DE2602996A1 - Zubereitung und verfahren zur untersuchung der empfindlichkeit von mikroben gegenueber antifolat-antimikrobenmittel sowie verfahren zur herstellung der zubereitungen - Google Patents
Zubereitung und verfahren zur untersuchung der empfindlichkeit von mikroben gegenueber antifolat-antimikrobenmittel sowie verfahren zur herstellung der zubereitungenInfo
- Publication number
- DE2602996A1 DE2602996A1 DE19762602996 DE2602996A DE2602996A1 DE 2602996 A1 DE2602996 A1 DE 2602996A1 DE 19762602996 DE19762602996 DE 19762602996 DE 2602996 A DE2602996 A DE 2602996A DE 2602996 A1 DE2602996 A1 DE 2602996A1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- preparation according
- enzyme
- agar
- phosphorylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000002360 preparation method Methods 0.000 title claims description 28
- 238000000034 method Methods 0.000 title claims description 25
- 230000035945 sensitivity Effects 0.000 title claims description 17
- 230000003432 anti-folate effect Effects 0.000 title claims description 10
- 229940127074 antifolate Drugs 0.000 title claims description 10
- 239000004052 folic acid antagonist Substances 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000003795 chemical substances by application Substances 0.000 title description 2
- 102000004190 Enzymes Human genes 0.000 claims description 41
- 108090000790 Enzymes Proteins 0.000 claims description 41
- 239000002609 medium Substances 0.000 claims description 22
- 230000001580 bacterial effect Effects 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 21
- 102000013537 Thymidine Phosphorylase Human genes 0.000 claims description 19
- 229920001817 Agar Polymers 0.000 claims description 17
- 241000894006 Bacteria Species 0.000 claims description 17
- 101710132082 Pyrimidine/purine nucleoside phosphorylase Proteins 0.000 claims description 17
- 239000008272 agar Substances 0.000 claims description 17
- 239000001963 growth medium Substances 0.000 claims description 14
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 102000009097 Phosphorylases Human genes 0.000 claims description 12
- 108010073135 Phosphorylases Proteins 0.000 claims description 12
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 10
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 10
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 10
- 239000000499 gel Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 238000000502 dialysis Methods 0.000 claims description 8
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 claims description 7
- 239000001506 calcium phosphate Substances 0.000 claims description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 7
- 235000011010 calcium phosphates Nutrition 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- 239000008363 phosphate buffer Substances 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 239000004599 antimicrobial Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000001166 ammonium sulphate Substances 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 239000012137 tryptone Substances 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 28
- 239000008280 blood Substances 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 17
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 16
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 14
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 14
- 229940104230 thymidine Drugs 0.000 description 14
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 11
- 229960001082 trimethoprim Drugs 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- 238000000746 purification Methods 0.000 description 8
- 229940113082 thymine Drugs 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000008057 potassium phosphate buffer Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 5
- 229960005404 sulfamethoxazole Drugs 0.000 description 5
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 150000003456 sulfonamides Chemical class 0.000 description 4
- 230000007423 decrease Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008174 sterile solution Substances 0.000 description 3
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 3
- 229940124530 sulfonamide Drugs 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 241000193385 Geobacillus stearothermophilus Species 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 229940047766 co-trimoxazole Drugs 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 241000193755 Bacillus cereus Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000588919 Citrobacter freundii Species 0.000 description 1
