DE2949491A1 - 1,4-dihydropyridine, ihre herstellung und verwendung - Google Patents

1,4-dihydropyridine, ihre herstellung und verwendung

Info

Publication number
DE2949491A1
DE2949491A1 DE19792949491 DE2949491A DE2949491A1 DE 2949491 A1 DE2949491 A1 DE 2949491A1 DE 19792949491 DE19792949491 DE 19792949491 DE 2949491 A DE2949491 A DE 2949491A DE 2949491 A1 DE2949491 A1 DE 2949491A1
Authority
DE
Germany
Prior art keywords
formula
group
compounds
compound
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19792949491
Other languages
German (de)
English (en)
Other versions
DE2949491C2 (sv
Inventor
Peter Dr Neumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE2949491A1 publication Critical patent/DE2949491A1/de
Priority to CH548480A priority Critical patent/CH654836A5/de
Priority to PH24383A priority patent/PH19536A/en
Application granted granted Critical
Publication of DE2949491C2 publication Critical patent/DE2949491C2/de
Priority to MX9203580A priority patent/MX9203580A/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE19792949491 1977-06-20 1979-12-08 1,4-dihydropyridine, ihre herstellung und verwendung Granted DE2949491A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH548480A CH654836A5 (en) 1979-12-08 1980-07-17 Heterocyclic organic compounds and therapeutic agents containing them
PH24383A PH19536A (en) 1977-06-20 1980-08-01 Benzoxadiazoles and benzothiadiazoles and pharmaceutical composition containing them
MX9203580A MX9203580A (es) 1979-12-08 1992-06-26 1,4-dihidropiridinas y composiciones farmaceuticas que las contienen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1283578A CH639659A5 (de) 1978-12-18 1978-12-18 Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.

Publications (2)

Publication Number Publication Date
DE2949491A1 true DE2949491A1 (de) 1980-06-26
DE2949491C2 DE2949491C2 (sv) 1988-10-27

Family

ID=4386824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792949491 Granted DE2949491A1 (de) 1977-06-20 1979-12-08 1,4-dihydropyridine, ihre herstellung und verwendung

Country Status (18)

Country Link
JP (1) JPS5583783A (sv)
AU (1) AU536055B2 (sv)
BE (1) BE880591A (sv)
CH (1) CH639659A5 (sv)
CY (1) CY1321A (sv)
DE (1) DE2949491A1 (sv)
FR (1) FR2444681A1 (sv)
GB (2) GB2103203B (sv)
HK (1) HK16086A (sv)
IE (1) IE49496B1 (sv)
IT (1) IT1164097B (sv)
KE (1) KE3593A (sv)
MY (1) MY8500130A (sv)
NL (2) NL193066C (sv)
NZ (1) NZ192422A (sv)
SE (1) SE445219B (sv)
SG (1) SG97585G (sv)
ZA (1) ZA796842B (sv)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042089A2 (de) * 1980-06-12 1981-12-23 Bayer Ag 4-Heteroring-substituierte Dihydropyridine, Verfahren zu ihrer Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung
DE3136031A1 (de) * 1980-09-18 1982-04-08 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische zusammensetzungen, wirksam gegen koronare herzkrankheiten und hohen blutdruck
FR2528431A1 (fr) * 1982-06-15 1983-12-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
AT384219B (de) * 1982-06-15 1987-10-12 Sandoz Ag Herstellung von neuen 1,4-dihydropyridinderivaten in optisch aktiver oder racematform
WO1994001405A1 (de) * 1992-07-10 1994-01-20 Siegfried Goldmann Lichtaktivierbare 1-(2-nitrobenzyl)-substituierte 1,4-dihydropyridine

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
NL194822C (nl) * 1985-10-01 2003-04-03 Novartis Ag Preparaat voor orale toediening met geregelde afgifte en werkwijze voor de bereiding ervan.
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
GB8626217D0 (en) * 1986-11-03 1986-12-03 Sandoz Ltd Pharmaceutical compositions
US4816263A (en) * 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
AU2003269482A1 (en) * 2003-09-10 2005-03-29 Shasun Chemicals And Drugs Limited Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde
CN103613584B (zh) * 2013-11-27 2016-04-27 沈阳药科大学 一种伊拉地平合成产物后处理的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824A1 (de) * 1967-03-20 1971-04-01 Bayer Ag Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten
DE2635916A1 (de) * 1975-08-12 1977-02-24 Hexachimie Dihydro-1,4-pyridine und diese enthaltende heilmittel
DE2616991A1 (de) * 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373327A (en) * 1976-12-13 1978-06-29 Matsushita Electric Ind Co Ltd Power source system
DK149855C (da) * 1977-06-20 1987-04-21 Sandoz Ag Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824A1 (de) * 1967-03-20 1971-04-01 Bayer Ag Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten
DE2635916A1 (de) * 1975-08-12 1977-02-24 Hexachimie Dihydro-1,4-pyridine und diese enthaltende heilmittel
DE2616991A1 (de) * 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURGER: Medicinal Chemistry, 4. Aufl., Bd. 3, S.319, (gutachtlich genannt) *
EP-PS 150 (gutachtlich genannt) *
J. of Cardiovescular Pharmacology, 6, 407, 1984 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042089A2 (de) * 1980-06-12 1981-12-23 Bayer Ag 4-Heteroring-substituierte Dihydropyridine, Verfahren zu ihrer Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung
EP0042089A3 (en) * 1980-06-12 1982-09-22 Bayer Ag 4-heterocylic substituted dihydropyridines, processes for preparing them, their therapeutical use and their preparation
DE3136031A1 (de) * 1980-09-18 1982-04-08 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische zusammensetzungen, wirksam gegen koronare herzkrankheiten und hohen blutdruck
FR2528431A1 (fr) * 1982-06-15 1983-12-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
WO1984000033A1 (en) * 1982-06-15 1984-01-05 Sandoz Ag 1,4-dihydro-pyridine derivatives, preparation thereof and pharmaceutical compositions containing them
AT384219B (de) * 1982-06-15 1987-10-12 Sandoz Ag Herstellung von neuen 1,4-dihydropyridinderivaten in optisch aktiver oder racematform
WO1994001405A1 (de) * 1992-07-10 1994-01-20 Siegfried Goldmann Lichtaktivierbare 1-(2-nitrobenzyl)-substituierte 1,4-dihydropyridine
US5606066A (en) * 1992-07-10 1997-02-25 Goldmann; Siegfried Light activable "caged" 1-(2-nitrobenzyl)-substituted 1,4-dihydropyridines

Also Published As

Publication number Publication date
CH639659A5 (de) 1983-11-30
GB2037766B (en) 1983-02-16
CY1321A (en) 1986-06-27
ZA796842B (en) 1981-07-29
HK16086A (en) 1986-03-14
NL7909024A (nl) 1980-06-20
SE445219B (sv) 1986-06-09
IT7951095A0 (it) 1979-12-14
JPH0369910B2 (sv) 1991-11-05
AU536055B2 (en) 1984-04-19
NZ192422A (en) 1982-09-14
NL193066C (nl) 1998-09-08
NL193066B (nl) 1998-05-06
GB2103203A (en) 1983-02-16
GB2103203B (en) 1983-06-08
NL990014I1 (nl) 1999-07-01
BE880591A (fr) 1980-06-13
GB2037766A (en) 1980-07-16
IE792445L (en) 1980-06-18
IE49496B1 (en) 1985-10-16
AU5389679A (en) 1980-06-26
SE7910188L (sv) 1980-06-19
DE2949491C2 (sv) 1988-10-27
FR2444681B1 (sv) 1982-10-29
JPS5583783A (en) 1980-06-24
MY8500130A (en) 1985-12-31
KE3593A (en) 1986-02-07
FR2444681A1 (fr) 1980-07-18
SG97585G (en) 1986-07-18
IT1164097B (it) 1987-04-08

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DE2949491A1 (de) 1,4-dihydropyridine, ihre herstellung und verwendung
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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630

V457 Spc granted

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

V464 Spc expired

Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029

Spc suppl protection certif: 193 75 087

Filing date: 19930630