DE2530898A1 - Sulfonsaeuresalze von s-adenosylmethionin, verfahren zu deren herstellung und die genannten salze enthaltende therapeutische zusammensetzungen - Google Patents

Sulfonsaeuresalze von s-adenosylmethionin, verfahren zu deren herstellung und die genannten salze enthaltende therapeutische zusammensetzungen

Info

Publication number
DE2530898A1
DE2530898A1 DE19752530898 DE2530898A DE2530898A1 DE 2530898 A1 DE2530898 A1 DE 2530898A1 DE 19752530898 DE19752530898 DE 19752530898 DE 2530898 A DE2530898 A DE 2530898A DE 2530898 A1 DE2530898 A1 DE 2530898A1
Authority
DE
Germany
Prior art keywords
acid
sam
solution
salts
sulfonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19752530898
Other languages
German (de)
English (en)
Other versions
DE2530898C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Albert Fiecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch Netherland Bv Rotterdam Nl
Original Assignee
BIORESEARCH Sas
BIORESEARCH Sas DEL DOTT LIVO CAMOZZI EC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH Sas, BIORESEARCH Sas DEL DOTT LIVO CAMOZZI EC filed Critical BIORESEARCH Sas
Publication of DE2530898A1 publication Critical patent/DE2530898A1/de
Application granted granted Critical
Publication of DE2530898C2 publication Critical patent/DE2530898C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19752530898 1974-07-12 1975-07-10 Sulfonsaeuresalze von s-adenosylmethionin, verfahren zu deren herstellung und die genannten salze enthaltende therapeutische zusammensetzungen Granted DE2530898A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2512874 1974-07-12

Publications (2)

Publication Number Publication Date
DE2530898A1 true DE2530898A1 (de) 1976-01-29
DE2530898C2 DE2530898C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-08-11

Family

ID=11215784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752530898 Granted DE2530898A1 (de) 1974-07-12 1975-07-10 Sulfonsaeuresalze von s-adenosylmethionin, verfahren zu deren herstellung und die genannten salze enthaltende therapeutische zusammensetzungen

Country Status (27)

Country Link
US (1) US4057686A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS51125717A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR221676A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT366064B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU498365B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE831310A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1057681A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH606085A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD118643A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2530898A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK144946C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES439316A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI63037C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2277590A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1506640A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU170264B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE41421B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL47656A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL171987C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO142175C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ178014A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL94268B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RO (1) RO77525A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE420204B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU676169A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU39271B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA754167B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471188A1 (fr) * 1979-12-04 1981-06-19 Kanegafuchi Chemical Ind Composition stable de s-adenosyl-l-methionine et son procede de preparation
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
US7667034B2 (en) 2004-06-23 2010-02-23 Orchid Chemicals & Pharmaceuticals Limited Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
JPS5428808A (en) * 1977-08-03 1979-03-03 Yamasa Shoyu Co Ltd Composition containing s-adenoyl-l-methionine and its preparation
JPS5596099A (en) * 1979-01-12 1980-07-21 Tanabe Seiyaku Co Ltd Production of s-adenosyl-l-methionine using enzyme
IT1137640B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1169772B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche per uso orale contenenti sali stabili della s-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
US4962451A (en) * 1985-11-07 1990-10-09 International Business Machines Corporation Cache-effective sort string generation method
ATE80165T1 (de) * 1987-10-09 1992-09-15 Vincenzo Zappia Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
FR2623396B1 (fr) * 1987-11-25 1990-03-30 Sanofi Sa Utilisation de l'ademetionine contre le vieillissement de la peau
IT1229477B (it) * 1989-03-13 1991-09-03 Bioresearch Spa Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
JPH02290896A (ja) * 1989-04-28 1990-11-30 Fuji Kagaku Kogyo Kk 新規なｓ―アデノシルメチオニン誘導体
JPH03123514U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-03-27 1991-12-16
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US6635615B1 (en) * 1999-11-17 2003-10-21 Rolland F. Hebert Stable salts of S-adenosyl-l-methionine
DE10022856A1 (de) * 2000-05-10 2001-11-15 Basf Ag Therapeutische Kombination von Liponsäure und C1-Donoren zur Behandlung von Störungen des Zentralen Nervensystems
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
FR2823211A1 (fr) * 2001-04-10 2002-10-11 Virbac Sa Composition a base d'un polyphosphate de s-adenosyl-l-methionine et utilisations d'un tel polyphosphate
US6649753B2 (en) 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
WO2002102823A1 (en) * 2001-06-14 2002-12-27 Orchid Chemicals & Pharmaceuticals Limited Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US8063024B2 (en) * 2005-01-26 2011-11-22 University Of Manitoba Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
FR2884421B1 (fr) 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
EP2151498A3 (en) * 2005-04-20 2010-12-15 BASF Plant Science GmbH Expression cassettes for seed-preferential expression in plants
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CN101437934B (zh) 2006-05-10 2013-03-20 三菱瓦斯化学株式会社 含s-腺苷-l-甲硫氨酸的干燥酵母的制备方法以及口服用组合物
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
CN101677543A (zh) * 2007-01-31 2010-03-24 甲基化物科学国际有限公司 S-腺苷甲硫氨酸的延时释放药物制剂
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
EP2193787A1 (en) * 2008-12-02 2010-06-09 Giorgio Stramentinoli Formulations for systemic buccal delivery comprising s-adenosylmethionine, their preparation and use
US20110027342A1 (en) 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) * 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
WO2012139227A1 (en) 2011-04-15 2012-10-18 Scimar Ltd. Use of s-adenosylmethionine, vitamin e, and vitamin c for the prevention and treatment of cardiovascular dysfunction
CN102321136B (zh) * 2011-09-19 2014-10-22 北京化工大学 S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法
US9801896B2 (en) 2012-10-17 2017-10-31 Methylation Sciences International Srl Compositions comprising S-adenosylmethionine and a gallic acid ester
ES2824807T3 (es) 2013-01-16 2021-05-13 Hebert Sam E Llc Sales de indol-3-propionato estables de S-adenosil-L-metionina
RU2537556C1 (ru) * 2013-07-30 2015-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения соли адеметионина с хондроитинсульфокислотой
US12239623B2 (en) 2023-05-15 2025-03-04 Bonafide Health, Llc Sleep-improving compositions and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1803978A1 (de) * 1968-10-18 1970-05-27 Boehringer Mannheim Gmbh Verfahren zur Isolierung und Reinigung von S-Adenosyl-1-methionin und S-Adenosyl-1-aethionin
DE2336401A1 (de) * 1972-08-02 1974-02-14 Biores S A S Del Dott Livio Ca Enzymatisches salz, verfahren zu dessen herstellung und therapeutische mittel, die es enthalten
DE2430999A1 (de) * 1973-06-27 1975-01-16 Errekappa Euroterapici Sas Neue enzymatische salze, verfahren zu ihrer herstellung und sie enthaltende mittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1803978A1 (de) * 1968-10-18 1970-05-27 Boehringer Mannheim Gmbh Verfahren zur Isolierung und Reinigung von S-Adenosyl-1-methionin und S-Adenosyl-1-aethionin
DE2336401A1 (de) * 1972-08-02 1974-02-14 Biores S A S Del Dott Livio Ca Enzymatisches salz, verfahren zu dessen herstellung und therapeutische mittel, die es enthalten
DE2430999A1 (de) * 1973-06-27 1975-01-16 Errekappa Euroterapici Sas Neue enzymatische salze, verfahren zu ihrer herstellung und sie enthaltende mittel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471188A1 (fr) * 1979-12-04 1981-06-19 Kanegafuchi Chemical Ind Composition stable de s-adenosyl-l-methionine et son procede de preparation
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
US7667034B2 (en) 2004-06-23 2010-02-23 Orchid Chemicals & Pharmaceuticals Limited Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer

Also Published As

Publication number Publication date
ZA754167B (en) 1976-05-26
NO142175B (no) 1980-03-31
JPS51125717A (en) 1976-11-02
US4057686A (en) 1977-11-08
ES439316A1 (es) 1977-02-16
FR2277590A1 (fr) 1976-02-06
IE41421L (en) 1976-01-12
FI63037C (fi) 1983-04-11
RO77525A (ro) 1982-09-09
BE831310A (fr) 1975-11-03
NZ178014A (en) 1978-03-06
PL94268B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-07-30
DD118643A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-03-12
NO142175C (no) 1980-07-09
YU39271B (en) 1984-10-31
NL171987B (nl) 1983-01-17
JPS5610920B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-03-11
YU174475A (en) 1982-08-31
FR2277590B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-07-28
CH606085A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-10-13
AU8295975A (en) 1977-01-13
SE7507966L (sv) 1976-01-13
SE420204B (sv) 1981-09-21
HU170264B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-05-28
ATA521275A (de) 1981-07-15
CA1057681A (en) 1979-07-03
NO752499L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-01-13
DE2530898C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-08-11
DK144946B (da) 1982-07-12
AR221676A1 (es) 1981-03-13
DK315375A (da) 1976-01-13
IL47656A (en) 1978-04-30
NL7508316A (nl) 1976-01-14
FI63037B (fi) 1982-12-31
GB1506640A (en) 1978-04-05
NL171987C (nl) 1983-06-16
SU676169A3 (ru) 1979-07-25
AT366064B (de) 1982-03-10
AU498365B2 (en) 1979-03-08
IE41421B1 (en) 1980-01-02
IL47656A0 (en) 1975-10-15
DK144946C (da) 1982-12-06
FI751946A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-01-13

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8127 New person/name/address of the applicant

Owner name: BIORESEARCH NETHERLAND B.V., ROTTERDAM, NL

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL., PAT.-ANW., 80

D2 Grant after examination
8364 No opposition during term of opposition