DE2743944C3 - 5-Alkoxy-picolinsäuren, Verfahren zur Herstellung derselben und blutdrucksenkende Arzneimittel, welche diese enthalten - Google Patents

5-Alkoxy-picolinsäuren, Verfahren zur Herstellung derselben und blutdrucksenkende Arzneimittel, welche diese enthalten

Info

Publication number
DE2743944C3
DE2743944C3 DE2743944A DE2743944A DE2743944C3 DE 2743944 C3 DE2743944 C3 DE 2743944C3 DE 2743944 A DE2743944 A DE 2743944A DE 2743944 A DE2743944 A DE 2743944A DE 2743944 C3 DE2743944 C3 DE 2743944C3
Authority
DE
Germany
Prior art keywords
acid
solution
concentrated
group
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2743944A
Other languages
German (de)
English (en)
Other versions
DE2743944B2 (de
DE2743944A1 (de
Inventor
Hiroyasu Yokohama Kanagawa Asaoka
Shigeharu Kanagawa Inouye
Osamu Itoh
Takashi Kawasaki Kanagawa Tsuruoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of DE2743944A1 publication Critical patent/DE2743944A1/de
Publication of DE2743944B2 publication Critical patent/DE2743944B2/de
Application granted granted Critical
Publication of DE2743944C3 publication Critical patent/DE2743944C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2743944A 1976-09-30 1977-09-29 5-Alkoxy-picolinsäuren, Verfahren zur Herstellung derselben und blutdrucksenkende Arzneimittel, welche diese enthalten Expired DE2743944C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11664176A JPS5344572A (en) 1976-09-30 1976-09-30 5-alkoxy-picolic acid, its preparation and hypotensives containing the same

Publications (3)

Publication Number Publication Date
DE2743944A1 DE2743944A1 (de) 1978-04-06
DE2743944B2 DE2743944B2 (de) 1980-09-11
DE2743944C3 true DE2743944C3 (de) 1981-07-16

Family

ID=14692226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2743944A Expired DE2743944C3 (de) 1976-09-30 1977-09-29 5-Alkoxy-picolinsäuren, Verfahren zur Herstellung derselben und blutdrucksenkende Arzneimittel, welche diese enthalten

Country Status (9)

Country Link
US (1) US4189489A (sv)
JP (1) JPS5344572A (sv)
BE (2) BE859198A (sv)
CA (1) CA1099720A (sv)
DE (1) DE2743944C3 (sv)
FR (1) FR2366279A1 (sv)
GB (1) GB1545358A (sv)
NL (1) NL179477C (sv)
SE (1) SE430250B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1115709A (en) * 1978-03-24 1982-01-05 Uichi Shibata 5-substituted-hydroxy picolinic acid derivatives
US4260620A (en) * 1979-10-26 1981-04-07 Ciba-Geigy Corporation 2-Pyridinecarboxylic acids
CN109646437B (zh) * 2017-10-12 2022-04-15 四川好医生攀西药业有限责任公司 具有促进创面愈合作用的6-羟甲基吡啶-3-醇及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3291805A (en) * 1965-01-28 1966-12-13 Squibb & Sons Inc Method for the production of hydroxypicolinic acid
US3519717A (en) * 1968-01-17 1970-07-07 Schering Corp Novel method for lowering high blood pressure and compositions therefor
US3697531A (en) * 1971-02-25 1972-10-10 Sterling Drug Inc N,n{40 -alkylenebis(pyridine-carboxamides)
BE795518A (fr) * 1972-02-17 1973-08-16 Ciba Geigy Nouveaux composes pyridiniques et leurs procedes de preparation
SE385883B (sv) * 1972-04-10 1976-07-26 Ciba Geigy Ag Forfarande for framstellning av nya pyridinkarbonsyraestrar
CH602110A5 (sv) * 1974-04-18 1978-07-31 Hoffmann La Roche
GB1502055A (en) * 1975-06-30 1978-02-22 Meiji Seika Kaisha 3-substituted-2(1h)pyridon-6-carboxylic acids and processes for preparing the same

Also Published As

Publication number Publication date
BE859198A (fr) 1978-01-16
US4189489A (en) 1980-02-19
NL7710653A (nl) 1978-04-03
JPS5344572A (en) 1978-04-21
NL179477C (nl) 1986-09-16
CA1099720A (en) 1981-04-21
DE2743944B2 (de) 1980-09-11
GB1545358A (en) 1979-05-10
SE430250B (sv) 1983-10-31
DE2743944A1 (de) 1978-04-06
NL179477B (nl) 1986-04-16
FR2366279B1 (sv) 1981-10-16
SE7710933L (sv) 1978-03-31
FR2366279A1 (fr) 1978-04-28
BE866977R (fr) 1978-09-01

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee