JPS58216186A - グアニジノチアゾ−ル誘導体、それらの製造法およびそれらの薬剤としての用途 - Google Patents
グアニジノチアゾ−ル誘導体、それらの製造法およびそれらの薬剤としての用途Info
- Publication number
- JPS58216186A JPS58216186A JP58092637A JP9263783A JPS58216186A JP S58216186 A JPS58216186 A JP S58216186A JP 58092637 A JP58092637 A JP 58092637A JP 9263783 A JP9263783 A JP 9263783A JP S58216186 A JPS58216186 A JP S58216186A
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- alkoxy
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 13
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- 125000001424 substituent group Chemical group 0.000 claims description 4
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- 230000007704 transition Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3220118.4 | 1982-05-28 | ||
| DE19823220118 DE3220118A1 (de) | 1982-05-28 | 1982-05-28 | Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58216186A true JPS58216186A (ja) | 1983-12-15 |
| JPH0518831B2 JPH0518831B2 (enExample) | 1993-03-15 |
Family
ID=6164727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58092637A Granted JPS58216186A (ja) | 1982-05-28 | 1983-05-27 | グアニジノチアゾ−ル誘導体、それらの製造法およびそれらの薬剤としての用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4581453A (enExample) |
| EP (1) | EP0095640B1 (enExample) |
| JP (1) | JPS58216186A (enExample) |
| AT (1) | ATE17727T1 (enExample) |
| CA (1) | CA1255299A (enExample) |
| DE (2) | DE3220118A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6475475A (en) * | 1987-09-14 | 1989-03-22 | Hisamitsu Pharmaceutical Co | Novel substituted diphenylthizole derivative |
| WO2016043260A1 (ja) * | 2014-09-19 | 2016-03-24 | 塩野義製薬株式会社 | 環状グアニジンまたはアミジン化合物 |
| WO2016098793A1 (ja) * | 2014-12-17 | 2016-06-23 | 塩野義製薬株式会社 | 環状グアニジル基を有するチアゾール誘導体 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
| DE3836184A1 (de) * | 1988-10-24 | 1990-05-03 | Bayer Ag | Substituierte 2-aminothiazole |
| DE3839758A1 (de) * | 1988-10-24 | 1990-04-26 | Bayer Ag | Substituierte 2-aminothiazole |
| US6132666A (en) * | 1997-06-30 | 2000-10-17 | Interface, Inc. | Method for making formed fabric treatments |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| NZ513639A (en) | 1999-04-15 | 2004-02-27 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors |
| DE19944342B4 (de) * | 1999-09-16 | 2005-05-04 | Primasoft Gmbh | Anlage zur Aufnahme und/oder Wiedergabe von Sprache, Ton, Musik, Daten oder dergleichen Signalen |
| US20060122387A1 (en) * | 2002-06-13 | 2006-06-08 | Cti Europe S.R.L. | Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells |
| CN101235018B (zh) * | 2007-01-30 | 2011-05-04 | 重庆医药工业研究院有限责任公司 | 一种制备(1,4,5,6-四氢-2-嘧啶基)硫脲或其盐的改进方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655685A (en) * | 1969-04-09 | 1972-04-11 | Boehringer Sohn Ingelheim | 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137317C (enExample) * | 1967-11-10 | |||
| DE2205745A1 (de) * | 1972-02-08 | 1973-08-23 | Thomae Gmbh Dr K | Neue durch den n-cyaniminorest substituierten heterocyclen und verfahren zu ihrer herstellung |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
-
1982
- 1982-05-28 DE DE19823220118 patent/DE3220118A1/de not_active Withdrawn
-
1983
- 1983-05-09 US US06/492,776 patent/US4581453A/en not_active Expired - Fee Related
- 1983-05-16 DE DE8383104793T patent/DE3361990D1/de not_active Expired
- 1983-05-16 AT AT83104793T patent/ATE17727T1/de not_active IP Right Cessation
- 1983-05-16 EP EP83104793A patent/EP0095640B1/de not_active Expired
- 1983-05-26 CA CA000428994A patent/CA1255299A/en not_active Expired
- 1983-05-27 JP JP58092637A patent/JPS58216186A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655685A (en) * | 1969-04-09 | 1972-04-11 | Boehringer Sohn Ingelheim | 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6475475A (en) * | 1987-09-14 | 1989-03-22 | Hisamitsu Pharmaceutical Co | Novel substituted diphenylthizole derivative |
| WO2016043260A1 (ja) * | 2014-09-19 | 2016-03-24 | 塩野義製薬株式会社 | 環状グアニジンまたはアミジン化合物 |
| WO2016098793A1 (ja) * | 2014-12-17 | 2016-06-23 | 塩野義製薬株式会社 | 環状グアニジル基を有するチアゾール誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1255299A (en) | 1989-06-06 |
| JPH0518831B2 (enExample) | 1993-03-15 |
| EP0095640A1 (de) | 1983-12-07 |
| US4581453A (en) | 1986-04-08 |
| DE3220118A1 (de) | 1983-12-01 |
| ATE17727T1 (de) | 1986-02-15 |
| EP0095640B1 (de) | 1986-01-29 |
| DE3361990D1 (en) | 1986-03-13 |
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