US6005071A
(en)
*
|
1987-01-23 |
1999-12-21 |
Merrell Pharmaceuticals Inc. |
Anticoagulant peptides
|
US5789540A
(en)
*
|
1987-01-23 |
1998-08-04 |
Merrell Pharmaceuticals Inc. |
Anticoagulant peptides
|
US5187157A
(en)
*
|
1987-06-05 |
1993-02-16 |
Du Pont Merck Pharmaceutical Company |
Peptide boronic acid inhibitors of trypsin-like proteases
|
US5242904A
(en)
*
|
1987-06-05 |
1993-09-07 |
The Dupont Merck Pharmaceutical Company |
Peptide boronic acid inhibitors of trypsin-like proteases
|
US5250720A
(en)
*
|
1987-06-05 |
1993-10-05 |
The Dupont Merck Pharmaceutical Company |
Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
|
US4935493A
(en)
*
|
1987-10-06 |
1990-06-19 |
E. I. Du Pont De Nemours And Company |
Protease inhibitors
|
EP0315574A3
(de)
*
|
1987-11-05 |
1990-08-22 |
Hoechst Aktiengesellschaft |
Renin-Inhibitoren
|
US4977268A
(en)
*
|
1988-04-08 |
1990-12-11 |
Duke University |
Boron dipeptide compounds
|
US6313096B1
(en)
|
1988-04-28 |
2001-11-06 |
Trigen Limited |
Inhibitors of trypsin-like enzymes
|
US5574014A
(en)
*
|
1988-04-28 |
1996-11-12 |
Thrombosis Research Institute |
Inhibitors of trypsin-like enzymes
|
NZ229053A
(en)
*
|
1988-05-11 |
1990-12-21 |
Du Pont |
Pharmaceutical compositions comprising a protein or peptide and an alpha-aminoboronic acid derivative to stabilise and improve the delivery of the protein or peptide
|
US5106948A
(en)
*
|
1988-05-27 |
1992-04-21 |
Mao Foundation For Medical Education And Research |
Cytotoxic boronic acid peptide analogs
|
US4963655A
(en)
*
|
1988-05-27 |
1990-10-16 |
Mayo Foundation For Medical Education And Research |
Boron analogs of amino acid/peptide protease inhibitors
|
US5159060A
(en)
*
|
1988-05-27 |
1992-10-27 |
Mayo Foundation For Medical Education And Research |
Cytotoxic boronic acid peptide analogs
|
DE3827340A1
(de)
*
|
1988-08-12 |
1990-02-15 |
Hoechst Ag |
Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
|
AU625292B2
(en)
*
|
1988-09-09 |
1992-07-09 |
Czechoslovak Academy Of Sciences |
Elastase inhibiting polymers and methods
|
DE3840452A1
(de)
*
|
1988-12-01 |
1990-06-07 |
Hoechst Ag |
(beta)-amino-boronsaeure-derivate
|
US5252463A
(en)
*
|
1990-06-22 |
1993-10-12 |
The Du Pont Merck Pharmaceutical Company |
Clipsin, a chymotrypsin-like protease and method of using same
|
GB9024129D0
(en)
*
|
1990-11-06 |
1990-12-19 |
Thrombosis Research Trust |
Inhibitors and substrates of thrombin
|
US5444042A
(en)
*
|
1990-12-28 |
1995-08-22 |
Cortex Pharmaceuticals |
Method of treatment of neurodegeneration with calpain inhibitors
|
US5157149A
(en)
*
|
1991-06-04 |
1992-10-20 |
The United States Of America As Represented By The United States Department Of Energy |
Enantioselective synthesis of L-(-)-4- boronophenylalanine (L-BPA)
|
EP0746324A1
(de)
*
|
1991-09-13 |
1996-12-11 |
Boron Biologicals, Inc. |
Verfahren zur bekämpfung von osteoporose und anderen krankheitszuständen bei säugern unter verwendung von organischen borverbindungen
|
US6825169B1
(en)
*
|
1991-10-22 |
2004-11-30 |
Trustees Of Tufts College |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
DE69314169T2
(de)
*
|
1992-04-16 |
1998-01-15 |
Zeneca Ltd |
Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer
|
JP2668003B2
(ja)
*
|
1992-06-12 |
1997-10-27 |
ファイザー インク. |
ヒトの心臓キマーゼを含むアンギオテンシンiキマーゼに関する阻害剤
|
IL108797A0
(en)
*
|
1993-03-03 |
1994-06-24 |
Sandoz Ag |
Amino acid derivatives, their preparation and pharmaceutical compositions containing them
|
US5384410A
(en)
*
|
1993-03-24 |
1995-01-24 |
The Du Pont Merck Pharmaceutical Company |
Removal of boronic acid protecting groups by transesterification
|
IL109319A0
(en)
*
|
1993-04-27 |
1994-07-31 |
Du Pont Merck Pharma |
Amidino and guanidino substituted boronic acid compounds
|
US5462964A
(en)
*
|
1993-10-20 |
1995-10-31 |
The Du Pont Merck Pharmaceutical Company |
Dipeptide boronic acid inhibitors of trypsin-like enzymes
|
US6060462A
(en)
*
|
1993-10-20 |
2000-05-09 |
Dupont Pharmaceuticals Company |
Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
|
US5693617A
(en)
*
|
1994-03-15 |
1997-12-02 |
Proscript, Inc. |
Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
|
FR2718451B1
(fr)
*
|
1994-04-12 |
1996-05-10 |
Synthelabo |
Dérivés de peptides boroniques, leur préparation et leur application en thérapeutique.
|
US6083903A
(en)
*
|
1994-10-28 |
2000-07-04 |
Leukosite, Inc. |
Boronic ester and acid compounds, synthesis and uses
|
US5614649A
(en)
*
|
1994-11-14 |
1997-03-25 |
Cephalon, Inc. |
Multicatalytic protease inhibitors
|
US5550262A
(en)
*
|
1994-11-14 |
1996-08-27 |
Cephalon, Inc. |
Multicatalytic protease inhibitors
|
US5639739A
(en)
*
|
1995-03-24 |
1997-06-17 |
The Dupont Merck Pharmaceutical Company |
Imidazole containing aminoboronic acids
|
US5731439A
(en)
*
|
1995-03-24 |
1998-03-24 |
The Dupont Merck Pharmaceutical Company |
Piperidine containing aminobornic acids
|
US5891909A
(en)
*
|
1996-03-29 |
1999-04-06 |
3-Dimensional Pharmaceuticals, Inc. |
Amidinohydrazones as protease inhibitors
|
US5965532A
(en)
|
1996-06-28 |
1999-10-12 |
Trustees Of Tufts College |
Multivalent compounds for crosslinking receptors and uses thereof
|
US5744339A
(en)
*
|
1996-08-30 |
1998-04-28 |
Cephalon, Inc. |
Thiomethylene group-containing aldehyde cysteine and serine protease inhibitors
|
UA66767C2
(uk)
*
|
1996-10-18 |
2004-06-15 |
Вертекс Фармасьютикалс Інкорпорейтед |
Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с
|
US6040145A
(en)
*
|
1997-05-07 |
2000-03-21 |
Tufts University |
Potentiation of the immune response
|
US6100234A
(en)
*
|
1997-05-07 |
2000-08-08 |
Tufts University |
Treatment of HIV
|
TR200000815T2
(tr)
|
1997-09-29 |
2000-12-21 |
Point Therapeutics Inc. |
In vitro hematopoietik hücrelerin stimulasyonu.
|
US6344486B1
(en)
|
1998-04-03 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
|
JP2003529528A
(ja)
|
1998-04-24 |
2003-10-07 |
3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド |
プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
|
NZ507730A
(en)
|
1998-05-04 |
2004-02-27 |
Point Therapeutics Inc |
Hematopoietic stimulation
|
DE69905038T2
(de)
|
1998-06-05 |
2003-06-05 |
Point Therapeutics Inc |
Cyclische boroprolinverbindungen
|
US6979697B1
(en)
*
|
1998-08-21 |
2005-12-27 |
Point Therapeutics, Inc. |
Regulation of substrate activity
|
US6890904B1
(en)
*
|
1999-05-25 |
2005-05-10 |
Point Therapeutics, Inc. |
Anti-tumor agents
|
MXPA01011956A
(es)
|
1999-05-27 |
2002-06-21 |
Dimensional Pharm Inc |
Oxazaheterociclos como inhibidores de proteasas.
|
US6649593B1
(en)
*
|
1999-10-13 |
2003-11-18 |
Tularik Inc. |
Modulators of SREBP processing
|
MXPA03000512A
(es)
*
|
2000-07-17 |
2003-10-06 |
Dimensional Pharm Inc |
Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas.
|
WO2002012207A1
(en)
|
2000-08-04 |
2002-02-14 |
3-Dimensional Pharmaceuticals, Inc. |
Cyclic oxyguanidine protease inhibitors
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
US6586615B1
(en)
|
2001-01-10 |
2003-07-01 |
Bristol-Myers Squibb Company |
α-aminoboronic acids prepared by novel synthetic methods
|
EP1355910B1
(de)
*
|
2001-01-25 |
2011-03-09 |
The United States of America, represented by the Secretary, Department of Health and Human Services |
Formulierungen von borsäure-verbindungen
|
US6933290B2
(en)
|
2001-05-30 |
2005-08-23 |
Novartis Ag |
2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives
|
US20060014697A1
(en)
*
|
2001-08-22 |
2006-01-19 |
Travis Mickle |
Pharmaceutical compositions for prevention of overdose or abuse
|
CA2468192A1
(en)
*
|
2001-11-26 |
2003-06-05 |
Trustees Of Tufts College |
Peptidomimetic inhibitors of post-proline cleaving enzymes
|
AU2003218232A1
(en)
*
|
2002-03-12 |
2003-09-29 |
Ariad Pharmaceuticals, Inc. |
Peptide analogues and uses thereof
|
IL148924A
(en)
*
|
2002-03-26 |
2015-06-30 |
Mor Research Applic Ltd |
Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
|
AU2003228793B2
(en)
|
2002-04-30 |
2008-01-03 |
Trustees Of Tufts College |
Smart Pro-Drugs of Serine Protease Inhibitors
|
AU2003265264A1
(en)
*
|
2002-07-09 |
2004-01-23 |
Point Therapeutics, Inc. |
Methods and compositions relating to isoleucine boroproline compounds
|
US20060084592A1
(en)
*
|
2002-09-09 |
2006-04-20 |
Trigen Limited |
Peptide boronic acid inhibitors
|
US20050282757A1
(en)
*
|
2002-09-09 |
2005-12-22 |
Trigen Limited |
Peptide boronic acid compounds useful in anticoagulation
|
US20050288253A1
(en)
*
|
2002-09-09 |
2005-12-29 |
Trigen Limited |
Boronic acid salts
|
US20050176651A1
(en)
*
|
2002-09-09 |
2005-08-11 |
Trigen Limited |
Peptide boronic acids useful in making salts thereof
|
US20050119226A1
(en)
*
|
2003-09-09 |
2005-06-02 |
Trigen Limited |
Methods for synthesizing organoboronic compounds and products thereof
|
KR20050057294A
(ko)
*
|
2002-09-09 |
2005-06-16 |
트라이젠 리미티드 |
보론산 염, 및 혈전증의 치료를 위한 그것의 용도
|
WO2004091613A2
(en)
|
2003-04-10 |
2004-10-28 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted phenyl acetamides and their use as protease inhibitors
|
AU2011203054B2
(en)
*
|
2003-04-11 |
2012-04-26 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of Serine Proteases, Particularly HCV NS3-NS4A Protease
|
US20050090450A1
(en)
*
|
2003-04-11 |
2005-04-28 |
Farmer Luc J. |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
US7223745B2
(en)
*
|
2003-08-14 |
2007-05-29 |
Cephalon, Inc. |
Proteasome inhibitors and methods of using the same
|
US7576206B2
(en)
*
|
2003-08-14 |
2009-08-18 |
Cephalon, Inc. |
Proteasome inhibitors and methods of using the same
|
AU2011265405B2
(en)
*
|
2003-08-14 |
2012-11-15 |
Takeda Pharmaceutical Company Limited |
Proteasome inhibitors and methods of using the same
|
TWI359147B
(en)
*
|
2003-09-05 |
2012-03-01 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hcv n
|
US20050152887A1
(en)
*
|
2004-01-14 |
2005-07-14 |
Doctor's Signature Sales And Marketing International Corp. [Dba Life Force International |
Protonic formulation
|
GB0405272D0
(en)
*
|
2004-03-09 |
2004-04-21 |
Trigen Ltd |
Compounds
|
EP2377868A1
(de)
|
2004-03-30 |
2011-10-19 |
Millennium Pharmaceuticals, Inc. |
Synthese von Bortezomib
|
US20060063719A1
(en)
*
|
2004-09-21 |
2006-03-23 |
Point Therapeutics, Inc. |
Methods for treating diabetes
|
US7468383B2
(en)
*
|
2005-02-11 |
2008-12-23 |
Cephalon, Inc. |
Proteasome inhibitors and methods of using the same
|
NZ565540A
(en)
*
|
2005-08-02 |
2011-06-30 |
Vertex Pharma |
Inhibitors of serine proteases
|
US7964624B1
(en)
|
2005-08-26 |
2011-06-21 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases
|
AR055395A1
(es)
*
