DE3448121C2 - - Google Patents
Info
- Publication number
- DE3448121C2 DE3448121C2 DE19843448121 DE3448121A DE3448121C2 DE 3448121 C2 DE3448121 C2 DE 3448121C2 DE 19843448121 DE19843448121 DE 19843448121 DE 3448121 A DE3448121 A DE 3448121A DE 3448121 C2 DE3448121 C2 DE 3448121C2
- Authority
- DE
- Germany
- Prior art keywords
- reaction
- station
- reagent
- sample
- turntable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 claims description 103
- 239000003153 chemical reaction reagent Substances 0.000 claims description 101
- 238000000034 method Methods 0.000 claims description 67
- 102000004190 Enzymes Human genes 0.000 claims description 41
- 108090000790 Enzymes Proteins 0.000 claims description 41
- 238000004458 analytical method Methods 0.000 claims description 33
- 239000000427 antigen Substances 0.000 claims description 29
- 102000036639 antigens Human genes 0.000 claims description 29
- 108091007433 antigens Proteins 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 29
- 238000003018 immunoassay Methods 0.000 claims description 18
- 239000000969 carrier Substances 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 11
- 230000002860 competitive effect Effects 0.000 claims description 10
- 230000001900 immune effect Effects 0.000 claims description 10
- 239000000523 sample Substances 0.000 description 87
- 238000000926 separation method Methods 0.000 description 25
- 239000000126 substance Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 18
- 238000005259 measurement Methods 0.000 description 17
- 238000011010 flushing procedure Methods 0.000 description 11
- 238000002372 labelling Methods 0.000 description 11
- 239000007853 buffer solution Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000012447 hatching Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000004848 nephelometry Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 239000000057 synthetic resin Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00564—Handling or washing solid phase elements, e.g. beads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843402304 DE3402304C3 (de) | 1983-01-24 | 1984-01-24 | Verfahren für die automatische immunologische Analyse |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP959983A JPS59135367A (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
| JP58009598A JPH0619358B2 (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
| JP58021555A JPH0614048B2 (ja) | 1983-02-14 | 1983-02-14 | 酵素免疫学的自動分析装置 |
| JP6816183A JPS59193359A (ja) | 1983-04-18 | 1983-04-18 | 免疫学的自動分析装置 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3448121C2 true DE3448121C2 (en, 2012) | 1992-01-09 |
Family
ID=27455213
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843448007 Expired DE3448007C2 (en) | 1983-01-24 | 1984-01-24 | Reaction vessel for immunological analysis |
| DE19843448210 Expired - Lifetime DE3448210C2 (en, 2012) | 1983-01-24 | 1984-01-24 | |
| DE19843448121 Expired - Lifetime DE3448121C2 (en, 2012) | 1983-01-24 | 1984-01-24 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843448007 Expired DE3448007C2 (en) | 1983-01-24 | 1984-01-24 | Reaction vessel for immunological analysis |
| DE19843448210 Expired - Lifetime DE3448210C2 (en, 2012) | 1983-01-24 | 1984-01-24 |
Country Status (1)
| Country | Link |
|---|---|
| DE (3) | DE3448007C2 (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2690802B2 (ja) * | 1990-04-24 | 1997-12-17 | オリンパス光学工業株式会社 | 免疫学的検査法 |
| DE4416640A1 (de) * | 1994-05-11 | 1995-11-16 | A I D Autoimmun Diagnostika Gm | Objektträger für die mikroskopische Diagnose aus Kunststoffmaterial, Herstellungsverfahren und Verwendung |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3031430A1 (de) * | 1979-08-22 | 1981-03-12 | Hitachi Ltd | Automatische chemische analysierverfahren und -vorrichtung |
| DE3142539A1 (de) * | 1980-10-28 | 1982-07-08 | Fujizoki Pharmaceutical Co., Ltd., Tokyo | Automatische enzym-immunpruefvorrichtung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1773584A1 (de) * | 1967-06-13 | 1973-01-04 | Xerox Corp | Reaktionsbehaelter |
| US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
| FR2142637A1 (en) * | 1971-06-22 | 1973-02-02 | Hoffmann La Roche | Plastic sample table - for use with automatic analysers |
| US3964867A (en) * | 1975-02-25 | 1976-06-22 | Hycel, Inc. | Reaction container |
| US4210418A (en) * | 1976-08-30 | 1980-07-01 | Mallinckrodt, Inc. | Container for immunochemical and enzymatical determinations or procedures |
-
1984
- 1984-01-24 DE DE19843448007 patent/DE3448007C2/de not_active Expired
- 1984-01-24 DE DE19843448210 patent/DE3448210C2/de not_active Expired - Lifetime
- 1984-01-24 DE DE19843448121 patent/DE3448121C2/de not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3031430A1 (de) * | 1979-08-22 | 1981-03-12 | Hitachi Ltd | Automatische chemische analysierverfahren und -vorrichtung |
| DE3142539A1 (de) * | 1980-10-28 | 1982-07-08 | Fujizoki Pharmaceutical Co., Ltd., Tokyo | Automatische enzym-immunpruefvorrichtung |
Non-Patent Citations (1)
| Title |
|---|
| Pharmazie heute, Bd. 3, Sept. 1980, S. 37-41 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3448007C2 (en) | 1988-03-10 |
| DE3448210C2 (en, 2012) | 1991-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| Q172 | Divided out of (supplement): |
Ref country code: DE Ref document number: 3402304 |
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| 8110 | Request for examination paragraph 44 | ||
| 8181 | Inventor (new situation) |
Free format text: TAKEKAWA, HIROSHI YAMADA, TAKSHI, SAGAMIHARA CITY, KANAGAWA, JP |
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| 8172 | Supplementary division/partition in: |
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| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
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| 8339 | Ceased/non-payment of the annual fee |