ES460026A1 - Un procedimiento mejorado para la preparacion de trihidrato de amoxicilina cristalino. - Google Patents
Un procedimiento mejorado para la preparacion de trihidrato de amoxicilina cristalino.Info
- Publication number
- ES460026A1 ES460026A1 ES460026A ES460026A ES460026A1 ES 460026 A1 ES460026 A1 ES 460026A1 ES 460026 A ES460026 A ES 460026A ES 460026 A ES460026 A ES 460026A ES 460026 A1 ES460026 A1 ES 460026A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- amoxicillin trihydrate
- solution
- translation
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 title abstract 2
- 229960004920 amoxicillin trihydrate Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- RXQUDZVKNQRCTM-UHFFFAOYSA-N 2-(4-hydroxyanilino)acetyl chloride;hydrochloride Chemical compound Cl.OC1=CC=C(NCC(Cl)=O)C=C1 RXQUDZVKNQRCTM-UHFFFAOYSA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3023976A GB1532672A (en) | 1976-07-20 | 1976-07-20 | Process for the preparation of amoxicillin trihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460026A1 true ES460026A1 (es) | 1978-11-16 |
Family
ID=10304500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460026A Expired ES460026A1 (es) | 1976-07-20 | 1977-06-22 | Un procedimiento mejorado para la preparacion de trihidrato de amoxicilina cristalino. |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5315397A (enExample) |
| DE (1) | DE2732528A1 (enExample) |
| ES (1) | ES460026A1 (enExample) |
| GB (1) | GB1532672A (enExample) |
| GR (1) | GR69921B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2240102B (en) * | 1990-01-22 | 1993-10-20 | Biochemie Gmbh | Improvements in or relating to beta lactam production |
| CN101845053B (zh) * | 2010-03-09 | 2012-07-25 | 河北科技大学 | 一种分离提纯阿莫西林三水化合物的方法 |
| CN103145733B (zh) * | 2013-03-20 | 2014-02-26 | 四川省惠达药业有限公司 | 一种阿莫西林化合物及该化合物和克拉维酸钾的药物组合物 |
| CN104059086B (zh) * | 2014-06-19 | 2016-04-13 | 河南牧翔动物药业有限公司 | 一种阿莫西林晶体及其制备方法 |
| CN105061468B (zh) * | 2015-09-23 | 2018-07-06 | 河北远征药业有限公司 | 一种阿莫西林缓释晶体的制备方法 |
| CN106399446B (zh) * | 2016-11-04 | 2021-05-04 | 内蒙古常盛制药有限公司 | 一种由脱酯液制备阿莫西林的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1347979A (en) * | 1970-11-12 | 1974-02-27 | Beecham Group Ltd | Penicillins |
| JPS5318515B2 (enExample) * | 1971-12-17 | 1978-06-15 | ||
| GB1339605A (en) * | 1972-03-28 | 1973-12-05 | Beecham Group Ltd | Penicillin synthesis |
-
1976
- 1976-07-20 GB GB3023976A patent/GB1532672A/en not_active Expired
-
1977
- 1977-06-18 GR GR53736A patent/GR69921B/el unknown
- 1977-06-22 ES ES460026A patent/ES460026A1/es not_active Expired
- 1977-07-18 JP JP8517077A patent/JPS5315397A/ja active Pending
- 1977-07-19 DE DE19772732528 patent/DE2732528A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB1532672A (en) | 1978-11-15 |
| DE2732528A1 (de) | 1978-01-26 |
| GR69921B (enExample) | 1982-07-21 |
| JPS5315397A (en) | 1978-02-13 |
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