DE2940483C2 - - Google Patents

Info

Publication number
DE2940483C2
DE2940483C2 DE2940483A DE2940483A DE2940483C2 DE 2940483 C2 DE2940483 C2 DE 2940483C2 DE 2940483 A DE2940483 A DE 2940483A DE 2940483 A DE2940483 A DE 2940483A DE 2940483 C2 DE2940483 C2 DE 2940483C2
Authority
DE
Germany
Prior art keywords
methyl
general formula
dimethoxy
radical
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2940483A
Other languages
German (de)
English (en)
Other versions
DE2940483A1 (de
Inventor
Jenoe Dr. Koeroesi
Tibor Dr. Lang
Jozsef Dr. Szekely
Ferenc Dr. Andrasi
Gabor Dr. Zolyomi
Jozsef Dr. Borsy
Geb. Horvath Katalin Budapest Hu Goldschmidt
Tamas Maklar Hu Hamori
Geb. Czibula Gabriella Szabo
Geb. Dunai Kovacs Zsuzsa Meszaros
Erzsebet Budapest Hu Miglecz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EGYT GYOGYSZERVEGYESZETI GYAR BUDAPEST HU
Original Assignee
EGYT GYOGYSZERVEGYESZETI GYAR BUDAPEST HU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGYT GYOGYSZERVEGYESZETI GYAR BUDAPEST HU filed Critical EGYT GYOGYSZERVEGYESZETI GYAR BUDAPEST HU
Publication of DE2940483A1 publication Critical patent/DE2940483A1/de
Application granted granted Critical
Publication of DE2940483C2 publication Critical patent/DE2940483C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19792940483 1978-10-19 1979-10-05 5h-2,3-benzodiazepinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel Granted DE2940483A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1426A HU179018B (en) 1978-10-19 1978-10-19 Process for producing new 5h-2,3-benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
DE2940483A1 DE2940483A1 (de) 1980-04-30
DE2940483C2 true DE2940483C2 (forum.php) 1989-06-22

Family

ID=10996876

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792940483 Granted DE2940483A1 (de) 1978-10-19 1979-10-05 5h-2,3-benzodiazepinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel

Country Status (25)

Country Link
US (1) US4322346A (forum.php)
JP (1) JPS5592377A (forum.php)
AT (1) AT373589B (forum.php)
AU (1) AU532079B2 (forum.php)
BE (1) BE879404A (forum.php)
BG (1) BG60270B2 (forum.php)
CA (1) CA1125749A (forum.php)
CH (1) CH643835A5 (forum.php)
CS (1) CS236456B2 (forum.php)
DD (1) DD146596A5 (forum.php)
DE (1) DE2940483A1 (forum.php)
DK (1) DK155327C (forum.php)
ES (1) ES485163A1 (forum.php)
FI (1) FI66604C (forum.php)
FR (1) FR2439189A1 (forum.php)
GB (1) GB2034706B (forum.php)
GR (1) GR74034B (forum.php)
HU (1) HU179018B (forum.php)
IT (1) IT1220947B (forum.php)
NL (1) NL190552C (forum.php)
NO (1) NO152048C (forum.php)
PL (1) PL124063B1 (forum.php)
SE (1) SE439919B (forum.php)
SU (1) SU1402258A3 (forum.php)
YU (1) YU41887B (forum.php)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
JPH01311400A (ja) * 1988-06-09 1989-12-15 Kyocera Corp 発光標識体の点灯方法
JPH0251568U (forum.php) * 1988-10-07 1990-04-11
JPH0324693U (forum.php) * 1989-07-18 1991-03-14
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
ES2190428T3 (es) * 1991-06-28 2003-08-01 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogeno.
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
SK283859B6 (sk) * 1995-02-09 2004-03-02 Egis Gy�Gyszergy�R Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
EP0726256A1 (en) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
DE19604919A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
FR2824065A1 (fr) * 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
ATE358488T1 (de) * 2002-09-13 2007-04-15 Motac Neuroscience Ltd Behandlung von dyskinesie mit 2,3-benzodiazepinen
ES2286453T3 (es) * 2002-09-17 2007-12-01 Motac Neuroscience Limited Tratamiento de la discinesia.
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040229867A1 (en) * 2003-05-16 2004-11-18 Kucharik Robert F. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (R) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
GB1202579A (en) * 1966-12-09 1970-08-19 Egyt Gyogyszervegyeszeti Gyar Pharmacologically active new isoquinoline derivative and process for preparing same
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
BE879404A (fr) 1980-04-15
BG60270B1 (bg) 1994-03-31
DK155327B (da) 1989-03-28
YU241079A (en) 1984-02-29
US4322346A (en) 1982-03-30
NL190552C (nl) 1994-04-18
AU532079B2 (en) 1983-09-15
CH643835A5 (de) 1984-06-29
NO152048B (no) 1985-04-15
NL7907692A (nl) 1980-04-22
IT1220947B (it) 1990-06-21
ES485163A1 (es) 1980-06-16
NL190552B (nl) 1993-11-16
NO793349L (no) 1980-04-22
JPS6350354B2 (forum.php) 1988-10-07
DD146596A5 (de) 1981-02-18
AT373589B (de) 1984-02-10
DK440179A (da) 1980-04-20
IT7926579A0 (it) 1979-10-18
GR74034B (forum.php) 1984-06-06
JPS5592377A (en) 1980-07-12
CS236456B2 (en) 1985-05-15
SE439919B (sv) 1985-07-08
SU1402258A3 (ru) 1988-06-07
CA1125749A (en) 1982-06-15
YU41887B (en) 1988-02-29
ATA647279A (de) 1983-06-15
FI66604C (fi) 1984-11-12
DK155327C (da) 1989-08-21
FI793209A7 (fi) 1980-04-20
DE2940483A1 (de) 1980-04-30
GB2034706B (en) 1982-08-04
SE7908481L (sv) 1980-04-20
HU179018B (en) 1982-08-28
BG60270B2 (bg) 1994-03-31
NO152048C (no) 1985-07-24
FR2439189A1 (fr) 1980-05-16
PL219034A1 (forum.php) 1980-12-01
GB2034706A (en) 1980-06-11
FR2439189B1 (forum.php) 1984-11-30
PL124063B1 (en) 1982-12-31
FI66604B (fi) 1984-07-31

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Legal Events

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8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee