DE2949491C2 - - Google Patents

Info

Publication number
DE2949491C2
DE2949491C2 DE2949491A DE2949491A DE2949491C2 DE 2949491 C2 DE2949491 C2 DE 2949491C2 DE 2949491 A DE2949491 A DE 2949491A DE 2949491 A DE2949491 A DE 2949491A DE 2949491 C2 DE2949491 C2 DE 2949491C2
Authority
DE
Germany
Prior art keywords
formula
group
compound
compounds according
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2949491A
Other languages
German (de)
English (en)
Other versions
DE2949491A1 (de
Inventor
Peter Dr. Bern Ch Neumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Patent GmbH filed Critical Sandoz Patent GmbH
Publication of DE2949491A1 publication Critical patent/DE2949491A1/de
Priority to CH548480A priority Critical patent/CH654836A5/de
Priority to PH24383A priority patent/PH19536A/en
Application granted granted Critical
Publication of DE2949491C2 publication Critical patent/DE2949491C2/de
Priority to MX9203580A priority patent/MX9203580A/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE19792949491 1977-06-20 1979-12-08 1,4-dihydropyridine, ihre herstellung und verwendung Granted DE2949491A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH548480A CH654836A5 (en) 1979-12-08 1980-07-17 Heterocyclic organic compounds and therapeutic agents containing them
PH24383A PH19536A (en) 1977-06-20 1980-08-01 Benzoxadiazoles and benzothiadiazoles and pharmaceutical composition containing them
MX9203580A MX9203580A (es) 1979-12-08 1992-06-26 1,4-dihidropiridinas y composiciones farmaceuticas que las contienen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1283578A CH639659A5 (de) 1978-12-18 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.

Publications (2)

Publication Number Publication Date
DE2949491A1 DE2949491A1 (de) 1980-06-26
DE2949491C2 true DE2949491C2 (sv) 1988-10-27

Family

ID=4386824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792949491 Granted DE2949491A1 (de) 1977-06-20 1979-12-08 1,4-dihydropyridine, ihre herstellung und verwendung

Country Status (18)

Country Link
JP (1) JPS5583783A (sv)
AU (1) AU536055B2 (sv)
BE (1) BE880591A (sv)
CH (1) CH639659A5 (sv)
CY (1) CY1321A (sv)
DE (1) DE2949491A1 (sv)
FR (1) FR2444681A1 (sv)
GB (2) GB2103203B (sv)
HK (1) HK16086A (sv)
IE (1) IE49496B1 (sv)
IT (1) IT1164097B (sv)
KE (1) KE3593A (sv)
MY (1) MY8500130A (sv)
NL (2) NL193066C (sv)
NZ (1) NZ192422A (sv)
SE (1) SE445219B (sv)
SG (1) SG97585G (sv)
ZA (1) ZA796842B (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3317691A1 (de) * 1982-03-22 1984-11-22 Bristol-Myers Co., New York, N.Y. Cyclische dihydropyridylimidatester, verfahren zu ihrer herstellung und pharmazeutische mittel

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
CH655658B (sv) * 1980-09-18 1986-05-15
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL68975A (en) * 1982-06-15 1987-01-30 Sandoz Ag 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives in optically active form,their preparation and pharmaceutical compositions containing them
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
NL194389C (nl) * 1984-06-14 2002-03-04 Novartis Ag Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager.
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
NL194822C (nl) * 1985-10-01 2003-04-03 Novartis Ag Preparaat voor orale toediening met geregelde afgifte en werkwijze voor de bereiding ervan.
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
GB8626217D0 (en) * 1986-11-03 1986-12-03 Sandoz Ltd Pharmaceutical compositions
US4816263A (en) * 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
DE4222770A1 (de) * 1992-07-10 1994-01-13 Bayer Ag Lichtaktivierbare 1-(2-Nitrobenzyl)-substituierte 1,4-Dihydropyridine
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
WO2005023787A1 (en) * 2003-09-10 2005-03-17 Shasun Chemicals And Drugs Limited Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde
CN103613584B (zh) * 2013-11-27 2016-04-27 沈阳药科大学 一种伊拉地平合成产物后处理的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2616991A1 (de) * 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5373327A (en) * 1976-12-13 1978-06-29 Matsushita Electric Ind Co Ltd Power source system
DK149855C (da) * 1977-06-20 1987-04-21 Sandoz Ag Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3317691A1 (de) * 1982-03-22 1984-11-22 Bristol-Myers Co., New York, N.Y. Cyclische dihydropyridylimidatester, verfahren zu ihrer herstellung und pharmazeutische mittel

Also Published As

Publication number Publication date
AU5389679A (en) 1980-06-26
SE445219B (sv) 1986-06-09
BE880591A (fr) 1980-06-13
HK16086A (en) 1986-03-14
SG97585G (en) 1986-07-18
GB2103203A (en) 1983-02-16
IT7951095A0 (it) 1979-12-14
NL193066B (nl) 1998-05-06
AU536055B2 (en) 1984-04-19
GB2037766A (en) 1980-07-16
NZ192422A (en) 1982-09-14
GB2037766B (en) 1983-02-16
FR2444681B1 (sv) 1982-10-29
SE7910188L (sv) 1980-06-19
NL7909024A (nl) 1980-06-20
FR2444681A1 (fr) 1980-07-18
DE2949491A1 (de) 1980-06-26
MY8500130A (en) 1985-12-31
KE3593A (en) 1986-02-07
NL990014I1 (nl) 1999-07-01
IT1164097B (it) 1987-04-08
JPH0369910B2 (sv) 1991-11-05
CH639659A5 (de) 1983-11-30
ZA796842B (en) 1981-07-29
JPS5583783A (en) 1980-06-24
NL193066C (nl) 1998-09-08
CY1321A (en) 1986-06-27
GB2103203B (en) 1983-06-08
IE49496B1 (en) 1985-10-16
IE792445L (en) 1980-06-18

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630

V457 Spc granted

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

V464 Spc expired

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630