DE2524813C3 - Verfahren zum Beschichten eines Arzneimittels mit einem darmlöslichen Überzug - Google Patents
Verfahren zum Beschichten eines Arzneimittels mit einem darmlöslichen ÜberzugInfo
- Publication number
- DE2524813C3 DE2524813C3 DE2524813A DE2524813A DE2524813C3 DE 2524813 C3 DE2524813 C3 DE 2524813C3 DE 2524813 A DE2524813 A DE 2524813A DE 2524813 A DE2524813 A DE 2524813A DE 2524813 C3 DE2524813 C3 DE 2524813C3
- Authority
- DE
- Germany
- Prior art keywords
- coating
- tablets
- acid
- water
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000576 coating method Methods 0.000 title claims description 40
- 239000011248 coating agent Substances 0.000 title claims description 37
- 238000000034 method Methods 0.000 title claims description 15
- 239000003814 drug Substances 0.000 title claims description 9
- 239000002702 enteric coating Substances 0.000 title claims description 3
- 238000009505 enteric coating Methods 0.000 title claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 20
- 229920002678 cellulose Polymers 0.000 claims description 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 5
- 229940126601 medicinal product Drugs 0.000 claims description 4
- 229920003086 cellulose ether Polymers 0.000 claims description 3
- 150000007522 mineralic acids Chemical class 0.000 claims description 3
- 239000003826 tablet Substances 0.000 description 40
- 239000000243 solution Substances 0.000 description 27
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 150000003839 salts Chemical group 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000000968 intestinal effect Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 239000012530 fluid Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000010306 acid treatment Methods 0.000 description 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 239000013065 commercial product Substances 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- -1 carboxy-benzoyl groups Chemical group 0.000 description 2
- 239000007931 coated granule Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002662 enteric coated tablet Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 2
- 229940012189 methyl orange Drugs 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- VPZYAXJVIUXFBS-BTJKTKAUSA-N (z)-but-2-enedioic acid;phthalic acid Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)C1=CC=CC=C1C(O)=O VPZYAXJVIUXFBS-BTJKTKAUSA-N 0.000 description 1
- KYARBIJYVGJZLB-UHFFFAOYSA-N 7-amino-4-hydroxy-2-naphthalenesulfonic acid Chemical compound OC1=CC(S(O)(=O)=O)=CC2=CC(N)=CC=C21 KYARBIJYVGJZLB-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241000270313 Crocodylus porosus Species 0.000 description 1
- 101150086776 FAM3C gene Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229920013820 alkyl cellulose Polymers 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000013039 cover film Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001225 polyester resin Polymers 0.000 description 1
- 239000004645 polyester resin Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49066271A JPS517116A (en) | 1974-06-11 | 1974-06-11 | Choyoseihifukuyakuzaino seizohoho |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2524813A1 DE2524813A1 (de) | 1976-01-02 |
| DE2524813B2 DE2524813B2 (de) | 1980-01-10 |
| DE2524813C3 true DE2524813C3 (de) | 1980-10-09 |
Family
ID=13311002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2524813A Expired DE2524813C3 (de) | 1974-06-11 | 1975-06-04 | Verfahren zum Beschichten eines Arzneimittels mit einem darmlöslichen Überzug |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4017647A (enExample) |
| JP (1) | JPS517116A (enExample) |
| AT (1) | AT340599B (enExample) |
| CA (1) | CA1050358A (enExample) |
| CH (1) | CH613620A5 (enExample) |
| DE (1) | DE2524813C3 (enExample) |
| FR (1) | FR2274281A1 (enExample) |
| GB (1) | GB1483423A (enExample) |
| IT (1) | IT1044657B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2612889B1 (de) * | 1976-03-26 | 1977-09-01 | Basf Ag | UEberzugsmittel fuer Arzneiformlinge |
| US4291016A (en) * | 1976-07-27 | 1981-09-22 | Sandoz Ltd. | Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate |
| US4180559A (en) * | 1978-01-05 | 1979-12-25 | Richardson-Merrell Inc. | Coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine compositions |
| GB1584130A (en) * | 1978-05-30 | 1981-02-04 | Wyeth John & Brother Ltd | Indole derivatives |
| JPS5535031A (en) * | 1978-09-04 | 1980-03-11 | Shin Etsu Chem Co Ltd | Enteric coating composition |
| WO1980000659A1 (en) * | 1978-10-02 | 1980-04-17 | Purdue Research Foundation | Food and pharmaceutical coating composition,method of preparation and products so coated |
| JPS5598120A (en) * | 1979-01-16 | 1980-07-25 | Shin Etsu Chem Co Ltd | Preparation of drug having enteric coating |
| US4365060A (en) * | 1979-04-28 | 1982-12-21 | Shin-Etsu Chemical Co. Ltd. | Enterosoluble capsules |
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| CH649216A5 (de) * | 1979-08-16 | 1985-05-15 | Sandoz Ag | Verfahren zur auftragung eines magensaftresistenten filmes auf einen heilmittelkern und feste einheitsdosierungsform mit magensaftresistentem film. |
| DK153363C (da) * | 1979-09-03 | 1988-12-05 | Shinetsu Chemical Co | Vandigt overtraeksprodukt til frembringelse af et i tarmen oploeseligt overtraek paa en tablet og fremgangsmaade til anvendelsen af produktet |
| US4340582A (en) * | 1981-01-15 | 1982-07-20 | Abbott Laboratories | Erythromycin base tablets |
| JPS584730A (ja) * | 1981-06-29 | 1983-01-11 | Shin Etsu Chem Co Ltd | 腸溶性コ−テイング組成物およびその製造方法 |
| JPS58135807A (ja) * | 1982-02-05 | 1983-08-12 | Shin Etsu Chem Co Ltd | 腸溶性被覆薬剤の製造方法 |
| JPS58169961U (ja) * | 1982-05-11 | 1983-11-12 | 稲毛 邦善 | 磁石の保持装置 |
| US4461759A (en) * | 1983-01-03 | 1984-07-24 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of veropamil |
| JPS6051124A (ja) * | 1983-08-31 | 1985-03-22 | Kohjin Co Ltd | 腸溶性材コ−ティング液 |
| US4556552A (en) * | 1983-09-19 | 1985-12-03 | Colorcon, Inc. | Enteric film-coating compositions |
| DK62184D0 (da) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
| JPH0759499B2 (ja) * | 1984-02-10 | 1995-06-28 | ベンツォン ファーマ エイ／エス | 拡散被覆された複合単位服用剤 |
| DE3405378A1 (de) * | 1984-02-15 | 1985-08-22 | Röhm GmbH, 6100 Darmstadt | Arzneimittelueberzug |
| EP0164669B1 (de) * | 1984-06-13 | 1991-01-23 | Röhm Gmbh | Verfahren zum Überziehen von Arzneiformen |
| US4912146A (en) * | 1985-01-30 | 1990-03-27 | Warner-Lambert Company | Coated dosage forms |
| US4693896A (en) * | 1985-10-07 | 1987-09-15 | Fmc Corporation | Ethylcellulose-coated, gastric-disintegrable aspirin tablet |
| US4900559A (en) * | 1985-12-12 | 1990-02-13 | Briston-Myers Company | Stabilized enteric coated aspirin granules and process of preparation |
| US4716042A (en) * | 1986-06-16 | 1987-12-29 | American Home Products Corporation | Stabilized coated aspirin tablets |
| US4816259A (en) * | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
| US4960814A (en) * | 1988-06-13 | 1990-10-02 | Eastman Kodak Company | Water-dispersible polymeric compositions |
| US5025004A (en) * | 1988-06-13 | 1991-06-18 | Eastman Kodak Company | Water-dispersible polymeric compositions |
| WO1990002546A1 (en) * | 1988-09-09 | 1990-03-22 | The Ronald T. Dodge Company | Pharmaceuticals microencapsulated by vapor deposited polymers and method |
| FR2659230A1 (fr) * | 1990-03-08 | 1991-09-13 | Rhone Poulenc Sante | Procede d'enrobage par un polymere ph sensible de principes actifs. |
| AT397345B (de) * | 1990-04-04 | 1994-03-25 | Chemiefaser Lenzing Ag | Pharmazeutisches präparat mit verzögerter wirkstofffreisetzung auf basis von hemicellulosen |
| JPH06508371A (ja) | 1991-06-21 | 1994-09-22 | ユニバーシティー オブ シンシナティ | 経口投与できる治療用タンパク質及びその製法 |
| US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
| US5225202A (en) * | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| ATE143803T1 (de) * | 1992-12-22 | 1996-10-15 | Univ Cincinnati | Orale verabreichung von immunologischen aktiven biomolekülen und anderen therapeutischen proteinen |
| US6224911B1 (en) * | 1993-03-16 | 2001-05-01 | Syntex (U.S.A.) Llc | Process for the preparation of enteric coated pharmaceutical dosage forms |
| US5416157A (en) * | 1993-09-09 | 1995-05-16 | Eastman Chemical Company | Process for improving mechanical shear stability of acrylic enteric polymers |
| US5380790A (en) * | 1993-09-09 | 1995-01-10 | Eastman Chemical Company | Process for the preparation of acrylic polymers for pharmaceutical coatings |
| US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| US5683718A (en) * | 1995-04-04 | 1997-11-04 | Time-Cap Labs, Inc. | Enteric coated tablet with raised identification character and method of manufacture |
| ID18663A (id) * | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| US5851579A (en) * | 1996-10-28 | 1998-12-22 | Eastman Chemical Company | Aqueous enteric coating compositions |
| US5910319A (en) | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
| ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
| JP2003534371A (ja) * | 2000-06-02 | 2003-11-18 | マトリックス ファーマシューティカル， インコーポレイテッド | ２’−デオキシ−２’−（フルオロメチレン）シチジンの薬学的組成物 |
| JP5529404B2 (ja) * | 2008-09-05 | 2014-06-25 | 東和薬品株式会社 | アスピリン腸溶錠 |
| EP2808019B1 (en) * | 2012-01-27 | 2019-09-25 | Siegfried Rhein S.A. De C.V. | Improved nitazoxanide composition and preparation method thereof |
| US20210267919A1 (en) * | 2020-02-28 | 2021-09-02 | Biokier, Inc. | Stabilized coated butyrate for colon release |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL255509A (enExample) * | 1959-09-02 | |||
| US3196827A (en) * | 1962-11-19 | 1965-07-27 | Wisconsin Alumni Res Found | Apparatus for the encapsulation of discrete particles |
| US3303051A (en) * | 1963-04-05 | 1967-02-07 | United Merchants & Mfg | Process of conditioning cellulose acetate with hydroxyethylcellulose |
| DE1216486B (de) * | 1964-04-23 | 1966-05-12 | Merck Ag E | Verfahren zur Herstellung von Dragees |
| US3256111A (en) * | 1964-12-04 | 1966-06-14 | Abbott Lab | Method for coating tablets |
| US3427182A (en) * | 1965-05-12 | 1969-02-11 | American Cyanamid Co | Pigment sealing coats |
| US3573966A (en) * | 1970-01-15 | 1971-04-06 | Lilly Co Eli | Tablet coating method |
| US3896108A (en) * | 1974-05-10 | 1975-07-22 | Hercules Inc | Carboxyalkyl modified ethyl cellulose |
-
1974
- 1974-06-11 JP JP49066271A patent/JPS517116A/ja active Granted
-
1975
- 1975-05-20 GB GB21562/75A patent/GB1483423A/en not_active Expired
- 1975-05-21 CA CA227,419A patent/CA1050358A/en not_active Expired
- 1975-06-04 DE DE2524813A patent/DE2524813C3/de not_active Expired
- 1975-06-09 US US05/584,914 patent/US4017647A/en not_active Expired - Lifetime
- 1975-06-09 IT IT24133/75A patent/IT1044657B/it active
- 1975-06-09 CH CH743075A patent/CH613620A5/xx not_active IP Right Cessation
- 1975-06-10 AT AT439375A patent/AT340599B/de not_active IP Right Cessation
- 1975-06-11 FR FR7518255A patent/FR2274281A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2274281A1 (fr) | 1976-01-09 |
| CA1050358A (en) | 1979-03-13 |
| GB1483423A (en) | 1977-08-17 |
| AT340599B (de) | 1977-12-27 |
| IT1044657B (it) | 1980-04-21 |
| JPS5312569B2 (enExample) | 1978-05-02 |
| US4017647A (en) | 1977-04-12 |
| DE2524813A1 (de) | 1976-01-02 |
| DE2524813B2 (de) | 1980-01-10 |
| AU8189475A (en) | 1976-12-09 |
| FR2274281B1 (enExample) | 1978-07-28 |
| CH613620A5 (enExample) | 1979-10-15 |
| JPS517116A (en) | 1976-01-21 |
| ATA439375A (de) | 1977-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2524813C3 (de) | Verfahren zum Beschichten eines Arzneimittels mit einem darmlöslichen Überzug | |
| EP0181515B1 (de) | Verfahren zur Herstellung einer wässrigen Überzugsmitteldispersion und ihre Verwendung zum Überziehen von Arzneimitteln | |
| DE69729950T2 (de) | Arzneimittel-Zuführsystem mit verzögerter Freisetzung für säurelabile Arzneistoffe | |
| DE69107686T2 (de) | Im Dickdarm zersetzbare Hartkapseln. | |
| EP0519870B1 (de) | Neue orale Diclofenaczubereitung | |
| DE69002604T2 (de) | Pharmazeutische Zubereitung mit verzögerter Freisetzung und seine Herstellung. | |
| DE69529050T2 (de) | Orale dosierungsformen mit pulverschicht | |
| DE60210552T2 (de) | Prozess zur Herstellung einer festen pharmazeutischen Zubereitung welche einen schwerlöslichen Wirkstoff enthält | |
| DE69109557T2 (de) | Überzogene feste Arzneiform mit Verabreichungsmöglichkeit im Dickdarm. | |
| DE3751860T2 (de) | Verwendung von spezifischem Kernmaterial und Schichten zur Herstellung pharmazeutischer Formulierungen, die stabil gegen die Verfärbung von Omeprazol sind | |
| AT396329B (de) | Pharmazeutische granulate und verfahren zu ihrer herstellung | |
| CH672736A5 (enExample) | ||
| DE3877331T2 (de) | Exifon und ein wasserloesliches polymer enthaltende pharmazeutische zubereitung. | |
| DE3148802A1 (de) | Tabletten mit einem gehalt an erythromycin-base | |
| DD298205A5 (de) | Verfahren zum herstellen von langzeitwirkenden arzneimittelzubereitungen | |
| DE3915150A1 (de) | Lang-wirkende diclofenac-natrium-praeparation | |
| WO1996037195A1 (de) | Neue pharmazeutische pelletformulierung | |
| DE69706969T2 (de) | Metall valproat-tabletten mit verzoegerter freisetzung | |
| DE69225979T2 (de) | Orale zubereitung zur freisetzung im unteren verdauungstract | |
| DE3029745A1 (de) | Magensaftresistente dosierungsformen | |
| DE69008107T2 (de) | Zubereitung mit verzögerter Freigabe eines Hydrochlorids eines basischen Arzneistoffs. | |
| DE60033519T2 (de) | Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen | |
| DE2035739A1 (en) | Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form | |
| DE2247060A1 (de) | Arzneibeschichtungsmittel und verfahren zur herstellung von beschichteten arzneimitteln | |
| DE60032704T2 (de) | Filmtabletten mit minimierter Abhängigkeit von Nahrungsmitteleinfluss Anfälligkeit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |