DE3126606C2 - (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäure-amide und -peptide sowie diese enthaltende Arzneimittel - Google Patents

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäure-amide und -peptide sowie diese enthaltende Arzneimittel

Info

Publication number
DE3126606C2
DE3126606C2 DE3126606A DE3126606A DE3126606C2 DE 3126606 C2 DE3126606 C2 DE 3126606C2 DE 3126606 A DE3126606 A DE 3126606A DE 3126606 A DE3126606 A DE 3126606A DE 3126606 C2 DE3126606 C2 DE 3126606C2
Authority
DE
Germany
Prior art keywords
amino
hydroxy
conh
cooh
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3126606A
Other languages
German (de)
English (en)
Other versions
DE3126606A1 (de
Inventor
Takaaki Fujisawa Kanagawa Aoyagi
Shunzo Tokio/Tokyo Fukatsu
Kenji Zama Kanagawa Kawamura
Tomio Tokio/Tokyo Takeuchi
Hamao Tokio/Toyko Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9169280A external-priority patent/JPS5718610A/ja
Priority claimed from JP9169080A external-priority patent/JPS5716842A/ja
Priority claimed from JP55091691A external-priority patent/JPS6014040B2/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of DE3126606A1 publication Critical patent/DE3126606A1/de
Application granted granted Critical
Publication of DE3126606C2 publication Critical patent/DE3126606C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3126606A 1980-07-07 1981-07-06 (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäure-amide und -peptide sowie diese enthaltende Arzneimittel Expired DE3126606C2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9169280A JPS5718610A (en) 1980-07-07 1980-07-07 Immunizator
JP9169080A JPS5716842A (en) 1980-07-07 1980-07-07 Substance related to bestatin and its preparation
JP55091691A JPS6014040B2 (ja) 1980-07-07 1980-07-07 ベスタチン新誘導体及びその製造法

Publications (2)

Publication Number Publication Date
DE3126606A1 DE3126606A1 (de) 1982-05-19
DE3126606C2 true DE3126606C2 (de) 1986-09-18

Family

ID=27306812

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3126606A Expired DE3126606C2 (de) 1980-07-07 1981-07-06 (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäure-amide und -peptide sowie diese enthaltende Arzneimittel
DE3153030A Expired DE3153030C2 (de) 1980-07-07 1981-07-06 Verwendung von (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäureverbindungen als Immunverstärkungsmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3153030A Expired DE3153030C2 (de) 1980-07-07 1981-07-06 Verwendung von (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäureverbindungen als Immunverstärkungsmittel

Country Status (6)

Country Link
US (1) US4370318A (enExample)
CA (1) CA1178610A (enExample)
DE (2) DE3126606C2 (enExample)
FR (1) FR2485924A1 (enExample)
GB (1) GB2083046B (enExample)
IT (2) IT1167937B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent
JPS58121259A (ja) * 1982-01-09 1983-07-19 Microbial Chem Res Found ベスタチン新規誘導体
WO1983003254A1 (en) * 1982-03-11 1983-09-29 Arthur Babson Stabilization of diazonium salt solutions
EP0215805A1 (en) * 1985-01-18 1987-04-01 MERCK PATENT GmbH Immunoregulatory peptides
JPS63233800A (ja) * 1987-03-20 1988-09-29 Toyo Jozo Co Ltd レシチンコレステロ−ルアシルトランスフエラ−ゼの活性測定法
USRE36718E (en) * 1993-06-29 2000-05-30 Kaneka Corporation Optically active aminoalcohol derivatives and method of producing same
WO1998048826A1 (en) * 1997-04-30 1998-11-05 Northwestern University Inhibition of nitric oxide synthase by amino acids and dipeptides
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema
CN104984318B (zh) * 2015-06-12 2018-02-06 上海来益生物药物研究开发中心有限责任公司 3‑氨基‑2‑羟基‑4‑苯基‑缬氨酰‑异亮氨酸的新应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1510477A (en) * 1975-07-22 1978-05-10 Microbial Chem Res Found Peptides and to amino acid intermediates thereof
DE2725732C2 (de) * 1977-06-07 1983-01-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Bestatin-Analoga, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
NL188162C (nl) * 1978-11-25 1992-04-16 Nippon Kayaku Kk Werkwijze voor het bereiden van een bestatinederivaat.

Also Published As

Publication number Publication date
DE3126606A1 (de) 1982-05-19
DE3153030C2 (de) 1986-01-09
US4370318A (en) 1983-01-25
IT1167937B (it) 1987-05-20
GB2083046B (en) 1984-01-11
FR2485924A1 (fr) 1982-01-08
IT8109465A0 (it) 1981-07-06
GB2083046A (en) 1982-03-17
FR2485924B1 (enExample) 1984-02-17
IT8109465A1 (it) 1983-01-06
CA1178610A (en) 1984-11-27

Similar Documents

Publication Publication Date Title
EP0150263B1 (de) Derivate der cis, endo-2-Azabicyclo-[3.3.0]-octan-3-carbonsäure, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
DE69305322T2 (de) Salpetersäureester von 2-(2,6-dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
EP0143746A2 (de) Substituierte 5-Amino-4-hydroxyvalerylderivate
EP0111873A1 (de) Derivate der cis, endo-2-Azabicyclo-(5.3.0)-decan-3-carbonsäure, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
DD217807A5 (de) Verfahren zur herstellung neuer substituierter tetrapeptide
DE3508251A1 (de) Dipeptide
DE69509254T2 (de) Metalloproteinase-inhibitoren
DE3126606C2 (de) (2S,3R)-3-Amino-2-hydroxy-4-phenylbutansäure-amide und -peptide sowie diese enthaltende Arzneimittel
DE69122831T2 (de) S-(niedere fettsäuren)-substituierte glutathionderivate
DE2802630A1 (de) 6-ethoxy-1,2-dihydro-2,2,4-trimethylchinolinderivate und verfahren zu ihrer herstellung
DE3138092C2 (de) Verwendung von 3-Amino-2-hydroxy-4-phenylbuttersäure und einigen ihrer verwandten Verbindungen
DE3586649T2 (de) Verwendung von spergualinderivaten zur herstellung von arzneimitteln mit immunodepressiver wirkung.
DE3017684A1 (de) Epoxysuccinylaminosaeurederivate und arzneimittel, welche diese enthalten
DE2840636A1 (de) Peptide, verfahren zu ihrer herstellung und ihre therapeutische verwendung
DE2618009C3 (de) 1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel
DE69018275T2 (de) Peptide, deren Verwendung als Hemmer gegen Entwicklung von t-Lymphocyten und Wirksamkeit von Makrophagen und Verfahren zu deren Herstellung.
EP0338308A2 (de) Substituierte N-Glycosylamide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE68906572T2 (de) Peptide mit inhibitorischer wirkung auf enzymatische systeme, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE2609154A1 (de) Histidin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0267179A2 (de) Neue Cystinverbindungen, ihre Herstellung und Verwendung
EP0013891B1 (de) Dipeptide zur Verwendung bei der Heilung von Krankheiten, einige neue Stoffe aus dieser Verbindungsgruppe, Dipeptide enthaltende Arzneimittel und deren Herstellung
DE69912315T2 (de) ((aminoiminomethyl)amino) alkanecarboxamide und deren therapeutische verwendungen
DE3200662C2 (de) Nitrosoharnstoffderivate, Verfahren zu deren Herstellung und Arzneimittel diese enthaltend
DE2725732C2 (de) Bestatin-Analoga, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
EP0564499A1 (en) Novel amines, process for producing them and medicaments containing said compounds.

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3153030

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3153030

AH Division in

Ref country code: DE

Ref document number: 3153030

Format of ref document f/p: P

8128 New person/name/address of the agent

Representative=s name: LEDERER, F., DIPL.-CHEM. DR., PAT.-ANW., 8000 MUEN

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee