KR840006812A - 해중합된 과황산염 헤파린의 제조방법 - Google Patents

해중합된 과황산염 헤파린의 제조방법 Download PDF

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KR840006812A
KR840006812A KR1019830006212A KR830006212A KR840006812A KR 840006812 A KR840006812 A KR 840006812A KR 1019830006212 A KR1019830006212 A KR 1019830006212A KR 830006212 A KR830006212 A KR 830006212A KR 840006812 A KR840006812 A KR 840006812A
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heparin
persulfate
depolymerized
salt
sulfuric acid
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KR1019830006212A
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KR910008329B1 (ko
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나지 안나마리아 (외 1)
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아니크 에스·피·에이 (외 1)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)

Abstract

내용 없음

Description

해중합된 과황산염 헤파린의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 출발헤파린(D-212)과 해중합되고 과항산염화된 헤파린(AH-16)을 염산에서 전기영동시킨 그래프이고,
제2도는 D-212와 AH-16의 초산바륨 전기영동그래프이고,
제3도는 D-212와 AH-16의 13C-NMR 스펙트럼이고,
제4도는 D-212/B와 AH-18의 초산바륨 전기영동 그래프이고,
제5도는 D-212와 AH-19의 초산바륨 전기영동그래프이고,
제6도는 D-212/A와 AH-17의 초산바륨 전기영동의 그래프.

Claims (7)

1) 천연의 헤파린 또는 그의 일부분을 황산과 클로로술폰산의 혼합물을 처리하고, 2) 그의 알칼리금속염으로서 수득된 생성물을 분리하거나 또는 3) 그것을 그의 조제상 허용된 염으로 전환시킴을 특징으로 하는 분자량이 2000 내지 9000이고 황산염화도가 2.5 이상인 하기 일반식으로 표시되는 해중합된 과황산염 헤파린, 또는 그의 염, 특히 그의 조제상 허용된 염의 제조방법.
상기 일반식중 A는 H 및 SO3를 나타내고, B는 SO3및 COCH3를 나타내며 m은 4 내지 15의 정수이다.
제1항에 있어서, 반응을 -20 내지 ＋40℃의 온도에서 수행함을 특징으로 하는 방법.
제1항에 있어서, 두산의 농도가 95중량% 이상임을 특징으로 하는 방법
제1항에 있어서, 황산 대 클로로술폰산의 비율이 약 2대 1임을 특징으로 하는 방법.
제1항에 있어서, 해중합된 과황산염 헤파린을 나트륨염으로 분리함을 특징으로 하는 방법.
제1항에 있어서, 해중합된 과황산염 헤파린의 황산염화도가 출발 헤파린 또는 일부분보다 20% 이상 높음을 특징으로 하는 방법.
제1 및 5항에 있어서, 제5항의 방법에 의해 수득된 나트륨염을 교환 반응시킴으로써 해중화된 과황산염 헤파린의 칼슘염을 수득함을 특징으로 하는 방법.
.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임
KR1019830006212A 1982-12-28 1983-12-27 해중합된 과황산염 헤파린의 제조방법 KR910008329B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8221934A FR2538404B1 (ko) 1982-12-28 1982-12-28
FR8221934 1982-12-28
FR21934/82 1982-12-28

Publications (2)

Publication Number Publication Date
KR840006812A true KR840006812A (ko) 1984-12-03
KR910008329B1 KR910008329B1 (ko) 1991-10-12

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ID=9280592

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KR1019830006212A KR910008329B1 (ko) 1982-12-28 1983-12-27 해중합된 과황산염 헤파린의 제조방법

Country Status (14)

Country Link
US (1) US4727063A (ko)
EP (1) EP0116801B1 (ko)
JP (2) JPS59133201A (ko)
KR (1) KR910008329B1 (ko)
AT (1) ATE26281T1 (ko)
AU (1) AU563289B2 (ko)
CA (1) CA1210760A (ko)
DE (1) DE3370632D1 (ko)
DK (1) DK597983A (ko)
FR (1) FR2538404B1 (ko)
IE (1) IE56566B1 (ko)
IL (1) IL70512A (ko)
NZ (1) NZ206697A (ko)
ZA (2) ZA839652B (ko)

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Also Published As

Publication number Publication date
JPS59133202A (ja) 1984-07-31
JPH0629282B2 (ja) 1994-04-20
ZA839651B (en) 1985-02-27
KR910008329B1 (ko) 1991-10-12
DK597983D0 (da) 1983-12-23
FR2538404B1 (ko) 1985-08-23
IE56566B1 (en) 1991-09-11
AU563289B2 (en) 1987-07-02
ZA839652B (en) 1984-08-29
ATE26281T1 (de) 1987-04-15
FR2538404A1 (ko) 1984-06-29
DE3370632D1 (en) 1987-05-07
IE833062L (en) 1984-06-28
EP0116801A1 (fr) 1984-08-29
NZ206697A (en) 1986-10-08
US4727063A (en) 1988-02-23
AU2285583A (en) 1984-07-05
CA1210760A (en) 1986-09-02
JPS59133201A (ja) 1984-07-31
IL70512A (en) 1989-08-15
EP0116801B1 (fr) 1987-04-01
DK597983A (da) 1984-06-29
IL70512A0 (en) 1984-03-30

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