DE3204588A1 - Im ring a substituierte apovincaminol-verbindungen, ihre saeureadditionssalze und verfahren zu ihrer herstellung - Google Patents
Im ring a substituierte apovincaminol-verbindungen, ihre saeureadditionssalze und verfahren zu ihrer herstellungInfo
- Publication number
- DE3204588A1 DE3204588A1 DE19823204588 DE3204588A DE3204588A1 DE 3204588 A1 DE3204588 A1 DE 3204588A1 DE 19823204588 DE19823204588 DE 19823204588 DE 3204588 A DE3204588 A DE 3204588A DE 3204588 A1 DE3204588 A1 DE 3204588A1
- Authority
- DE
- Germany
- Prior art keywords
- acid addition
- compounds
- hydrogen
- addition salts
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011269 tar Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 108010072897 transcription factor Brn-2 Proteins 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU81324A HU183326B (en) | 1981-02-11 | 1981-02-11 | Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted in the a ring and acid addition salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3204588A1 true DE3204588A1 (de) | 1982-12-30 |
| DE3204588C2 DE3204588C2 (en, 2012) | 1990-10-04 |
Family
ID=10949091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19823204588 Granted DE3204588A1 (de) | 1981-02-11 | 1982-02-10 | Im ring a substituierte apovincaminol-verbindungen, ihre saeureadditionssalze und verfahren zu ihrer herstellung |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4432982A (en, 2012) |
| JP (1) | JPS57150685A (en, 2012) |
| AR (1) | AR228385A1 (en, 2012) |
| AT (1) | AT382375B (en, 2012) |
| AU (1) | AU545745B2 (en, 2012) |
| BE (1) | BE892070A (en, 2012) |
| CA (1) | CA1199637A (en, 2012) |
| DD (1) | DD201593A5 (en, 2012) |
| DE (1) | DE3204588A1 (en, 2012) |
| DK (1) | DK151022C (en, 2012) |
| ES (1) | ES509418A0 (en, 2012) |
| FI (1) | FI70019C (en, 2012) |
| FR (1) | FR2499573B1 (en, 2012) |
| GB (1) | GB2096597B (en, 2012) |
| GR (1) | GR75858B (en, 2012) |
| HU (1) | HU183326B (en, 2012) |
| IT (1) | IT1157921B (en, 2012) |
| NL (1) | NL8200493A (en, 2012) |
| NO (1) | NO820395L (en, 2012) |
| PT (1) | PT74402B (en, 2012) |
| SE (1) | SE8200524L (en, 2012) |
| SU (1) | SU1069626A3 (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT389307B (de) * | 1984-04-25 | 1989-11-27 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von neuen apovincaminolderivaten und ihren saeureadditionssalzen |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2458164A1 (de) * | 1973-12-18 | 1975-06-26 | Sandoz Ag | Verfahren zur herstellung von neuen heterocyclischen verbindungen |
| US4065458A (en) * | 1975-06-10 | 1977-12-27 | Richter Gedeon Vegyeszeti Gyar Rt. | Eburnamenine derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035784A1 (en) * | 1969-03-27 | 1970-12-24 | Olivier Louisette | Vincamine derivs with therapeutic propert- - ies |
| US4146643A (en) * | 1973-12-18 | 1979-03-27 | Sandoz Ltd. | Increasing vigilance or treating cerebral insufficiency with substituted vincamines |
| US4123535A (en) * | 1974-09-06 | 1978-10-31 | Sandoz Ltd. | Psychostimulating 14-amino-14,15-dihydroeburnamenines |
| HU177370B (en) * | 1977-07-27 | 1981-09-28 | Richter Gedeon Vegyeszet | Process for producing new bracket-cross-bracket-vincaminol-esters |
| IL60613A (en) * | 1979-08-16 | 1983-12-30 | Richter Gedeon Vegyeszet | Dermatological compositions applicable directly to the skin comprising an eburnamenine derivative and process for their preparation |
-
1981
- 1981-02-11 HU HU81324A patent/HU183326B/hu not_active IP Right Cessation
-
1982
- 1982-01-26 AT AT0026282A patent/AT382375B/de not_active IP Right Cessation
- 1982-01-29 SE SE8200524A patent/SE8200524L/xx not_active Application Discontinuation
- 1982-02-01 CA CA000395305A patent/CA1199637A/en not_active Expired
- 1982-02-04 US US06/345,633 patent/US4432982A/en not_active Expired - Fee Related
- 1982-02-04 FI FI820364A patent/FI70019C/fi not_active IP Right Cessation
- 1982-02-08 GR GR67243A patent/GR75858B/el unknown
- 1982-02-08 ES ES509418A patent/ES509418A0/es active Granted
- 1982-02-09 NL NL8200493A patent/NL8200493A/nl not_active Application Discontinuation
- 1982-02-09 FR FR8202046A patent/FR2499573B1/fr not_active Expired
- 1982-02-09 PT PT74402A patent/PT74402B/pt unknown
- 1982-02-09 BE BE0/207262A patent/BE892070A/fr not_active IP Right Cessation
- 1982-02-10 NO NO820395A patent/NO820395L/no unknown
- 1982-02-10 IT IT19588/82A patent/IT1157921B/it active
- 1982-02-10 SU SU823388657A patent/SU1069626A3/ru active
- 1982-02-10 DE DE19823204588 patent/DE3204588A1/de active Granted
- 1982-02-10 AU AU80339/82A patent/AU545745B2/en not_active Ceased
- 1982-02-10 JP JP57019012A patent/JPS57150685A/ja active Granted
- 1982-02-10 DK DK057682A patent/DK151022C/da not_active IP Right Cessation
- 1982-02-10 DD DD82237317A patent/DD201593A5/de not_active IP Right Cessation
- 1982-02-11 AR AR288400A patent/AR228385A1/es active
- 1982-02-11 GB GB8204017A patent/GB2096597B/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2458164A1 (de) * | 1973-12-18 | 1975-06-26 | Sandoz Ag | Verfahren zur herstellung von neuen heterocyclischen verbindungen |
| US4065458A (en) * | 1975-06-10 | 1977-12-27 | Richter Gedeon Vegyeszeti Gyar Rt. | Eburnamenine derivatives |
Non-Patent Citations (1)
| Title |
|---|
| Arzneim.-Forsch. 26, 1976, 1923-26 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT389307B (de) * | 1984-04-25 | 1989-11-27 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von neuen apovincaminolderivaten und ihren saeureadditionssalzen |
Also Published As
| Publication number | Publication date |
|---|---|
| PT74402A (en) | 1982-03-01 |
| DK151022B (da) | 1987-10-12 |
| DK151022C (da) | 1988-06-20 |
| SE8200524L (sv) | 1982-08-12 |
| JPH0378393B2 (en, 2012) | 1991-12-13 |
| GB2096597B (en) | 1984-10-24 |
| ES8307803A1 (es) | 1983-08-01 |
| DD201593A5 (de) | 1983-07-27 |
| GB2096597A (en) | 1982-10-20 |
| IT1157921B (it) | 1987-02-18 |
| NO820395L (no) | 1982-08-12 |
| NL8200493A (nl) | 1982-09-01 |
| FR2499573B1 (fr) | 1985-12-27 |
| AU545745B2 (en) | 1985-08-01 |
| FI820364L (fi) | 1982-08-12 |
| DK57682A (da) | 1982-08-12 |
| SU1069626A3 (ru) | 1984-01-23 |
| CA1199637A (en) | 1986-01-21 |
| JPS57150685A (en) | 1982-09-17 |
| BE892070A (fr) | 1982-08-09 |
| ES509418A0 (es) | 1983-08-01 |
| GR75858B (en, 2012) | 1984-08-02 |
| HU183326B (en) | 1984-04-28 |
| DE3204588C2 (en, 2012) | 1990-10-04 |
| PT74402B (en) | 1983-07-07 |
| FI70019C (fi) | 1986-09-12 |
| AT382375B (de) | 1987-02-25 |
| US4432982A (en) | 1984-02-21 |
| FR2499573A1 (fr) | 1982-08-13 |
| FI70019B (fi) | 1986-01-31 |
| AR228385A1 (es) | 1983-02-28 |
| IT8219588A0 (it) | 1982-02-10 |
| AU8033982A (en) | 1982-08-19 |
| ATA26282A (de) | 1986-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |