CH639659A5 - Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. - Google Patents

Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. Download PDF

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Publication number
CH639659A5
CH639659A5 CH1283578A CH1283578A CH639659A5 CH 639659 A5 CH639659 A5 CH 639659A5 CH 1283578 A CH1283578 A CH 1283578A CH 1283578 A CH1283578 A CH 1283578A CH 639659 A5 CH639659 A5 CH 639659A5
Authority
CH
Switzerland
Prior art keywords
compounds
formula
ch2ch
new
production
Prior art date
Application number
CH1283578A
Other languages
German (de)
English (en)
Inventor
Peter Dr Neumann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH1283578A priority Critical patent/CH639659A5/de
Priority to DE19792949491 priority patent/DE2949491A1/de
Priority to SE7910188A priority patent/SE445219B/sv
Priority to BE1/9643A priority patent/BE880591A/fr
Priority to IT51095/79A priority patent/IT1164097B/it
Priority to GB7943113A priority patent/GB2037766B/en
Priority to NL7909024A priority patent/NL193066C/nl
Priority to CY1321A priority patent/CY1321A/xx
Priority to GB08215988A priority patent/GB2103203B/en
Priority to IE2445/79A priority patent/IE49496B1/en
Priority to FR7930829A priority patent/FR2444681A1/fr
Priority to JP16396579A priority patent/JPS5583783A/ja
Priority to AU53896/79A priority patent/AU536055B2/en
Priority to NZ192422A priority patent/NZ192422A/xx
Priority to IE1165/83A priority patent/IE49497B1/en
Priority to ZA00796842A priority patent/ZA796842B/xx
Priority to PH24383A priority patent/PH19536A/en
Priority to NZ199437A priority patent/NZ199437A/en
Priority to US06/359,751 priority patent/US4466972A/en
Publication of CH639659A5 publication Critical patent/CH639659A5/de
Priority to SG975/85A priority patent/SG97585G/en
Priority to MY130/85A priority patent/MY8500130A/xx
Priority to KE3593A priority patent/KE3593A/xx
Priority to HK160/86A priority patent/HK16086A/xx
Priority to NL990014C priority patent/NL990014I1/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CH1283578A 1977-06-20 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. CH639659A5 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
CH1283578A CH639659A5 (de) 1978-12-18 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
DE19792949491 DE2949491A1 (de) 1978-12-18 1979-12-08 1,4-dihydropyridine, ihre herstellung und verwendung
SE7910188A SE445219B (sv) 1978-12-18 1979-12-11 1,4-dihydropyridinderivat, forfarande for framstellning derav samt farmaceutisk komposition
BE1/9643A BE880591A (fr) 1978-12-18 1979-12-13 Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicaments
IT51095/79A IT1164097B (it) 1978-12-18 1979-12-14 "1,4-di idropiridine loro preparazione e loro applicazione come medicamenti"
GB7943113A GB2037766B (en) 1978-12-18 1979-12-14 1,4-dihydropyridines their preparation and pharmaceutical compositions containing them
NL7909024A NL193066C (nl) 1978-12-18 1979-12-14 Methyl,isopropyl-4-(2,1,3-benzoxadiazool-4-yl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylaat en farmaceutisch preparaat dat deze verbinding bevat.
CY1321A CY1321A (en) 1978-12-18 1979-12-14 1,4-dihydropyridines their preparation and pharmaceutical compositions containing them
GB08215988A GB2103203B (en) 1978-12-18 1979-12-14 1,4-dihydropyridines, their preparation and pharmaceutical compositions containing them
JP16396579A JPS5583783A (en) 1978-12-18 1979-12-17 1*44dihydropyridine derivative
FR7930829A FR2444681A1 (fr) 1978-12-18 1979-12-17 Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicaments
IE2445/79A IE49496B1 (en) 1978-12-18 1979-12-17 A 1,4-dihydropyridine derivative,its preparation and pharmaceutical compositions containing it
AU53896/79A AU536055B2 (en) 1978-12-18 1979-12-17 Derivatives of 1,4 dihydropyridine substituted by benzoxadiazole or benzthiadiazole
NZ192422A NZ192422A (en) 1978-12-18 1979-12-17 Benzoxadiazoles and benzothiadiazoles with 1,4-dihydropyridine moiety pharmaceutical compositions
IE1165/83A IE49497B1 (en) 1978-12-18 1979-12-17 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them
ZA00796842A ZA796842B (en) 1978-12-18 1979-12-18 1,4-dihydropyridines, their preparation and pharmaceutical compositions containing them
PH24383A PH19536A (en) 1977-06-20 1980-08-01 Benzoxadiazoles and benzothiadiazoles and pharmaceutical composition containing them
NZ199437A NZ199437A (en) 1978-12-18 1982-01-07 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-methoxycarbonylpyridine-5-carboxylic acid isopropyl ester and pharmaceutical compositions
US06/359,751 US4466972A (en) 1977-06-20 1982-03-19 Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
SG975/85A SG97585G (en) 1978-12-18 1985-12-20 A 1,4-dihydropyridine derivative,its preparation and pharmaceutical compositions containing it
MY130/85A MY8500130A (en) 1978-12-18 1985-12-30 A 1,4-dihydropyridine derivative its preparation and pharmaceutical compositions containing it
KE3593A KE3593A (en) 1978-12-18 1986-01-08 A 1,4-dihydropyridine derivative its preparation and pharmaceutical compositions containing it
HK160/86A HK16086A (en) 1978-12-18 1986-03-06 A 1,4-dihydropyridine derivate its preparation and pharmaceutical compositions containing it
NL990014C NL990014I1 (nl) 1978-12-18 1999-05-11 Methyl, isopropyl-4-(2,1,3-benzoxadiazool-4-yl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylaat en farmaceutisch preparaat dat deze verbinding bevat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1283578A CH639659A5 (de) 1978-12-18 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.

Publications (1)

Publication Number Publication Date
CH639659A5 true CH639659A5 (de) 1983-11-30

Family

ID=4386824

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1283578A CH639659A5 (de) 1977-06-20 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.

Country Status (18)

Country Link
JP (1) JPS5583783A (sv)
AU (1) AU536055B2 (sv)
BE (1) BE880591A (sv)
CH (1) CH639659A5 (sv)
CY (1) CY1321A (sv)
DE (1) DE2949491A1 (sv)
FR (1) FR2444681A1 (sv)
GB (2) GB2103203B (sv)
HK (1) HK16086A (sv)
IE (1) IE49496B1 (sv)
IT (1) IT1164097B (sv)
KE (1) KE3593A (sv)
MY (1) MY8500130A (sv)
NL (2) NL193066C (sv)
NZ (1) NZ192422A (sv)
SE (1) SE445219B (sv)
SG (1) SG97585G (sv)
ZA (1) ZA796842B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
CH655658B (sv) * 1980-09-18 1986-05-15
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
IL68975A (en) * 1982-06-15 1987-01-30 Sandoz Ag 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives in optically active form,their preparation and pharmaceutical compositions containing them
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
HU197201B (en) * 1985-10-01 1989-03-28 Sandoz Ag Process for producing oral pharmaceutical compositions of controlled solubility of the active components
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
GB8626217D0 (en) * 1986-11-03 1986-12-03 Sandoz Ltd Pharmaceutical compositions
US4816263A (en) * 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
DE4222770A1 (de) * 1992-07-10 1994-01-13 Bayer Ag Lichtaktivierbare 1-(2-Nitrobenzyl)-substituierte 1,4-Dihydropyridine
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
AU2003269482A1 (en) * 2003-09-10 2005-03-29 Shasun Chemicals And Drugs Limited Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde
CN103613584B (zh) * 2013-11-27 2016-04-27 沈阳药科大学 一种伊拉地平合成产物后处理的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2616991A1 (de) * 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5373327A (en) * 1976-12-13 1978-06-29 Matsushita Electric Ind Co Ltd Power source system
DK149855C (da) * 1977-06-20 1987-04-21 Sandoz Ag Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater

Also Published As

Publication number Publication date
MY8500130A (en) 1985-12-31
IE792445L (en) 1980-06-18
CY1321A (en) 1986-06-27
HK16086A (en) 1986-03-14
SE7910188L (sv) 1980-06-19
SE445219B (sv) 1986-06-09
IT7951095A0 (it) 1979-12-14
NL990014I1 (nl) 1999-07-01
SG97585G (en) 1986-07-18
DE2949491A1 (de) 1980-06-26
JPS5583783A (en) 1980-06-24
GB2037766B (en) 1983-02-16
NL7909024A (nl) 1980-06-20
ZA796842B (en) 1981-07-29
FR2444681B1 (sv) 1982-10-29
AU536055B2 (en) 1984-04-19
JPH0369910B2 (sv) 1991-11-05
DE2949491C2 (sv) 1988-10-27
GB2103203B (en) 1983-06-08
IE49496B1 (en) 1985-10-16
NZ192422A (en) 1982-09-14
GB2037766A (en) 1980-07-16
BE880591A (fr) 1980-06-13
NL193066C (nl) 1998-09-08
KE3593A (en) 1986-02-07
NL193066B (nl) 1998-05-06
IT1164097B (it) 1987-04-08
FR2444681A1 (fr) 1980-07-18
GB2103203A (en) 1983-02-16
AU5389679A (en) 1980-06-26

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PFA Name/firm changed

Owner name: SANDOZ AG TRANSFER- NOVARTIS AG

PL Patent ceased