezifische t-zell-rezeptoren und deren verwendung
WO2020070089A1 (en) 2018-10-01 2020-04-09 Ospedale San Raffaele S.R.L. Chromogranin a and uses thereof
US20210386788A1 (en) 2018-10-24 2021-12-16 Obsidian Therapeutics, Inc. Er tunable protein regulation
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
MX2021007556A (es) 2018-12-21 2021-09-10 Biontech Us Inc Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+.
SG11202109172TA (en) 2019-03-08 2021-09-29 Obsidian Therapeutics Inc Human carbonic anhydrase 2 compositions and methods for tunable regulation
EP3714941A1 (de) 2019-03-27 2020-09-30 Medigene Immunotherapies GmbH Mage-a4-tcrs
TWI850360B (zh) 2019-04-04 2024-08-01 德商梅迪基因免疫治療公司 黑色素瘤相關抗原１（ｍａｇｅａ１）特異性ｔ細胞受體及其用途
JP2022537670A (ja) 2019-06-12 2022-08-29 オブシディアン セラピューティクス， インコーポレイテッド Ｃａ２の組成物および調整可能な制御方法
EP3983537A1 (de) 2019-06-12 2022-04-20 Obsidian Therapeutics, Inc. Ca2-zusammensetzungen und verfahren zur abstimmbaren regulierung
EP3997116A1 (de) 2019-07-09 2022-05-18 Medigene Immunotherapies GmbH Magea10-spezifische t-zell-rezeptoren und deren verwendung
US20220348937A1 (en) 2019-09-06 2022-11-03 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
WO2021067741A1 (en) 2019-10-02 2021-04-08 University Of Georgia Research Foundation, Inc. Glycopeptides for inducing an immune response and methods of use
US20230211004A1 (en) 2019-11-22 2023-07-06 University Of Georgia Research Foundation, Inc. Tetanus toxoid and crm-based peptides and methods of use
WO2021118976A1 (en) 2019-12-09 2021-06-17 University Of Georgia Research Foundation, Inc. M. tuberculosis ag85 proteins and methods of use
WO2022016035A1 (en) 2020-07-17 2022-01-20 University Of Georgia Research Foundation, Inc. Β-glucuronidase proteins having pneumococcal capsule degrading activity and methods of use
US20230340064A1 (en) 2020-09-24 2023-10-26 Medigene Immunotherapies Gmbh Mage-a3 specific t cell receptors and their use
US20240125773A1 (en) 2021-02-05 2024-04-18 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
EP4334331A1 (de) 2021-05-07 2024-03-13 Medigene Immunotherapies GmbH Kombination aus prame-spezifischen t-zell-rezeptoren und chimären costimulatorischen rezeptoren
WO2023025779A1 (en) 2021-08-25 2023-03-02 Medigene Immunotherapies Gmbh Combination of antigen specific t cell receptors and chimeric co-stimulatory receptors
US20240400893A1 (en) 2021-09-30 2024-12-05 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
EP4577232A1 (de) 2022-08-23 2025-07-02 Medigene Immunotherapies GmbH Kombination von ny-eso-1-spezifischen t-zell-rezeptoren und chimären costimulatorischen rezeptoren
EP4635976A1 (de) 2024-04-19 2025-10-22 Medigene Immunotherapies GmbH Konstante uni-laschen
WO2025219541A1 (en) 2024-04-19 2025-10-23 Medigene Immunotherapies Gmbh Constant uni-tabs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
US4563424A (en) * 1979-11-05 1986-01-07 Genentech, Inc. Method and means for somatostatin protein conjugate expression
SE7811458L (sv) * 1977-11-08 1979-05-09 Genentech Inc Forfarande och medel for polypeptidbildning via mikrober
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4571421A (en) * 1979-11-05 1986-02-18 Genentech, Inc. Mammalian gene for microbial expression
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4503142A (en) * 1982-06-25 1985-03-05 Litton Bionetics, Inc. Open reading frame vectors
US4559302A (en) * 1982-11-01 1985-12-17 Eli Lilly And Company DNA for directing transcription and expression of structural genes

Also Published As

Publication number Publication date
JPS60222429A (ja) 1985-11-07
US4703004A (en) 1987-10-27
EP0150126A3 (en) 1987-06-03
EP0150126B1 (de) 1991-10-02
DE3584260D1 (de) 1991-11-07
EP0150126A2 (de) 1985-07-31
JPH074255B2 (ja) 1995-01-25

Similar Documents

Publication Publication Date Title
ATE68014T1 (de) Die synthese eines proteins mittels eines identifizierungspeptids.
Sanger Chemistry of insulin: determination of the structure of insulin opens the way to greater understanding of life processes
ISEMURA et al. Isolation and amino acid sequence of SAP-1, an acidic protein of human whole saliva, and sequence homology with human γ-trace
DE69109109D1 (de) Ubiquitinspezifische protease.
Watson et al. The amino acid sequence of chymopapain from Carica papaya
Grant et al. Amino acid sequence of a collagenolytic protease from the hepatopancreas of the fiddler crab, Uca pugilator
IE883612L (en) Vectors and compounds for direct expression of activated human protein c
ATE73460T1 (de) Peptide aus alpha-aminoboronsaeuren.
NZ232742A (en) Yeast heterologous protein production method, vectors, dna constructs and proteins so produced and aprotinin (1-58) so produced
ES8500325A1 (es) Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
ZA8860B (en) Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof
EP0195680A3 (de) Proteinsynthese mit einem Identifizierungspeptid
CA2273196A1 (en) Isolated mammalian monocyte cell genes; related reagents
Graf et al. Cathepsin D generates γ-endorphin from β-endorphin
Proost et al. Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines
DE69233245D1 (de) Verfahren zur Herstellung von Peptiden
ATE317443T1 (de) N-terminal verlängerte proteine exprimiert in hefe
BR9714133A (pt) ácido nucleico isolado, molécula do mesmo, sonda, vetor de expressão recombinante, célula, polipeptìdeo, proteìna de fusão formulação de vacina e processos para produzir um polipeptìdeo de h. pylori, para detctar a presença de um ácido nucleico de helicobacter em uma amostra, para tratar ou reduzir um risco de infecção por h. pylori em um indivìduo e para produzir uma formulação de vacina
ATE79409T1 (de) Herstellungsverfahren fuer humanes atriales natriuretisches polypeptid.
AR013618A1 (es) Metodo y composiciones para la distribucion y expresion de acidos nucleicos de interferon
Limeback et al. Nature of collagens synthesized by monkey periodontal-ligament fibroblasts in vitro
KR860006484A (ko) 단백질 또는 당단백질의 제조방법
Desai et al. Carboxyl-terminal sequence of the glycine-arginine-rich histone from bovine lymphosarcoma, Novikoff hepatoma and fetal calf thymus
KR860008282A (ko) 재조합 사람 레닌의 제조방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time