DE2256574A1 - Insulinderivate - Google Patents
InsulinderivateInfo
- Publication number
- DE2256574A1 DE2256574A1 DE2256574A DE2256574A DE2256574A1 DE 2256574 A1 DE2256574 A1 DE 2256574A1 DE 2256574 A DE2256574 A DE 2256574A DE 2256574 A DE2256574 A DE 2256574A DE 2256574 A1 DE2256574 A1 DE 2256574A1
- Authority
- DE
- Germany
- Prior art keywords
- insulin
- radical
- substituted
- tetra
- tri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 82
- 102000004877 Insulin Human genes 0.000 claims description 39
- 108090001061 Insulin Proteins 0.000 claims description 39
- 229940125396 insulin Drugs 0.000 claims description 33
- 239000004026 insulin derivative Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 18
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- -1 alkali metal cyanate Chemical class 0.000 claims description 8
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 5
- 230000010933 acylation Effects 0.000 claims description 5
- 238000005917 acylation reaction Methods 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 5
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- 239000001257 hydrogen Substances 0.000 claims description 3
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000012948 isocyanate Substances 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
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- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5362371 | 1971-11-18 | ||
| GB5362271A GB1408757A (en) | 1971-11-18 | 1971-11-18 | Insulin derivatives 35and hydrocarbons including normal paraffins a gasoline product of higher octane number than said gasoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2256574A1 true DE2256574A1 (de) | 1973-05-30 |
Family
ID=26267305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2256574A Pending DE2256574A1 (de) | 1971-11-18 | 1972-11-17 | Insulinderivate |
Country Status (11)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2141679A (en) * | 1983-04-23 | 1985-01-03 | William Brydson | Motor vehicle turntable |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE36225B1 (en) * | 1971-01-28 | 1976-09-15 | Nat Res Dev | Improvements relating to insulin derivatives |
-
0
- BE BE791585D patent/BE791585A/xx unknown
-
1971
- 1971-11-18 GB GB5362271A patent/GB1408757A/en not_active Expired
-
1972
- 1972-11-10 IE IE1539/72A patent/IE37131B1/xx unknown
- 1972-11-15 AU AU48872/72A patent/AU475066B2/en not_active Expired
- 1972-11-17 NL NL7215599A patent/NL7215599A/xx unknown
- 1972-11-17 CH CH1677972A patent/CH564519A5/xx not_active IP Right Cessation
- 1972-11-17 SE SE7215023A patent/SE396947B/xx unknown
- 1972-11-17 JP JP47115486A patent/JPS4861493A/ja active Pending
- 1972-11-17 DE DE2256574A patent/DE2256574A1/de active Pending
- 1972-11-17 CH CH1677774A patent/CH574393A5/xx not_active IP Right Cessation
- 1972-11-17 CA CA156,852A patent/CA1002517A/en not_active Expired
- 1972-11-17 FR FR7240950A patent/FR2160619B1/fr not_active Expired
-
1975
- 1975-10-17 SE SE7511703A patent/SE7511703L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2160619B1 (enrdf_load_stackoverflow) | 1977-04-15 |
| IE37131L (en) | 1973-05-18 |
| JPS4861493A (enrdf_load_stackoverflow) | 1973-08-28 |
| IE37131B1 (en) | 1977-05-11 |
| BE791585A (fr) | 1973-05-17 |
| SE7511703L (sv) | 1975-10-17 |
| SE396947B (sv) | 1977-10-10 |
| GB1408757A (en) | 1975-10-01 |
| CA1002517A (en) | 1976-12-28 |
| NL7215599A (enrdf_load_stackoverflow) | 1973-05-22 |
| AU4887272A (en) | 1974-05-16 |
| CH574393A5 (enrdf_load_stackoverflow) | 1976-04-15 |
| AU475066B2 (en) | 1976-08-12 |
| FR2160619A1 (enrdf_load_stackoverflow) | 1973-06-29 |
| CH564519A5 (enrdf_load_stackoverflow) | 1975-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |