DE3370632D1 - Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them - Google Patents

Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them

Info

Publication number
DE3370632D1
DE3370632D1 DE8383402533T DE3370632T DE3370632D1 DE 3370632 D1 DE3370632 D1 DE 3370632D1 DE 8383402533 T DE8383402533 T DE 8383402533T DE 3370632 T DE3370632 T DE 3370632T DE 3370632 D1 DE3370632 D1 DE 3370632D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
depolymerized
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383402533T
Other languages
German (de)
English (en)
Inventor
Annamaria Naggi
Giangiacomo Torri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Sclavo SpA
Original Assignee
Sanofi SA
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9280592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3370632(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi SA, Sclavo SpA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE3370632D1 publication Critical patent/DE3370632D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
DE8383402533T 1982-12-28 1983-12-26 Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them Expired DE3370632D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8221934A FR2538404B1 (enExample) 1982-12-28 1982-12-28

Publications (1)

Publication Number Publication Date
DE3370632D1 true DE3370632D1 (en) 1987-05-07

Family

ID=9280592

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383402533T Expired DE3370632D1 (en) 1982-12-28 1983-12-26 Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US4727063A (enExample)
EP (1) EP0116801B1 (enExample)
JP (2) JPH0629282B2 (enExample)
KR (1) KR910008329B1 (enExample)
AT (1) ATE26281T1 (enExample)
AU (1) AU563289B2 (enExample)
CA (1) CA1210760A (enExample)
DE (1) DE3370632D1 (enExample)
DK (1) DK597983A (enExample)
FR (1) FR2538404B1 (enExample)
IE (1) IE56566B1 (enExample)
IL (1) IL70512A (enExample)
NZ (1) NZ206697A (enExample)
ZA (2) ZA839651B (enExample)

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FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US5262403A (en) * 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
AR243204A1 (es) * 1986-11-21 1993-07-30 Ajorca Sa Un metodo para la depolimerizacion quimica de polisacaridos.
EP0356435B1 (en) * 1987-03-19 1995-10-18 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
AU3434889A (en) * 1988-03-15 1989-10-05 Jewish Hospital Of St. Louis, The Inhibition of intestinal cholesterol and fatty acid absorption
US4945086A (en) * 1988-05-03 1990-07-31 The Board Of Trustees Of The Leland Stanford Junior University Smooth muscle cell growth inhibitor
AU630359B2 (en) * 1988-06-03 1992-10-29 Italfarmaco S.P.A. Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them
US5484777A (en) * 1989-04-20 1996-01-16 Lange, Iii; Louis G. Pancreatic cholesterol esterase inhibitor
US5017565A (en) * 1989-04-20 1991-05-21 Lange Iii Louis G Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
US5063210A (en) * 1989-04-20 1991-11-05 Lange Iii Louis G Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
US5340932A (en) * 1989-08-18 1994-08-23 Ajorca S.A. Substances with heparin-like structure and their method of production
DE69005251T2 (de) * 1989-10-04 1994-05-05 Akzo Nv Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung.
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
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FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1244373B (it) * 1991-01-18 1994-07-08 Sclavo Spa Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso
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US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
NZ258367A (en) * 1992-11-10 1997-02-24 Yeda Res & Dev Oligosaccharide compositions comprising carboxylated and/or sulphated oligosaccharides for use in regulating tnf alpha production
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
WO1995033468A1 (en) * 1994-06-06 1995-12-14 Oestergaard Per Bjoern A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase
AU682792B2 (en) 1994-10-13 1997-10-16 Cv Therapeutics, Inc. Method of manufacturing non-absorbable synthetic sulfated polysaccharides
US5922690A (en) * 1996-04-25 1999-07-13 Van Gorp; Cornelius L. Dermatan disulfate, an inhibitor of thrombin generation and activation
AU3596797A (en) 1996-07-09 1998-02-02 Keith A. Crutcher Methods for the treatment of apolipoprotein e related diseases
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US6388060B1 (en) 1998-11-06 2002-05-14 Vascular Therapeutics Inc. Process for the sulfation of uronic acid-containing polysaccharides
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
BR0012202A (pt) * 1999-06-30 2002-04-02 Hamilton Civic Hospitals Res Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
FR2807918B1 (fr) 2000-04-21 2003-07-04 Equip Tech Ind Alimentaires Retourneur avec galets mobiles sur surfaces de guidage
IL154771A0 (en) * 2000-09-08 2003-10-31 Hamilton Civic Hospitals Res Antithrombotic compositions
KR20040066090A (ko) * 2001-08-31 2004-07-23 아이박스 리서치, 인코포레이티드 사카라이드를 황산화시키기 위한 방법
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
US8071569B2 (en) * 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
JP4636818B2 (ja) * 2004-06-07 2011-02-23 マルホ株式会社 多硫酸化コンドロイチン硫酸の製造方法
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ES2299795T3 (es) * 2004-09-13 2008-06-01 Laboratori Derivati Organici S.P.A. Procedimiento de sulfatacion de la condroitina.
AU2006275822B2 (en) * 2005-07-29 2012-02-02 Onconova Therapeutics, Inc. Formulation of radioprotective alpha, beta unsaturated aryl sulfones
EP2046343B1 (en) * 2006-07-28 2014-05-14 Onconova Therapeutics, Inc. Formulations of radioprotective alpha, beta unsaturated aryl sulfones
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
RU2408379C2 (ru) * 2009-03-04 2011-01-10 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран Антикоагулянтное средство с противовоспалительной и противоопухолевой активностью
CN101597343B (zh) * 2009-05-07 2011-06-15 张丽萍 一种低分子肝素的基团修饰方法
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US20190002596A1 (en) * 2015-12-30 2019-01-03 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Sulfated heparin oligosaccharide and preparation method and application thereof
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JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
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Also Published As

Publication number Publication date
US4727063A (en) 1988-02-23
KR840006812A (ko) 1984-12-03
IL70512A0 (en) 1984-03-30
FR2538404A1 (enExample) 1984-06-29
JPS59133201A (ja) 1984-07-31
ATE26281T1 (de) 1987-04-15
DK597983A (da) 1984-06-29
EP0116801B1 (fr) 1987-04-01
DK597983D0 (da) 1983-12-23
JPS59133202A (ja) 1984-07-31
IL70512A (en) 1989-08-15
JPH0629282B2 (ja) 1994-04-20
EP0116801A1 (fr) 1984-08-29
AU563289B2 (en) 1987-07-02
FR2538404B1 (enExample) 1985-08-23
IE56566B1 (en) 1991-09-11
IE833062L (en) 1984-06-28
AU2285583A (en) 1984-07-05
ZA839652B (en) 1984-08-29
NZ206697A (en) 1986-10-08
ZA839651B (en) 1985-02-27
KR910008329B1 (ko) 1991-10-12
CA1210760A (en) 1986-09-02

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Legal Events

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8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8339 Ceased/non-payment of the annual fee