DE2551446B2 - Verfahren zur herstellung von suppositorien - Google Patents
Verfahren zur herstellung von suppositorienInfo
- Publication number
- DE2551446B2 DE2551446B2 DE19752551446 DE2551446A DE2551446B2 DE 2551446 B2 DE2551446 B2 DE 2551446B2 DE 19752551446 DE19752551446 DE 19752551446 DE 2551446 A DE2551446 A DE 2551446A DE 2551446 B2 DE2551446 B2 DE 2551446B2
- Authority
- DE
- Germany
- Prior art keywords
- suppositories
- glycol
- production
- propylene glycol
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000829 suppository Substances 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- 238000000034 method Methods 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- -1 glycol ester Chemical class 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 4
- 239000002831 pharmacologic agent Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 16
- 238000002844 melting Methods 0.000 description 10
- 230000008018 melting Effects 0.000 description 10
- 239000011230 binding agent Substances 0.000 description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000021314 Palmitic acid Nutrition 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 238000010309 melting process Methods 0.000 description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- 238000007670 refining Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- AOHAPDDBNAPPIN-UHFFFAOYSA-N 3-Methoxy-4,5-methylenedioxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC2=C1OCO2 AOHAPDDBNAPPIN-UHFFFAOYSA-N 0.000 description 2
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 229960000212 aminophenazone Drugs 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- JZGXQKWQIKFIBT-UHFFFAOYSA-N hexadecanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCCCCCCCCCC(O)=O JZGXQKWQIKFIBT-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 229920002554 vinyl polymer Chemical class 0.000 description 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- QMEWZVHQJNALJD-UHFFFAOYSA-N 4-(2,3-dimethylphenyl)pyrazol-3-one Chemical compound CC1=CC=CC(C=2C(N=NC=2)=O)=C1C QMEWZVHQJNALJD-UHFFFAOYSA-N 0.000 description 1
- VCCNKWWXYVWTLT-CYZBKYQRSA-N 7-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 VCCNKWWXYVWTLT-CYZBKYQRSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical class CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001903 ergotamine tartrate Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- IUYIRQQAVVYNBK-UHFFFAOYSA-N propane-1,2-diol;tetradecanoic acid Chemical compound CC(O)CO.CCCCCCCCCCCCCC(O)=O IUYIRQQAVVYNBK-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752551446 DE2551446B2 (de) | 1975-11-15 | 1975-11-15 | Verfahren zur herstellung von suppositorien |
| PT65757A PT65757B (de) | 1975-11-15 | 1976-10-25 | Verfahren zur herstellung von suppositorien |
| BE171768A BE847616A (fr) | 1975-11-15 | 1976-10-25 | Procede pour la preparation de suppositoires, |
| CH1387476A CH603163A5 (cg-RX-API-DMAC7.html) | 1975-11-15 | 1976-11-03 | |
| GR52097A GR61717B (en) | 1975-11-15 | 1976-11-04 | Preparation process of suppository |
| GB47346/76A GB1507418A (en) | 1975-11-15 | 1976-11-12 | Process for producing tablets and suppositories and a composition for use therein |
| FR7634122A FR2331326A1 (fr) | 1975-11-15 | 1976-11-12 | Procede pour la preparation de suppositoires |
| NL7612649A NL7612649A (nl) | 1975-11-15 | 1976-11-12 | Werkwijze ter vervaardiging van suppositoria, alsmede aldus vervaardigde suppositoria. |
| ES453300A ES453300A1 (es) | 1975-11-15 | 1976-11-13 | Procedimiento para la obtencion de supositorios. |
| US05/741,986 US4151274A (en) | 1975-11-15 | 1976-11-15 | Process and composition for the production of suppositories |
| JP13719876A JPS5282718A (en) | 1975-11-15 | 1976-11-15 | Prepation of suppository |
| AR265473A AR210914A1 (es) | 1975-11-15 | 1976-11-15 | Ptocedimiento para la produccion de elementos moldeados por compresion,como ser supositorios y comrimidos en particular de uso medicinal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752551446 DE2551446B2 (de) | 1975-11-15 | 1975-11-15 | Verfahren zur herstellung von suppositorien |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2551446A1 DE2551446A1 (de) | 1977-05-26 |
| DE2551446B2 true DE2551446B2 (de) | 1977-09-15 |
Family
ID=5961880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752551446 Withdrawn DE2551446B2 (de) | 1975-11-15 | 1975-11-15 | Verfahren zur herstellung von suppositorien |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4151274A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5282718A (cg-RX-API-DMAC7.html) |
| AR (1) | AR210914A1 (cg-RX-API-DMAC7.html) |
| BE (1) | BE847616A (cg-RX-API-DMAC7.html) |
| CH (1) | CH603163A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2551446B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES453300A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2331326A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1507418A (cg-RX-API-DMAC7.html) |
| GR (1) | GR61717B (cg-RX-API-DMAC7.html) |
| NL (1) | NL7612649A (cg-RX-API-DMAC7.html) |
| PT (1) | PT65757B (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421735A1 (de) * | 1984-06-12 | 1985-12-12 | Klinge Pharma GmbH, 8000 München | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
| RU2129422C1 (ru) * | 1998-08-05 | 1999-04-27 | Аваков Анатолий Эдуардович | Промышленный способ изготовления суппозиториев, содержащих живые бактерии, и устройство для его осуществления |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5547610A (en) * | 1978-09-29 | 1980-04-04 | Kao Corp | Hair cosmetic |
| CH637014A5 (de) * | 1978-09-29 | 1983-07-15 | Sandoz Ag | Verfahren zur herstellung von suppositorien. |
| JPS6042766B2 (ja) * | 1978-12-09 | 1985-09-25 | 日本化薬株式会社 | 基剤 |
| JPS5592312A (en) * | 1978-12-29 | 1980-07-12 | Yamanouchi Pharmaceut Co Ltd | Suppository containing bronchodilating compound |
| US4322399A (en) * | 1979-10-19 | 1982-03-30 | Ortho Pharmaceutical Corporation | Vaginal suppository |
| JPS5958173A (ja) * | 1982-09-27 | 1984-04-03 | Shin Meiwa Ind Co Ltd | 斜板型アキシヤルプランジヤポンプ・モ−タ |
| DE3241263A1 (de) * | 1982-11-09 | 1984-05-10 | Troponwerke GmbH & Co KG, 5000 Köln | Indometacin enthaltende rektale zubereitungen |
| JPS60157988U (ja) * | 1984-03-28 | 1985-10-21 | 株式会社 スギノマシン | プランジヤポンプにおける弁装置 |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
| US4937081A (en) * | 1988-01-14 | 1990-06-26 | Daicel Chemical Industries Ltd. | Process for producing porous, spherical particles |
| US5417985A (en) * | 1989-07-20 | 1995-05-23 | Farmalyoc | Solid and porous single dosage form comprising particles in the form of beads and its preparation |
| GB9821620D0 (en) | 1998-10-06 | 1998-11-25 | Stanelco Fibre Optics Ltd | Capsules |
| GB0015617D0 (en) * | 2000-06-26 | 2000-08-16 | Vectura Ltd | Improved preparations for dermal delivery of active substances |
| WO2003092784A1 (en) * | 2002-05-06 | 2003-11-13 | Vectura Limited | Application device for topical administration of pharmaceutical agents |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2820741A (en) * | 1954-04-29 | 1958-01-21 | Abbott Lab | Aluminum aspirin granulation and method for making |
| US3234091A (en) * | 1955-07-08 | 1966-02-08 | Ciba Geigy Corp | Shaped medicaments and process for their manufacture |
| US3121663A (en) * | 1956-02-09 | 1964-02-18 | Plough Lab Inc | Carbon dioxide releasing laxative suppository |
| DE1128600B (de) * | 1958-05-22 | 1962-04-26 | Schlueter Edelfett | Grundlage fuer Suppositorien |
| US2975099A (en) * | 1958-06-25 | 1961-03-14 | Upjohn Co | Polyethylene glycol suppository bases |
| US3102845A (en) * | 1960-11-18 | 1963-09-03 | Mcneilab Inc | Pharmaceutical tablet |
| US3133863A (en) * | 1961-03-10 | 1964-05-19 | Strong Cobb Arner Inc | Sustained release therapeutic tablet compositions comprising organic solvent-gelled gums |
| US3163576A (en) * | 1961-06-12 | 1964-12-29 | Olin Mathieson | Suppository base comprising glycerin and a diester of polyethylene glycol |
| US3136692A (en) * | 1961-06-30 | 1964-06-09 | Strong Cobb Arner Inc | Effervescent composition containing polyvinylpyrrolidone |
| BE627516A (cg-RX-API-DMAC7.html) * | 1962-01-25 | |||
| NL159577B (nl) * | 1968-02-15 | 1979-03-15 | Organon Nv | Werkwijze ter bereiding van snel desintegrerende vaste vormstukken. |
| US3632778A (en) * | 1970-06-10 | 1972-01-04 | Hoffmann La Roche | Tablets containing l-dopa |
| US3756238A (en) * | 1971-03-24 | 1973-09-04 | Kimberly Clark Co | Self-lubricating compound for use in hygienic and medical applications, and coated tampons and suppositories made therefrom |
| DE2143203A1 (de) * | 1971-08-28 | 1973-03-01 | Degussa | Arzneimittel mit ulcusheilender wirkung |
| DE2244558A1 (de) * | 1971-08-28 | 1974-04-04 | Degussa | Arzneimittel mit ulcusheilender wirkung |
| US3826823A (en) * | 1972-09-25 | 1974-07-30 | Syntex Inc | Stabilized prostaglandin preparations |
| JPS563846B2 (cg-RX-API-DMAC7.html) * | 1972-10-12 | 1981-01-27 |
-
1975
- 1975-11-15 DE DE19752551446 patent/DE2551446B2/de not_active Withdrawn
-
1976
- 1976-10-25 BE BE171768A patent/BE847616A/xx unknown
- 1976-10-25 PT PT65757A patent/PT65757B/pt unknown
- 1976-11-03 CH CH1387476A patent/CH603163A5/xx not_active IP Right Cessation
- 1976-11-04 GR GR52097A patent/GR61717B/el unknown
- 1976-11-12 FR FR7634122A patent/FR2331326A1/fr active Granted
- 1976-11-12 GB GB47346/76A patent/GB1507418A/en not_active Expired
- 1976-11-12 NL NL7612649A patent/NL7612649A/xx not_active Application Discontinuation
- 1976-11-13 ES ES453300A patent/ES453300A1/es not_active Expired
- 1976-11-15 AR AR265473A patent/AR210914A1/es active
- 1976-11-15 JP JP13719876A patent/JPS5282718A/ja active Granted
- 1976-11-15 US US05/741,986 patent/US4151274A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421735A1 (de) * | 1984-06-12 | 1985-12-12 | Klinge Pharma GmbH, 8000 München | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
| RU2129422C1 (ru) * | 1998-08-05 | 1999-04-27 | Аваков Анатолий Эдуардович | Промышленный способ изготовления суппозиториев, содержащих живые бактерии, и устройство для его осуществления |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5711283B2 (cg-RX-API-DMAC7.html) | 1982-03-03 |
| BE847616A (fr) | 1977-02-14 |
| FR2331326B1 (cg-RX-API-DMAC7.html) | 1981-07-17 |
| FR2331326A1 (fr) | 1977-06-10 |
| GB1507418A (en) | 1978-04-12 |
| PT65757A (de) | 1976-11-01 |
| NL7612649A (nl) | 1977-05-17 |
| JPS5282718A (en) | 1977-07-11 |
| AR210914A1 (es) | 1977-09-30 |
| DE2551446A1 (de) | 1977-05-26 |
| ES453300A1 (es) | 1977-11-16 |
| GR61717B (en) | 1978-12-28 |
| US4151274A (en) | 1979-04-24 |
| CH603163A5 (cg-RX-API-DMAC7.html) | 1978-08-15 |
| PT65757B (de) | 1978-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8230 | Patent withdrawn |