FR2398046A1 - Synthese enzymatique de la l-carnitine - Google Patents

Synthese enzymatique de la l-carnitine

Info

Publication number
FR2398046A1
FR2398046A1 FR7722183A FR7722183A FR2398046A1 FR 2398046 A1 FR2398046 A1 FR 2398046A1 FR 7722183 A FR7722183 A FR 7722183A FR 7722183 A FR7722183 A FR 7722183A FR 2398046 A1 FR2398046 A1 FR 2398046A1
Authority
FR
France
Prior art keywords
carnitine
enzymatic synthesis
coenzyme
synthesis
dehydrocarnitine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7722183A
Other languages
English (en)
Other versions
FR2398046B1 (fr
Inventor
Jean-Paul Vandecasteele
Jeannine Lemal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IFP Energies Nouvelles IFPEN
Original Assignee
IFP Energies Nouvelles IFPEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IFP Energies Nouvelles IFPEN filed Critical IFP Energies Nouvelles IFPEN
Priority to FR7722183A priority Critical patent/FR2398046A1/fr
Priority to CH750578A priority patent/CH634878A5/fr
Priority to IT25551/78A priority patent/IT1097009B/it
Priority to US05/925,356 priority patent/US4221869A/en
Priority to ES471845A priority patent/ES471845A1/es
Publication of FR2398046A1 publication Critical patent/FR2398046A1/fr
Application granted granted Critical
Publication of FR2398046B1 publication Critical patent/FR2398046B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01108—Carnitine 3-dehydrogenase (1.1.1.108)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y10S435/875—Pseudomonas aeruginosa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y10S435/876—Pseudomonas fluorescens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y10S435/877—Pseudomonas putida

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procédé de synthèse de la L-carnitine consistant à soumettre la 3-déshydrocarnitine à l'action de la carnitine déshydrogénase, d'un coenzyme tel que le nicotinamide adénine dinucléotide et d'un système réducteur du coenzyme.
FR7722183A 1977-07-18 1977-07-18 Synthese enzymatique de la l-carnitine Granted FR2398046A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR7722183A FR2398046A1 (fr) 1977-07-18 1977-07-18 Synthese enzymatique de la l-carnitine
CH750578A CH634878A5 (fr) 1977-07-18 1978-07-11 Synthese enzymatique de la l-carnitine.
IT25551/78A IT1097009B (it) 1977-07-18 1978-07-11 Sintesi enzimatica della l-carnitina
US05/925,356 US4221869A (en) 1977-07-18 1978-07-17 Enzymatic synthesis of L-carnitine
ES471845A ES471845A1 (es) 1977-07-18 1978-07-18 Procedimiento de produccion de l-carnitina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7722183A FR2398046A1 (fr) 1977-07-18 1977-07-18 Synthese enzymatique de la l-carnitine

Publications (2)

Publication Number Publication Date
FR2398046A1 true FR2398046A1 (fr) 1979-02-16
FR2398046B1 FR2398046B1 (fr) 1980-01-04

Family

ID=9193544

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7722183A Granted FR2398046A1 (fr) 1977-07-18 1977-07-18 Synthese enzymatique de la l-carnitine

Country Status (5)

Country Link
US (1) US4221869A (fr)
CH (1) CH634878A5 (fr)
ES (1) ES471845A1 (fr)
FR (1) FR2398046A1 (fr)
IT (1) IT1097009B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023346A2 (fr) * 1979-07-25 1981-02-04 Degussa Aktiengesellschaft Procédé de transformation enzymatique continue d'acides alpha-céto-carboniques hydrosolubles en acides aminés correspondants
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
DE3123975A1 (de) * 1980-06-24 1982-03-11 Sigma Tau S.p.A. Industrie Farmaceutiche Riunite, 00144 Roma Verfahren zur enzymatischen herstellung von l-carnitin
FR2526442A1 (fr) * 1982-05-06 1983-11-10 Inst Francais Du Petrole Production de glucose deshydrogenase et utilisation de l'enzyme obtenu dans la synthese enzymatique de la l-carnitine
EP0132557A2 (fr) * 1983-07-22 1985-02-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Procédé de préparation enzymatique en continu de l'acide gluconique ou de ses dérivés ou de sorbitol et/ou de mannitol
EP0240423A2 (fr) * 1986-04-04 1987-10-07 Societe Nationale Elf Aquitaine Procédé perfectionné de préparation de L-carnitine
FR2605316A1 (fr) * 1986-04-04 1988-04-22 Elf Aquitaine Procede perfectionne de preparation de l-carnitine.
FR2621325A1 (fr) * 1987-10-02 1989-04-07 Elf Aquitaine Procede perfectionne de preparation de l-carnitine
FR2623520A1 (fr) * 1987-11-23 1989-05-26 Sanofi Sa Procede enzymatique continu de preparation de la l-carnitine
EP0437373A1 (fr) * 1990-01-11 1991-07-17 Asahi Kasei Kogyo Kabushiki Kaisha Méthode d'essai à sensibilité élevée pour la L-carnitine et composition pour un essai

