DE3408127A1 - Neue azole, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Neue azole, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
DE3408127A1
DE3408127A1 DE19843408127 DE3408127A DE3408127A1 DE 3408127 A1 DE3408127 A1 DE 3408127A1 DE 19843408127 DE19843408127 DE 19843408127 DE 3408127 A DE3408127 A DE 3408127A DE 3408127 A1 DE3408127 A1 DE 3408127A1
Authority
DE
Germany
Prior art keywords
substituted
phenyl
halogen
alkyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843408127
Other languages
German (de)
English (en)
Inventor
Helmut Dr. Wien Egger
Anton Dr. Maria Enzersdorf Stütz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Sandoz Patent GmbH
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Publication of DE3408127A1 publication Critical patent/DE3408127A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
DE19843408127 1983-03-11 1984-03-06 Neue azole, verfahren zu ihrer herstellung und ihre verwendung Withdrawn DE3408127A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1332/83A CH655103A5 (de) 1983-03-11 1983-03-11 Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.

Publications (1)

Publication Number Publication Date
DE3408127A1 true DE3408127A1 (de) 1984-09-13

Family

ID=4207992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843408127 Withdrawn DE3408127A1 (de) 1983-03-11 1984-03-06 Neue azole, verfahren zu ihrer herstellung und ihre verwendung

Country Status (24)

Country Link
JP (1) JPS59175472A (fr)
KR (1) KR890000377B1 (fr)
AU (1) AU571494B2 (fr)
BE (1) BE899073A (fr)
CA (1) CA1242723A (fr)
CH (1) CH655103A5 (fr)
DE (1) DE3408127A1 (fr)
DK (1) DK149784A (fr)
ES (1) ES530461A0 (fr)
FI (1) FI840968A (fr)
FR (1) FR2542315B1 (fr)
GB (1) GB2136801B (fr)
GR (1) GR81869B (fr)
HU (1) HUT36098A (fr)
IL (1) IL71203A (fr)
IT (1) IT1199085B (fr)
LU (1) LU85245A1 (fr)
NL (1) NL8400730A (fr)
NZ (1) NZ207453A (fr)
PH (1) PH24667A (fr)
PL (1) PL146072B1 (fr)
PT (1) PT78226B (fr)
SE (1) SE8401321L (fr)
ZA (1) ZA841782B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3644615A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazol- und triazolderivate zur verwendung als antimykotische mittel
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
EP0575122A3 (en) * 1992-06-17 1994-05-25 Rohm & Haas Fungicidal (2-aryl-2-substituted) ethyl-1,2,4-triazoles
US5462931A (en) * 1992-06-25 1995-10-31 Rohm And Haas Company Fungicidal 2-heterocyclic-2,2-disubstituted-ethyl 1,2,4-triazoles
EP0683156A1 (fr) * 1994-05-18 1995-11-22 Sandoz Ltd. Aminoalkanimidazoles et -triazoles acyles
US7125997B2 (en) * 2002-12-20 2006-10-24 Irm Llc Differential tumor cytotoxicity compounds and compositions

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE4412358A1 (de) * 1994-04-11 1995-10-12 Bayer Ag Cyclopropyl-ethyl-azole
JP3214987B2 (ja) * 1994-09-05 2001-10-02 日本碍子株式会社 半導体装置およびその製造方法
WO2004056744A1 (fr) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
US9012494B2 (en) 2004-05-07 2015-04-21 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
MX2007002449A (es) 2004-08-30 2007-10-10 Janssen Pharmaceutica Nv Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide.
ES2334246T3 (es) 2004-08-30 2010-03-08 Janssen Pharmaceutica Nv Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa.
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
WO2006034279A1 (fr) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation comme agents therapeutiques
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051026A1 (es) 2004-09-20 2006-12-13 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
TW200624427A (en) 2004-09-20 2006-07-16 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
EP2316458A1 (fr) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Derives de pyridazine destines a l'inhibition du desaturase-coa-stearoyl de l'humain
US8541457B2 (en) 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
CN104530038A (zh) * 2014-12-10 2015-04-22 沈阳药科大学 酰胺咪唑类衍生物及其用途
CN112142673B (zh) * 2020-09-18 2023-06-30 聊城大学 芳基烯烃唑类衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
CA1189857A (fr) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Triazoles derives antimicrobiens
AU8314482A (en) * 1981-05-19 1982-11-25 Imperial Chemical Industries Plc 3-triazolyl(imidazolyl)-2,2 bis phenyl-propionamides
EP0117462A3 (fr) * 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1H-imidazol-1-yl)alkyl)arylamides

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3644615A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazol- und triazolderivate zur verwendung als antimykotische mittel
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
EP0575122A3 (en) * 1992-06-17 1994-05-25 Rohm & Haas Fungicidal (2-aryl-2-substituted) ethyl-1,2,4-triazoles
TR26895A (tr) * 1992-06-17 1994-08-22 Rohm & Haas Comp Fungisidal (2-aril-2-ikame-edilmis)etil-1,2,4-triazoller.
US5462931A (en) * 1992-06-25 1995-10-31 Rohm And Haas Company Fungicidal 2-heterocyclic-2,2-disubstituted-ethyl 1,2,4-triazoles
US5624916A (en) * 1992-06-25 1997-04-29 Rohm And Haas Company Fungicidal 1,2,4-triazoles
EP0683156A1 (fr) * 1994-05-18 1995-11-22 Sandoz Ltd. Aminoalkanimidazoles et -triazoles acyles
US5622982A (en) * 1994-05-18 1997-04-22 Sandoz Ltd. Acylated aminoalkanimidazoles and - triazoles
US7125997B2 (en) * 2002-12-20 2006-10-24 Irm Llc Differential tumor cytotoxicity compounds and compositions

Also Published As

Publication number Publication date
IT8447817A0 (it) 1984-03-08
FI840968A0 (fi) 1984-03-09
FR2542315A1 (fr) 1984-09-14
PT78226B (en) 1986-07-15
GB2136801B (en) 1987-03-04
AU2547584A (en) 1984-09-13
DK149784D0 (da) 1984-02-29
CH655103A5 (de) 1986-03-27
DK149784A (da) 1984-09-12
NL8400730A (nl) 1984-10-01
BE899073A (fr) 1984-09-05
GB2136801A (en) 1984-09-26
IL71203A (en) 1988-10-31
IL71203A0 (en) 1984-06-29
GB8405900D0 (en) 1984-04-11
JPS59175472A (ja) 1984-10-04
PH24667A (en) 1990-09-07
CA1242723A (fr) 1988-10-04
PT78226A (en) 1984-04-01
GR81869B (fr) 1984-12-12
NZ207453A (en) 1987-09-30
KR890000377B1 (ko) 1989-03-15
ES8506639A1 (es) 1985-07-16
SE8401321L (sv) 1984-09-12
KR850006386A (ko) 1985-10-05
FR2542315B1 (fr) 1986-02-07
AU571494B2 (en) 1988-04-21
FI840968A (fi) 1984-09-12
IT1199085B (it) 1988-12-30
LU85245A1 (fr) 1984-11-14
SE8401321D0 (sv) 1984-03-09
PL146072B1 (en) 1988-12-31
ZA841782B (en) 1985-10-30
HUT36098A (en) 1985-08-28
PL246600A1 (en) 1985-03-12
ES530461A0 (es) 1985-07-16

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination