DE2831507A1 - (alle-z)-5,8,11,14,17-eicosapentaensaeure und/oder deren derivate enthaltende formulierungen, sowie verfahren zu ihrer herstellung - Google Patents
(alle-z)-5,8,11,14,17-eicosapentaensaeure und/oder deren derivate enthaltende formulierungen, sowie verfahren zu ihrer herstellungInfo
- Publication number
- DE2831507A1 DE2831507A1 DE19782831507 DE2831507A DE2831507A1 DE 2831507 A1 DE2831507 A1 DE 2831507A1 DE 19782831507 DE19782831507 DE 19782831507 DE 2831507 A DE2831507 A DE 2831507A DE 2831507 A1 DE2831507 A1 DE 2831507A1
- Authority
- DE
- Germany
- Prior art keywords
- formulation according
- formulation
- acid
- eicosapentaenoic acid
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
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- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical class CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 1
- MBMBGCFOFBJSGT-SFGLVEFQSA-N docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCC(O)=O MBMBGCFOFBJSGT-SFGLVEFQSA-N 0.000 description 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002499 effect on thrombus formation Effects 0.000 description 1
- 229940066279 eicosapentaenoate Drugs 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
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- 238000011534 incubation Methods 0.000 description 1
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- 238000010253 intravenous injection Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229940080435 lactose 250 mg Drugs 0.000 description 1
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- 210000004072 lung Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
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- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
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- 230000001575 pathological effect Effects 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
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- 229940075579 propyl gallate Drugs 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- DDMGAAYEUNWXSI-XVSDJDOKSA-M sodium;(5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate Chemical compound [Na+].CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC([O-])=O DDMGAAYEUNWXSI-XVSDJDOKSA-M 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C15/00—Butter; Butter preparations; Making thereof
- A23C15/12—Butter preparations
- A23C15/126—Butter containing a minority of vegetable oils; Enrichment of butter with fatty acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
- A23D9/013—Other fatty acid esters, e.g. phosphatides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2357578A GB1604554A (en) | 1978-05-26 | 1978-05-26 | Pharmaceutical and food formulations |
| GB2357478 | 1978-05-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2831507A1 true DE2831507A1 (de) | 1979-11-29 |
| DE2831507C2 DE2831507C2 (enrdf_load_stackoverflow) | 1989-07-13 |
Family
ID=26256599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782831507 Granted DE2831507A1 (de) | 1978-05-26 | 1978-07-18 | (alle-z)-5,8,11,14,17-eicosapentaensaeure und/oder deren derivate enthaltende formulierungen, sowie verfahren zu ihrer herstellung |
Country Status (13)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3325130A1 (de) * | 1983-06-29 | 1985-01-03 | Pierre-Richard Nizza Dick | Pharmazeutische zusammensetzung zur anwendung fuer die haut auf der basis von essentiellen fettsaeuren und diese enthaltende vorrichtung |
| DE3438630A1 (de) * | 1983-10-24 | 1985-05-02 | Century Laboratories, Inc., Port Washington, N.Y. | Kombinierte fettsaeurezusammensetzung zur senkung des cholesterin- und triglycerid-blutspiegels |
| DE19503993A1 (de) * | 1995-02-08 | 1996-08-14 | Johann Friedrich Dr Med Desaga | Verwendung eines Produktes zur enteralen Versorgung mit Lebensmittelinhaltsstoffen oder Arzneimittelinhaltsstoffen |
| DE10056351A1 (de) * | 2000-11-14 | 2002-05-29 | Weylandt Karsten Henrich | Pharmazeutisches Präparat |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5735512A (en) * | 1980-06-27 | 1982-02-26 | Nippon Oil & Fats Co Ltd | Preventive and remedy for thrombosis |
| JPS59172416A (ja) * | 1983-03-18 | 1984-09-29 | Terumo Corp | 脂肪輸液 |
| JPS60132916A (ja) * | 1983-12-21 | 1985-07-16 | Nisshin Oil Mills Ltd:The | 血栓症予防食品または医薬品 |
| US4752618A (en) * | 1984-07-12 | 1988-06-21 | New England Deaconess Hospital | Method of minimizing efects of infection through diet |
| JPH0748991B2 (ja) * | 1984-08-29 | 1995-05-31 | 日本油脂株式会社 | 経管栄養組成物 |
| GB8710780D0 (en) * | 1987-05-07 | 1987-06-10 | Scras | Opthalmological application of eicosapentaenoic acid |
| GB8819110D0 (en) * | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| US5922345A (en) * | 1990-12-07 | 1999-07-13 | Scotia Holdings Plc | Nutrition |
| WO1993020717A2 (en) * | 1992-04-13 | 1993-10-28 | Research Corporation Technologies, Inc. | Reducing gastrointestinal irritation in infant nutrition |
| NL9401743A (nl) * | 1994-10-20 | 1996-06-03 | Prospa Bv | Zouten van aminoalcoholen en farmaceutische formuleringen die deze bevatten. |
| GB0403247D0 (en) | 2004-02-13 | 2004-03-17 | Tillotts Pharma Ag | A pharmaceutical composition |
| LT3278665T (lt) | 2009-04-29 | 2020-12-10 | Amarin Pharmaceuticals Ireland Limited | Stabili farmacinė kompozicija ir jos panaudojimo būdai |
| MY205872A (en) | 2009-04-29 | 2024-11-18 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising omega-3 fatty acids |
| PT2443246T (pt) | 2009-06-15 | 2018-03-14 | Amarin Pharmaceuticals Ie Ltd | Composições e métodos para reduzir os triglicéridos sem aumentar os níveis de ldl-c num indivíduo em terapia de estatinas concomitante |
| BR112012006692B8 (pt) | 2009-09-23 | 2021-05-25 | Amarin Corp Plc | composição farmacêutica compreendendo um derivado de hidróxi de atorvastatina e um óleo compreendendo etil eicosapentaenoato ou etil docosahexaenoato |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| SG10201913647QA (en) | 2012-06-29 | 2020-03-30 | Amarin Pharmaceuticals Ie Ltd | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| SG10201706205RA (en) | 2013-02-06 | 2017-08-30 | Agency Science Tech & Res | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| WO2018213663A1 (en) | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| EP4056176B1 (en) | 2018-09-24 | 2024-04-24 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of cardiovascular events in a subject |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476624A (en) * | 1973-05-30 | 1977-06-16 | Cepbepe | Tranquiliser medicaments |
| DE2749492A1 (de) * | 1976-11-04 | 1978-05-11 | Bio Oil Res | Antithrombosemittel |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE319677B (enrdf_load_stackoverflow) * | 1965-03-27 | 1970-01-19 | Sumitomo Chemical Co | |
| FR2097036A1 (en) * | 1970-07-29 | 1972-03-03 | Sopharga Lab | Lipids contg fatty acids - for treatment of atheroslerosis |
| JPS6257605A (ja) * | 1985-09-05 | 1987-03-13 | Kaizuka Kazutoshi | 多元素鉱物からの有効成分抽出方法 |
-
1978
- 1978-07-17 AU AU38084/78A patent/AU527784B2/en not_active Expired
- 1978-07-18 DE DE19782831507 patent/DE2831507A1/de active Granted
- 1978-07-19 JP JP8824578A patent/JPS5515444A/ja active Pending
- 1978-07-19 NZ NZ187908A patent/NZ187908A/en unknown
- 1978-07-27 IL IL55227A patent/IL55227A/xx unknown
-
1979
- 1979-01-19 IT IT47717/79A patent/IT1116505B/it active
- 1979-05-23 FR FR7913122A patent/FR2426461A1/fr active Granted
- 1979-05-25 ES ES480921A patent/ES480921A0/es active Granted
- 1979-05-25 NL NL7904144A patent/NL191332C/xx not_active IP Right Cessation
- 1979-05-25 CH CH490379A patent/CH644267A5/de not_active IP Right Cessation
- 1979-05-25 SE SE7904570A patent/SE448678B/sv not_active IP Right Cessation
- 1979-05-25 CA CA000328419A patent/CA1151068A/en not_active Expired
- 1979-08-08 IE IE1023/79A patent/IE48287B1/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476624A (en) * | 1973-05-30 | 1977-06-16 | Cepbepe | Tranquiliser medicaments |
| DE2749492A1 (de) * | 1976-11-04 | 1978-05-11 | Bio Oil Res | Antithrombosemittel |
Non-Patent Citations (3)
| Title |
|---|
| Chemical Abstracts CA Vol. 81, 1974, Nr. 612516 * |
| Pharmazeutische Zeitung 118, Nr.40, 04.10.1973 * |
| SILVER, M. J., et al., Prostaglandins 4, 1973, S. 863-875 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3325130A1 (de) * | 1983-06-29 | 1985-01-03 | Pierre-Richard Nizza Dick | Pharmazeutische zusammensetzung zur anwendung fuer die haut auf der basis von essentiellen fettsaeuren und diese enthaltende vorrichtung |
| DE3438630A1 (de) * | 1983-10-24 | 1985-05-02 | Century Laboratories, Inc., Port Washington, N.Y. | Kombinierte fettsaeurezusammensetzung zur senkung des cholesterin- und triglycerid-blutspiegels |
| DE19503993A1 (de) * | 1995-02-08 | 1996-08-14 | Johann Friedrich Dr Med Desaga | Verwendung eines Produktes zur enteralen Versorgung mit Lebensmittelinhaltsstoffen oder Arzneimittelinhaltsstoffen |
| DE10056351A1 (de) * | 2000-11-14 | 2002-05-29 | Weylandt Karsten Henrich | Pharmazeutisches Präparat |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2426461B1 (enrdf_load_stackoverflow) | 1983-02-11 |
| NL7904144A (nl) | 1979-11-28 |
| JPS5515444A (en) | 1980-02-02 |
| ES8104983A1 (es) | 1981-05-16 |
| AU3808478A (en) | 1980-01-17 |
| DE2831507C2 (enrdf_load_stackoverflow) | 1989-07-13 |
| NL191332B (nl) | 1995-01-02 |
| ES480921A0 (es) | 1981-05-16 |
| NL191332C (nl) | 1995-06-01 |
| IT1116505B (it) | 1986-02-10 |
| NZ187908A (en) | 1984-05-31 |
| FR2426461A1 (fr) | 1979-12-21 |
| CH644267A5 (en) | 1984-07-31 |
| IE48287B1 (en) | 1984-11-28 |
| SE448678B (sv) | 1987-03-16 |
| IE791023L (en) | 1979-11-26 |
| SE7904570L (sv) | 1979-11-27 |
| CA1151068A (en) | 1983-08-02 |
| IT7947717A0 (it) | 1979-01-19 |
| IL55227A (en) | 1982-12-31 |
| AU527784B2 (en) | 1983-03-24 |
| IL55227A0 (en) | 1978-09-29 |
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