DE2525725C3 - Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung - Google Patents

Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung

Info

Publication number
DE2525725C3
DE2525725C3 DE2525725A DE2525725A DE2525725C3 DE 2525725 C3 DE2525725 C3 DE 2525725C3 DE 2525725 A DE2525725 A DE 2525725A DE 2525725 A DE2525725 A DE 2525725A DE 2525725 C3 DE2525725 C3 DE 2525725C3
Authority
DE
Germany
Prior art keywords
acid
methyl
addition salts
acid addition
damage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2525725A
Other languages
German (de)
English (en)
Other versions
DE2525725B2 (de
DE2525725A1 (de
Inventor
Walter Dr. 7950 Biberach Haarmann
Herbert Dr. Koeppe
Werner Dr. Kummer
Richard Dr. 6507 Ingelheim Reichl
Helmut Dr. Staehle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG filed Critical C.H. Boehringer Sohn AG and Co KG
Priority to DE2525725A priority Critical patent/DE2525725C3/de
Priority to AT366676A priority patent/AT351020B/de
Priority to FI761423A priority patent/FI62069C/fi
Priority to GR50828A priority patent/GR60041B/el
Priority to US05/692,325 priority patent/US4058616A/en
Priority to PT65201A priority patent/PT65201B/pt
Priority to LU75114A priority patent/LU75114A1/xx
Priority to CH719176A priority patent/CH622785A5/de
Priority to IL49747A priority patent/IL49747A/xx
Priority to DK255976A priority patent/DK142172C/da
Priority to BE167776A priority patent/BE842768A/xx
Priority to ZA00763422A priority patent/ZA763422B/xx
Priority to AU14770/76A priority patent/AU498253B2/en
Priority to JP51067548A priority patent/JPS603066B2/ja
Priority to CA254,445A priority patent/CA1069514A/en
Priority to SE7606497A priority patent/SE422936B/xx
Priority to NO761970A priority patent/NO144214C/no
Priority to GB23913/76A priority patent/GB1481948A/en
Priority to ES448696A priority patent/ES448696A1/es
Priority to FR7617539A priority patent/FR2313926A1/fr
Priority to MX000300U priority patent/MX3153E/es
Priority to NL7606266A priority patent/NL7606266A/xx
Priority to IE1256/76A priority patent/IE43793B1/en
Publication of DE2525725A1 publication Critical patent/DE2525725A1/de
Priority to US05/837,692 priority patent/US4105765A/en
Publication of DE2525725B2 publication Critical patent/DE2525725B2/de
Application granted granted Critical
Publication of DE2525725C3 publication Critical patent/DE2525725C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE2525725A 1975-06-10 1975-06-10 Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung Expired DE2525725C3 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE2525725A DE2525725C3 (de) 1975-06-10 1975-06-10 Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
AT366676A AT351020B (de) 1975-06-10 1976-05-20 Verfahren zur herstellung neuer 4-phenyl- imidazoline und ihrer saeureadditionssalze
FI761423A FI62069C (fi) 1975-06-10 1976-05-20 Foerfarande foer framstaellning av terapeutiskt vaerdefulla baiskt substituerade 2-alkylamino-4-fenyl-imidazoliner
GR50828A GR60041B (en) 1975-06-10 1976-05-27 Substituted 4-phenyl-imidazolines,their salts by acid addition and process for their preparation
US05/692,325 US4058616A (en) 1975-06-10 1976-06-03 2-[N-(1,3-diamino-isopropyl)-amino]-4-phenyl-2-imidazolines and salts thereof
LU75114A LU75114A1 (enExample) 1975-06-10 1976-06-08
CH719176A CH622785A5 (enExample) 1975-06-10 1976-06-08
PT65201A PT65201B (de) 1975-06-10 1976-06-08 Substituierte 4-pheny-imidazoline deren saureadditionssalze und verfahren zu ihrer herstellung
JP51067548A JPS603066B2 (ja) 1975-06-10 1976-06-09 イミダゾリン化合物の製造方法
BE167776A BE842768A (fr) 1975-06-10 1976-06-09 4-phenyl-imidazolines substitues, leurs sels d'addition avec des acides et procedes pour leur preparation
ZA00763422A ZA763422B (en) 1975-06-10 1976-06-09 Improvements relating to substituted 4-phenyl-imidazolines
AU14770/76A AU498253B2 (en) 1975-06-10 1976-06-09 2-(disubstituted amino)-4-phenyl-imidazolines
IL49747A IL49747A (en) 1975-06-10 1976-06-09 2-amino-4-phenylimidazoline derivatives, their preparationand pharmaceutical compositions containing them
CA254,445A CA1069514A (en) 1975-06-10 1976-06-09 Substituted 4-phenyl-imidazolines, their acid addition salts and process for their production
SE7606497A SE422936B (sv) 1975-06-10 1976-06-09 Forfarande for framstellning av substituerade 2-alkylamino-4-fenylimidazoliner och deras syraadditionssalter
NO761970A NO144214C (no) 1975-06-10 1976-06-09 Analogifremgangsmaate for fremstilling av terapeutiak aktive fenyl-imidazoliner
GB23913/76A GB1481948A (en) 1975-06-10 1976-06-09 2-(disubstituted-amino)-4-phenyl-imidazolines and their use in pharmaceutical compositions
ES448696A ES448696A1 (es) 1975-06-10 1976-06-09 Procedimiento para la preparacion de 4-fenil-imidazolinas sustituidas.
DK255976A DK142172C (da) 1975-06-10 1976-06-09 Analogifremgangsmaade til fremstilling af basisk substituerede2-alkylamino-4-phenylimidazoliner eller syreadditionssalte heraf
FR7617539A FR2313926A1 (fr) 1975-06-10 1976-06-10 4-phenyl-imidazolines substituees, leurs sels d'addition avec des acides et procedes pour leur preparation
MX000300U MX3153E (es) 1975-06-10 1976-06-10 Procedimiento para la preparacion de 4 - fenil - imidazolinas sustituidas
NL7606266A NL7606266A (nl) 1975-06-10 1976-06-10 Werkwijze ter bereiding van gesubstitueerde 4-fe- nyl-imidazolinen en hun additiezouten met zuren.
IE1256/76A IE43793B1 (en) 1975-06-10 1976-06-10 2-(disubstituted amino)-4-phenyl-imidazolines and their use in pharmaceutical compositions
US05/837,692 US4105765A (en) 1975-06-10 1977-09-29 2-(N-(1,3-diamino-isopropyl)-amino)-4-phenyl-2-imidazolines and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2525725A DE2525725C3 (de) 1975-06-10 1975-06-10 Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung

Publications (3)

Publication Number Publication Date
DE2525725A1 DE2525725A1 (de) 1976-12-30
DE2525725B2 DE2525725B2 (de) 1979-01-18
DE2525725C3 true DE2525725C3 (de) 1979-09-13

Family

ID=5948681

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2525725A Expired DE2525725C3 (de) 1975-06-10 1975-06-10 Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung

Country Status (23)

Country Link
US (1) US4058616A (enExample)
JP (1) JPS603066B2 (enExample)
AT (1) AT351020B (enExample)
AU (1) AU498253B2 (enExample)
BE (1) BE842768A (enExample)
CA (1) CA1069514A (enExample)
CH (1) CH622785A5 (enExample)
DE (1) DE2525725C3 (enExample)
DK (1) DK142172C (enExample)
ES (1) ES448696A1 (enExample)
FI (1) FI62069C (enExample)
FR (1) FR2313926A1 (enExample)
GB (1) GB1481948A (enExample)
GR (1) GR60041B (enExample)
IE (1) IE43793B1 (enExample)
IL (1) IL49747A (enExample)
LU (1) LU75114A1 (enExample)
MX (1) MX3153E (enExample)
NL (1) NL7606266A (enExample)
NO (1) NO144214C (enExample)
PT (1) PT65201B (enExample)
SE (1) SE422936B (enExample)
ZA (1) ZA763422B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105765A (en) * 1975-06-10 1978-08-08 Boehringer Ingelheim Gmbh 2-(N-(1,3-diamino-isopropyl)-amino)-4-phenyl-2-imidazolines and salts thereof
US4288591A (en) * 1979-02-06 1981-09-08 A. H. Robins Company, Inc. 4-Substituted 2-iminoimidazolidine compounds
US4288447A (en) * 1979-02-06 1981-09-08 A. H. Robins Company, Inc. Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions
US4647557A (en) * 1982-12-28 1987-03-03 Gerard Moinet Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2586844A (en) * 1947-10-21 1952-02-26 Ayerst Mckenna & Harrison Preparation of delta2-1, 3-diazacycloalkenes
FR2081571B1 (enExample) * 1970-03-12 1973-04-06 Synthelabo

Also Published As

Publication number Publication date
PT65201A (de) 1976-07-01
IL49747A0 (en) 1976-08-31
NO144214C (no) 1981-07-15
IE43793B1 (en) 1981-06-03
AU1477076A (en) 1977-12-15
DK142172B (da) 1980-09-15
AU498253B2 (en) 1979-02-22
JPS603066B2 (ja) 1985-01-25
ZA763422B (en) 1978-02-22
GB1481948A (en) 1977-08-03
ATA366676A (de) 1978-12-15
LU75114A1 (enExample) 1978-01-18
IL49747A (en) 1979-03-12
DE2525725B2 (de) 1979-01-18
FR2313926A1 (fr) 1977-01-07
FI62069B (fi) 1982-07-30
BE842768A (fr) 1976-12-09
IE43793L (en) 1976-12-10
PT65201B (de) 1978-05-08
NO761970L (enExample) 1976-12-13
CA1069514A (en) 1980-01-08
DK255976A (da) 1976-12-11
DE2525725A1 (de) 1976-12-30
SE7606497L (sv) 1976-12-11
FI761423A7 (enExample) 1976-12-11
AT351020B (de) 1979-07-10
JPS51149273A (en) 1976-12-22
ES448696A1 (es) 1977-07-01
GR60041B (en) 1978-04-01
MX3153E (es) 1980-05-12
NO144214B (no) 1981-04-06
FI62069C (fi) 1982-11-10
US4058616A (en) 1977-11-15
NL7606266A (nl) 1976-12-14
SE422936B (sv) 1982-04-05
FR2313926B1 (enExample) 1978-10-20
DK142172C (da) 1981-02-09
CH622785A5 (enExample) 1981-04-30

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee