JPS52133994A - Method of fluorination - Google Patents
Method of fluorinationInfo
- Publication number
- JPS52133994A JPS52133994A JP4916376A JP4916376A JPS52133994A JP S52133994 A JPS52133994 A JP S52133994A JP 4916376 A JP4916376 A JP 4916376A JP 4916376 A JP4916376 A JP 4916376A JP S52133994 A JPS52133994 A JP S52133994A
- Authority
- JP
- Japan
- Prior art keywords
- fluorination
- fluorouracil
- fluorine
- conveniently
- prepare
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003682 fluorination reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4916376A JPS52133994A (en) | 1976-04-29 | 1976-04-29 | Method of fluorination |
| IT67956/77A IT1072723B (it) | 1976-04-29 | 1977-04-28 | Procedimento per la fluorurazione dell uracile |
| CH531577A CH626354A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-04-29 | 1977-04-28 | |
| DE19772719245 DE2719245A1 (de) | 1976-04-29 | 1977-04-29 | Verfahren zur fluorierung von uracil |
| US05/792,223 US4082752A (en) | 1976-04-29 | 1977-04-29 | Process for fluorination of uracil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4916376A JPS52133994A (en) | 1976-04-29 | 1976-04-29 | Method of fluorination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS52133994A true JPS52133994A (en) | 1977-11-09 |
| JPS543875B2 JPS543875B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-02-27 |
Family
ID=12823406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4916376A Granted JPS52133994A (en) | 1976-04-29 | 1976-04-29 | Method of fluorination |
Country Status (5)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
| JP2007515465A (ja) * | 2003-12-23 | 2007-06-14 | ジーイー・ヘルスケア・リミテッド | ヨードニウム塩のフッ素化におけるラジカル捕捉剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3682917A (en) * | 1970-03-25 | 1972-08-08 | Ivan Ljudvigovich Knuniants | Method for producing 5-fluorouracil |
| US3954758A (en) * | 1970-05-27 | 1976-05-04 | Pcr, Inc. | Process for fluorinating uracil and derivatives thereof |
| FR2110952A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1970-10-05 | 1972-06-02 | Res Inst Medic | |
| US3846429A (en) * | 1971-09-22 | 1974-11-05 | S Giller | Method of producing 5-fluorouracil |
| US3954458A (en) * | 1973-11-12 | 1976-05-04 | Kaiser Aluminum & Chemical Corporation | Degassing powder metallurgical products |
-
1976
- 1976-04-29 JP JP4916376A patent/JPS52133994A/ja active Granted
-
1977
- 1977-04-28 CH CH531577A patent/CH626354A5/de not_active IP Right Cessation
- 1977-04-28 IT IT67956/77A patent/IT1072723B/it active
- 1977-04-29 DE DE19772719245 patent/DE2719245A1/de not_active Ceased
- 1977-04-29 US US05/792,223 patent/US4082752A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
| JP2007515465A (ja) * | 2003-12-23 | 2007-06-14 | ジーイー・ヘルスケア・リミテッド | ヨードニウム塩のフッ素化におけるラジカル捕捉剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US4082752A (en) | 1978-04-04 |
| IT1072723B (it) | 1985-04-10 |
| JPS543875B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-02-27 |
| DE2719245A1 (de) | 1977-11-10 |
| CH626354A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-11-13 |
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