DE2330702C2 - Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe und Vorrichtung zur Durchführung des Verfahrens - Google Patents

Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe und Vorrichtung zur Durchführung des Verfahrens

Info

Publication number
DE2330702C2
DE2330702C2 DE2330702A DE2330702A DE2330702C2 DE 2330702 C2 DE2330702 C2 DE 2330702C2 DE 2330702 A DE2330702 A DE 2330702A DE 2330702 A DE2330702 A DE 2330702A DE 2330702 C2 DE2330702 C2 DE 2330702C2
Authority
DE
Germany
Prior art keywords
protein
substrate
antigen
layer
metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2330702A
Other languages
German (de)
English (en)
Other versions
DE2330702A1 (de
Inventor
Ivar Schenectady N.Y. Giaever
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of DE2330702A1 publication Critical patent/DE2330702A1/de
Application granted granted Critical
Publication of DE2330702C2 publication Critical patent/DE2330702C2/de
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/263—Coating layer not in excess of 5 mils thick or equivalent
    • Y10T428/264—Up to 3 mils
    • Y10T428/265—1 mil or less

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE2330702A 1972-06-26 1973-06-16 Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe und Vorrichtung zur Durchführung des Verfahrens Expired DE2330702C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26627872A 1972-06-26 1972-06-26

Publications (2)

Publication Number Publication Date
DE2330702A1 DE2330702A1 (de) 1974-01-10
DE2330702C2 true DE2330702C2 (de) 1985-11-28

Family

ID=23013914

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2330702A Expired DE2330702C2 (de) 1972-06-26 1973-06-16 Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe und Vorrichtung zur Durchführung des Verfahrens
DE2366615A Expired DE2366615C2 (de) 1972-06-26 1973-06-16 Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologishen Probe und Vorrichtung zur Durchführung des Verfahrens

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2366615A Expired DE2366615C2 (de) 1972-06-26 1973-06-16 Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologishen Probe und Vorrichtung zur Durchführung des Verfahrens

Country Status (8)

Country Link
US (1) US4172827A (sv)
JP (2) JPS5938543B2 (sv)
CA (1) CA1025772A (sv)
DE (2) DE2330702C2 (sv)
FR (1) FR2191744A5 (sv)
GB (1) GB1443181A (sv)
IT (1) IT990685B (sv)
SE (2) SE459455B (sv)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1047918A (en) * 1973-07-30 1979-02-06 General Electric Company Method and apparatus for detection and purification of proteins and antibodies
US3904367A (en) * 1973-08-15 1975-09-09 Gen Electric Contrast enhancement for immunological film detection
SE387746B (sv) * 1974-05-29 1976-09-13 Pharmacia Diagnostics Ab Forfarande for visuellt pavisande av antikroppar i ett vattenhaltigt prov
US3979509A (en) * 1974-09-03 1976-09-07 General Electric Company Opaque layer method for detecting biological particles
US4041146A (en) * 1975-05-01 1977-08-09 General Electric Company Method for detection of biological particles
US3979184A (en) * 1975-05-27 1976-09-07 General Electric Company Diagnostic device for visually detecting presence of biological particles
GB1555142A (en) * 1975-08-14 1979-11-07 Sinai School Medicine Blood cell typing and compatibility test procedure
JPS5238789A (en) * 1975-08-14 1977-03-25 Sinai School Medicine Method of identifying hematocyte type and adaptability
DE2638251A1 (de) * 1975-08-27 1977-06-08 Gen Electric Verfahren und vorrichtung zum konzentrieren und reinigen von antigenen und antikoerpern
DE2638250C2 (de) * 1975-08-27 1985-11-28 General Electric Co., Schenectady, N.Y. Diagnostisches Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe, sowie Vorrichtung zur Durchführung des Verfahrens
US4090849A (en) * 1976-12-20 1978-05-23 General Electric Company Diagnostic device and manufacture thereof
US4066646A (en) * 1976-12-23 1978-01-03 General Electric Company Diagnostic device and housing therefor
SE7811630L (sv) * 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4280815A (en) * 1979-06-18 1981-07-28 Technicon Instruments Corporation Electrochemiluminescent immunoassay and apparatus therefor
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
DE3176524D1 (en) * 1981-06-22 1987-12-17 Battelle Memorial Institute A method for determining bioactive substances
US4414197A (en) * 1982-03-19 1983-11-08 Ortho Diagnostic Systems Inc. Method for preparing permanent slides of rare sorted cells
US4489133A (en) * 1982-11-16 1984-12-18 The Board Of Trustees Of The Leland Stanford Jr. University Two-dimensional crystallization technique
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
DE3506703C1 (de) * 1985-02-26 1986-04-30 Sagax Instrument AB, Sundbyberg Verfahren zur Sequenzanalyse von Nucleinsaeuren,insbesondere der Desoxyribonucleinsaeure (DNA) und der Ribonucleinsaeure (RNA),sowie Traeger zur Durchfuehrung des Verfahrens und Verfahren zur Herstellung des Traegers
US4634599A (en) * 1985-05-02 1987-01-06 General Electric Company Method for making ordered monolayers of macromolecules
US4668584A (en) * 1985-12-23 1987-05-26 General Electric Company Method for forming 2-D crystals of proteins and macromolecules
US5482830A (en) * 1986-02-25 1996-01-09 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5468606A (en) * 1989-09-18 1995-11-21 Biostar, Inc. Devices for detection of an analyte based upon light interference
US5089387A (en) * 1988-07-07 1992-02-18 Adeza Biomedical Corporation Dna probe diffraction assay and reagents
CA1337173C (en) * 1989-04-28 1995-10-03 Westaim Biomedical Corp. Thin film diagnostic device
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US5639671A (en) * 1989-09-18 1997-06-17 Biostar, Inc. Methods for optimizing of an optical assay device
EP0546222B1 (en) * 1991-10-01 1997-09-10 Biostar, Inc. Highly sensitive optical immunoassay using enzyme-labeled reagents
US5955377A (en) * 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
US5550063A (en) * 1991-02-11 1996-08-27 Biostar, Inc. Methods for production of an optical assay device
US5418136A (en) * 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
US5494829A (en) * 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5552272A (en) * 1993-06-10 1996-09-03 Biostar, Inc. Detection of an analyte by fluorescence using a thin film optical device
US5413939A (en) * 1993-06-29 1995-05-09 First Medical, Inc. Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
US5679579A (en) * 1996-01-29 1997-10-21 First Medical, Inc. Immunofluorescence measurement of analytes bound to a substrate and apparatus therefor
DE19629243A1 (de) * 1996-07-19 1998-01-29 Udo Dr Ris Verfahren zur quantitativen und/oder qualitativen Bestimmung von Atomen oder Molekülen
DE19631413A1 (de) * 1996-08-05 1998-02-12 Stefan Prof Dr Seeger Verfahren und Vorrichtung zur Präparierung von Molekülen und Partikeln
WO2019104438A1 (en) * 2017-12-01 2019-06-06 Valorisation-Recherche, Limited Partnership Coated glass slide for enhanced thin tissue section adhesion
CN109540829A (zh) * 2018-12-12 2019-03-29 暨南大学 一种红外光谱检测技术用于克罗恩病鉴别诊断的制样方法

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US2666355A (en) * 1951-10-12 1954-01-19 Hans J Trurnit Method of studying chemical reactions by measuring interfacial film thicknesses
US3236732A (en) * 1962-01-22 1966-02-22 Edward R Arquilla Pregnancy test method and immunological indicator therefor
US3171783A (en) * 1962-08-15 1965-03-02 Hyland Lab Diagnostic procedure
US3313706A (en) * 1965-06-08 1967-04-11 Johnson & Johnson Diagnostic antigen for viral hepatitis
GB1179435A (en) * 1966-06-17 1970-01-28 Ortho Pharma Corp Stable Reagent for the Detection of Rheumatoid Arthritis
US3492396A (en) * 1967-03-13 1970-01-27 Becton Dickinson Co Agglutinate separation method and apparatus
AT279804B (de) 1967-08-22 1970-03-25 Barbara Dr Polheim Verfahren zur Isolierung von Antigenen und Antikörpern
US3639558A (en) * 1968-02-19 1972-02-01 Louis Csizmas Immunological reagent particles having proteinaceous materials covalently bonded thereto
US3646346A (en) * 1968-12-26 1972-02-29 Pharmacia Ab Antibody-coated tube system for radioimmunoassay
US3697645A (en) * 1971-04-28 1972-10-10 Us Army Purification of antibodies

Also Published As

Publication number Publication date
SE440657B (sv) 1985-08-12
US4172827A (en) 1979-10-30
DE2366615C2 (de) 1986-10-23
IT990685B (it) 1975-07-10
FR2191744A5 (sv) 1974-02-01
SE7610478L (sv) 1976-09-21
SE459455B (sv) 1989-07-03
CA1025772A (en) 1978-02-07
JPS5938543B2 (ja) 1984-09-18
JPS5798216A (en) 1982-06-18
JPS4948820A (sv) 1974-05-11
DE2330702A1 (de) 1974-01-10
GB1443181A (en) 1976-07-21
JPS628149B2 (sv) 1987-02-20

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