DE2623420C2 - Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe - Google Patents
Verfahren zur Herstellung unsymmetrisch 13-disubstituierter NitrosoharnstoffeInfo
- Publication number
- DE2623420C2 DE2623420C2 DE2623420A DE2623420A DE2623420C2 DE 2623420 C2 DE2623420 C2 DE 2623420C2 DE 2623420 A DE2623420 A DE 2623420A DE 2623420 A DE2623420 A DE 2623420A DE 2623420 C2 DE2623420 C2 DE 2623420C2
- Authority
- DE
- Germany
- Prior art keywords
- chloroethyl
- alkyl
- nitrosoureas
- cold
- disubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (43)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2623420A DE2623420C2 (de) | 1976-05-25 | 1976-05-25 | Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe |
YU1243/77A YU40901B (en) | 1976-05-25 | 1977-05-18 | Process for preparing non-symetrically 1,3-disubstituted nitrosoureas |
FR7715503A FR2361357A1 (fr) | 1976-05-25 | 1977-05-20 | Preparation de nitrosourees disubstituees asymetriquement en 1,3, les produits mis en oeuvre dans cette preparation et leurs applications |
IL52142A IL52142A (en) | 1976-05-25 | 1977-05-22 | Process for the preparation of unsymmetrically 1,3-disubstituted nitrosourea and some such novel compounds |
GB1398/80A GB1585822A (en) | 1976-05-25 | 1977-05-23 | Process for the preparation of n-(unsubstituted or substituted)alkyl - n - nitrosocarbamoyl azides |
LU77389A LU77389A1 (US07652168-20100126-C00055.png) | 1976-05-25 | 1977-05-23 | |
HU77DE987A HU176768B (en) | 1976-05-25 | 1977-05-23 | Process for preparing n-haloalkyl-n-nitroso-carbamoyl-azides |
DD7700199064A DD130035A5 (de) | 1976-05-25 | 1977-05-23 | Verfahren zur herstellung unsymmetrisch 1,3-disubstituierter nitrosoharnstoffe |
GB21715/77A GB1585821A (en) | 1976-05-25 | 1977-05-23 | Process for the preparation of a symmetrically 1,3-disubstituted nitroso-urea |
CH623377A CH639947A5 (de) | 1976-05-25 | 1977-05-24 | Verfahren zur herstellung unsymmetrisch 1,3-disubstituierter nitrosoharnstoffe. |
CA279,049A CA1092143A (en) | 1976-05-25 | 1977-05-24 | Method for production of unsymmetrical 1,3- disubstituted nitrosourea |
SE7706074A SE434152B (sv) | 1976-05-25 | 1977-05-24 | Forfarande for framstellning av osymmetriskt 1,3-disubstituerade nitrosourinemnen |
JP6093277A JPS535118A (en) | 1976-05-25 | 1977-05-24 | Process for adjusting asymmetrically 1*33diisubstituted nitrosourea |
DK227277A DK165786C (da) | 1976-05-25 | 1977-05-24 | Fremgangsmaade til fremstilling af 1-(2-chlorethyl)-1-nitrosourinstoffer |
NO771804A NO151410C (no) | 1976-05-25 | 1977-05-24 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive n-(2-klorethyl)-n-nitrosourea-forbindelser |
ES459137A ES459137A1 (es) | 1976-05-25 | 1977-05-25 | Procedimiento para la fabricacion de nitrosoureas 1,3 disus-tituidas asimetricamente. |
IT24002/77A IT1085808B (it) | 1976-05-25 | 1977-05-25 | Processo per la preparazione di nitrosouree asimmetriche 1,3-disostituite |
IE534/82A IE45287B1 (en) | 1976-05-25 | 1977-05-25 | Improvements in or relating to a process for the preparation of n-(unsubstituted or substituted) alkyl-n-nitrosocarbamoylazides |
NLAANVRAGE7705769,A NL187066C (nl) | 1976-05-25 | 1977-05-25 | Werkwijze voor het bereiden van 1,3-digesubstitueerde nitrosoureumderivaten; werkwijze voor het bereiden van een farmaceutisch preparaat met antitumorwerking dat een dergelijk nitrosoureumderivaat bevat, alsmede het gevormde farmaceutisch preparaat. |
MC771246A MC1142A1 (fr) | 1976-05-25 | 1977-05-25 | Preparation de nitrosourees disubstituees asymetriquement en 1,3 les produits mis en oeuvre dans cette preparation et leurs applications |
AU25495/77A AU525278B2 (en) | 1976-05-25 | 1977-05-25 | Process for the preparation of an asymmetrically 1,3- disubstituted nitroso-urea |
HU77DE935A HU173579B (hu) | 1976-05-25 | 1977-05-25 | Sposob poluchenija asimmetricheskikh 1,3-dvoe-zamehhennykh nitrozo-mochevin |
ZA00786785A ZA786785B (en) | 1976-05-25 | 1977-05-25 | Process for the preparation of n,n-disubstituted azides |
BE177911A BE855043A (fr) | 1976-05-25 | 1977-05-25 | Preparation de nitrosourees disubstituees asymetriquement en 1,3, les produits mis en oeuvre dans cette preparation et leurs applications |
SU772484357A SU963464A3 (ru) | 1976-05-25 | 1977-05-25 | Способ получени 1,3-дизамещенных нитрозомочевин |
FI771665A FI771665A (US07652168-20100126-C00055.png) | 1976-05-25 | 1977-05-25 | |
AT373177A AT360551B (de) | 1976-05-25 | 1977-05-25 | Verfahren zur herstellung asymmetrisch 1,3- -disubstituierter nitrosoharnstoffe |
ZA00773144A ZA773144B (en) | 1976-05-25 | 1977-05-25 | Process for the preparation of unsymmetrically 1,3-disubstituted nitrosoureas |
IE1082/77A IE45286B1 (en) | 1976-05-25 | 1977-05-25 | Improvements in or relating to a process for the preparation of asymmetrically 1,3-disubstituted nitroso-urea |
US05/800,452 US4150146A (en) | 1976-05-25 | 1977-05-25 | Process for the preparation of unsymmetrically 1,3-disubstituted nitroso ureas |
MX10093577U MX6904E (es) | 1976-05-25 | 1977-05-30 | Procedimiento para preparar nitrosoureas 1,3-disustituidas |
FR7805483A FR2372800A1 (fr) | 1976-05-25 | 1978-02-27 | N-halogenoalkyl-n-nitrosocarbamoylazides, leur procede de preparation et leurs applications, notamment dans le traitement des tumeurs |
US06/022,714 US4228086A (en) | 1976-05-25 | 1979-03-21 | N-Substituted alkyl-N-nitrosocarbamoyl azides |
AT566179A AT367741B (de) | 1976-05-25 | 1979-08-22 | Verfahren zur herstellung von neuen n-halogenalkyl-n-nitrosocarbamoylaziden |
SU792806959A SU973019A3 (ru) | 1976-05-25 | 1979-08-27 | Способ получени N-галогеналкил-N-нитрозокарбамоилазида |
CA350,316A CA1097685A (en) | 1976-05-25 | 1980-04-22 | Method for production of unsymmetrical 1,3- disubstituted nitrosourea |
NO801626A NO151744C (no) | 1976-05-25 | 1980-05-30 | Utgangsmateriale for anvendelse ved fremstilling av terapeutisk aktive 1,3-disubstituerte nitrosourea-fobindelser |
YU2619/81A YU41264B (en) | 1976-05-25 | 1981-11-04 | Process for preparing new halo-alkyl-n-nitroso carbamoyl azides |
SE8201694A SE453081B (sv) | 1976-05-25 | 1982-03-17 | Nya n-halogenalkyl-n-nitroso-karbamoylazider som utgangsmaterial for framstellning av kemoterapeutiskt aktiva osymmetriskt 1,3-disubstituerade nitrosourinemnen |
HK287/82A HK28782A (en) | 1976-05-25 | 1982-06-30 | Improvements in or relating to a process for the preparation of asymmetrically 1,3-disubstituted nitroso-urea |
HK288/82A HK28882A (en) | 1976-05-25 | 1982-06-30 | Improvements in or relating to a process for the preparation of n-(unsubstituted or substituted)alkyl-n-nitrosocarbamoyl azides |
FI844255A FI73974C (fi) | 1976-05-25 | 1984-10-31 | N-(2-halogenetyl) -n-nitrosokarbamoylfoerening. |
JP61171484A JPS6226263A (ja) | 1976-05-25 | 1986-07-21 | N−ハロゲンアルキル−n−ニトロソカルバモイルアジドの製造法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2623420A DE2623420C2 (de) | 1976-05-25 | 1976-05-25 | Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2623420B1 DE2623420B1 (de) | 1977-10-13 |
DE2623420C2 true DE2623420C2 (de) | 1978-07-06 |
Family
ID=5978961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2623420A Expired DE2623420C2 (de) | 1976-05-25 | 1976-05-25 | Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe |
Country Status (27)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377687A (en) | 1978-10-19 | 1983-03-22 | Stiftung Deutsches Krebsforschungszentrum | Analogs of 1-(2-chloroethyl)-1-nitroso-3-(cycloheyl)-urea substituted by heterocyclic rings or alkyl radicals |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2623420C2 (de) * | 1976-05-25 | 1978-07-06 | Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg | Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe |
JPS57116043A (en) * | 1981-01-12 | 1982-07-19 | Tetsuo Suami | New nitrosourea derivative and its preparation |
JPH0323616U (US07652168-20100126-C00055.png) * | 1989-07-19 | 1991-03-12 | ||
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
CA2388844A1 (en) * | 1999-11-12 | 2001-05-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
KR100441764B1 (ko) * | 2000-12-30 | 2004-07-27 | 한국과학기술연구원 | 비닐카바모일아지드 유도체 |
DE60230863D1 (de) † | 2001-02-21 | 2009-03-05 | Ben Z Cohen | Präzisionsdosierpumpe und zubehör dafür |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
RU2695787C1 (ru) * | 2018-11-07 | 2019-07-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации | Применение соединения 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиол для лечения her2-положительных опухолей в эксперименте |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2623420C2 (de) * | 1976-05-25 | 1978-07-06 | Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg | Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe |
DE2659862C3 (de) * | 1976-05-25 | 1979-09-20 | Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg | N-(2-Chloräthyl)-N-nitrosocarbamoylazid und Verfahren zu dessen Herstellung |
-
1976
- 1976-05-25 DE DE2623420A patent/DE2623420C2/de not_active Expired
-
1977
- 1977-05-18 YU YU1243/77A patent/YU40901B/xx unknown
- 1977-05-20 FR FR7715503A patent/FR2361357A1/fr active Granted
- 1977-05-22 IL IL52142A patent/IL52142A/xx unknown
- 1977-05-23 DD DD7700199064A patent/DD130035A5/xx unknown
- 1977-05-23 LU LU77389A patent/LU77389A1/xx unknown
- 1977-05-23 HU HU77DE987A patent/HU176768B/hu not_active IP Right Cessation
- 1977-05-23 GB GB1398/80A patent/GB1585822A/en not_active Expired
- 1977-05-23 GB GB21715/77A patent/GB1585821A/en not_active Expired
- 1977-05-24 SE SE7706074A patent/SE434152B/xx not_active IP Right Cessation
- 1977-05-24 CH CH623377A patent/CH639947A5/de not_active IP Right Cessation
- 1977-05-24 DK DK227277A patent/DK165786C/da active
- 1977-05-24 NO NO771804A patent/NO151410C/no unknown
- 1977-05-24 CA CA279,049A patent/CA1092143A/en not_active Expired
- 1977-05-24 JP JP6093277A patent/JPS535118A/ja active Granted
- 1977-05-25 ZA ZA00786785A patent/ZA786785B/xx unknown
- 1977-05-25 ES ES459137A patent/ES459137A1/es not_active Expired
- 1977-05-25 IT IT24002/77A patent/IT1085808B/it active
- 1977-05-25 HU HU77DE935A patent/HU173579B/hu not_active IP Right Cessation
- 1977-05-25 US US05/800,452 patent/US4150146A/en not_active Expired - Lifetime
- 1977-05-25 AU AU25495/77A patent/AU525278B2/en not_active Expired
- 1977-05-25 IE IE1082/77A patent/IE45286B1/en not_active IP Right Cessation
- 1977-05-25 NL NLAANVRAGE7705769,A patent/NL187066C/xx not_active IP Right Cessation
- 1977-05-25 BE BE177911A patent/BE855043A/xx not_active IP Right Cessation
- 1977-05-25 ZA ZA00773144A patent/ZA773144B/xx unknown
- 1977-05-25 AT AT373177A patent/AT360551B/de not_active IP Right Cessation
- 1977-05-25 SU SU772484357A patent/SU963464A3/ru active
- 1977-05-25 FI FI771665A patent/FI771665A/fi not_active Application Discontinuation
- 1977-05-25 MC MC771246A patent/MC1142A1/xx unknown
-
1978
- 1978-02-27 FR FR7805483A patent/FR2372800A1/fr active Granted
-
1979
- 1979-03-21 US US06/022,714 patent/US4228086A/en not_active Expired - Lifetime
- 1979-08-27 SU SU792806959A patent/SU973019A3/ru active
-
1980
- 1980-05-30 NO NO801626A patent/NO151744C/no unknown
-
1981
- 1981-11-04 YU YU2619/81A patent/YU41264B/xx unknown
-
1982
- 1982-03-17 SE SE8201694A patent/SE453081B/sv not_active IP Right Cessation
- 1982-06-30 HK HK287/82A patent/HK28782A/xx unknown
- 1982-06-30 HK HK288/82A patent/HK28882A/xx unknown
-
1986
- 1986-07-21 JP JP61171484A patent/JPS6226263A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377687A (en) | 1978-10-19 | 1983-03-22 | Stiftung Deutsches Krebsforschungszentrum | Analogs of 1-(2-chloroethyl)-1-nitroso-3-(cycloheyl)-urea substituted by heterocyclic rings or alkyl radicals |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Publication of the examined application without previous publication of unexamined application | ||
C2 | Grant after previous publication (2nd publication) |