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
US4751182A (en) * 1984-04-20 1988-06-14 Wisconsin Alumni Research Foundation Process for preparing L-carnitine from DL-carnitine
ZA852808B (en) * 1984-04-20 1985-11-27 Wisconsin Alumni Res Found Process for preparing l-carnitine
JP3059735B2 (ja) * 1989-10-13 2000-07-04 旭化成工業株式会社 Ｌ―カルニチンデヒドロゲナーゼおよびその製造法
JP2850515B2 (ja) * 1990-09-25 1999-01-27 東洋紡績株式会社 グルコースデヒドロゲナーゼおよびその製造法
JP2684238B2 (ja) * 1990-10-09 1997-12-03 旭化成工業株式会社 アシルカルニチンエステラーゼ及びその製造法
US5316917A (en) * 1992-11-04 1994-05-31 Duke University Automated analysis of free l-carnitine and total short-chain acylcarnitine
US5807926A (en) * 1996-10-11 1998-09-15 Mcgill University Immobilized cofactor-dependent enzymes
DE60042090D1 (de) * 1999-03-11 2009-06-04 Eastman Chem Co Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung
US20030162241A1 (en) * 2000-04-17 2003-08-28 Fritz Pittner Method for determining the concentration of carnitine in fluids
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7815894B2 (en) * 2003-05-29 2010-10-19 Jay W. Pettegrew Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
KR100713103B1 (ko) * 2005-07-07 2007-05-02 씨제이 주식회사 뉴로스포라 크라사 유래 ｌ-카르니틴 생합성 관련 유전자를포함하는 엔테로박테리아세 속 미생물 및 이를 이용한ｌ-카르니틴의 제조방법
ATE472600T1 (de) 2005-07-19 2010-07-15 Cj Cheiljedang Corp Mikroorganismus der gattung enterobacteriacae mit genen in zusammenhang mit der biosynthese von l- carnitin sowie verfahren zur produktion von l- carnitin mit dem mikroorganismus
JP5992142B2 (ja) * 2007-12-10 2016-09-14 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ エノエートレダクターゼを用いるα−およびβ−デヒドロアミノ酸の酵素的還元法
CN104030934B (zh) * 2014-07-04 2016-06-15 东北制药集团股份有限公司 一种左卡尼汀化合物的制备方法

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023346A2 (fr) * 1979-07-25 1981-02-04 Degussa Aktiengesellschaft Procédé de transformation enzymatique continue d'acides alpha-céto-carboniques hydrosolubles en acides aminés correspondants
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
EP0024547A2 (fr) * 1979-07-25 1981-03-11 Degussa Aktiengesellschaft Procédé de transformation enzymatique continue d'acides alpha-céto-carboniques hydrosolubles en acides alpha-hydroxy-carboniques correspondants
EP0024547A3 (en) * 1979-07-25 1981-05-06 Degussa Aktiengesellschaft Process for the continuous enzymatic transformation of water-soluble alpha-keto carbonic acids into the corresponding alpha-hydroxy carbonic acids
EP0023346A3 (en) * 1979-07-25 1981-05-13 Degussa Aktiengesellschaft Process for the continuous enzymatic transformation of water-soluble alpha-keto carbonic acids into the corresponding amino acids
DE3123975A1 (de) * 1980-06-24 1982-03-11 Sigma Tau S.p.A. Industrie Farmaceutiche Riunite, 00144 Roma Verfahren zur enzymatischen herstellung von l-carnitin
US4371618A (en) * 1980-06-24 1983-02-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Process for enzymatically producing L-carnitine
FR2526442A1 (fr) * 1982-05-06 1983-11-10 Inst Francais Du Petrole Production de glucose deshydrogenase et utilisation de l'enzyme obtenu dans la synthese enzymatique de la l-carnitine
EP0095950A1 (fr) * 1982-05-06 1983-12-07 Institut Français du Pétrole Production de glucose deshydrogenase
EP0132557A2 (fr) * 1983-07-22 1985-02-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Procédé de préparation enzymatique en continu de l'acide gluconique ou de ses dérivés ou de sorbitol et/ou de mannitol
EP0132557A3 (en) * 1983-07-22 1987-05-27 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for the continuous enzymatic production of gluconic acid or its derivatives and sorbitol and/or mannitol
EP0240423A2 (fr) * 1986-04-04 1987-10-07 Societe Nationale Elf Aquitaine Procédé perfectionné de préparation de L-carnitine
FR2605316A1 (fr) * 1986-04-04 1988-04-22 Elf Aquitaine Procede perfectionne de preparation de l-carnitine.
EP0240423A3 (fr) * 1986-04-04 1988-08-17 Societe Nationale Elf Aquitaine Procédé perfectionné de préparation de L-carnitine
FR2621325A1 (fr) * 1987-10-02 1989-04-07 Elf Aquitaine Procede perfectionne de preparation de l-carnitine
FR2623520A1 (fr) * 1987-11-23 1989-05-26 Sanofi Sa Procede enzymatique continu de preparation de la l-carnitine
EP0437373A1 (fr) * 1990-01-11 1991-07-17 Asahi Kasei Kogyo Kabushiki Kaisha Méthode d'essai à sensibilité élevée pour la L-carnitine et composition pour un essai

Also Published As

Publication number Publication date
IT1097009B (it) 1985-08-26
CH634878A5 (fr) 1983-02-28
IT7825551A0 (it) 1978-07-11
US4221869A (en) 1980-09-09
FR2398046B1 (fr) 1980-01-04
ES471845A1 (es) 1979-02-01

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