DE3144009A1 - "neue 17-oxazolin-steroid-derivate, verfahren zu deren herstellung und deren verwendung zur herstellung von corticosteroiden" - Google Patents

"neue 17-oxazolin-steroid-derivate, verfahren zu deren herstellung und deren verwendung zur herstellung von corticosteroiden"

Info

Publication number
DE3144009A1
DE3144009A1 DE19813144009 DE3144009A DE3144009A1 DE 3144009 A1 DE3144009 A1 DE 3144009A1 DE 19813144009 DE19813144009 DE 19813144009 DE 3144009 A DE3144009 A DE 3144009A DE 3144009 A1 DE3144009 A1 DE 3144009A1
Authority
DE
Germany
Prior art keywords
formula
compounds
radical
agent
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813144009
Other languages
German (de)
English (en)
Inventor
Derek Harold Richard Prof. Barton
William Branks Motherwell
Samir 91190 Gif-sur-Yvette Zard Zard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE3144009A1 publication Critical patent/DE3144009A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19813144009 1980-11-05 1981-11-05 "neue 17-oxazolin-steroid-derivate, verfahren zu deren herstellung und deren verwendung zur herstellung von corticosteroiden" Withdrawn DE3144009A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8023575A FR2493324B1 (OSRAM) 1980-11-05 1980-11-05

Publications (1)

Publication Number Publication Date
DE3144009A1 true DE3144009A1 (de) 1982-06-16

Family

ID=9247684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813144009 Withdrawn DE3144009A1 (de) 1980-11-05 1981-11-05 "neue 17-oxazolin-steroid-derivate, verfahren zu deren herstellung und deren verwendung zur herstellung von corticosteroiden"

Country Status (14)

Country Link
US (1) US4401596A (OSRAM)
JP (1) JPS57106700A (OSRAM)
AT (1) AT386602B (OSRAM)
CH (1) CH652726A5 (OSRAM)
DE (1) DE3144009A1 (OSRAM)
DK (1) DK162771C (OSRAM)
FI (1) FI72526C (OSRAM)
FR (1) FR2493324B1 (OSRAM)
GB (1) GB2086907B (OSRAM)
HU (1) HU183666B (OSRAM)
IT (1) IT1171613B (OSRAM)
NL (1) NL8104985A (OSRAM)
PT (1) PT73933B (OSRAM)
SE (1) SE440505B (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123736A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process
FR2620708B1 (fr) * 1984-02-03 1994-11-04 Roussel Uclaf Nouveaux produits industriels, leur procede de preparation et leur application
EP0153001B1 (en) * 1984-02-03 1992-03-11 The Upjohn Company Steroids having an enamide or enimide group and their preparation
US4831131A (en) * 1984-02-03 1989-05-16 The Upjohn Company 11β,17α-Dihydroxy-17β-cyano-androstanes
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
US4548748A (en) * 1984-02-03 1985-10-22 The Upjohn Company Cyanohydrin process
FR2559156B1 (fr) * 1984-02-03 1989-03-24 Roussel Uclaf Procede de preparation de derives de la prednisone et produits intermediaires de ce procede
FR2571727B1 (fr) * 1984-10-16 1987-06-12 Roussel Uclaf Nouveaux produits steroides comportant, en position 23, un radical dihydro oxazolyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20 cetopregnanes et intermediaires de cette application
AU618350B2 (en) * 1988-04-08 1991-12-19 Aventis Pharma S.A. 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
MY105302A (en) * 1989-11-27 1994-09-30 Schering Corp Process for dehydrating corticosteroid intermediates.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646012A (en) * 1967-10-05 1972-02-29 Wyeth John & Brother Ltd Enamine salt protection of steroidal alpha beta-unsaturated ketones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338892A (en) * 1964-11-24 1967-08-29 Lilly Co Eli Steroidal carbamic acid-gamma-lactones
CH549001A (de) * 1970-04-17 1974-05-15 Ciba Geigy Ag Verfahren zur herstellung neuer halogensteroide.
US4232013A (en) * 1977-12-03 1980-11-04 Lark S.P.A. 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives
HU178397B (en) * 1978-04-01 1982-04-28 Gyogyszerkutato Intezet Process for preparing substituted derivatives of steroid-spiro-oxazolidione derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646012A (en) * 1967-10-05 1972-02-29 Wyeth John & Brother Ltd Enamine salt protection of steroidal alpha beta-unsaturated ketones

Also Published As

Publication number Publication date
IT8149576A0 (it) 1981-10-27
NL8104985A (nl) 1982-06-01
FI813459L (fi) 1982-05-06
DK162771C (da) 1992-04-27
US4401596A (en) 1983-08-30
FI72526B (fi) 1987-02-27
FR2493324A1 (OSRAM) 1982-05-07
GB2086907B (en) 1984-12-12
JPS57106700A (en) 1982-07-02
CH652726A5 (fr) 1985-11-29
PT73933B (fr) 1983-11-30
ATA475081A (de) 1988-02-15
PT73933A (fr) 1981-12-01
IT8149576A1 (it) 1983-04-27
IT1171613B (it) 1987-06-10
DK487081A (da) 1982-05-06
FI72526C (fi) 1987-06-08
SE440505B (sv) 1985-08-05
JPH026359B2 (OSRAM) 1990-02-08
HU183666B (en) 1984-05-28
SE8105686L (sv) 1982-05-06
FR2493324B1 (OSRAM) 1983-01-21
GB2086907A (en) 1982-05-19
DK162771B (da) 1991-12-09
AT386602B (de) 1988-09-26

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8136 Disposal/non-payment of the fee for publication/grant