DE2732528A1 - Verfahren zur herstellung von amoxicillintrihydrat - Google Patents

Verfahren zur herstellung von amoxicillintrihydrat

Info

Publication number
DE2732528A1
DE2732528A1 DE19772732528 DE2732528A DE2732528A1 DE 2732528 A1 DE2732528 A1 DE 2732528A1 DE 19772732528 DE19772732528 DE 19772732528 DE 2732528 A DE2732528 A DE 2732528A DE 2732528 A1 DE2732528 A1 DE 2732528A1
Authority
DE
Germany
Prior art keywords
solution
amine
acylation
stage
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19772732528
Other languages
German (de)
English (en)
Inventor
Joseph Herman Grossman
Jun Glenn Alfred Hardcastle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE2732528A1 publication Critical patent/DE2732528A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19772732528 1976-07-20 1977-07-19 Verfahren zur herstellung von amoxicillintrihydrat Ceased DE2732528A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3023976A GB1532672A (en) 1976-07-20 1976-07-20 Process for the preparation of amoxicillin trihydrate

Publications (1)

Publication Number Publication Date
DE2732528A1 true DE2732528A1 (de) 1978-01-26

Family

ID=10304500

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772732528 Ceased DE2732528A1 (de) 1976-07-20 1977-07-19 Verfahren zur herstellung von amoxicillintrihydrat

Country Status (5)

Country Link
JP (1) JPS5315397A (enExample)
DE (1) DE2732528A1 (enExample)
ES (1) ES460026A1 (enExample)
GB (1) GB1532672A (enExample)
GR (1) GR69921B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0439096A3 (en) * 1990-01-22 1992-06-10 Biochemie Gesellschaft M.B.H. Improvements in or relating to beta lactam production

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101845053B (zh) * 2010-03-09 2012-07-25 河北科技大学 一种分离提纯阿莫西林三水化合物的方法
CN103145733B (zh) * 2013-03-20 2014-02-26 四川省惠达药业有限公司 一种阿莫西林化合物及该化合物和克拉维酸钾的药物组合物
CN104059086B (zh) * 2014-06-19 2016-04-13 河南牧翔动物药业有限公司 一种阿莫西林晶体及其制备方法
CN105061468B (zh) * 2015-09-23 2018-07-06 河北远征药业有限公司 一种阿莫西林缓释晶体的制备方法
CN106399446B (zh) * 2016-11-04 2021-05-04 内蒙古常盛制药有限公司 一种由脱酯液制备阿莫西林的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2240442A1 (de) * 1971-12-17 1973-07-26 Cipan Comp Ind Prod Verfahren zur herstellung von aminopenicillinen
GB1339605A (en) * 1972-03-28 1973-12-05 Beecham Group Ltd Penicillin synthesis
GB1347979A (en) * 1970-11-12 1974-02-27 Beecham Group Ltd Penicillins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1347979A (en) * 1970-11-12 1974-02-27 Beecham Group Ltd Penicillins
DE2240442A1 (de) * 1971-12-17 1973-07-26 Cipan Comp Ind Prod Verfahren zur herstellung von aminopenicillinen
GB1339605A (en) * 1972-03-28 1973-12-05 Beecham Group Ltd Penicillin synthesis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0439096A3 (en) * 1990-01-22 1992-06-10 Biochemie Gesellschaft M.B.H. Improvements in or relating to beta lactam production
EP0976755A1 (en) * 1990-01-22 2000-02-02 BIOCHEMIE Gesellschaft m.b.H. Improvements in or relating to beta lactam production

Also Published As

Publication number Publication date
GB1532672A (en) 1978-11-15
GR69921B (enExample) 1982-07-21
JPS5315397A (en) 1978-02-13
ES460026A1 (es) 1978-11-16

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection