DE2314478C3 - 3-Substituierte Rifamycin-SV-derivate, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält - Google Patents

3-Substituierte Rifamycin-SV-derivate, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält

Info

Publication number
DE2314478C3
DE2314478C3 DE2314478A DE2314478A DE2314478C3 DE 2314478 C3 DE2314478 C3 DE 2314478C3 DE 2314478 A DE2314478 A DE 2314478A DE 2314478 A DE2314478 A DE 2314478A DE 2314478 C3 DE2314478 C3 DE 2314478C3
Authority
DE
Germany
Prior art keywords
rna
compounds
virus
cells
viruses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2314478A
Other languages
German (de)
English (en)
Other versions
DE2314478A1 (de
DE2314478B2 (de
Inventor
Renato Varese Chricchio
Giancarlo Pavia Lancini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of DE2314478A1 publication Critical patent/DE2314478A1/de
Publication of DE2314478B2 publication Critical patent/DE2314478B2/de
Application granted granted Critical
Publication of DE2314478C3 publication Critical patent/DE2314478C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2314478A 1972-03-27 1973-03-23 3-Substituierte Rifamycin-SV-derivate, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält Expired DE2314478C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2242172 1972-03-27

Publications (3)

Publication Number Publication Date
DE2314478A1 DE2314478A1 (de) 1973-10-04
DE2314478B2 DE2314478B2 (de) 1980-04-30
DE2314478C3 true DE2314478C3 (de) 1981-01-08

Family

ID=11196065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2314478A Expired DE2314478C3 (de) 1972-03-27 1973-03-23 3-Substituierte Rifamycin-SV-derivate, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält

Country Status (24)

Country Link
US (1) US3865812A (OSRAM)
JP (1) JPS5142120B2 (OSRAM)
AR (3) AR205434A1 (OSRAM)
AT (1) AT322106B (OSRAM)
AU (1) AU467606B2 (OSRAM)
BE (1) BE797344A (OSRAM)
CA (1) CA999858A (OSRAM)
CH (1) CH567511A5 (OSRAM)
CS (1) CS168642B2 (OSRAM)
DD (1) DD104517A5 (OSRAM)
DE (1) DE2314478C3 (OSRAM)
ES (1) ES413043A1 (OSRAM)
FR (1) FR2182906B1 (OSRAM)
GB (1) GB1388652A (OSRAM)
HU (1) HU167316B (OSRAM)
IE (1) IE37817B1 (OSRAM)
IL (1) IL41532A0 (OSRAM)
LU (1) LU67287A1 (OSRAM)
NL (1) NL171360C (OSRAM)
PL (1) PL89269B1 (OSRAM)
RO (1) RO62882A (OSRAM)
SE (1) SE381257B (OSRAM)
SU (1) SU497777A3 (OSRAM)
ZA (1) ZA73939B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1053787B (it) * 1974-10-29 1981-10-10 Pastori A Macrolidi azotati e loro preparazione
GB1478563A (en) * 1975-03-05 1977-07-06 Lepetit Spa Rifamycin derivatives
DE2728869A1 (de) * 1976-06-25 1977-12-29 Antibiotice Iasi Intreprindere Rifamycinen und verfahren zu deren herstellung
US4179439A (en) * 1977-07-01 1979-12-18 Intreprinderea De Antibiotice Iasi Rifamycins and method for their preparation
JPS6025436B2 (ja) * 1977-07-15 1985-06-18 イントレプリンデレア・デ・アンテイビオテイスイアシ 水溶性リフアマイシン
JPS5419997A (en) * 1977-07-15 1979-02-15 Intorepurinderea De Anteibiote 33formylrifamycin sv derivative
DE2918140C2 (de) * 1979-05-05 1985-02-07 Fresenius AG, 6380 Bad Homburg Dialysator
AU536524B2 (en) * 1979-06-28 1984-05-10 Gruppo Lepetit S.P.A. Water soluble hydrozones of 3-formylifamyan
US4447432A (en) * 1981-11-17 1984-05-08 Farmitalia Carlo Erba S.P.A. Azino rifamycins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH489521A (fr) * 1964-07-31 1970-04-30 Lepetit Spa Procédé de préparation d'un dérivé de la rifamycine SV
FR208F (OSRAM) * 1964-07-31

