JPS5718610A - Immunizator - Google Patents

Immunizator

Info

Publication number
JPS5718610A
JPS5718610A JP9169280A JP9169280A JPS5718610A JP S5718610 A JPS5718610 A JP S5718610A JP 9169280 A JP9169280 A JP 9169280A JP 9169280 A JP9169280 A JP 9169280A JP S5718610 A JPS5718610 A JP S5718610A
Authority
JP
Japan
Prior art keywords
amino
immunizator
immunity
ahpa
bestatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9169280A
Other languages
Japanese (ja)
Other versions
JPS646165B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyanagi
Kenji Kawamura
Shunzo Fukatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP9169280A priority Critical patent/JPS5718610A/en
Priority to US06/272,211 priority patent/US4370318A/en
Priority to GB8119397A priority patent/GB2083046B/en
Priority to DE3153030A priority patent/DE3153030C2/en
Priority to CA000381174A priority patent/CA1178610A/en
Priority to IT1981A09465A priority patent/IT8109465A1/en
Priority to DE3126606A priority patent/DE3126606C2/en
Priority to IT09465/81A priority patent/IT1167937B/en
Priority to FR8113332A priority patent/FR2485924A1/en
Publication of JPS5718610A publication Critical patent/JPS5718610A/en
Publication of JPS646165B2 publication Critical patent/JPS646165B2/ja
Granted legal-status Critical Current

Links

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: An immunizator that contains 3-amino-2-hydroxy-4-phenylbutyric acid and its derivative as major active principles, thus being suitably used for immunotherapy and infection immunity, because it can increase cellular immunity with a low-dose administration.
CONSTITUTION: The objective immunizator contains as major active principles 3-amino-2-hydroxy-4-phenylbutyric acid (AHPA) of the formula (R1 is H, hydroxyl; R2 is hydroxyl, alkoxy, benzyloxy, amino, substituted amino) and its derivatve. The compound of the formula has strong immunization activity, i.e., greatly increases cellular immunity with an extremely low-dose adminitration compared with bestatin that is known as an immunologically carcinostatic agent. Therefore, it can find broad appliction in the fields of immunotherapy and infection immunity. (2S,3R)-AHPA is otained by acidic hydrolysis of bestatin through the known process.
COPYRIGHT: (C)1982,JPO&Japio
JP9169280A 1980-07-07 1980-07-07 Immunizator Granted JPS5718610A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP9169280A JPS5718610A (en) 1980-07-07 1980-07-07 Immunizator
US06/272,211 US4370318A (en) 1980-07-07 1981-06-10 Bestatin-related compounds as immunopotentiator
GB8119397A GB2083046B (en) 1980-07-07 1981-06-24 Bestatin-related compounds
DE3153030A DE3153030C2 (en) 1980-07-07 1981-07-06 Use of (2S, 3R) -3-amino-2-hydroxy-4-phenylbutanoic acid compounds as immune boosting agents
CA000381174A CA1178610A (en) 1980-07-07 1981-07-06 Bestatin-related compounds as immunopotentiator
IT1981A09465A IT8109465A1 (en) 1980-07-07 1981-07-06 COMPOUNDS CONNECTED TO BABY AS AN IMMUNOPOTENTIATOR
DE3126606A DE3126606C2 (en) 1980-07-07 1981-07-06 (2S, 3R) -3-Amino-2-hydroxy-4-phenylbutanoic acid amides and peptides and pharmaceuticals containing them
IT09465/81A IT1167937B (en) 1980-07-07 1981-07-06 COMPOUNDS LINKED TO THE SKEWER AS AN IMMUNOPOTENTIATOR
FR8113332A FR2485924A1 (en) 1980-07-07 1981-07-07 NOVEL IMMUNOPOTENTIALIZING PHARMACEUTICAL COMPOSITIONS, AND NOVEL BESTATIN-RELATED COMPOUNDS ENTERING THESE COMPOSITIONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9169280A JPS5718610A (en) 1980-07-07 1980-07-07 Immunizator

Publications (2)

Publication Number Publication Date
JPS5718610A true JPS5718610A (en) 1982-01-30
JPS646165B2 JPS646165B2 (en) 1989-02-02

Family

ID=14033554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9169280A Granted JPS5718610A (en) 1980-07-07 1980-07-07 Immunizator

Country Status (1)

Country Link
JP (1) JPS5718610A (en)

Also Published As

Publication number Publication date
JPS646165B2 (en) 1989-02-02

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