DE3402304C2 - - Google Patents
Info
- Publication number
- DE3402304C2 DE3402304C2 DE19843402304 DE3402304A DE3402304C2 DE 3402304 C2 DE3402304 C2 DE 3402304C2 DE 19843402304 DE19843402304 DE 19843402304 DE 3402304 A DE3402304 A DE 3402304A DE 3402304 C2 DE3402304 C2 DE 3402304C2
- Authority
- DE
- Germany
- Prior art keywords
- carrier
- reaction
- reaction vessel
- turntable
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000006243 chemical reaction Methods 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 50
- 102000004190 Enzymes Human genes 0.000 claims description 47
- 108090000790 Enzymes Proteins 0.000 claims description 47
- 239000003153 chemical reaction reagent Substances 0.000 claims description 46
- 239000000427 antigen Substances 0.000 claims description 29
- 108091007433 antigens Proteins 0.000 claims description 29
- 102000036639 antigens Human genes 0.000 claims description 29
- 238000000926 separation method Methods 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 25
- 238000004458 analytical method Methods 0.000 claims description 24
- 239000007853 buffer solution Substances 0.000 claims description 24
- 238000003018 immunoassay Methods 0.000 claims description 18
- 239000000969 carrier Substances 0.000 claims description 12
- 238000005259 measurement Methods 0.000 claims description 10
- 230000001900 immune effect Effects 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 8
- 230000002860 competitive effect Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 2
- 230000005875 antibody response Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 description 25
- 238000002372 labelling Methods 0.000 description 12
- 238000011010 flushing procedure Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 239000012295 chemical reaction liquid Substances 0.000 description 5
- 101100441413 Caenorhabditis elegans cup-15 gene Proteins 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000004848 nephelometry Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00564—Handling or washing solid phase elements, e.g. beads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP959983A JPS59135367A (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
JP58009598A JPH0619358B2 (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
JP58021555A JPH0614048B2 (ja) | 1983-02-14 | 1983-02-14 | 酵素免疫学的自動分析装置 |
JP6816183A JPS59193359A (ja) | 1983-04-18 | 1983-04-18 | 免疫学的自動分析装置 |
DE19843448121 DE3448121C2 (en, 2012) | 1983-01-24 | 1984-01-24 | |
DE19843448007 DE3448007C2 (en) | 1983-01-24 | 1984-01-24 | Reaction vessel for immunological analysis |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3402304A1 DE3402304A1 (de) | 1984-07-26 |
DE3402304C2 true DE3402304C2 (en, 2012) | 1987-11-26 |
DE3402304C3 DE3402304C3 (de) | 1995-11-09 |
Family
ID=27544383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19843402304 Expired - Fee Related DE3402304C3 (de) | 1983-01-24 | 1984-01-24 | Verfahren für die automatische immunologische Analyse |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3402304C3 (en, 2012) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7182912B2 (en) | 1991-03-04 | 2007-02-27 | Bayer Corporation | Fluid handling apparatus for an automated analyzer |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0690211B2 (ja) * | 1984-09-21 | 1994-11-14 | オリンパス光学工業株式会社 | 免疫学的分析装置およびその方法 |
JPH0656383B2 (ja) * | 1985-02-22 | 1994-07-27 | オリンパス光学工業株式会社 | 酵素免疫学的自動分析装置 |
US4933147A (en) * | 1985-07-15 | 1990-06-12 | Abbott Laboratories | Unitized reagent containment system for clinical analyzer |
EP0217000B1 (en) * | 1985-07-15 | 1991-01-23 | Abbott Laboratories | Reagent containment system for a clinical analyser |