Also Published As

Publication number Publication date
AU5342973A (en) 1974-09-19
GB1388652A (en) 1975-03-26
BE797344A (fr) 1973-07-16
AR203839A1 (es) 1975-10-31
CA999858A (en) 1976-11-16
CH567511A5 (OSRAM) 1975-10-15
SE381257B (sv) 1975-12-01
HU167316B (OSRAM) 1975-09-27
DE2314478A1 (de) 1973-10-04
DE2314478B2 (de) 1980-04-30
RO62882A (fr) 1977-11-15
IE37817L (en) 1973-09-27
NL171360C (nl) 1983-03-16
DD104517A5 (OSRAM) 1974-03-12
IE37817B1 (en) 1977-10-26
AT322106B (de) 1975-05-12
ZA73939B (en) 1973-11-28
SU497777A3 (ru) 1975-12-30
ATA266074A (de) 1975-06-15
JPS495998A (OSRAM) 1974-01-19
FR2182906A1 (OSRAM) 1973-12-14
AR205434A1 (es) 1976-05-07
JPS5142120B2 (OSRAM) 1976-11-13
AU467606B2 (en) 1975-12-04
FR2182906B1 (OSRAM) 1975-10-31
AR199720A1 (es) 1974-09-23
ES413043A1 (es) 1976-01-16
US3865812A (en) 1975-02-11
IL41532A0 (en) 1973-04-30
CS168642B2 (OSRAM) 1976-06-29
NL7304085A (OSRAM) 1973-10-01
NL171360B (nl) 1982-10-18
LU67287A1 (OSRAM) 1973-07-13
PL89269B1 (OSRAM) 1976-11-30

Similar Documents

Publication Publication Date Title
DE3789561T2 (de) Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern.
DE69409107T2 (de) Reagenz zum gebrauch in biolumineszenz
DE3854297T2 (de) Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
DE69911935T2 (de) Granulatimide-derivate zur behandlung von krebs
CH630957A5 (de) Verfahren zur herstellung von neuen antibiotischen verbindungen auf basis eines bohemsaeurekomplexes.
DE2314478B2 (de) 3-Substituierte Rifamycin-SV-derivate, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält
DE69126038T2 (de) Diagnose von krebs-metastasen durch das mts-1 gen
DE2521197A1 (de) Neues antibiotikum
US4264729A (en) Method and reagent for detecting cancerigenic and anticancerous substances
DE2029768C2 (de) Antitumorverbindung 593A, Verfahren zu ihrer Herstellung und Arzneimittel
DE2302567C3 (de) 3-Substituierte Rifamycine, Verfahren zu ihrer Herstellung und therapeutische Zubereitung, die diese Verbindungen enthält
DE2301766C3 (de) 3-substituierte Rifamycine, Verfahren zu ihrer Herstellung und therapeutische Zubereitungen, die diese Verbindungen enthalten
EP0131942A1 (de) Anthracyclin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Cytostatika
DE3782169T2 (de) Verfahren zur herstellung von antibiotica 10381b.
DE2227173C2 (OSRAM)
DE2314518A1 (de) Pyrono-rifamycine und verfahren zu ihrer herstellung
EP0173950A2 (de) Neuer alpha-Glukosidase Inhibitor, Verfahren zur seiner Herstellung, seine Verwendung und pharmazeutische Präparate
DE2326698A1 (de) 3-formylrifamycinazine
DE2326916C2 (de) Anhydro-4-carbamoyl-5-hydroxy-1-ribofuranosylimidazoliumhydroxyd
EP0257418B1 (de) Oxiran-Pseudooligosaccharide, Verfahren zu deren Herstellung, deren Verwendung und pharmazeutische Präparate
US3933800A (en) New 3-formylrifamycin SV derivatives
EP0173948A2 (de) Neue Pseudooligosaccharide mit alpha-Glukosidase-hemmender Wirkung, Verfahren zur deren Herstellung, deren Verwendung und pharmazeutische Präparate
EP0167954A2 (de) 1-Hydroxy-Cytorhodine, ein mikrobiologisches Verfahren zu ihrer Herstellung und ihre Verwendung als Cytostatika
DE1620473B2 (de) Verfahren zur Herstellung von l-Nitro-9-(3'-dimethylaminopropylamino)-acridin-dihydrochlorid
DE69720101T2 (de) Makrolid Verbindung 0406

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee