DE3145082A1 - "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" - Google Patents
"ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung"Info
- Publication number
- DE3145082A1 DE3145082A1 DE19813145082 DE3145082A DE3145082A1 DE 3145082 A1 DE3145082 A1 DE 3145082A1 DE 19813145082 DE19813145082 DE 19813145082 DE 3145082 A DE3145082 A DE 3145082A DE 3145082 A1 DE3145082 A1 DE 3145082A1
- Authority
- DE
- Germany
- Prior art keywords
- latex
- biologically active
- monomers
- groups
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004816 latex Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 229920000126 latex Polymers 0.000 claims abstract description 52
- 229940088623 biologically active substance Drugs 0.000 claims abstract 2
- 239000000178 monomer Substances 0.000 claims description 20
- 239000004793 Polystyrene Substances 0.000 claims description 6
- 229920002223 polystyrene Polymers 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000003368 amide group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 17
- 125000003172 aldehyde group Chemical group 0.000 abstract description 10
- 125000004036 acetal group Chemical group 0.000 abstract description 5
- 125000003277 amino group Chemical group 0.000 abstract description 5
- 238000006268 reductive amination reaction Methods 0.000 abstract description 3
- 230000020477 pH reduction Effects 0.000 abstract description 2
- 229920000642 polymer Polymers 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 10
- 229920001213 Polysorbate 20 Polymers 0.000 description 7
- 239000011149 active material Substances 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 7
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 150000001241 acetals Chemical group 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 238000009739 binding Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000001900 immune effect Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229960000814 tetanus toxoid Drugs 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical class NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- SPJOZZSIXXJYBT-UHFFFAOYSA-N Fenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=CC=C1 SPJOZZSIXXJYBT-UHFFFAOYSA-N 0.000 description 2
- OFKKPUNNTZKBSR-VIFPVBQESA-N N(6)-(2,4-dinitrophenyl)-L-lysine Chemical compound OC(=O)[C@@H](N)CCCCNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O OFKKPUNNTZKBSR-VIFPVBQESA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- -1 acrylamido Chemical group 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 239000007822 coupling agent Substances 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 125000003700 epoxy group Chemical group 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 2
- VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003254 radicals Chemical group 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- QKWWDTYDYOFRJL-UHFFFAOYSA-N 2,2-dimethoxyethanamine Chemical compound COC(CN)OC QKWWDTYDYOFRJL-UHFFFAOYSA-N 0.000 description 1
- LYIIBVSRGJSHAV-UHFFFAOYSA-N 2-aminoacetaldehyde Chemical compound NCC=O LYIIBVSRGJSHAV-UHFFFAOYSA-N 0.000 description 1
- PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 1
- ZHIBWAALKHRAJR-UHFFFAOYSA-N 2-methyl-n-(2-oxoethyl)prop-2-enamide Chemical compound CC(=C)C(=O)NCC=O ZHIBWAALKHRAJR-UHFFFAOYSA-N 0.000 description 1
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 description 1
- SBVKVAIECGDBTC-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanamide Chemical compound NC(=O)C(=C)CCO SBVKVAIECGDBTC-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- DBFNZYOPYFHSHP-UHFFFAOYSA-N CCCCCOC(C=C)(O)OCCCCC Chemical compound CCCCCOC(C=C)(O)OCCCCC DBFNZYOPYFHSHP-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102100024452 DNA-directed RNA polymerase III subunit RPC1 Human genes 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- FMGZEUWROYGLAY-UHFFFAOYSA-N Halosulfuron-methyl Chemical compound ClC1=NN(C)C(S(=O)(=O)NC(=O)NC=2N=C(OC)C=C(OC)N=2)=C1C(=O)OC FMGZEUWROYGLAY-UHFFFAOYSA-N 0.000 description 1
- 101000864318 Homo sapiens Binder of sperm protein homolog 1 Proteins 0.000 description 1
- 101000689002 Homo sapiens DNA-directed RNA polymerase III subunit RPC1 Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102100025744 Mothers against decapentaplegic homolog 1 Human genes 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000001994 activation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical class [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 229940073579 ethanolamine hydrochloride Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012092 latex agglutination test Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N monoethanolamine hydrochloride Natural products NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 125000005385 peroxodisulfate group Chemical group 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/902—Core-shell
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Graft Or Block Polymers (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Polymerisation Methods In General (AREA)
- Saccharide Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813145082 DE3145082A1 (de) | 1981-11-13 | 1981-11-13 | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
| AT82110273T ATE26583T1 (de) | 1981-11-13 | 1982-11-08 | Ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung. |
| DE8282110273T DE3276064D1 (en) | 1981-11-13 | 1982-11-08 | Latex, biologically active latex conjugates and process for their preparation |
| IN1308/CAL/82A IN155560B (enrdf_load_stackoverflow) | 1981-11-13 | 1982-11-08 | |
| EP82110273A EP0080614B1 (de) | 1981-11-13 | 1982-11-08 | Ein Latex, biologisch aktive Latexkonjugate und Verfahren zu ihrer Herstellung |
| KR8205101A KR890001703B1 (ko) | 1981-11-13 | 1982-11-11 | 라텍스 제조방법 |
| FI823878A FI72127C (fi) | 1981-11-13 | 1982-11-11 | Ett latex, biologiskt aktiv latexkonjugat och ett foerfarande foer deras framstaellning. |
| ES517265A ES8308339A1 (es) | 1981-11-13 | 1982-11-11 | Procedimiento para la preparacion de un latex. |
| JP57197861A JPS5896616A (ja) | 1981-11-13 | 1982-11-12 | 抗原、抗体またはハプテンの検出試薬およびそれに使用するラテックス並びにそれらの製法 |
| US06/440,986 US4448908A (en) | 1981-11-13 | 1982-11-12 | Latex, biologically active latex conjugates and a process for their preparation |
| IE2693/82A IE53822B1 (en) | 1981-11-13 | 1982-11-12 | A latex, biologically active latex conjugates and a process for their preparation |
| MX195169A MX163044B (es) | 1981-11-13 | 1982-11-12 | Metodo para elaborar un conjugado de latex |
| CA000415450A CA1206656A (en) | 1981-11-13 | 1982-11-12 | Latex, biologically active latex conjugates and a process for their preparation |
| DK506582A DK163188C (da) | 1981-11-13 | 1982-11-12 | Polymerlatex med kerne-skal-opbygning, fremgangsmaade til dens fremstilling, konjugat deraf og dettes anvendelse |
| AU90451/82A AU560045B2 (en) | 1981-11-13 | 1982-11-12 | Latex graft copolymer containing aldehyde realtive with biological agents |
| US06/593,301 US4563431A (en) | 1981-11-13 | 1984-03-26 | Biologically active latex conjugate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813145082 DE3145082A1 (de) | 1981-11-13 | 1981-11-13 | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3145082A1 true DE3145082A1 (de) | 1983-05-19 |
Family
ID=6146299
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813145082 Withdrawn DE3145082A1 (de) | 1981-11-13 | 1981-11-13 | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
| DE8282110273T Expired DE3276064D1 (en) | 1981-11-13 | 1982-11-08 | Latex, biologically active latex conjugates and process for their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282110273T Expired DE3276064D1 (en) | 1981-11-13 | 1982-11-08 | Latex, biologically active latex conjugates and process for their preparation |
Country Status (14)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3145082A1 (de) * | 1981-11-13 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
| US4508594A (en) * | 1984-06-28 | 1985-04-02 | Nalco Chemical Company | Polyaldehyde/polyacetal compositions |
| DE3586314D1 (de) * | 1984-11-27 | 1992-08-13 | Behringwerke Ag | Bifunktionelle haptene, verfahren zu ihrer herstellung und ihre verwendung. |
| US4864055A (en) * | 1985-03-21 | 1989-09-05 | Air Products And Chemicals, Inc. | Self- and diol reactive formaldehyde-free crosslinking monomers and their derived polymers |
| US4788288A (en) * | 1985-07-30 | 1988-11-29 | Air Products And Chemicals, Inc. | Self-and Hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers |
| US4691026A (en) * | 1985-07-30 | 1987-09-01 | Air Products And Chemicals, Inc. | Self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers |
| BR8603599A (pt) * | 1985-08-06 | 1987-03-10 | Air Prod & Chem | Polimeros de monomeros de inter-ligacao isentos de formaldeido auto-reagentes e reagentes ao diol |
| US4663410A (en) * | 1985-08-06 | 1987-05-05 | Air Products And Chemicals, Inc. | Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers |
| DE3545595A1 (de) * | 1985-12-21 | 1987-06-25 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| US4698384A (en) * | 1986-02-19 | 1987-10-06 | Air Products And Chemicals, Inc. | Nonwoven binder emulsions of vinyl acetate/ethylene copolymers having improved solvent resistance |
| US4745025A (en) * | 1986-02-19 | 1988-05-17 | Air Products And Chemicals, Inc. | Nonwoven products bonded with binder emulsions of vinyl acetate/ethylene copolymers having improved solvent resistance |
| US4647611A (en) * | 1986-03-12 | 1987-03-03 | Air Products And Chemicals, Inc. | Trail addition of acrylamidobutyraldehyde dialkyl acetal-type monomers during the polymerization of vinyl acetate copolymer binders |
| US5183766A (en) * | 1986-04-18 | 1993-02-02 | Behringwerke Aktiengesellschaft | Dispersion polymers, processes for their preparation and their use |
| DE3613111A1 (de) * | 1986-04-18 | 1987-10-22 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| DE3622993A1 (de) * | 1986-07-09 | 1988-01-21 | Behringwerke Ag | Dispersionspolymere, biologisch aktive dispersionspolymere, verfahren zu ihrer herstellung und verwendung als diagnostisches mittel |
| AU8173387A (en) * | 1986-10-10 | 1988-05-06 | Peter Grandics | A novel immunoaffinity purification system |
| US4997772A (en) * | 1987-09-18 | 1991-03-05 | Eastman Kodak Company | Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use |
| US4774283A (en) * | 1987-03-02 | 1988-09-27 | Air Products And Chemicals, Inc. | Nonwoven binders of vinyl acetate/ethylene/self-crosslinking monomers/acrylamide copolymers having improved blocking resistance |
| US4814226A (en) * | 1987-03-02 | 1989-03-21 | Air Products And Chemicals, Inc. | Nonwoven products bonded with vinyl acetate/ethylene/self-crosslinking monomer/acrylamide copolymers having improved blocking resistance |
| JPH064686B2 (ja) * | 1987-03-30 | 1994-01-19 | 工業技術院長 | 水及びアルコール溶媒依存性熱可逆型材料及びその製造方法 |
| US5166077A (en) * | 1987-04-30 | 1992-11-24 | Nitto Denko Corporation | Latex for immobilization of physiologically active substances for immuno nephelometry |
| DE3715333A1 (de) * | 1987-05-08 | 1988-11-24 | Behringwerke Ag | Verfahren zur quantitativen bestimmung von serumproteinen in koerperfluessigkeiten und mittel zur durchfuehrung des verfahrens |
| DE3717402A1 (de) * | 1987-05-23 | 1988-12-08 | Behringwerke Ag | Verfahren zur bestimmung von proteinen und mittel dazu |
| US5232981A (en) * | 1987-09-11 | 1993-08-03 | Behringwerke Aktiengesellschaft | Dispersion polymers, a process for the preparation thereof, and the use thereof |
| DE3730515A1 (de) * | 1987-09-11 | 1989-03-23 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| AT393385B (de) * | 1987-10-08 | 1991-10-10 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| JPH02114180A (ja) * | 1988-09-06 | 1990-04-26 | Eastman Kodak Co | 分析試薬、要素及び方法用のラテックス粒子 |
| US5100805A (en) * | 1989-01-26 | 1992-03-31 | Seradyn, Inc. | Quantitative immunoassay system and method for agglutination assays |
| ATE160019T1 (de) * | 1990-07-13 | 1997-11-15 | Canon Kk | Nachweisreagens |
| DE4211351A1 (de) * | 1992-04-04 | 1993-10-07 | Behringwerke Ag | Verfahren zur Analyse partikelverstärkter Agglutinationsreaktionen auf Zentrifugalanalysatoren durch Bestimmung der Trübungsaufhellung |
| US5401633A (en) * | 1992-10-01 | 1995-03-28 | Eastman Kodak Company | Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use |
| CA2127605A1 (en) * | 1993-12-23 | 1995-06-24 | Peter J. Degen | Affinity separation method |
| FR2726279B1 (fr) * | 1994-10-28 | 1997-01-17 | Prolabo Sa | Particule de latex ou d'oxyde mineral glucosylee, procede de preparation d'une telle particule et utilisation de celle-ci en tant qu'agent de detection biologique ou de chromatographie d'affinite |
| DE19505204A1 (de) | 1995-02-16 | 1996-08-22 | Behringwerke Ag | Modifikation der Reaktivität von Agglutinationsreagenzien durch Cobeschichtung mit nicht gegen den Analyten gerichteten Substanzen |
| DE50014159D1 (de) | 1999-12-22 | 2007-04-26 | Dade Behring Marburg Gmbh | Lösungen von humanem Procalcitonin |
| ATE395364T1 (de) | 1999-12-22 | 2008-05-15 | Dade Behring Marburg Gmbh | Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung |
| DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
| EP1481029A1 (en) * | 2002-03-07 | 2004-12-01 | Akzo Nobel Coatings International B.V. | Coating composition comprising an acetal-functional binder |
| DE20213920U1 (de) | 2002-07-03 | 2003-01-16 | Böhm, Martina, 60439 Frankfurt | Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13 |
| CA2547351A1 (en) | 2003-12-01 | 2005-07-07 | Dade Behring Marburg Gmbh | Homogeneous detection method |
| US20050118727A1 (en) * | 2003-12-01 | 2005-06-02 | Carsten Schelp | Conjugates and their use in detection methods |
| DE102005026163A1 (de) | 2004-08-24 | 2006-03-02 | Dade Behring Marburg Gmbh | Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung |
| DE102005022047A1 (de) | 2005-05-09 | 2006-11-30 | Dade Behring Marburg Gmbh | Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung |
| EP2982963B1 (en) | 2006-11-02 | 2019-08-21 | Fluidigm Canada Inc. | Particles containing detectable elemental code |
| DE102008049601A1 (de) | 2008-09-30 | 2010-04-01 | Siemens Healthcare Diagnostics Products Gmbh | Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay |
| US8475652B2 (en) * | 2009-10-19 | 2013-07-02 | Jan A. K. Paul | Method for purification of uncatalyzed natural fuels from metal ions by means of at least one hemeprotein and use of the at least on hemeprotein |
| US20110306148A1 (en) * | 2010-06-14 | 2011-12-15 | Siemens Healthcare Diagnostics Inc. | Composition for use as an assay reagent |
| EP2829878A1 (de) | 2013-07-23 | 2015-01-28 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung der GPIb-Rezeptor-abhängigen Plättchenfunktion |
| US10596330B2 (en) | 2015-08-26 | 2020-03-24 | Medtronic Xomed, Inc. | Resorbable, drug-eluting submucosal turbinate implant device and method |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2552510C3 (de) * | 1975-11-22 | 1981-02-19 | Behringwerke Ag, 3550 Marburg | Biologisch aktive Verbindungen und Verfahren zu ihrer Herstellung |
| US4210723A (en) * | 1976-07-23 | 1980-07-01 | The Dow Chemical Company | Method of coupling a protein to an epoxylated latex |
| JPS55110118A (en) * | 1979-02-20 | 1980-08-25 | Dow Chemical Co | Method of combining epoxylated latex with protein and product formed therefrom |
| DE2918342A1 (de) * | 1979-05-07 | 1980-11-20 | Behringwerke Ag | Latex-reagenz |
| DE3116995A1 (de) * | 1981-04-29 | 1982-11-25 | Röhm GmbH, 6100 Darmstadt | Latex zur immobilisierung von biologisch wirksamen substanzen |
| JPS5847258A (ja) * | 1981-09-01 | 1983-03-18 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 光散乱イムノアツセイ用粒子試薬 |
| DE3145082A1 (de) * | 1981-11-13 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
-
1981
- 1981-11-13 DE DE19813145082 patent/DE3145082A1/de not_active Withdrawn
-
1982
- 1982-11-08 IN IN1308/CAL/82A patent/IN155560B/en unknown
- 1982-11-08 AT AT82110273T patent/ATE26583T1/de not_active IP Right Cessation
- 1982-11-08 DE DE8282110273T patent/DE3276064D1/de not_active Expired
- 1982-11-08 EP EP82110273A patent/EP0080614B1/de not_active Expired
- 1982-11-11 ES ES517265A patent/ES8308339A1/es not_active Expired
- 1982-11-11 KR KR8205101A patent/KR890001703B1/ko not_active Expired
- 1982-11-11 FI FI823878A patent/FI72127C/fi not_active IP Right Cessation
- 1982-11-12 JP JP57197861A patent/JPS5896616A/ja active Granted
- 1982-11-12 US US06/440,986 patent/US4448908A/en not_active Expired - Lifetime
- 1982-11-12 MX MX195169A patent/MX163044B/es unknown
- 1982-11-12 IE IE2693/82A patent/IE53822B1/en not_active IP Right Cessation
- 1982-11-12 AU AU90451/82A patent/AU560045B2/en not_active Expired
- 1982-11-12 CA CA000415450A patent/CA1206656A/en not_active Expired
- 1982-11-12 DK DK506582A patent/DK163188C/da active
-
1984
- 1984-03-26 US US06/593,301 patent/US4563431A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK163188B (da) | 1992-02-03 |
| FI823878A0 (fi) | 1982-11-11 |
| JPS5896616A (ja) | 1983-06-08 |
| CA1206656A (en) | 1986-06-24 |
| JPH0361143B2 (enrdf_load_stackoverflow) | 1991-09-18 |
| US4448908A (en) | 1984-05-15 |
| DE3276064D1 (en) | 1987-05-21 |
| AU9045182A (en) | 1983-05-19 |
| FI823878L (fi) | 1983-05-14 |
| IE53822B1 (en) | 1989-03-01 |
| KR840002417A (ko) | 1984-07-02 |
| IE822693L (en) | 1983-05-13 |
| US4563431A (en) | 1986-01-07 |
| DK163188C (da) | 1992-06-22 |
| ES517265A0 (es) | 1983-08-16 |
| DK506582A (da) | 1983-05-14 |
| EP0080614A3 (en) | 1984-06-06 |
| ES8308339A1 (es) | 1983-08-16 |
| FI72127B (fi) | 1986-12-31 |
| MX163044B (es) | 1991-08-05 |
| EP0080614A2 (de) | 1983-06-08 |
| ATE26583T1 (de) | 1987-05-15 |
| EP0080614B1 (de) | 1987-04-15 |
| KR890001703B1 (ko) | 1989-05-18 |
| AU560045B2 (en) | 1987-03-26 |
| FI72127C (fi) | 1987-04-13 |
| IN155560B (enrdf_load_stackoverflow) | 1985-02-16 |
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