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
US8039475B2
(en)
|
2006-02-27 |
2011-10-18 |
Vertex Pharmaceuticals Incorporated |
Co-crystals and pharmaceutical compositions comprising the same
|
WO2007109080A2
(en)
*
|
2006-03-16 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Deuterated hepatitis c protease inhibitors
|
JO3598B1
(ar)
|
2006-10-10 |
2020-07-05 |
Infinity Discovery Inc |
الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
|
CN101903392A
(zh)
*
|
2007-02-27 |
2010-12-01 |
弗特克斯药品有限公司 |
丝氨酸蛋白酶的抑制剂
|
JP2010519330A
(ja)
*
|
2007-02-27 |
2010-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
共結晶体およびそれを含む医薬組成物
|
US7442830B1
(en)
*
|
2007-08-06 |
2008-10-28 |
Millenium Pharmaceuticals, Inc. |
Proteasome inhibitors
|
PL2178888T3
(pl)
|
2007-08-06 |
2012-11-30 |
Millennium Pharm Inc |
Inhibitory proteasomów
|
CN101835774B
(zh)
*
|
2007-08-30 |
2014-09-17 |
弗特克斯药品有限公司 |
共晶体和包含该共晶体的药物组合物
|
US7838673B2
(en)
*
|
2007-10-16 |
2010-11-23 |
Millennium Pharmaceuticals, Inc. |
Proteasome inhibitors
|
TW201000107A
(en)
|
2008-04-09 |
2010-01-01 |
Infinity Pharmaceuticals Inc |
Inhibitors of fatty acid amide hydrolase
|
GEP201706703B
(en)
|
2008-06-17 |
2017-07-25 |
Millennium Pharmaceuticals Inc (A Delaware Corporation) |
Boronate ester compounds and pharmaceutical compositions thereof
|
AR075090A1
(es)
|
2008-09-29 |
2011-03-09 |
Millennium Pharm Inc |
Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
|
EA201170527A1
(ru)
*
|
2008-10-01 |
2011-10-31 |
Др. Редди'С Лабораторис Лтд. |
Фармацевтические композиции, включающие соединения бороновой кислоты
|
US20120149663A1
(en)
|
2009-08-18 |
2012-06-14 |
Georgetown University |
Boronic acid compositions and methods related to cancer
|
HUE032571T2
(en)
|
2009-10-01 |
2017-09-28 |
Janssen Pharmaceutica Nv |
Proteasome inhibitors for cancer treatment
|
CN102725300B
(zh)
|
2009-12-22 |
2015-03-11 |
赛福伦公司 |
蛋白酶体抑制剂及其制备、纯化、和应用的方法
|
RU2569061C2
(ru)
|
2010-02-03 |
2015-11-20 |
Инфинити Фармасьютикалз, Инк. |
Ингибиторы амид-гидролазы жирных кислот
|
US8513218B2
(en)
|
2010-03-31 |
2013-08-20 |
Millennium Pharmaceuticals, Inc. |
Derivatives of 1-amino-2-cyclopropylethylboronic acid
|
EP2624818B1
(de)
|
2010-10-05 |
2017-04-05 |
Fresenius Kabi USA, LLC |
Mit borsäure stabilisierte bortezomib-formulierungen
|
HUE060305T2
(hu)
|
2011-08-30 |
2023-02-28 |
Tufts College |
FAP-aktivált proteaszóma inhibitorok a szolid tumorok kezelésére
|
WO2013110005A1
(en)
|
2012-01-18 |
2013-07-25 |
Wisconsin Alumni Research Foundation |
Boronate-mediated delivery of molecules into cells
|
US9732101B2
(en)
|
2012-01-18 |
2017-08-15 |
Wisconsin Alumni Research Foundation |
Bioreversible boronates for delivery of molecules into cells
|
WO2013123456A1
(en)
|
2012-02-16 |
2013-08-22 |
Rqx Pharmaceuticals, Inc. |
Linear peptide antibiotics
|
US10293048B2
(en)
|
2012-03-02 |
2019-05-21 |
Dr. Reddy's Laboratories Limited |
Pharmaceutical compositions comprising boronic acid compounds
|
WO2014072985A1
(en)
|
2012-11-06 |
2014-05-15 |
Natco Pharma Limited |
Novel boronic acid derivatives as anti cancer agents
|
IN2013MU01431A
(de)
|
2013-04-16 |
2015-06-26 |
Cipla Ltd |
|
WO2015003146A1
(en)
|
2013-07-03 |
2015-01-08 |
Georgetown University |
Boronic acid derivatives of resveratrol for activating deacetylase enzymes
|
US10167311B2
(en)
|
2014-02-03 |
2019-01-01 |
Ohio State Innovation Foundation |
Boronic acid esters and pharmaceutical formulations thereof
|
MA39964A
(fr)
|
2014-05-20 |
2015-11-26 |
Millennium Pharm Inc |
Inhibiteurs du protéasome contenant du bore destinés à être utilisés après une thérapie contre le cancer primaire
|
MA41505A
(fr)
|
2015-02-11 |
2017-12-19 |
Millennium Pharm Inc |
Nouvelle forme cristalline d'un inhibiteur de protéasome
|
JP2018510859A
(ja)
|
2015-03-17 |
2018-04-19 |
レオン−ナノドラッグズ ゲーエムベーハー |
安定化されたボロン酸化合物を含むナノ粒子
|