JPS6475475A - Novel substituted diphenylthizole derivative - Google Patents

Novel substituted diphenylthizole derivative

Info

Publication number
JPS6475475A
JPS6475475A JP23007487A JP23007487A JPS6475475A JP S6475475 A JPS6475475 A JP S6475475A JP 23007487 A JP23007487 A JP 23007487A JP 23007487 A JP23007487 A JP 23007487A JP S6475475 A JPS6475475 A JP S6475475A
Authority
JP
Japan
Prior art keywords
compound shown
formula
drug
diphenylthizole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP23007487A
Other languages
Japanese (ja)
Other versions
JPH0753666B2 (en
Inventor
Masayoshi Tsuji
Toshitaka Inoue
Koichi Ikesue
Masaru Saida
Yasuaki Taniguchi
Yoshiki Deguchi
Kanji Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP62230074A priority Critical patent/JPH0753666B2/en
Publication of JPS6475475A publication Critical patent/JPS6475475A/en
Publication of JPH0753666B2 publication Critical patent/JPH0753666B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by formula I [X and Y are H, halogen or lower alkoxy; n is 0-7; R1 is H or acyl; R2 is long-chain alkyl, cycloalkyl, lower alkoxy, (substituted)phenoxy, heterocyclic group or cyclic amino] and an acid addition salt thereof useful as a drug. EXAMPLE:4,5-Diphenyl-2-(2'-morpholinoethyl)aminothiazole. USE:A drug useful as an excellent anti-inflammatory drug, analgesic, antipyretic, antirheumatic. A dose is about 1-300mg calculated as an active ingredient daily and preferably administered dividedly once-three times daily. PREPARATION:A compound shown by formula II (HI is halogen) is reacted with a compound shown by formula III in an organic solvent such as ethanol at 20-120 deg.C for 1-48hr to give a compound shown by formula I.
JP62230074A 1987-09-14 1987-09-14 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative Expired - Lifetime JPH0753666B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62230074A JPH0753666B2 (en) 1987-09-14 1987-09-14 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62230074A JPH0753666B2 (en) 1987-09-14 1987-09-14 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative

Publications (2)

Publication Number Publication Date
JPS6475475A true JPS6475475A (en) 1989-03-22
JPH0753666B2 JPH0753666B2 (en) 1995-06-07

Family

ID=16902136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62230074A Expired - Lifetime JPH0753666B2 (en) 1987-09-14 1987-09-14 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative

Country Status (1)

Country Link
JP (1) JPH0753666B2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145860A (en) * 1989-01-05 1992-09-08 Fujisawa Pharmaceutical Co., Ltd. Thiazole compounds and pharmaceutical composition comprising the same
WO1992015570A1 (en) * 1991-03-07 1992-09-17 Hisamitsu Pharmaceutical Co., Inc. Novel diphenylthyazole derivative
WO2001017995A1 (en) * 1999-09-10 2001-03-15 Merck & Co., Inc. Tyrosine kinase inhibitors
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
US7514566B2 (en) 2006-01-18 2009-04-07 Amgen, Inc. Thiazole compounds and methods of use
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
US7919504B2 (en) 2007-07-17 2011-04-05 Amgen Inc. Thiadiazole modulators of PKB

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles
JPS50121269A (en) * 1974-01-31 1975-09-23
JPS5455566A (en) * 1977-09-28 1979-05-02 Upjohn Co Organic compound and pharmaceutical composition
JPS54160369A (en) * 1978-06-02 1979-12-19 Pfizer Novel aminothiazoles
US4307106A (en) * 1978-06-02 1981-12-22 Pfizer Inc. Aminothiazoles
JPS57118574A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same
JPS58216186A (en) * 1982-05-28 1983-12-15 バイエル・アクチエンゲゼルシヤフト Guanidinothiazole derivatives, manufacture and use as drug
JPS63243080A (en) * 1987-03-12 1988-10-07 サノフイ Novel thiazole derivative active to choline action system, manufacture and medicinal composition

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles
JPS50121269A (en) * 1974-01-31 1975-09-23
JPS5455566A (en) * 1977-09-28 1979-05-02 Upjohn Co Organic compound and pharmaceutical composition
JPS54160369A (en) * 1978-06-02 1979-12-19 Pfizer Novel aminothiazoles
US4307106A (en) * 1978-06-02 1981-12-22 Pfizer Inc. Aminothiazoles
JPS57118574A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same
JPS58216186A (en) * 1982-05-28 1983-12-15 バイエル・アクチエンゲゼルシヤフト Guanidinothiazole derivatives, manufacture and use as drug
JPS63243080A (en) * 1987-03-12 1988-10-07 サノフイ Novel thiazole derivative active to choline action system, manufacture and medicinal composition

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145860A (en) * 1989-01-05 1992-09-08 Fujisawa Pharmaceutical Co., Ltd. Thiazole compounds and pharmaceutical composition comprising the same
WO1992015570A1 (en) * 1991-03-07 1992-09-17 Hisamitsu Pharmaceutical Co., Inc. Novel diphenylthyazole derivative
WO2001017995A1 (en) * 1999-09-10 2001-03-15 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2003509342A (en) * 1999-09-10 2003-03-11 メルク エンド カムパニー インコーポレーテッド Tyrosine kinase inhibitor
US6586424B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6586423B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
US7514566B2 (en) 2006-01-18 2009-04-07 Amgen, Inc. Thiazole compounds and methods of use
US8084479B2 (en) 2006-01-18 2011-12-27 Amgen Inc. Thiazole compounds and methods of use
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
US7919504B2 (en) 2007-07-17 2011-04-05 Amgen Inc. Thiadiazole modulators of PKB

Also Published As

Publication number Publication date
JPH0753666B2 (en) 1995-06-07

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