- 241000186810 Erysipelothrix rhusiopathiae Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000405383 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Species 0.000 description 1
- 241000277284 Salvelinus fontinalis Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000000424 optical density measurement Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 239000012313 reversal agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- -1 »agents Chemical compound 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3445/75A GB1513461A (en) | 1975-01-27 | 1975-01-27 | Bacterial culture medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2602996A1 true DE2602996A1 (de) | 1976-07-29 |
Family
ID=9758474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762602996 Ceased DE2602996A1 (de) | 1975-01-27 | 1976-01-27 | Zubereitung und verfahren zur untersuchung der empfindlichkeit von mikroben gegenueber antifolat-antimikrobenmittel sowie verfahren zur herstellung der zubereitungen |
Country Status (17)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000071B1 (en) * | 1977-06-14 | 1981-08-05 | The Wellcome Foundation Limited | Stabilised thymidine phosphorylase preparation and culture medium containing it |
| CA1187388A (en) * | 1978-09-20 | 1985-05-21 | American Monitor Corporation | Stabilization of working reagent solutions containing nadh, nadph, and/or enzymes, and the use of such stabilized reagents in enzymes or substrate assays |
| DE3868125D1 (de) * | 1987-04-24 | 1992-03-12 | Wellcome Found | Antivirale mischungen. |
| RU2188234C2 (ru) * | 2000-08-11 | 2002-08-27 | Институт биоорганической химии им. М.М.Шемякина и Ю.А.Овчинникова РАН | Способ получения рекомбинантной тимидин-фосфорилазы, рекомбинантная плазмидная днк pertpho1 и штамм escherichia coli bl21(de3)/pertpho1-продуцент тимидин-форфорилазы |
| JP4788202B2 (ja) | 2004-07-09 | 2011-10-05 | Ｊｎｃ株式会社 | 発光材料およびこれを用いた有機電界発光素子 |
| JP6485491B2 (ja) | 2017-06-08 | 2019-03-20 | Tdk株式会社 | 磁気センサ及びカメラモジュール |
-
1975
- 1975-01-27 GB GB3445/75A patent/GB1513461A/en not_active Expired
-
1976
- 1976-01-27 NL NL7600802A patent/NL7600802A/xx not_active Application Discontinuation
- 1976-01-27 CH CH102676A patent/CH628682A5/de not_active IP Right Cessation
- 1976-01-27 IT IT47830/76A patent/IT1053463B/it active
- 1976-01-27 ES ES444643A patent/ES444643A1/es not_active Expired
- 1976-01-27 BE BE163834A patent/BE837946A/xx not_active IP Right Cessation
- 1976-01-27 DK DK33076A patent/DK145880C/da active
- 1976-01-27 FR FR7602108A patent/FR2298554A1/fr active Granted
- 1976-01-27 DE DE19762602996 patent/DE2602996A1/de not_active Ceased
- 1976-01-27 ZA ZA760459A patent/ZA76459B/xx unknown
- 1976-01-27 HU HU76WE533A patent/HU173410B/hu unknown
- 1976-01-27 US US05/652,770 patent/US4097337A/en not_active Expired - Lifetime
- 1976-01-27 SE SE7600819A patent/SE7600819L/xx not_active Application Discontinuation
- 1976-01-27 CA CA244,671A patent/CA1077379A/en not_active Expired
- 1976-01-27 IL IL48906A patent/IL48906A/xx unknown
- 1976-01-27 FI FI760181A patent/FI56856C/fi not_active IP Right Cessation
- 1976-01-27 JP JP51007871A patent/JPS5843079B2/ja not_active Expired
- 1976-06-10 FR FR7617505A patent/FR2303855A1/fr active Granted
-
1983
- 1983-02-17 JP JP58025460A patent/JPS58170478A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58170478A (ja) | 1983-10-07 |
| IL48906A0 (en) | 1976-03-31 |
| CH628682A5 (de) | 1982-03-15 |
| FR2303855A1 (fr) | 1976-10-08 |
| FR2298554A1 (fr) | 1976-08-20 |
| SE7600819L (sv) | 1976-07-28 |
| BE837946A (fr) | 1976-07-27 |
| FI760181A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-07-28 |
| HU173410B (hu) | 1979-05-28 |
| FR2303855B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-08-17 |
| GB1513461A (en) | 1978-06-07 |
| NL7600802A (nl) | 1976-07-29 |
| JPS5843079B2 (ja) | 1983-09-24 |
| DK145880B (da) | 1983-03-28 |
| US4097337A (en) | 1978-06-27 |
| IT1053463B (it) | 1981-08-31 |
| FR2298554B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-03-23 |
| FI56856B (fi) | 1979-12-31 |
| JPS5198378A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-30 |
| FI56856C (fi) | 1980-04-10 |
| CA1077379A (en) | 1980-05-13 |
| DK33076A (da) | 1976-07-28 |
| ZA76459B (en) | 1977-09-28 |
| ES444643A1 (es) | 1977-10-01 |
| IL48906A (en) | 1978-10-31 |
| AU1059076A (en) | 1977-08-04 |
| DK145880C (da) | 1983-09-12 |
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