DE2836770C2 - - Google Patents
Info
- Publication number
- DE2836770C2 DE2836770C2 DE2836770A DE2836770A DE2836770C2 DE 2836770 C2 DE2836770 C2 DE 2836770C2 DE 2836770 A DE2836770 A DE 2836770A DE 2836770 A DE2836770 A DE 2836770A DE 2836770 C2 DE2836770 C2 DE 2836770C2
- Authority
- DE
- Germany
- Prior art keywords
- gas
- outer packaging
- hydrogen
- oxygen
- introduces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical group CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 claims description 28
- 238000004806 packaging method and process Methods 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 17
- 238000002347 injection Methods 0.000 claims description 15
- 239000007924 injection Substances 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 14
- 239000001301 oxygen Substances 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000003054 catalyst Substances 0.000 claims description 8
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 5
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 4
- 229960002748 norepinephrine Drugs 0.000 claims description 4
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052763 palladium Inorganic materials 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 239000003245 coal Substances 0.000 claims description 3
- 238000006864 oxidative decomposition reaction Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 229910052741 iridium Inorganic materials 0.000 claims description 2
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052762 osmium Inorganic materials 0.000 claims description 2
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 229910052703 rhodium Inorganic materials 0.000 claims description 2
- 239000010948 rhodium Substances 0.000 claims description 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 2
- 229910052707 ruthenium Inorganic materials 0.000 claims description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 229910001882 dioxygen Inorganic materials 0.000 claims 2
- 239000011521 glass Substances 0.000 description 6
- 239000003589 local anesthetic agent Substances 0.000 description 4
- 239000002985 plastic film Substances 0.000 description 4
- 229920006255 plastic film Polymers 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- -1 platinum group metals Chemical class 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- YLXIPWWIOISBDD-NDAAPVSOSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CNC[C@H](O)C1=CC=C(O)C(O)=C1 YLXIPWWIOISBDD-NDAAPVSOSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229960003150 bupivacaine Drugs 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960002409 mepivacaine Drugs 0.000 description 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Packages (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7709970A SE407778B (sv) | 1977-09-06 | 1977-09-06 | Forpackning och forfarande for skyddande av lekemedelsaktiva losningar innehallande oxidativt nedbrytbara substanser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2836770A1 DE2836770A1 (de) | 1979-03-15 |
| DE2836770C2 true DE2836770C2 (cg-RX-API-DMAC10.html) | 1992-06-11 |
Family
ID=20332187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782836770 Granted DE2836770A1 (de) | 1977-09-06 | 1978-08-23 | Verfahren zur verhinderung der oxidativen zersetzung von substanzen in pharmazeutischen praeparaten und packung hierfuer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4236633A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5449283A (cg-RX-API-DMAC10.html) |
| AR (1) | AR216688A1 (cg-RX-API-DMAC10.html) |
| AT (1) | AT362880B (cg-RX-API-DMAC10.html) |
| AU (1) | AU523245B2 (cg-RX-API-DMAC10.html) |
| BE (1) | BE870242A (cg-RX-API-DMAC10.html) |
| BR (1) | BR7805697A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1108993A (cg-RX-API-DMAC10.html) |
| CH (1) | CH642539A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2836770A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK148649C (cg-RX-API-DMAC10.html) |
| FI (1) | FI63713C (cg-RX-API-DMAC10.html) |
| FR (1) | FR2401835A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB2003821A (cg-RX-API-DMAC10.html) |
| IE (1) | IE47339B1 (cg-RX-API-DMAC10.html) |
| IT (1) | IT1107683B (cg-RX-API-DMAC10.html) |
| LU (1) | LU80191A1 (cg-RX-API-DMAC10.html) |
| NL (1) | NL190835C (cg-RX-API-DMAC10.html) |
| NO (1) | NO148548C (cg-RX-API-DMAC10.html) |
| SE (1) | SE407778B (cg-RX-API-DMAC10.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59156317A (ja) * | 1983-02-28 | 1984-09-05 | 金沢工業株式会社 | コ−ヒ−等の抽出装置 |
| JPS61103445A (ja) * | 1984-10-24 | 1986-05-21 | 三菱瓦斯化学株式会社 | 脱酸素剤包装容器 |
| LU85954A1 (fr) * | 1985-06-17 | 1986-06-25 | Paul Henri Lefebvre | Systeme de magasinage aseptique de liquides fermentescibles en reservoirs souples |
| JPS62221352A (ja) * | 1986-03-22 | 1987-09-29 | 株式会社新素材総合研究所 | 酸素による薬液の変質を防止する薬液入りプラスチック容器の製造方法 |
| FR2618762B1 (fr) * | 1987-07-30 | 1989-12-29 | Roussel Uclaf | Dispositif permettant le stockage prolonge de produits nutritifs |
| DE3912153C1 (en) * | 1989-04-13 | 1990-08-02 | Christoph V. Dr.Rer.Nat. Stein | Preventing deterioration of solns. by oxidn. - by feeding solns. in containers from which air has been expelled by injected protective gas |
| JPH0384543A (ja) * | 1989-08-29 | 1991-04-10 | Brother Ind Ltd | マイクロカプセルシートを内包するパトローネ |
| WO1998008523A1 (de) * | 1996-08-27 | 1998-03-05 | Messer Griesheim Gmbh | Wasserstoffhaltiges medikament |
| CA2286002C (en) | 1997-04-10 | 2008-01-29 | Andrew N. Lamborne | Gaz syringe and package therefor |
| FR2811292B1 (fr) * | 2000-07-04 | 2002-10-18 | Air Liquide | Procede pour le conditionnement de produits perissables sous atmosphere modifiee contenant de l'hydrogene et produits ainsi conditionnes |
| US20050020554A1 (en) * | 2003-06-06 | 2005-01-27 | Ahmed Salah U. | Stability of hormone formulations |
| DE10361306A1 (de) * | 2003-12-24 | 2005-07-28 | Lts Lohmann Therapie-Systeme Ag | Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür |
| DE102005055632A1 (de) * | 2005-11-22 | 2007-05-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verbundsystem und dessen Verwendung sowie Verfahren zum sauerstofffreien Verpacken von oxidationsempfindlichen Verpackungsgütern |
| AU2011286179B2 (en) * | 2010-08-06 | 2016-05-05 | Hospira Australia Pty Ltd | Vial preparation method and system |
| WO2018140894A1 (en) | 2017-01-30 | 2018-08-02 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
| US20250177328A1 (en) | 2017-01-30 | 2025-06-05 | Nevakar Injectables Inc. | Norepinephrine compositions and methods therefor |
| CN109969596B (zh) * | 2019-03-26 | 2020-10-27 | 永兴县鸿福金属有限公司 | 一种生产金属银用放置箱 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1081592A (en) * | 1912-08-06 | 1913-12-16 | Hoechst Ag | Medicinal preparation. |
| US2215479A (en) * | 1938-03-07 | 1940-09-24 | Jacob William Frankel | Device for preserving local anesthetic solutions |
| GB734197A (en) * | 1952-06-23 | 1955-07-27 | Mini Of Supply | Improved process for the preservation of foodstuffs or the like |
| GB890550A (en) * | 1959-06-15 | 1962-03-07 | Metal Box Company Of South Afr | Improvements in or relating to the vacuum-packing of edible and like products in containers |
| CH437989A (fr) * | 1963-07-22 | 1967-06-15 | Catalytic Gas Pack Limited | Dispositif pour éliminer l'oxygène résiduel par réaction catalytique avec de l'hydrogène dans un récipient et procédé pour sa fabrication |
| US3255020A (en) * | 1963-08-23 | 1966-06-07 | Air Prod & Chem | System for packaging |
| US3369859A (en) * | 1963-08-23 | 1968-02-20 | Air Prod & Chem | Packaging system |
| US3815315A (en) * | 1971-04-29 | 1974-06-11 | American Cyanamid Co | Ethylene oxide sterilization of moisture sensitive surgical elements |
| CH581992A5 (cg-RX-API-DMAC10.html) * | 1975-08-15 | 1976-11-30 | Laib Jakob C | |
| US4038148A (en) * | 1975-12-22 | 1977-07-26 | Marion Laboratories, Inc. | Anaerobic environmental system for bacteria culture testing |
-
1977
- 1977-09-06 SE SE7709970A patent/SE407778B/sv not_active IP Right Cessation
-
1978
- 1978-08-22 CA CA309,812A patent/CA1108993A/en not_active Expired
- 1978-08-23 DE DE19782836770 patent/DE2836770A1/de active Granted
- 1978-08-23 AT AT0613278A patent/AT362880B/de active
- 1978-08-25 AU AU39265/78A patent/AU523245B2/en not_active Expired
- 1978-08-25 US US05/936,772 patent/US4236633A/en not_active Expired - Lifetime
- 1978-08-30 DK DK383178A patent/DK148649C/da not_active IP Right Cessation
- 1978-08-31 BR BR7805697A patent/BR7805697A/pt unknown
- 1978-09-01 AR AR273540A patent/AR216688A1/es active
- 1978-09-01 NO NO782986A patent/NO148548C/no unknown
- 1978-09-04 FR FR7825414A patent/FR2401835A1/fr active Granted
- 1978-09-05 IE IE1787/78A patent/IE47339B1/en not_active IP Right Cessation
- 1978-09-05 IT IT50976/78A patent/IT1107683B/it active
- 1978-09-05 CH CH930178A patent/CH642539A5/de not_active IP Right Cessation
- 1978-09-05 GB GB7835602A patent/GB2003821A/en not_active Withdrawn
- 1978-09-05 FI FI782721A patent/FI63713C/fi not_active IP Right Cessation
- 1978-09-05 LU LU80191A patent/LU80191A1/xx unknown
- 1978-09-06 NL NL7809106A patent/NL190835C/xx not_active IP Right Cessation
- 1978-09-06 BE BE190284A patent/BE870242A/xx not_active IP Right Cessation
- 1978-09-06 JP JP10870378A patent/JPS5449283A/ja active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |