DE2719245A1 - Verfahren zur fluorierung von uracil - Google Patents
Verfahren zur fluorierung von uracilInfo
- Publication number
- DE2719245A1 DE2719245A1 DE19772719245 DE2719245A DE2719245A1 DE 2719245 A1 DE2719245 A1 DE 2719245A1 DE 19772719245 DE19772719245 DE 19772719245 DE 2719245 A DE2719245 A DE 2719245A DE 2719245 A1 DE2719245 A1 DE 2719245A1
- Authority
- DE
- Germany
- Prior art keywords
- uracil
- reaction
- fluorouracil
- concentration
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4916376A JPS52133994A (en) | 1976-04-29 | 1976-04-29 | Method of fluorination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2719245A1 true DE2719245A1 (de) | 1977-11-10 |
Family
ID=12823406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772719245 Ceased DE2719245A1 (de) | 1976-04-29 | 1977-04-29 | Verfahren zur fluorierung von uracil |
Country Status (5)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60190769A (ja) * | 1984-03-09 | 1985-09-28 | Sagami Chem Res Center | ５−フルオロウラシルの製造方法 |
| GB0329716D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Radical trap |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149504A1 (de) * | 1970-10-05 | 1972-07-06 | Res Inst Medicine Chem | 5-Fluoruracile |
| US3846429A (en) * | 1971-09-22 | 1974-11-05 | S Giller | Method of producing 5-fluorouracil |
| US3954458A (en) * | 1973-11-12 | 1976-05-04 | Kaiser Aluminum & Chemical Corporation | Degassing powder metallurgical products |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3682917A (en) * | 1970-03-25 | 1972-08-08 | Ivan Ljudvigovich Knuniants | Method for producing 5-fluorouracil |
| US3954758A (en) * | 1970-05-27 | 1976-05-04 | Pcr, Inc. | Process for fluorinating uracil and derivatives thereof |
-
1976
- 1976-04-29 JP JP4916376A patent/JPS52133994A/ja active Granted
-
1977
- 1977-04-28 CH CH531577A patent/CH626354A5/de not_active IP Right Cessation
- 1977-04-28 IT IT67956/77A patent/IT1072723B/it active
- 1977-04-29 DE DE19772719245 patent/DE2719245A1/de not_active Ceased
- 1977-04-29 US US05/792,223 patent/US4082752A/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149504A1 (de) * | 1970-10-05 | 1972-07-06 | Res Inst Medicine Chem | 5-Fluoruracile |
| US3846429A (en) * | 1971-09-22 | 1974-11-05 | S Giller | Method of producing 5-fluorouracil |
| US3954458A (en) * | 1973-11-12 | 1976-05-04 | Kaiser Aluminum & Chemical Corporation | Degassing powder metallurgical products |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS52133994A (en) | 1977-11-09 |
| US4082752A (en) | 1978-04-04 |
| IT1072723B (it) | 1985-04-10 |
| JPS543875B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-02-27 |
| CH626354A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |