GB1177610A - A Process for the Preparation of Benzodiazepine Derivatives - Google Patents

A Process for the Preparation of Benzodiazepine Derivatives

Info

Publication number
GB1177610A
GB1177610A GB0421/69A GB142169A GB1177610A GB 1177610 A GB1177610 A GB 1177610A GB 0421/69 A GB0421/69 A GB 0421/69A GB 142169 A GB142169 A GB 142169A GB 1177610 A GB1177610 A GB 1177610A
Authority
GB
United Kingdom
Prior art keywords
preparation
benzodiazepine derivatives
jan
halogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB0421/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1177610A publication Critical patent/GB1177610A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1,177,610. Benzodiazepine derivatives preparation. F. HOFFMANN-LA ROCHE & CO. A.G. 9 Jan., 1969 [25 Jan., 1968], No. 1421/69. Heading C2C. Compounds of the general formula (R = C 1-7 alkyl, R 1 = H, halogen, NO 2 or CF 3 , R 2 = H or halogen, R 3 = H or CHO) are prepared by reacting a compound of the formula with benzaldehyde or a halobenzaldehyde in the presence of formic acid, optionally followed by hydrolysis.
GB0421/69A 1968-01-25 1969-01-09 A Process for the Preparation of Benzodiazepine Derivatives Expired GB1177610A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70034768A 1968-01-25 1968-01-25

Publications (1)

Publication Number Publication Date
GB1177610A true GB1177610A (en) 1970-01-14

Family

ID=24813158

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0421/69A Expired GB1177610A (en) 1968-01-25 1969-01-09 A Process for the Preparation of Benzodiazepine Derivatives

Country Status (10)

Country Link
AT (1) AT284131B (en)
BE (1) BE727353A (en)
CH (1) CH506539A (en)
DE (1) DE1902586A1 (en)
ES (1) ES362887A1 (en)
FI (1) FI48591C (en)
FR (1) FR2000745A1 (en)
GB (1) GB1177610A (en)
NL (1) NL6900518A (en)
SE (1) SE355812B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2636595A1 (en) * 1976-08-13 1978-02-16 Jung Gmbh Lokomotivfab Arn ARMOR
FR3106629B1 (en) 2020-01-27 2022-01-14 Psa Automobiles Sa COMBUSTION ENGINE TORQUE CONTROL OF A MOTOR VEHICLE DURING CLUTCH CLOSING

Also Published As

Publication number Publication date
BE727353A (en) 1969-07-24
ES362887A1 (en) 1970-11-16
CH506539A (en) 1971-04-30
SE355812B (en) 1973-05-07
FI48591C (en) 1974-11-11
FI48591B (en) 1974-07-31
DE1902586A1 (en) 1969-08-28
FR2000745A1 (en) 1969-09-12
AT284131B (en) 1970-09-10
NL6900518A (en) 1969-07-29

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