DE2324239C3 - Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden - Google Patents

Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden

Info

Publication number
DE2324239C3
DE2324239C3 DE2324239A DE2324239A DE2324239C3 DE 2324239 C3 DE2324239 C3 DE 2324239C3 DE 2324239 A DE2324239 A DE 2324239A DE 2324239 A DE2324239 A DE 2324239A DE 2324239 C3 DE2324239 C3 DE 2324239C3
Authority
DE
Germany
Prior art keywords
otbu
glu
mmol
ala
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2324239A
Other languages
German (de)
English (en)
Other versions
DE2324239A1 (de
DE2324239B2 (de
Inventor
Sandor Dipl.-Chem. Dr. Bajusz
Rozsa Dipl.-Chem. Beke
Laszlo Dipl.- Chem.Ing.Dr. Graf
Attila Dipl.-Chem.Ing. Juhasz
Lajos Dipl.-Chem.Ing. Dr. Kisfaludy
Miklos Dipl.-Chem. Loew
Kalman Dipl.-Chem.Dr. Medzihradszky
Istvan Dipl.-Chem. Schoen
Maria Dipl.- Chem. Sz.Sarkoezi
Tamas Dipl.-Chem. Szirtes
Laszlo Dr. Szporny
Andras Dipl.-Chem.Ing. Turan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of DE2324239A1 publication Critical patent/DE2324239A1/de
Publication of DE2324239B2 publication Critical patent/DE2324239B2/de
Application granted granted Critical
Publication of DE2324239C3 publication Critical patent/DE2324239C3/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/066General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695Corticotropin [ACTH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
DE2324239A 1972-05-15 1973-05-14 Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden Expired DE2324239C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI465A HU166913B (US07608600-20091027-C00054.png) 1972-05-15 1972-05-15

Publications (3)

Publication Number Publication Date
DE2324239A1 DE2324239A1 (de) 1973-12-06
DE2324239B2 DE2324239B2 (de) 1974-10-10
DE2324239C3 true DE2324239C3 (de) 1975-05-28

Family

ID=11000888

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2324239A Expired DE2324239C3 (de) 1972-05-15 1973-05-14 Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden

Country Status (26)

Country Link
US (1) US3953415A (US07608600-20091027-C00054.png)
JP (1) JPS5516417B2 (US07608600-20091027-C00054.png)
AT (1) AT351683B (US07608600-20091027-C00054.png)
BE (1) BE799552A (US07608600-20091027-C00054.png)
BG (1) BG20341A3 (US07608600-20091027-C00054.png)
CA (1) CA1027111A (US07608600-20091027-C00054.png)
CH (1) CH580064A5 (US07608600-20091027-C00054.png)
CS (1) CS173632B2 (US07608600-20091027-C00054.png)
DD (1) DD105603A5 (US07608600-20091027-C00054.png)
DE (1) DE2324239C3 (US07608600-20091027-C00054.png)
DK (1) DK147944C (US07608600-20091027-C00054.png)
EG (1) EG11309A (US07608600-20091027-C00054.png)
ES (1) ES414589A1 (US07608600-20091027-C00054.png)
FI (1) FI56830C (US07608600-20091027-C00054.png)
FR (1) FR2184814B1 (US07608600-20091027-C00054.png)
GB (1) GB1429251A (US07608600-20091027-C00054.png)
HU (1) HU166913B (US07608600-20091027-C00054.png)
IL (1) IL42108A (US07608600-20091027-C00054.png)
NL (1) NL176946C (US07608600-20091027-C00054.png)
NO (1) NO139268C (US07608600-20091027-C00054.png)
PL (1) PL91030B1 (US07608600-20091027-C00054.png)
RO (1) RO72336A (US07608600-20091027-C00054.png)
SE (1) SE421790B (US07608600-20091027-C00054.png)
SU (1) SU505352A3 (US07608600-20091027-C00054.png)
YU (1) YU36689B (US07608600-20091027-C00054.png)
ZA (1) ZA733242B (US07608600-20091027-C00054.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296427A1 (fr) * 1974-12-31 1976-07-30 Choay Sa Agent peptidique de regulation de la glycemie
CA1315229C (en) * 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
US6031074A (en) * 1989-08-25 2000-02-29 National Institutes Of Health Automated Peptide design and synthesis
JP2593495Y2 (ja) * 1991-05-31 1999-04-12 矢崎総業株式会社 高圧抵抗電線の端部構造
SE520392C2 (sv) * 1996-09-27 2003-07-01 Creative Peptides Sweden Ab C Specifika peptider för behandling av diabetes mellitus
DE10054687A1 (de) * 2000-11-03 2002-05-16 N Zyme Biotec Gmbh Inhibitoren von Transglutaminasen
WO2022217395A1 (zh) 2021-04-12 2022-10-20 南京汉欣医药科技有限公司 一种高纯的人促肾上腺皮质激素或其类似物及其规模化制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6509727A (US07608600-20091027-C00054.png) * 1965-07-28 1967-01-30
NL6611701A (US07608600-20091027-C00054.png) * 1965-08-24 1967-02-27

Also Published As

Publication number Publication date
YU127373A (en) 1982-02-25
DE2324239A1 (de) 1973-12-06
CS173632B2 (US07608600-20091027-C00054.png) 1977-02-28
FI56830C (fi) 1980-04-10
RO72336A (ro) 1982-02-26
PL91030B1 (US07608600-20091027-C00054.png) 1977-02-28
JPS5516417B2 (US07608600-20091027-C00054.png) 1980-05-01
NL176946B (nl) 1985-02-01
ES414589A1 (es) 1976-02-01
ZA733242B (en) 1974-04-24
IL42108A (en) 1975-12-31
NO139268B (no) 1978-10-23
FI56830B (fi) 1979-12-31
CA1027111A (en) 1978-02-28
US3953415A (en) 1976-04-27
DK147944C (da) 1985-08-26
AU5457673A (en) 1974-10-17
NL7306764A (US07608600-20091027-C00054.png) 1973-11-19
ATA306973A (de) 1979-01-15
DE2324239B2 (de) 1974-10-10
DK147944B (da) 1985-01-14
BE799552A (fr) 1973-08-31
FR2184814A1 (US07608600-20091027-C00054.png) 1973-12-28
SE421790B (sv) 1982-02-01
HU166913B (US07608600-20091027-C00054.png) 1975-06-28
AT351683B (de) 1979-08-10
NL176946C (nl) 1985-07-01
NO139268C (no) 1979-01-31
SU505352A3 (ru) 1976-02-28
FR2184814B1 (US07608600-20091027-C00054.png) 1977-04-22
YU36689B (en) 1984-08-31
IL42108A0 (en) 1973-06-29
EG11309A (en) 1978-03-29
JPS49100031A (US07608600-20091027-C00054.png) 1974-09-20
CH580064A5 (US07608600-20091027-C00054.png) 1976-09-30
BG20341A3 (US07608600-20091027-C00054.png) 1975-11-05
GB1429251A (en) 1976-03-24
DD105603A5 (US07608600-20091027-C00054.png) 1974-05-05

Similar Documents

Publication Publication Date Title
DE2858718C2 (US07608600-20091027-C00054.png)
DE2324239C3 (de) Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden
DE2463205C2 (de) Octapeptid und Verfahren zu dessen Herstellung
CH570972A5 (en) Decapeptide
DE2731308A1 (de) Psychopharmakologisch wirksame peptide und peptidderivate und verfahren zu deren herstellung
DE1518097B1 (de) Verfahren zur Herstellung von Polypeptiden
DE3340208A1 (de) Neue biologisch aktive peptide, verfahren zu deren herstellung und veterinaerpraeparate, welche diese enthalten
DE1643496C3 (de) Verfahren zur Herstellung von menschlichem Corticotropin bzw. analoger Verbindungen
DE3886656T2 (de) Lösungssynthese eines Oktapeptids.
DE2311786C2 (de) Verfahren zur Herstellung von Peptiden
DE2460469A1 (de) Neue peptide mit biologischer wirkung und verfahren zu ihrer herstellung
DE2341775B2 (de) In Nterminaler Stellung den Rest einer Aminooxysäure aufweisende Peptide mit ACTH-Wirkung, Verfahren zu ihrer Herstellung sowie diese Peptide enthaltende Arzneimittel
DE1941511C2 (de) Calcitonin-Analoga und ihre α-Desamino- und N↑α↑-Acylaminoderivate, diese Peptide enthaltende pharmazeutische Präparate, und synthetische Verfahren zu ihrer Herstellung sowie zur Herstellung von Calcitonin M
DE2754770C2 (de) N-Acyltetrapeptidamide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3886655T2 (de) Verfahren zur Herstellung eines Oktapeptids.
DE3312399A1 (de) Biologisch aktive peptide und arzneimittel, welche diese enthalten
DE1493559C3 (de) Neue Peptide mit adrenocorticotroper Wirkung und Verfahren zu ihrer Herstellung
DE2727048C2 (de) 8-Norleucyl-ceruletide
DE1800129C3 (de) Biologisch aktive Polypeptide und Verfahren zu ihrer Herstellung
US4407745A (en) Heptacosapeptide
AT300207B (de) Verfahren zur Herstellung neuer hypocalcämischer Peptide
DE1768814A1 (de) Neue Peptide mit ACTH-Wirkung und Verfahren zu ihrer Herstellung
DE1543485A1 (de) Neue Peptide mit ACTH-Wirkung
DE1800129B2 (de) Biologisch aktive Polypeptide und Verfahren zu ihrer Herstellung
DE1493559B2 (de) Neue peptide mit adrenocorticotroper wirkung und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977