JPS6475475A - Novel substituted diphenylthizole derivative - Google Patents
Novel substituted diphenylthizole derivativeInfo
- Publication number
- JPS6475475A JPS6475475A JP23007487A JP23007487A JPS6475475A JP S6475475 A JPS6475475 A JP S6475475A JP 23007487 A JP23007487 A JP 23007487A JP 23007487 A JP23007487 A JP 23007487A JP S6475475 A JPS6475475 A JP S6475475A
- Authority
- JP
- Japan
- Prior art keywords
- compound shown
- formula
- drug
- diphenylthizole
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by formula I [X and Y are H, halogen or lower alkoxy; n is 0-7; R1 is H or acyl; R2 is long-chain alkyl, cycloalkyl, lower alkoxy, (substituted)phenoxy, heterocyclic group or cyclic amino] and an acid addition salt thereof useful as a drug. EXAMPLE:4,5-Diphenyl-2-(2'-morpholinoethyl)aminothiazole. USE:A drug useful as an excellent anti-inflammatory drug, analgesic, antipyretic, antirheumatic. A dose is about 1-300mg calculated as an active ingredient daily and preferably administered dividedly once-three times daily. PREPARATION:A compound shown by formula II (HI is halogen) is reacted with a compound shown by formula III in an organic solvent such as ethanol at 20-120 deg.C for 1-48hr to give a compound shown by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62230074A JPH0753666B2 (en) | 1987-09-14 | 1987-09-14 | Anti-inflammatory agent consisting of substituted diphenylthiazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62230074A JPH0753666B2 (en) | 1987-09-14 | 1987-09-14 | Anti-inflammatory agent consisting of substituted diphenylthiazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6475475A true JPS6475475A (en) | 1989-03-22 |
JPH0753666B2 JPH0753666B2 (en) | 1995-06-07 |
Family
ID=16902136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62230074A Expired - Lifetime JPH0753666B2 (en) | 1987-09-14 | 1987-09-14 | Anti-inflammatory agent consisting of substituted diphenylthiazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0753666B2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145860A (en) * | 1989-01-05 | 1992-09-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds and pharmaceutical composition comprising the same |
WO1992015570A1 (en) * | 1991-03-07 | 1992-09-17 | Hisamitsu Pharmaceutical Co., Inc. | Novel diphenylthyazole derivative |
WO2001017995A1 (en) * | 1999-09-10 | 2001-03-15 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6872724B2 (en) | 2002-07-24 | 2005-03-29 | Merck & Co., Inc. | Polymorphs with tyrosine kinase activity |
US6875767B2 (en) | 2001-06-22 | 2005-04-05 | Merck & Co., Inc. | (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors |
US7514566B2 (en) | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
US7919504B2 (en) | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3458526A (en) * | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
JPS50121269A (en) * | 1974-01-31 | 1975-09-23 | ||
JPS5455566A (en) * | 1977-09-28 | 1979-05-02 | Upjohn Co | Organic compound and pharmaceutical composition |
JPS54160369A (en) * | 1978-06-02 | 1979-12-19 | Pfizer | Novel aminothiazoles |
US4307106A (en) * | 1978-06-02 | 1981-12-22 | Pfizer Inc. | Aminothiazoles |
JPS57118574A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
JPS58216186A (en) * | 1982-05-28 | 1983-12-15 | バイエル・アクチエンゲゼルシヤフト | Guanidinothiazole derivatives, manufacture and use as drug |
JPS63243080A (en) * | 1987-03-12 | 1988-10-07 | サノフイ | Novel thiazole derivative active to choline action system, manufacture and medicinal composition |
-
1987
- 1987-09-14 JP JP62230074A patent/JPH0753666B2/en not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3458526A (en) * | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
JPS50121269A (en) * | 1974-01-31 | 1975-09-23 | ||
JPS5455566A (en) * | 1977-09-28 | 1979-05-02 | Upjohn Co | Organic compound and pharmaceutical composition |
JPS54160369A (en) * | 1978-06-02 | 1979-12-19 | Pfizer | Novel aminothiazoles |
US4307106A (en) * | 1978-06-02 | 1981-12-22 | Pfizer Inc. | Aminothiazoles |
JPS57118574A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
JPS58216186A (en) * | 1982-05-28 | 1983-12-15 | バイエル・アクチエンゲゼルシヤフト | Guanidinothiazole derivatives, manufacture and use as drug |
JPS63243080A (en) * | 1987-03-12 | 1988-10-07 | サノフイ | Novel thiazole derivative active to choline action system, manufacture and medicinal composition |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145860A (en) * | 1989-01-05 | 1992-09-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds and pharmaceutical composition comprising the same |
WO1992015570A1 (en) * | 1991-03-07 | 1992-09-17 | Hisamitsu Pharmaceutical Co., Inc. | Novel diphenylthyazole derivative |
WO2001017995A1 (en) * | 1999-09-10 | 2001-03-15 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
JP2003509342A (en) * | 1999-09-10 | 2003-03-11 | メルク エンド カムパニー インコーポレーテッド | Tyrosine kinase inhibitor |
US6586424B2 (en) | 1999-09-10 | 2003-07-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6586423B2 (en) | 1999-09-10 | 2003-07-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6875767B2 (en) | 2001-06-22 | 2005-04-05 | Merck & Co., Inc. | (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors |
US6872724B2 (en) | 2002-07-24 | 2005-03-29 | Merck & Co., Inc. | Polymorphs with tyrosine kinase activity |
US7514566B2 (en) | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
US8084479B2 (en) | 2006-01-18 | 2011-12-27 | Amgen Inc. | Thiazole compounds and methods of use |
US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
US7919504B2 (en) | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
Also Published As
Publication number | Publication date |
---|---|
JPH0753666B2 (en) | 1995-06-07 |
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