GR871619B (en) * | 1986-10-31 | 1988-03-03 | Genetic Systems Corp | Automated patient sample analysis instrument |
US4857471A (en) * | 1987-07-20 | 1989-08-15 | Eastman Kodak Company | Analyzer with wash station separate from incubator |
JP2731229B2 (ja) * | 1989-04-25 | 1998-03-25 | オリンパス光学工業株式会社 | 自動分析装置 |
DE3923833C2 (de) * | 1989-07-19 | 1998-07-02 | Boehringer Mannheim Gmbh | Analysegerät für heterogene immunologische Tests |
EP0497019B1 (en) * | 1991-01-30 | 1996-12-27 | Olympus Optical Co., Ltd. | Automatic immunological analysing system |
CA2384514C (en) * | 1991-03-04 | 2006-07-25 | Bayer Corporation | Automated analyzer |
DE4118547A1 (de) * | 1991-06-06 | 1992-12-10 | Kilian & Co Gmbh | Tablettenprobensammler |
DE4118886A1 (de) * | 1991-06-10 | 1992-12-17 | Ismatec S A | Probenbehandlungsapparat |
FR2695729B1 (fr) * | 1992-09-11 | 1994-11-04 | Biotrol Sa Lab | Appareil automatique de dosage immunologique. |
DE19605814A1 (de) * | 1996-02-16 | 1997-08-21 | Innova Gmbh | Vorrichtung und Verfahren zur Aufarbeitung einer Mehrzahl von Proben |
DE19925658C2 (de) * | 1999-06-04 | 2002-04-18 | Andreas Zucker | Vorrichtung zur automatischen Probenvorbereitung und deren Verwendung |
DE19954840A1 (de) * | 1999-11-09 | 2001-05-17 | Biopsytec Gmbh | Vorrichtung zur Aufbereitung biologischer Proben für die DNA-Analyse |
DE10018876A1 (de) * | 2000-04-14 | 2001-10-25 | Mettler Toledo Gmbh | Analysenvorrichtung und Analysiereinrichtung |
EP1754973B1 (de) * | 2005-07-26 | 2010-11-03 | Raudszus Electronic GmbH | Verfahren und Vorrichtung zur Probennahme und unmittelbaren Analyse fliessfähiger Sammelgutmengen, insbesondere von Milchlieferungen |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2276774A (en) * | 1940-06-08 | 1942-03-17 | Du Pont | Oxidizing hydrocarbons |
DE1773584U (de) | 1957-02-04 | 1958-09-04 | Heinrich Woehrle | Reinigungsmaschine fuer getreide, saemereien, huelsenfruechte usw. |
US3646346A (en) | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
US3951605A (en) * | 1974-08-08 | 1976-04-20 | Rohe Scientific Corporation | Instrument for automated immunochemical analysis |
US3964867A (en) | 1975-02-25 | 1976-06-22 | Hycel, Inc. | Reaction container |
GB1582434A (en) * | 1976-05-13 | 1981-01-07 | Secr Social Service Brit | Analytical apparatus and methods incorporating cuvette cleaning and cleanliness testing |
US4210418A (en) | 1976-08-30 | 1980-07-01 | Mallinckrodt, Inc. | Container for immunochemical and enzymatical determinations or procedures |
US4265855A (en) * | 1978-11-03 | 1981-05-05 | Electro-Nucleonics, Inc. | System for performing immunochemical and other analyses involving phase separation |
JPS5630650A (en) * | 1979-08-22 | 1981-03-27 | Hitachi Ltd | Automatic chemical analyzer |
SE8004687L (sv) * | 1980-06-25 | 1981-12-26 | Clinicon Ab | Automatisk analysapparat |
DE3029440C2 (de) * | 1980-08-02 | 1983-01-13 | Ernst 4030 Ratingen Fooke | Vorrichtung zum Waschen von Festkörpern |
JPS5774662A (en) * | 1980-10-28 | 1982-05-10 | Fujirebio Inc | Automatic measuring apparatus for enzyme immunity |
US4415098A (en) * | 1981-06-15 | 1983-11-15 | Abbott Laboratories | Single bead dispenser |
-
1984
- 1984-01-24 DE DE19843402304 patent/DE3402304C3/de not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7182912B2 (en) | 1991-03-04 | 2007-02-27 | Bayer Corporation | Fluid handling apparatus for an automated analyzer |
Also Published As
Publication number | Publication date |
---|---|
DE3402304C3 (de) | 1995-11-09 |
DE3402304A1 (de) | 1984-07-26 |
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