DE3519218A1 - H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung - Google Patents
H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendungInfo
- Publication number
- DE3519218A1 DE3519218A1 DE19853519218 DE3519218A DE3519218A1 DE 3519218 A1 DE3519218 A1 DE 3519218A1 DE 19853519218 DE19853519218 DE 19853519218 DE 3519218 A DE3519218 A DE 3519218A DE 3519218 A1 DE3519218 A1 DE 3519218A1
- Authority
- DE
- Germany
- Prior art keywords
- sarcosine
- down arrow
- enzyme
- creatinine
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 34
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 102000004190 Enzymes Human genes 0.000 claims abstract description 24
- 108090000790 Enzymes Proteins 0.000 claims abstract description 24
- 229940109239 creatinine Drugs 0.000 claims abstract description 17
- 108010077895 Sarcosine Proteins 0.000 claims abstract description 13
- 229940043230 sarcosine Drugs 0.000 claims abstract description 13
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000000694 effects Effects 0.000 claims abstract description 10
- 229960003624 creatine Drugs 0.000 claims abstract description 6
- 239000006046 creatine Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- 241000204060 Streptomycetaceae Species 0.000 claims abstract description 4
- 239000013543 active substance Substances 0.000 claims abstract description 3
- 230000000977 initiatory effect Effects 0.000 claims abstract description 3
- 108010060059 Sarcosine Oxidase Proteins 0.000 claims description 29
- 102000008118 Sarcosine oxidase Human genes 0.000 claims description 29
- 229910019142 PO4 Inorganic materials 0.000 claims description 15
- 239000010452 phosphate Substances 0.000 claims description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 2
- 239000002028 Biomass Substances 0.000 claims 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract description 4
- 102000004316 Oxidoreductases Human genes 0.000 abstract description 2
- 108090000854 Oxidoreductases Proteins 0.000 abstract description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 abstract description 2
- 235000011009 potassium phosphates Nutrition 0.000 abstract description 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 description 23
- 229940088598 enzyme Drugs 0.000 description 21
- 241000187747 Streptomyces Species 0.000 description 16
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 15
- 239000007994 TES buffer Substances 0.000 description 15
- 230000002255 enzymatic effect Effects 0.000 description 11
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003599 detergent Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 5
- 239000000287 crude extract Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108010066906 Creatininase Proteins 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 239000004367 Lipase Substances 0.000 description 3
- 102000003992 Peroxidases Human genes 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 229940099352 cholate Drugs 0.000 description 3
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- YDBHVMTTYXWHLI-UHFFFAOYSA-N 2,4,6-tribromo-3-hydroxybenzoic acid Chemical compound OC(=O)C1=C(Br)C=C(Br)C(O)=C1Br YDBHVMTTYXWHLI-UHFFFAOYSA-N 0.000 description 2
- 108010024957 Ascorbate Oxidase Proteins 0.000 description 2
- 108010077078 Creatinase Proteins 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000186249 Corynebacterium sp. Species 0.000 description 1
- 241000723247 Cylindrocarpon Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101710084378 Lipase 2 Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 101710132589 Peroxidase 2 Proteins 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 description 1
- 241000187095 Streptomyces purpureus Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- -1 aralkyl alcohols Chemical class 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000001000 lipidemic effect Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000006395 oxidase reaction Methods 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/841—Chainia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/908—Streptovirticillium
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853519218 DE3519218A1 (de) | 1985-05-29 | 1985-05-29 | H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung |
| ZA863143A ZA863143B (en) | 1985-05-29 | 1986-04-28 | H2o2-forming sarcosine oxidase,its production and use |
| AU56794/86A AU561098B2 (en) | 1985-05-29 | 1986-04-29 | Sarcosine oxidase (e.c. 1.5.3.1) |
| CA000507950A CA1277269C (en) | 1985-05-29 | 1986-04-30 | Hydrogen peroxide-forming sarcosine oxidase |
| ES554907A ES8800345A1 (es) | 1985-05-29 | 1986-05-13 | Procedimiento para la obtencion de sarcosinoxidasa |
| DE8686107203T DE3679455D1 (de) | 1985-05-29 | 1986-05-27 | H2o2-bildende sarcosinoxidase, ihre herstellung und verwendung. |
| AT86107203T ATE63944T1 (de) | 1985-05-29 | 1986-05-27 | H2o2-bildende sarcosinoxidase, ihre herstellung und verwendung. |
| JP61120358A JPS61280271A (ja) | 1985-05-29 | 1986-05-27 | Ｈ↓２ｏ↓２−形成サルコシンオキシダーゼ、その取得法及びサルコシン、クレアチン又はクレアチニンの測定法 |
| EP86107203A EP0205967B1 (de) | 1985-05-29 | 1986-05-27 | H2O2-bildende Sarcosinoxidase, ihre Herstellung und Verwendung |
| KR1019860004175A KR890004091B1 (ko) | 1985-05-29 | 1986-05-28 | 과산화 수소를 형성하는 살코신 산화효소 및 그 제법 |
| FI862258A FI91645C (fi) | 1985-05-29 | 1986-05-28 | Vetyperoksidia (H202) muodostava sarkosinoksidaasi, sen valmistaminen ja käyttö |
| SU4027546A SU1582993A3 (ru) | 1985-05-29 | 1986-05-28 | Способ определени содержани креатинина, креатина и саркозина в биологической жидкости |
| US06/868,262 US4743549A (en) | 1985-05-29 | 1986-05-28 | Hydrogen peroxide-forming sarcosine oxidase |
| US07/153,976 US4845029A (en) | 1985-05-29 | 1988-02-09 | Method for the determination of sarcosine creatine or creatinine |
| LV930453A LV5343A3 (lv) | 1985-05-29 | 1993-06-01 | Panemiens kreatinina kreatina un sarkozina noteiksanai biologiska skidruma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853519218 DE3519218A1 (de) | 1985-05-29 | 1985-05-29 | H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3519218A1 true DE3519218A1 (de) | 1986-12-04 |
Family
ID=6271899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853519218 Withdrawn DE3519218A1 (de) | 1985-05-29 | 1985-05-29 | H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung |
| DE8686107203T Expired - Lifetime DE3679455D1 (de) | 1985-05-29 | 1986-05-27 | H2o2-bildende sarcosinoxidase, ihre herstellung und verwendung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686107203T Expired - Lifetime DE3679455D1 (de) | 1985-05-29 | 1986-05-27 | H2o2-bildende sarcosinoxidase, ihre herstellung und verwendung. |
Country Status (12)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3519218A1 (de) * | 1985-05-29 | 1986-12-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung |
| JPH0674408B2 (ja) * | 1986-08-28 | 1994-09-21 | ユニオン、カ−バイド、カナダ、リミテッド | 航空機用除氷および着氷防止組成物 |
| JP2588707B2 (ja) * | 1987-02-27 | 1997-03-12 | 小林製薬株式会社 | サルコシン・オキシダーゼの製造法 |
| TW257792B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1992-10-01 | 1995-09-21 | Lilly Co Eli | |
| US9804154B2 (en) | 2013-03-12 | 2017-10-31 | Epinex Diagnostics, Inc. | Rapid test for urine albumin and urine creatinine |
| EP3415910A1 (en) | 2017-06-16 | 2018-12-19 | Prevention Medicals s.r.o. | A method of quantitative determination of sarcosine in a biological sample using anti-arcosine antibodies and peroxidase-active gold nanoparticles or quantum dots |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6029473B2 (ja) * | 1977-10-04 | 1985-07-10 | 東洋醸造株式会社 | ザルコシン・オキシダ−ゼの製法 |
| JPS5692790A (en) * | 1979-12-26 | 1981-07-27 | Hideaki Yamada | Preparation of sarcosine oxidase |
| DE3326888A1 (de) * | 1983-07-26 | 1985-02-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Sarcosin-oxidase |
| JPS61162174A (ja) * | 1985-01-11 | 1986-07-22 | Noda Sangyo Kagaku Kenkyusho | 耐熱性ザルコシン・オキシダ−ゼｎ及びその製造法 |
| DE3519218A1 (de) * | 1985-05-29 | 1986-12-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung |
-
1985
- 1985-05-29 DE DE19853519218 patent/DE3519218A1/de not_active Withdrawn
-
1986
- 1986-04-28 ZA ZA863143A patent/ZA863143B/xx unknown
- 1986-04-29 AU AU56794/86A patent/AU561098B2/en not_active Ceased
- 1986-04-30 CA CA000507950A patent/CA1277269C/en not_active Expired - Lifetime
- 1986-05-13 ES ES554907A patent/ES8800345A1/es not_active Expired
- 1986-05-27 AT AT86107203T patent/ATE63944T1/de not_active IP Right Cessation
- 1986-05-27 EP EP86107203A patent/EP0205967B1/de not_active Expired - Lifetime
- 1986-05-27 JP JP61120358A patent/JPS61280271A/ja active Granted
- 1986-05-27 DE DE8686107203T patent/DE3679455D1/de not_active Expired - Lifetime
- 1986-05-28 KR KR1019860004175A patent/KR890004091B1/ko not_active Expired
- 1986-05-28 SU SU4027546A patent/SU1582993A3/ru active
- 1986-05-28 FI FI862258A patent/FI91645C/fi not_active IP Right Cessation
- 1986-05-28 US US06/868,262 patent/US4743549A/en not_active Expired - Lifetime
-
1988
- 1988-02-09 US US07/153,976 patent/US4845029A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI862258L (fi) | 1986-11-30 |
| EP0205967B1 (de) | 1991-05-29 |
| AU561098B2 (en) | 1987-04-30 |
| JPH0414957B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-03-16 |
| KR860009127A (ko) | 1986-12-20 |
| KR890004091B1 (ko) | 1989-10-20 |
| ES8800345A1 (es) | 1987-11-16 |
| CA1277269C (en) | 1990-12-04 |
| ES554907A0 (es) | 1987-11-16 |
| ZA863143B (en) | 1986-12-30 |
| EP0205967A2 (de) | 1986-12-30 |
| FI91645B (fi) | 1994-04-15 |
| FI91645C (fi) | 1994-07-25 |
| SU1582993A3 (ru) | 1990-07-30 |
| AU5679486A (en) | 1986-12-04 |
| FI862258A0 (fi) | 1986-05-28 |
| DE3679455D1 (de) | 1991-07-04 |
| JPS61280271A (ja) | 1986-12-10 |
| US4845029A (en) | 1989-07-04 |
| US4743549A (en) | 1988-05-10 |
| EP0205967A3 (en) | 1988-07-27 |
| ATE63944T1 (de) | 1991-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |