FR2000745A1 - Benzodiazepine derivs intermediates - Google Patents

Benzodiazepine derivs intermediates

Info

Publication number
FR2000745A1
FR2000745A1 FR6901391A FR6901391A FR2000745A1 FR 2000745 A1 FR2000745 A1 FR 2000745A1 FR 6901391 A FR6901391 A FR 6901391A FR 6901391 A FR6901391 A FR 6901391A FR 2000745 A1 FR2000745 A1 FR 2000745A1
Authority
FR
France
Prior art keywords
et2o
intermediates
evapd
extd
sepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6901391A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2000745A1 publication Critical patent/FR2000745A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Method for R = lower alkyl R' = H, hal, NO2 or CF3 R2 = H or hal Intermediates for 2,3,4,5-tetrahydro-1,4-benzodiazepines (II) with anti-convulsant, muscle relaxant, and sedative activity. 98% HCO2H (100 ml) was added to N-(p-chlorophenyl)-N-methyl-ethylenediamine (70 g.) at 0 deg., followed by PhCHO (40 g.) at 25 deg. The mixture was heated 17 h. at 95 deg., cooled, poured into an ice-Et2O-3N NaOH mixture, sepd., and the H2O phase extd. with Et2O (3X100 ml). The Et2O was washed with H2O, dried, evapd., the oily residue dissolved in N-HCl (500 ml) and Et2O (250 ml), the Et2O sepd., the H2O phase extd. with Et2O (3X250 ml) and the combined Et2O dried, evapd., and recryst. from PriOH, giving I, m.p.120-121 deg.
FR6901391A 1968-01-25 1969-01-24 Benzodiazepine derivs intermediates Withdrawn FR2000745A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70034768A 1968-01-25 1968-01-25

Publications (1)

Publication Number Publication Date
FR2000745A1 true FR2000745A1 (en) 1969-09-12

Family

ID=24813158

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6901391A Withdrawn FR2000745A1 (en) 1968-01-25 1969-01-24 Benzodiazepine derivs intermediates

Country Status (10)

Country Link
AT (1) AT284131B (en)
BE (1) BE727353A (en)
CH (1) CH506539A (en)
DE (1) DE1902586A1 (en)
ES (1) ES362887A1 (en)
FI (1) FI48591C (en)
FR (1) FR2000745A1 (en)
GB (1) GB1177610A (en)
NL (1) NL6900518A (en)
SE (1) SE355812B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021152224A1 (en) 2020-01-27 2021-08-05 Psa Automobiles Sa Control of the torque of a motor vehicle combustion engine when closing the clutch

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2636595A1 (en) * 1976-08-13 1978-02-16 Jung Gmbh Lokomotivfab Arn ARMOR

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021152224A1 (en) 2020-01-27 2021-08-05 Psa Automobiles Sa Control of the torque of a motor vehicle combustion engine when closing the clutch

Also Published As

Publication number Publication date
GB1177610A (en) 1970-01-14
FI48591B (en) 1974-07-31
FI48591C (en) 1974-11-11
CH506539A (en) 1971-04-30
NL6900518A (en) 1969-07-29
ES362887A1 (en) 1970-11-16
DE1902586A1 (en) 1969-08-28
BE727353A (en) 1969-07-24
SE355812B (en) 1973-05-07
AT284131B (en) 1970-09-10

Similar Documents

Publication Publication Date Title
NL7409838A (en) METHOD AND INSTALLATION FOR ROENTGENOGRAPHIC RESEARCH.
MA21184A1 (en) PROCESS FOR THE PREPARATION OF THE ALPHA- (TETRAHYDRO-4,5,6,7THIERO (3,2-C) PYRIDYL-5) (2-CHLORO-2 PHENYL) ERXTANGYRE ERRANTIOMER.
RU92016415A (en) NEURO-PROTECTIVE DERIVATIVES OF INDOLON AND RELATED DERIVATIVES
IT7826853A0 (en) TRIAZOLE-2,4-BENZODIAZEPINES.
SE8001227L (en) WASTE ORGANIZATION FOR CLOSES IN A CONCRETE FORM
NL7809270A (en) NEW 5-SUBSTITUTED PHENOLS, METHOD FOR PREPARING THERAPEUTIC PREPARATIONS CONTAINING SUCH PHENOLS AND METHOD OF GENERATING ANALGESIA IN MAMMALS.
TR28355A (en) Hydraulic cement "BUGHOLE" (gap) number of additional mixtures to reduce the number and method for their use.
DE69112007T2 (en) Ferritic, heat-resistant cast steel and process for its manufacture.
LU80601A1 (en) NEW CONDENSED PYRIMIDINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
FR2000745A1 (en) Benzodiazepine derivs intermediates
DE3868840D1 (en) HEAT-INSULATING COMBUSTION CHAMBER AND METHOD FOR THE PRODUCTION THEREOF.
BE822588A (en) PROCESS FOR THE PREPARATION OF (HYDROXY-2 PHENYL) -2 BENZOTRIAZOLES
An Semantics of Korean tense markers
IT8023137A0 (en) INCLINED DEGASSIFIER SUITABLE FOR MINIMIZING THE QUANTITY OF GAS ENGAGED BY THE TRANSFER OF SOLID PARTICLES TOWARDS A PIPELINE FROM THE DENSE PHASE OF A FLUIDIFIED BED.
FR2325677A1 (en) PRIMER COMPOSITION, COMPOSITE PRODUCT USING THIS COMPOSITION AND PROCESS FOR ITS PREPARATION
BE859488A (en) IMPROVED HYDRAULIC CEMENT MIXTURE AND PROCESS FOR THEIR PREPARATION.
BE870201A (en) COOLER FOR OBLONG HEATED PARTS, ESPECIALLY FOR ALLUMINUM ALLOY BARS BEFORE SPINNING
BR7600460A (en) IMPROVEMENT IN THE PROCESS OF TRANSPORTING CHARCOAL PARTICLES IN DENSE PHASE THROUGH A TRANSFER LINE;
OA06503A (en) Method for the construction of wall elements made of concrete.
PT66500B (en) PROCESS FOR THE PREPARATION OF NEW BENZODIAZEPINE DERIVATIVES
AT279631B (en) PROCESS FOR THE PREPARATION OF NEW 10,11-DIHYDRODIBENZO <B, F> -ACEPINE DERIVATIVES AND THEIR ACID-ADDITION SALTS AND QUATERNAL AMMONIUM COMPOUNDS
ES428597A1 (en) 1-Lower alkyl-2-substituted-1,4-benzodiazepines
FR2346337A1 (en) URACIL DERIVATIVES, THEIR PROCESS FOR PREPARATION AND THEIR PHARMACOLOGICAL APPLICATION
ES491059A0 (en) PROCEDURE AND SYSTEM TO VERIFY THE CONVERSION OF IRON MINERALS IN HIGH IRON CONTENTS NODES.
ATE15802T1 (en) 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPIN COMPOUNDS, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING SUCH COMPOUNDS.

Legal Events

Date Code Title Description
ST Notification of lapse