DE3123975A1 - Verfahren zur enzymatischen herstellung von l-carnitin - Google Patents

Verfahren zur enzymatischen herstellung von l-carnitin

Info

Publication number
DE3123975A1
DE3123975A1 DE19813123975 DE3123975A DE3123975A1 DE 3123975 A1 DE3123975 A1 DE 3123975A1 DE 19813123975 DE19813123975 DE 19813123975 DE 3123975 A DE3123975 A DE 3123975A DE 3123975 A1 DE3123975 A1 DE 3123975A1
Authority
DE
Germany
Prior art keywords
carnitine
spores
atcc
butyrobetaine
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813123975
Other languages
German (de)
English (en)
Other versions
DE3123975C2 (https=
Inventor
Claudio 00144 Roma Carvazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE3123975A1 publication Critical patent/DE3123975A1/de
Application granted granted Critical
Publication of DE3123975C2 publication Critical patent/DE3123975C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01108—Carnitine 3-dehydrogenase (1.1.1.108)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19813123975 1980-06-24 1981-06-19 Verfahren zur enzymatischen herstellung von l-carnitin Granted DE3123975A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT86253/80A IT1142201B (it) 1980-06-24 1980-06-24 Procedimento per la produzione enzimatica di l-carnitina

Publications (2)

Publication Number Publication Date
DE3123975A1 true DE3123975A1 (de) 1982-03-11
DE3123975C2 DE3123975C2 (https=) 1990-10-11

Family

ID=11330417

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813123975 Granted DE3123975A1 (de) 1980-06-24 1981-06-19 Verfahren zur enzymatischen herstellung von l-carnitin

Country Status (9)

Country Link
US (1) US4371618A (https=)
JP (1) JPS5739791A (https=)
AT (1) AT379615B (https=)
CH (1) CH650274A5 (https=)
DE (1) DE3123975A1 (https=)
FR (1) FR2485564B1 (https=)
GB (1) GB2078742B (https=)
IT (1) IT1142201B (https=)
SE (1) SE443803B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718414B2 (en) 2005-07-07 2010-05-18 Cj Cheiljedang Corp. Microorganism of Enterobacteriacae genus haboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism
US7901923B2 (en) 2005-07-19 2011-03-08 Cj Cheiljedang Corporation Microorganism of Enterobacteriacae genus harboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642290A (en) * 1982-12-06 1987-02-10 Sih Charles J Process for preparing a compound for use in the production of L-carnitine
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
US4710468A (en) * 1983-10-24 1987-12-01 Sigma-Tau Industrie Pharmaceutiche Riunite S.P.A. Process for preparing L-carnitine and chemical intermediates employed therein
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
US4584270A (en) * 1984-01-23 1986-04-22 Wisconsin Alumni Research Foundation Process for preparing optically-active 4-amino-3-hydroxybutyric acid
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
ZA852808B (en) * 1984-04-20 1985-11-27 Wisconsin Alumni Res Found Process for preparing l-carnitine
US4751182A (en) * 1984-04-20 1988-06-14 Wisconsin Alumni Research Foundation Process for preparing L-carnitine from DL-carnitine
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
GB2195630B (en) * 1986-08-26 1990-07-18 Chuo Kaseihin Co Inc Method for producing carnitine, l-carnitineamide hydrolase and method for producing same
JPH0669381B2 (ja) * 1987-12-04 1994-09-07 協和醗酵工業株式会社 カルニチンの製造法
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
CA2018137C (en) * 1989-06-14 2000-01-11 Thomas Scholl L-carnitine magnesium citrate
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
JP2002528468A (ja) 1998-10-27 2002-09-03 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ Ｌ−カルニチンの合成に有用な補酵素
US6337197B2 (en) * 1998-10-27 2002-01-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Coenzymes useful for the synthesis of L-carnitine
DE10315760A1 (de) * 2003-04-07 2004-10-21 Basf Ag L-Carnitin Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von substituierten (S)-Alkanolen
KR100565732B1 (ko) * 2004-02-26 2006-03-28 씨제이 주식회사 뉴로스포라 크라사 기원의 감마부티로베타인 하이드록실라제

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2398046A1 (fr) * 1977-07-18 1979-02-16 Inst Francais Du Petrole Synthese enzymatique de la l-carnitine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2398046A1 (fr) * 1977-07-18 1979-02-16 Inst Francais Du Petrole Synthese enzymatique de la l-carnitine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718414B2 (en) 2005-07-07 2010-05-18 Cj Cheiljedang Corp. Microorganism of Enterobacteriacae genus haboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism
US7901923B2 (en) 2005-07-19 2011-03-08 Cj Cheiljedang Corporation Microorganism of Enterobacteriacae genus harboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism

Also Published As

Publication number Publication date
IT8086253A0 (it) 1980-06-24
FR2485564A1 (fr) 1981-12-31
JPH022591B2 (https=) 1990-01-18
JPS5739791A (en) 1982-03-05
DE3123975C2 (https=) 1990-10-11
FR2485564B1 (fr) 1985-07-12
CH650274A5 (it) 1985-07-15
SE443803B (sv) 1986-03-10
GB2078742A (en) 1982-01-13
US4371618A (en) 1983-02-01
SE8103851L (sv) 1981-12-25
IT1142201B (it) 1986-10-08
GB2078742B (en) 1984-01-18
AT379615B (de) 1986-02-10
ATA276881A (de) 1985-06-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee