ES472934A1 - Procedimiento para la obtencion de oligiheteropolizacaridos,aplicables especialmente al tratamiento de la trombosis - Google Patents
Procedimiento para la obtencion de oligiheteropolizacaridos,aplicables especialmente al tratamiento de la trombosisInfo
- Publication number
- ES472934A1 ES472934A1 ES472934A ES472934A ES472934A1 ES 472934 A1 ES472934 A1 ES 472934A1 ES 472934 A ES472934 A ES 472934A ES 472934 A ES472934 A ES 472934A ES 472934 A1 ES472934 A1 ES 472934A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- oligo
- preparation
- heteropolysaccharides
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Procedimiento para la obtención de oligoheteropolisacáridos, aplicables especialmente al tratamiento de la trombosis, constituidos por una fracción heparínica que tiene un peso molecular comprendido entre 2000 y 5000, y que contiene grupos activos sulfúricos que tienen la cantidad y la posición características de la heparina, caracterizado porque comprende las fases de: depolimerizar la heparina para obtener fracciones de oligoheteropolisacáridos y tratar dichas fracciones para reconstituir los grupos sulfúricos activos en las cantidades y posición características de la molécula de heparina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT26608/77A IT1083903B (it) | 1977-08-09 | 1977-08-09 | Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche |
Publications (1)
Publication Number | Publication Date |
---|---|
ES472934A1 true ES472934A1 (es) | 1979-10-16 |
Family
ID=11219874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472934A Expired ES472934A1 (es) | 1977-08-09 | 1978-08-09 | Procedimiento para la obtencion de oligiheteropolizacaridos,aplicables especialmente al tratamiento de la trombosis |
Country Status (10)
Country | Link |
---|---|
US (1) | US4757057A (es) |
JP (1) | JPS5430277A (es) |
AU (1) | AU3873878A (es) |
CH (1) | CH642979A5 (es) |
DE (1) | DE2833898A1 (es) |
DK (1) | DK159278B (es) |
ES (1) | ES472934A1 (es) |
FR (1) | FR2400037A1 (es) |
GB (1) | GB2002406B (es) |
IT (1) | IT1083903B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
FR2461719A2 (fr) * | 1979-07-20 | 1981-02-06 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
USRE35770E (en) * | 1978-11-06 | 1998-04-14 | Choay, S.A. | Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them |
FR2478646A2 (fr) * | 1980-03-20 | 1981-09-25 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
US4826827A (en) * | 1979-10-05 | 1989-05-02 | Choay S.A. | Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs |
JPS56120704A (en) * | 1980-01-28 | 1981-09-22 | Hepar Ind Inc | Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use |
US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
FR2503714B1 (fr) * | 1981-04-10 | 1986-11-21 | Choay Sa | Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine |
FR2538404B1 (es) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
IT1195497B (it) * | 1983-03-08 | 1988-10-19 | Opocrin Spa | Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina |
IT1163772B (it) * | 1983-07-13 | 1987-04-08 | Baldacci Lab Spa | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
US4745105A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Low molecular weight heparin derivatives with improved permeability |
US4745107A (en) * | 1986-08-20 | 1988-05-17 | Foley Kevin M | Heparin derivatives with improved permeability |
US4745106A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Heparin derivatives having improved anti-Xa specificity |
US4942156A (en) * | 1986-08-20 | 1990-07-17 | Hepar Industries, Inc. | Low molecular weight heparin derivatives having improved anti-Xa specificity |
IT1234508B (it) * | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
US4994367A (en) * | 1988-10-07 | 1991-02-19 | East Carolina University | Extended shelf life platelet preparations and process for preparing the same |
IT1237518B (it) * | 1989-11-24 | 1993-06-08 | Renato Conti | Eparine supersolfatate |
US7387253B1 (en) | 1996-09-03 | 2008-06-17 | Hand Held Products, Inc. | Optical reader system comprising local host processor and optical reader |
US5784102A (en) * | 1995-05-15 | 1998-07-21 | Welch Allyn, Inc. | Optical reader having improved interactive image sensing and control circuitry |
US6569840B1 (en) | 1997-11-20 | 2003-05-27 | Ikuo Yamashina | Low-molecular heparin modification and remedy for skin ulcer |
DE60237553D1 (de) | 2001-01-22 | 2010-10-14 | Hand Held Prod Inc | Optisches Lesegerät mit Partial-Frame-Betriebsmodus |
US7270273B2 (en) | 2001-01-22 | 2007-09-18 | Hand Held Products, Inc. | Optical reader having partial frame operating mode |
US7268924B2 (en) | 2001-01-22 | 2007-09-11 | Hand Held Products, Inc. | Optical reader having reduced parameter determination delay |
EP1582531A1 (en) * | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
JP4679138B2 (ja) * | 2004-12-24 | 2011-04-27 | 株式会社日本バリアフリー | 高純度化されたムコ多糖類の製造方法 |
WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
EP3997238A1 (en) | 2019-07-09 | 2022-05-18 | Optimvia, LLC | Methods for synthesizing anticoagulant polysaccharides |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB674607A (en) * | 1949-10-20 | 1952-06-25 | Roche Products Ltd | Process for the manufacture of substances preventing the coagulation of blood |
US2832766A (en) * | 1952-04-17 | 1958-04-29 | Univ Ohio State Res Found | Sulfated aminopolysaccharides |
DE968752C (de) * | 1954-01-29 | 1958-03-27 | Hoffmann La Roche | Verfahren zur Herstellung von Chondroitinpolyschwefelsaeureestern |
DE1032731B (de) * | 1955-09-22 | 1958-06-26 | Upjohn Co | Verfahren zur selektiven Sulfatierung von Aminoalkoholen in der Aminogruppe |
US3585184A (en) * | 1967-12-29 | 1971-06-15 | Univ Ohio State | 2-amino - 2 - deoxy-d-glucopyrano-d-glucopyranans having the alpha-d-glucose configuration,method,and use |
-
1977
- 1977-08-09 IT IT26608/77A patent/IT1083903B/it active
-
1978
- 1978-08-01 GB GB7831825A patent/GB2002406B/en not_active Expired
- 1978-08-02 DE DE19782833898 patent/DE2833898A1/de active Granted
- 1978-08-02 CH CH823778A patent/CH642979A5/it not_active IP Right Cessation
- 1978-08-08 DK DK349678A patent/DK159278B/da unknown
- 1978-08-08 AU AU38738/78A patent/AU3873878A/en active Pending
- 1978-08-09 JP JP9627778A patent/JPS5430277A/ja active Granted
- 1978-08-09 FR FR7823499A patent/FR2400037A1/fr active Granted
- 1978-08-09 ES ES472934A patent/ES472934A1/es not_active Expired
-
1986
- 1986-01-07 US US06/816,838 patent/US4757057A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2400037A1 (fr) | 1979-03-09 |
JPS5430277A (en) | 1979-03-06 |
AU3873878A (en) | 1980-02-14 |
DK349678A (da) | 1979-02-10 |
DK159278B (da) | 1990-09-24 |
GB2002406A (en) | 1979-02-21 |
GB2002406B (en) | 1982-10-20 |
US4757057A (en) | 1988-07-12 |
DE2833898C2 (es) | 1988-06-23 |
IT1083903B (it) | 1985-05-25 |
CH642979A5 (it) | 1984-05-15 |
FR2400037B1 (es) | 1980-06-20 |
JPS6234041B2 (es) | 1987-07-24 |
DE2833898A1 (de) | 1979-02-22 |
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