JPS5716842A - Substance related to bestatin and its preparation - Google Patents

Substance related to bestatin and its preparation

Info

Publication number
JPS5716842A
JPS5716842A JP9169080A JP9169080A JPS5716842A JP S5716842 A JPS5716842 A JP S5716842A JP 9169080 A JP9169080 A JP 9169080A JP 9169080 A JP9169080 A JP 9169080A JP S5716842 A JPS5716842 A JP S5716842A
Authority
JP
Japan
Prior art keywords
formula
alkyl
bestatin
hydroxyalkyl
substance related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9169080A
Other languages
Japanese (ja)
Other versions
JPS6325579B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyanagi
Kenji Kawamura
Shunzo Fukatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP9169080A priority Critical patent/JPS5716842A/en
Priority to US06/272,211 priority patent/US4370318A/en
Priority to GB8119397A priority patent/GB2083046B/en
Priority to DE3153030A priority patent/DE3153030C2/en
Priority to DE3126606A priority patent/DE3126606C2/en
Priority to IT1981A09465A priority patent/IT8109465A1/en
Priority to IT09465/81A priority patent/IT1167937B/en
Priority to CA000381174A priority patent/CA1178610A/en
Priority to FR8113332A priority patent/FR2485924A1/en
Publication of JPS5716842A publication Critical patent/JPS5716842A/en
Publication of JPS6325579B2 publication Critical patent/JPS6325579B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A substance related to bestatin shown by the formula I [R'1 is H or OH; R2 is H or 1W7C acyl; R3 is -CH2OH, group shown by the formula II or formula III (R4 is 1W7C alkyl, hydroxyalkyl, mercaptoalkyl, carboxamidealkyl, etc.), etc.; * is R, S, or its combination of configuration].
EXAMPLE: (2S, 3R)-3-Amino-2-phydroxy-4-phenyl-1-butanol hydrochloride.
USE: An immunological activator. Exhibiting aminopeptidase inhibiting actions and immunologically enhancing effect at a low dose. A dose per adult is 50W200mg/day orally.
PROCESS: A compound shown by the formula IV [R6 is OR7(R7 is 1W7C alyl or aralkyl), shown by the formula V, formula VI (R4 and R5 are same or different to each other, being 1W7C alkyl, hydroxyalkyl or mercapto alkyl)], or its derivative with a functional group protected not participating in reduction is reduced conventionally, and, if necessary, the protecting group is removed, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP9169080A 1980-07-07 1980-07-07 Substance related to bestatin and its preparation Granted JPS5716842A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP9169080A JPS5716842A (en) 1980-07-07 1980-07-07 Substance related to bestatin and its preparation
US06/272,211 US4370318A (en) 1980-07-07 1981-06-10 Bestatin-related compounds as immunopotentiator
GB8119397A GB2083046B (en) 1980-07-07 1981-06-24 Bestatin-related compounds
DE3153030A DE3153030C2 (en) 1980-07-07 1981-07-06 Use of (2S, 3R) -3-amino-2-hydroxy-4-phenylbutanoic acid compounds as immune boosting agents
DE3126606A DE3126606C2 (en) 1980-07-07 1981-07-06 (2S, 3R) -3-Amino-2-hydroxy-4-phenylbutanoic acid amides and peptides and pharmaceuticals containing them
IT1981A09465A IT8109465A1 (en) 1980-07-07 1981-07-06 COMPOUNDS CONNECTED TO BABY AS AN IMMUNOPOTENTIATOR
IT09465/81A IT1167937B (en) 1980-07-07 1981-07-06 COMPOUNDS LINKED TO THE SKEWER AS AN IMMUNOPOTENTIATOR
CA000381174A CA1178610A (en) 1980-07-07 1981-07-06 Bestatin-related compounds as immunopotentiator
FR8113332A FR2485924A1 (en) 1980-07-07 1981-07-07 NOVEL IMMUNOPOTENTIALIZING PHARMACEUTICAL COMPOSITIONS, AND NOVEL BESTATIN-RELATED COMPOUNDS ENTERING THESE COMPOSITIONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9169080A JPS5716842A (en) 1980-07-07 1980-07-07 Substance related to bestatin and its preparation

Publications (2)

Publication Number Publication Date
JPS5716842A true JPS5716842A (en) 1982-01-28
JPS6325579B2 JPS6325579B2 (en) 1988-05-26

Family

ID=14033494

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9169080A Granted JPS5716842A (en) 1980-07-07 1980-07-07 Substance related to bestatin and its preparation

Country Status (1)

Country Link
JP (1) JPS5716842A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63300064A (en) * 1987-05-29 1988-12-07 Tokinori Kudo Sheet container
JPH0229774U (en) * 1988-08-12 1990-02-26

Also Published As

Publication number Publication date
JPS6325579B2 (en) 1988-05-26

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