DE3220118A1 - Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel - Google Patents
Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittelInfo
- Publication number
- DE3220118A1 DE3220118A1 DE19823220118 DE3220118A DE3220118A1 DE 3220118 A1 DE3220118 A1 DE 3220118A1 DE 19823220118 DE19823220118 DE 19823220118 DE 3220118 A DE3220118 A DE 3220118A DE 3220118 A1 DE3220118 A1 DE 3220118A1
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- carbon atoms
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000000034 method Methods 0.000 title claims abstract description 16
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 229940114079 arachidonic acid Drugs 0.000 claims description 13
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- 235000021342 arachidonic acid Nutrition 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- -1 carbomethoxy, carboethoxy Chemical group 0.000 claims description 11
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
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- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000019432 tissue death Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823220118 DE3220118A1 (de) | 1982-05-28 | 1982-05-28 | Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US06/492,776 US4581453A (en) | 1982-05-28 | 1983-05-09 | Guanidinothiazole derivatives containing alkylene bridges, and their use for influencing lipid metabolism |
| DE8383104793T DE3361990D1 (en) | 1982-05-28 | 1983-05-16 | Alkylene-bridged guanidino-thiazole derivatives, method for their preparation and their use as medicaments |
| EP83104793A EP0095640B1 (de) | 1982-05-28 | 1983-05-16 | Alkylenverbrückte Guanidinothiazolderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| AT83104793T ATE17727T1 (de) | 1982-05-28 | 1983-05-16 | Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel. |
| CA000428994A CA1255299A (en) | 1982-05-28 | 1983-05-26 | Guanidinothiazole derivatives containing alkylene bridges, a process for their preparation and their use as medicaments |
| JP58092637A JPS58216186A (ja) | 1982-05-28 | 1983-05-27 | グアニジノチアゾ−ル誘導体、それらの製造法およびそれらの薬剤としての用途 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823220118 DE3220118A1 (de) | 1982-05-28 | 1982-05-28 | Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3220118A1 true DE3220118A1 (de) | 1983-12-01 |
Family
ID=6164727
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19823220118 Withdrawn DE3220118A1 (de) | 1982-05-28 | 1982-05-28 | Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE8383104793T Expired DE3361990D1 (en) | 1982-05-28 | 1983-05-16 | Alkylene-bridged guanidino-thiazole derivatives, method for their preparation and their use as medicaments |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8383104793T Expired DE3361990D1 (en) | 1982-05-28 | 1983-05-16 | Alkylene-bridged guanidino-thiazole derivatives, method for their preparation and their use as medicaments |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4581453A (enExample) |
| EP (1) | EP0095640B1 (enExample) |
| JP (1) | JPS58216186A (enExample) |
| AT (1) | ATE17727T1 (enExample) |
| CA (1) | CA1255299A (enExample) |
| DE (2) | DE3220118A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
| US4956370A (en) * | 1988-10-24 | 1990-09-11 | Bayer Aktiengesellschaft | Antimycotically active substituted 2-aminothiazoles |
| EP1169038A4 (en) * | 1999-04-15 | 2004-10-13 | Bristol Myers Squibb Co | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS |
| DE19944342B4 (de) * | 1999-09-16 | 2005-05-04 | Primasoft Gmbh | Anlage zur Aufnahme und/oder Wiedergabe von Sprache, Ton, Musik, Daten oder dergleichen Signalen |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0753666B2 (ja) * | 1987-09-14 | 1995-06-07 | 久光製薬株式会社 | 置換ジフェニルチアゾール誘導体からなる抗炎症剤 |
| DE3836184A1 (de) * | 1988-10-24 | 1990-05-03 | Bayer Ag | Substituierte 2-aminothiazole |
| US6132666A (en) * | 1997-06-30 | 2000-10-17 | Interface, Inc. | Method for making formed fabric treatments |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| US20060122387A1 (en) * | 2002-06-13 | 2006-06-08 | Cti Europe S.R.L. | Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells |
| CN101235018B (zh) * | 2007-01-30 | 2011-05-04 | 重庆医药工业研究院有限责任公司 | 一种制备(1,4,5,6-四氢-2-嘧啶基)硫脲或其盐的改进方法 |
| WO2016043260A1 (ja) * | 2014-09-19 | 2016-03-24 | 塩野義製薬株式会社 | 環状グアニジンまたはアミジン化合物 |
| WO2016098793A1 (ja) * | 2014-12-17 | 2016-06-23 | 塩野義製薬株式会社 | 環状グアニジル基を有するチアゾール誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137317C (enExample) * | 1967-11-10 | |||
| DE1918070A1 (de) * | 1969-04-09 | 1971-01-21 | Thomae Gmbh Dr K | Neue,an der Aminogruppe substituierte 2-Amino-5-nitro-thiazole und Verfahren zur Herstellung |
| DE2205745A1 (de) * | 1972-02-08 | 1973-08-23 | Thomae Gmbh Dr K | Neue durch den n-cyaniminorest substituierten heterocyclen und verfahren zu ihrer herstellung |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
-
1982
- 1982-05-28 DE DE19823220118 patent/DE3220118A1/de not_active Withdrawn
-
1983
- 1983-05-09 US US06/492,776 patent/US4581453A/en not_active Expired - Fee Related
- 1983-05-16 DE DE8383104793T patent/DE3361990D1/de not_active Expired
- 1983-05-16 AT AT83104793T patent/ATE17727T1/de not_active IP Right Cessation
- 1983-05-16 EP EP83104793A patent/EP0095640B1/de not_active Expired
- 1983-05-26 CA CA000428994A patent/CA1255299A/en not_active Expired
- 1983-05-27 JP JP58092637A patent/JPS58216186A/ja active Granted
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
| US4956370A (en) * | 1988-10-24 | 1990-09-11 | Bayer Aktiengesellschaft | Antimycotically active substituted 2-aminothiazoles |
| CZ302788B6 (cs) * | 1999-04-15 | 2011-11-09 | Bristol-Myers Squibb Company | ´N-(2-Chlor-6-methylfenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolkarboxamid, jeho použití a farmaceutický prostredek s jeho obsahem |
| US6979694B2 (en) | 1999-04-15 | 2005-12-27 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7091223B2 (en) | 1999-04-15 | 2006-08-15 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7153856B2 (en) | 1999-04-15 | 2006-12-26 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7189854B2 (en) | 1999-04-15 | 2007-03-13 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| EP1169038A4 (en) * | 1999-04-15 | 2004-10-13 | Bristol Myers Squibb Co | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS |
| US8716323B2 (en) | 1999-04-15 | 2014-05-06 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US8993567B2 (en) | 1999-04-15 | 2015-03-31 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US9382219B2 (en) | 1999-04-15 | 2016-07-05 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| DE19944342B4 (de) * | 1999-09-16 | 2005-05-04 | Primasoft Gmbh | Anlage zur Aufnahme und/oder Wiedergabe von Sprache, Ton, Musik, Daten oder dergleichen Signalen |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1255299A (en) | 1989-06-06 |
| JPH0518831B2 (enExample) | 1993-03-15 |
| JPS58216186A (ja) | 1983-12-15 |
| EP0095640A1 (de) | 1983-12-07 |
| US4581453A (en) | 1986-04-08 |
| ATE17727T1 (de) | 1986-02-15 |
| EP0095640B1 (de) | 1986-01-29 |
| DE3361990D1 (en) | 1986-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8130 | Withdrawal |