FI56856C - Komposition foer proevning av kaesligheten hos bakterierna foer antifolatmedel - Google Patents
Komposition foer proevning av kaesligheten hos bakterierna foer antifolatmedel Download PDFInfo
- Publication number
- FI56856C FI56856C FI760181A FI760181A FI56856C FI 56856 C FI56856 C FI 56856C FI 760181 A FI760181 A FI 760181A FI 760181 A FI760181 A FI 760181A FI 56856 C FI56856 C FI 56856C
- Authority
- FI
- Finland
- Prior art keywords
- thymidine
- enzyme
- composition
- thymidine phosphorylase
- medium
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title description 7
- 230000003432 anti-folate effect Effects 0.000 title description 6
- 229940127074 antifolate Drugs 0.000 title description 6
- 239000004052 folic acid antagonist Substances 0.000 title description 6
- 241000894006 Bacteria Species 0.000 title description 4
- 102000004190 Enzymes Human genes 0.000 description 17
- 108090000790 Enzymes Proteins 0.000 description 17
- 101710132082 Pyrimidine/purine nucleoside phosphorylase Proteins 0.000 description 17
- 102000013537 Thymidine Phosphorylase Human genes 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 17
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 16
- 229920001817 Agar Polymers 0.000 description 13
- 239000008272 agar Substances 0.000 description 13
- 239000001963 growth medium Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 230000001580 bacterial effect Effects 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 9
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 8
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 8
- 229940104230 thymidine Drugs 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 7
- 229960005404 sulfamethoxazole Drugs 0.000 description 6
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 6
- 229940124530 sulfonamide Drugs 0.000 description 5
- 150000003456 sulfonamides Chemical class 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000001802 infusion Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 4
- 229960001082 trimethoprim Drugs 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229940014144 folate Drugs 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940072176 sulfonamides and trimethoprim antibacterials for systemic use Drugs 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 241000193755 Bacillus cereus Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- 241000588919 Citrobacter freundii Species 0.000 description 1
- 241000186810 Erysipelothrix rhusiopathiae Species 0.000 description 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 101710122429 Pyrimidine/purine nucleoside phosphorylase 1 Proteins 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 238000002829 antibacterial sensitivity test Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940047766 co-trimoxazole Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000000424 optical density measurement Methods 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940006995 sulfamethoxazole and trimethoprim Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI791481A FI63061C (fi) | 1975-01-27 | 1979-05-09 | Stabiliserat tymidinfosforylaspreparat innehaollande renad tymidinfosforylas med foerbaettrad lagringsstabilitet |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB344575 | 1975-01-27 | ||
| GB3445/75A GB1513461A (en) | 1975-01-27 | 1975-01-27 | Bacterial culture medium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI760181A7 FI760181A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-07-28 |
| FI56856B FI56856B (fi) | 1979-12-31 |
| FI56856C true FI56856C (fi) | 1980-04-10 |
Family
ID=9758474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760181A FI56856C (fi) | 1975-01-27 | 1976-01-27 | Komposition foer proevning av kaesligheten hos bakterierna foer antifolatmedel |
Country Status (17)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000071B1 (en) * | 1977-06-14 | 1981-08-05 | The Wellcome Foundation Limited | Stabilised thymidine phosphorylase preparation and culture medium containing it |
| CA1187388A (en) * | 1978-09-20 | 1985-05-21 | American Monitor Corporation | Stabilization of working reagent solutions containing nadh, nadph, and/or enzymes, and the use of such stabilized reagents in enzymes or substrate assays |
| DE3868125D1 (de) * | 1987-04-24 | 1992-03-12 | Wellcome Found | Antivirale mischungen. |
| RU2188234C2 (ru) * | 2000-08-11 | 2002-08-27 | Институт биоорганической химии им. М.М.Шемякина и Ю.А.Овчинникова РАН | Способ получения рекомбинантной тимидин-фосфорилазы, рекомбинантная плазмидная днк pertpho1 и штамм escherichia coli bl21(de3)/pertpho1-продуцент тимидин-форфорилазы |
| JP4788202B2 (ja) | 2004-07-09 | 2011-10-05 | Ｊｎｃ株式会社 | 発光材料およびこれを用いた有機電界発光素子 |
| JP6485491B2 (ja) | 2017-06-08 | 2019-03-20 | Tdk株式会社 | 磁気センサ及びカメラモジュール |
-
1975
- 1975-01-27 GB GB3445/75A patent/GB1513461A/en not_active Expired
-
1976
- 1976-01-27 NL NL7600802A patent/NL7600802A/xx not_active Application Discontinuation
- 1976-01-27 CH CH102676A patent/CH628682A5/de not_active IP Right Cessation
- 1976-01-27 IT IT47830/76A patent/IT1053463B/it active
- 1976-01-27 ES ES444643A patent/ES444643A1/es not_active Expired
- 1976-01-27 BE BE163834A patent/BE837946A/xx not_active IP Right Cessation
- 1976-01-27 DK DK33076A patent/DK145880C/da active
- 1976-01-27 FR FR7602108A patent/FR2298554A1/fr active Granted
- 1976-01-27 DE DE19762602996 patent/DE2602996A1/de not_active Ceased
- 1976-01-27 ZA ZA760459A patent/ZA76459B/xx unknown
- 1976-01-27 HU HU76WE533A patent/HU173410B/hu unknown
- 1976-01-27 US US05/652,770 patent/US4097337A/en not_active Expired - Lifetime
- 1976-01-27 SE SE7600819A patent/SE7600819L/xx not_active Application Discontinuation
- 1976-01-27 CA CA244,671A patent/CA1077379A/en not_active Expired
- 1976-01-27 IL IL48906A patent/IL48906A/xx unknown
- 1976-01-27 FI FI760181A patent/FI56856C/fi not_active IP Right Cessation
- 1976-01-27 JP JP51007871A patent/JPS5843079B2/ja not_active Expired
- 1976-06-10 FR FR7617505A patent/FR2303855A1/fr active Granted
-
1983
- 1983-02-17 JP JP58025460A patent/JPS58170478A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58170478A (ja) | 1983-10-07 |
| IL48906A0 (en) | 1976-03-31 |
| CH628682A5 (de) | 1982-03-15 |
| FR2303855A1 (fr) | 1976-10-08 |
| FR2298554A1 (fr) | 1976-08-20 |
| SE7600819L (sv) | 1976-07-28 |
| BE837946A (fr) | 1976-07-27 |
| FI760181A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-07-28 |
| HU173410B (hu) | 1979-05-28 |
| FR2303855B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-08-17 |
| GB1513461A (en) | 1978-06-07 |
| NL7600802A (nl) | 1976-07-29 |
| JPS5843079B2 (ja) | 1983-09-24 |
| DK145880B (da) | 1983-03-28 |
| US4097337A (en) | 1978-06-27 |
| IT1053463B (it) | 1981-08-31 |
| FR2298554B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-03-23 |
| FI56856B (fi) | 1979-12-31 |
| DE2602996A1 (de) | 1976-07-29 |
| JPS5198378A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-30 |
| CA1077379A (en) | 1980-05-13 |
| DK33076A (da) | 1976-07-28 |
| ZA76459B (en) | 1977-09-28 |
| ES444643A1 (es) | 1977-10-01 |
| IL48906A (en) | 1978-10-31 |
| AU1059076A (en) | 1977-08-04 |
| DK145880C (da) | 1983-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LIMITED |